Article
Plant Sciences
Vijakhana Pilaisangsuree, Kanitha Supdensong, Pimpimon Lumpa, Jintana Pankam, Apinun Limmongkon
Summary: Pre-treatment with methyl jasmonate and methyl-beta-cyclodextrin followed by cadmium induced the highest ferric reducing antioxidant power in peanut hairy root culture. Crude extracts showed DNA-protective activity at low concentrations, but exhibited pro-oxidant activity at higher concentrations. The bioactive compounds in hairy root extracts have the potential to serve as health-promoting or cancer chemotherapeutic agents, with both antioxidant and pro-oxidant activities in a concentration-dependent manner.
ACTA PHYSIOLOGIAE PLANTARUM
(2021)
Article
Chemistry, Physical
Kamila Gryko, Monika Kalinowska, Piotr Ofman, Renata Choinska, Grzegorz Swiderski, Renata Swislocka, Wlodzimierz Lewandowski
Summary: The research studied the structural, antioxidant properties, and biodegradability of several acids using various experimental methods, as well as their impact on the environment. The results indicate that these acids exhibit antioxidant properties and can influence transformation processes in biological wastewater treatment.
Article
Polymer Science
Veronika Gajdosova, Miroslav Slouf, Danuse Michalkova, Jiri Dybal, Jan Pila
Summary: The study investigated the accelerated photooxidation aging of polymer plaques made of high-density polyethylene and cycloolefin copolymer, and found that the natural phenolic stabilizer CAT exhibited pro-oxidant activity during the aging process, leading to higher concentration of oxidation products and changes in local mechanical properties.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Chemistry, Physical
Monika Kalinowska, Kamila Gryko, Ewelina Golebiewska, Grzegorz Swiderski, Hanna Lewandowska, Marek Pruszynski, Malgorzata Zawadzka, Maciej Kozlowski, Justyna Sienkiewicz-Gromiuk, Wlodzimierz Lewandowski
Summary: This study synthesized complexes of chlorogenic acid (5-CQA) with copper(II) and iron(III) and analyzed their properties using various methods. The results showed the possible coordination of the complexes through the carboxylate group and the hydroxyl group from the catechol moiety. The complexes exhibited lower antioxidant properties in aqueous solution compared to 5-CQA alone, but showed higher antioxidant activity in the lipid peroxidation inhibition assay. Cu(II) 5-CQA exhibited the highest pro-oxidant activity among the studied compounds. The complexes were not toxic to HaCaT cells within the tested concentration range.
Article
Pharmacology & Pharmacy
Raquel Bridi, Javier Echeverria, Arturo Larena, Paula Nunez Pizarro, Elias Atala, Adriano Costa De Camargo, Won Young Oh, Fereidoon Shahidi, Olga Garcia, Kong S. Ah-Hen, Gloria Montenegro
Summary: Honeybee pollen from the Southern region of Chile is a rich source of phenolic antioxidants that can protect DNA from damage, potentially contributing to the prevention of gastric and/or intestinal cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Jakub Frankowski, Anna Przybylska-Balcerek, Kinga Stuper-Szablewska
Summary: The study revealed that sorghum grains are rich in antioxidant compounds and nutrients, making them a potential functional food source.
Review
Biochemistry & Molecular Biology
Amanda Shen-Yee Kong, Sathiya Maran, Polly Soo-Xi Yap, Swee-Hua Erin Lim, Shun-Kai Yang, Wan-Hee Cheng, Yong-Hui Tan, Kok-Song Lai
Summary: The rapid evolution of antimicrobial resistance is a major public health issue, and natural products such as plant extracts and essential oils have the potential to combat this issue due to their complex chemistry. The pro-oxidant and antioxidant activities in essential oils represent a promising strategy to tackle antimicrobial resistance.
Article
Biochemistry & Molecular Biology
Michal Nowak, Wieslaw Tryniszewski, Agata Sarniak, Anna Wlodarczyk, Piotr J. Nowak, Dariusz Nowak
Summary: This study investigated the effects of 17 phenolic compounds on ultra-weak photon emission from a modified Fenton system. Eight compounds showed inhibition effects, while five compounds enhanced the emission. The activity of four compounds changed with increasing concentrations. Three of the most active compounds contained structures associated with scavenging hydroxyl radicals and regenerating Fe2+.
Article
Ophthalmology
Hassan Boskabadi, Maryam Marefat, Gholamali Maamouri, Majid Abrishami, Mojtaba Abrishami, Nasser Shoeibi, Mostafa Soltan Sanjari, Majid Ghayour Mobarhan, Seyed Reza Habibzadeh Shojaei, Shima Tavallaei, Fathemeh Sanei, Mahsa Kakavandi, Ali Moradi, Maryam Zakerihamidi
Summary: This study aimed to evaluate the role of oxidative stress and peroxidant antioxidant balance (PAB) in the pathogenesis and prediction of Retinopathy of Prematurity (RoP). The results showed that PAB level could be helpful in predicting the incidence of RoP, with increasing PAB associated with increased severity of RoP.
Article
Multidisciplinary Sciences
Kavita Pal, Gorantla Raghuram, Jenevieve Dsouza, Sushma Shinde, Vishalkumar Jadhav, Alfina Shaikh, Bhagyeshri Rane, Harshali Tandel, Dipali Kondhalkar, Shahid Chaudhary, Indraneel Mittra
Summary: Cell-free chromatin particles (cfChPs) may act as instigators of aging and neurodegeneration, and the therapeutic use of resveratrol and copper mixture (R-Cu) may help to delay the aging process.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Josiane Marcia Maria Canaan, Giovana Sant'Ana Pegorin Brasil, Natan Roberto de Barros, Cassamo Ussemane Mussagy, Nayrim Brizuela Guerra, Rondinelli Donizetti Herculano
Summary: This study evaluated the composition, safety, and antioxidant activity of soybean processing wastes (okara and okara flour) and soymilk, finding them to be rich in nutrients, safe for consumption, and possessing high antioxidant properties. These waste products have the potential to generate high value added products due to their bioactive compounds.
Article
Multidisciplinary Sciences
Anshul Agarwal, Aakanksha Khandelwal, Kavita Pal, Naveen Kumar Khare, Vishal Jadhav, Murarilal Gurjar, Sachin Punatar, Anant Gokarn, Avinash Bonda, Lingaraj Nayak, Sadhana Kannan, Vikram Gota, Navin Khattry, Indraneel Mittra
Summary: A combination of resveratrol and copper reduced transplant-related toxicities in patients with multiple myeloma. This suggests that relatively inexpensive nutraceuticals may be useful as adjuncts to chemotherapy to reduce its toxicity.
Article
Biochemistry & Molecular Biology
Raffaella Marina Lecci, Isabella D'Antuono, Angela Cardinali, Antonella Garbetta, Vito Linsalata, Antonio F. Logrieco, Antonella Leone
Summary: This study aimed to evaluate the antioxidant, pro-oxidant, and photoprotective effects of ultra-filtered (UF) olive mill wastewater (OMWW) fractions, as well as their underlying action mechanisms, to substantiate their potential use as natural cosmeceutical ingredients.
Review
Biochemistry & Molecular Biology
Agnieszka Wolnicka-Glubisz, Anna Wisniewska-Becker
Summary: Curcumin, a natural polyphenol with antioxidant properties, can have therapeutic effects on different disorders. However, it can also be toxic under certain conditions, such as exposure to blue light or excessive use.
Article
Medicine, General & Internal
Hassan Boskabadi, Majid Ghayour-Mobarhan, Amin Saeidinia
Summary: This study compared the levels of serum pro-oxidant/antioxidant balance (PAB) in preterm versus term neonates and found that the PAB level was significantly lower in preterm neonates. Additionally, there was a significant negative correlation between PAB levels and gestational age.
Article
Biotechnology & Applied Microbiology
Yoshikazu Arai, Koji Hayakawa, Daisuke Arai, Rie Ito, Yusuke Iwasaki, Koichi Saito, Kazuhiko Akutsu, Satoshi Takatori, Rie Ishii, Rumiko Hayashi, Shun-Ichiro Izumi, Norihiro Sugino, Fumio Kondo, Masakazu Horie, Hiroyuki Nakazawa, Tsunehisa Makino, Mitsuko Hirosawa, Kunio Shiota, Jun Ohgane
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Food Science & Technology
Yusuke Iwasaki, Momoko Oda, Yuri Tsukuda, Yuki Nagamori, Hiroyuki Nakazawa, Rie Ito, Koichi Saito
FOOD HYGIENE AND SAFETY SCIENCE
(2014)
Article
Chemistry, Analytical
Yoshiyuki Kobayashi, Rie Ito, Koichi Saito
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2019)
Article
Chemistry, Analytical
Koichi Saito, Junki Ishii, Misaki Naniwa, Rie Ishii, Mihoko Kato, Takahide Kondo, Hikaru Sakurai, Masaru Taniguchi, Shigeki Hashiguchi, Takako Hayashi, Rie Ito
JOURNAL OF AOAC INTERNATIONAL
(2020)
Article
Chemistry, Medicinal
Koichi Saito, Nami Hagiwara, Miho Sakamoto, Daigo Wakana, Rie Ito, Tomoo Hosoe
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Chemistry, Analytical
Koichi Saito, Rieko Saito, Rie Ito
Summary: A simple and rapid analytical method for determining MA and MPD in urine was developed using LC/TOF-MS and SPDE, which could be applied in pharmacokinetic studies. The method showed good linearity, high recovery rates, and the ability to detect MPD metabolites. This study provides valuable insights into the pharmacokinetics of MPD.
FORENSIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Koichi Saito, Akihiro Sonoda, Rie Ito, Hiroshi Akiyama
Summary: This study developed a highly sensitive blood detection method using ultra-weak chemiluminescence (uwCL) measurement. The uwCL method was approximately 125 times more sensitive than the conventional luminol reaction method. The study also demonstrated the effectiveness of using a melamine sponge soaked in a sodium dodecyl sulfate solution for sampling evidence materials suspected of having traces of blood at appraisal sites.
ANALYTICAL SCIENCES
(2023)
Article
Chemistry, Analytical
Tomohide Fukiwake, Sachiyo Oosawa, Hiroki Yoshino, Tatsuya Shinozuka, Maki Nishimura, Rie Ito, Hiroshi Akiyama
Summary: The Public Health Center in Chiba Prefecture, Japan received a consultation from a resident who experienced health problems after consuming a diet jelly health food product. Analysis revealed the presence of sibutramine and phenolphthalein in the product, with the amount exceeding the recommended dose. The study suggests that ingestion of this jelly health food product may cause health problems.
ANALYTICAL SCIENCES
(2023)
Article
Food Science & Technology
Akira Torii, Yusuke Seki, Chisato Arimoto, Naomi Hojo, Ken Iijima, Kosuke Nakamura, Rie Ito, Hirohito Yamakawa, Hiroshi Akiyama
Summary: We developed a simple and reliable analytical method using LC-MS/MS to simultaneously detect walnut and almond in processed foods for allergen labelling. Specific target peptides from walnut and almond proteins were selected and had good linearity and recovery rates. This method is applicable to a wide variety of processed foods.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Food Science & Technology
Yusuke Iwasaki, Saki Yamada, Shinya Sakuma, Shunpei Kanba, Chinatsu Youda, Mizuki Ono, Rie Ito, Junzo Kamei, Hiroshi Akiyama
Summary: In this study, the optimal conditions for the extraction of multiple compounds from orange juice were determined using design of experiments and response surface methodology. The LC/MS/MS analysis method achieved specific detection and precise quantification. Most of the analytes were quantifiable in orange juice. The optimized method offered ease of operation, short extraction time, minimal residues, and reliability.
Article
Food Science & Technology
Hiroshi Akiyama, Aya Takagi, Koichi Inoue, Yoshinari Suzuki, Rie Ito, Nobuyuki Wakui, Mayumi Asai, Junkichi Sugiura
Summary: The symposium on risk communication regarding pesticide residues was evaluated, showing that the program effectively increased participants' understanding and interest. Pre-program risk perception and awareness of safety assessments were found to be significantly correlated with post-program risk perception.
FOOD HYGIENE AND SAFETY SCIENCE
(2021)
Article
Chemistry, Analytical
Koichi Saito, Mayuka Kogure, Akihiro Sonoda, Rie Ito
FORENSIC CHEMISTRY
(2020)
Article
Chemistry, Analytical
Koichi Saito, Yoshie Kokaji, Yuki Muranaka, Rie Ito
FORENSIC CHEMISTRY
(2020)
Article
Chemistry, Analytical
Koichi Saito, Satomi Kaneko, Yuka Furuya, Yumi Asada, Rie Ito, Ken-ichi Sugie, Mamoru Akutsu, Youichi Yanagawa
FORENSIC CHEMISTRY
(2019)
Article
Obstetrics & Gynecology
Ryo Maekawa, Rie Ito, Yusuke Iwasaki, Koichi Saito, Kazuhiko Akutsu, Satoshi Takatori, Rie Ishii, Fumio Kondo, Yoshikazu Arai, Jun Ohgane, Kunio Shiota, Tsunehisa Makino, Norihiro Sugino
REPRODUCTIVE MEDICINE AND BIOLOGY
(2017)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
