Article
Biochemistry & Molecular Biology
Rashid Alijani Ardeshir, Sara Rastgar, Amir Parviz Salati, Ebrahim Zabihi, Abdolali Movahedinia, Farideh Feizi
Summary: This study investigated the formation of melanomacrophage centers (MMCs) in goldfish exposed to nonylphenol (NP) and its relationship with sexual hormones, estrogen receptor expression, and pigment content. The results showed that NP affected the formation of MMCs and ER alpha gene expression in various organs of goldfish, and the pigment content and hormone levels were associated with NP dose and gender.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Dongling Liu, Qianhan Shi, Cuiqing Liu, Qinghua Sun, Xiang Zeng
Summary: Heavy metals play an important endocrine-disrupting role in health consequences, but the mechanisms behind this disruption are unclear. Animal models exposed to high doses of heavy metals may not provide relevant information for understanding human diseases. This review collects current knowledge on the endocrine-disrupting effects of heavy metals like lead, cadmium, arsenic, mercury, nickel, copper, zinc, and manganese. It also summarizes the potential molecular mechanisms of these endocrine-disrupting chemicals and their toxic effects on animals and humans.
Article
Environmental Sciences
Walaa Faiad, Chadi Soukkarieh, Abdulsamie Hanano
Summary: This study assessed the toxicity of TCDD on the male reproductive system in BALB/C mice. Direct exposure to TCDD led to testicular pathological symptoms and altered gene expression, while indirect exposure across generations resulted in reduced body and testis weight, decreased gene expression, testicular histopathology, declined serum testosterone, decreased male-to-female ratio, and decreased sperm count with increasing abnormalities.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Joanna Stragierowicz, Sylwia Stypula-Trebas, Lidia Radko, Andrzej Posyniak, Marzenna Nasiadek, Michal Klimczak, Anna Kilanowicz
Summary: The study found that 1,2,3,5,6,7-hexachloronaphthalane (PCN67) exhibited antiestrogenic activity, while both 1,3,5,8-tetrachloronaphthalene (PCN43) and PCN67 showed strong antiandrogenic effects. Exposure to PCNs, along with other endocrine disrupting chemicals, may contribute to the deregulation of sex steroid hormone signaling.
Article
Reproductive Biology
Anna Corry Gerald, Srividya Ganapathy, Jianmin Zhu, Yudan Wei
Summary: This cross-sectional study investigated the association between blood levels of endocrine-disrupting metals (cadmium, lead, and mercury) and serum estradiol levels in 1618 women. The results showed that increased levels of blood cadmium and lead were associated with increased and decreased levels of estrogen, respectively. Age-specific associations were observed, suggesting that the relationship between these metals and estrogen levels may vary among different age groups of women.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Engineering, Environmental
Jun Wu, Fuming Deng, Xiangliang Tang, Wenbin Chen, Rui Zhou, Tianxin Zhao, Xiangming Mao, Fangpeng Shu
Summary: This study investigated the association between prenatal exposure to PBDE-99 in pregnant ICR mice and spermatogenic impairments in male offspring. It was found that exposure to PBDE-99 caused significant spermatogenic injuries, partly due to the accumulation of reactive oxygen species, dys-regulation of autophagy, and induced spermatogenic cell apoptosis. Stimulation of autophagy could alleviate spermatogenic cell injury induced by PBDE-99.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Hannah Gardener, Chela Wallin, Jaclyn Bowen
Summary: The study quantified levels of heavy metals and phthalates, as well as CBD labeling accuracy, in a selection of commercially available CBD products in the US. It found that there was low-level contamination of edible CBD products with heavy metals and phthalates, and a substantial discrepancy between the CBD potency claimed on product labels and the actual measured amount in both edible and topical products. This underscores the need for tight regulations to ensure CBD product label integrity and protect consumers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Zuxiang Wu, Huan Hu, Chenxi Wang, Ji Wu, Yurong Xiong, Yang Fu, Xiaoshu Cheng, Hai Su, Ping Li
Summary: The study found a negative correlation between serum folate concentration and blood levels of cadmium and lead, with a more stable association in adults with higher estimated glomerular filtration rate. Further research is needed to explore the mechanisms behind the beneficial role of folate in regulating cadmium and lead concentrations in the blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Hai Duc Nguyen, Hojin Oh, Ngoc Hong Minh Hoang, Won Hee Jo, Min-Sun Kim
Summary: The study found that females are more likely to suffer from depression, while elevated serum cadmium levels are associated with an increased risk of depression. On the other hand, doubling daily vitamin B1, B3, and vitamin A intakes can reduce the risk of depression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Mohammad Mazbah Uddin, Zhenfang Chen, Fuliu Xu, Lingfeng Huang
Summary: This study aimed to investigate the physiological and cellular mechanisms of Sesuvium portulacastrum under heavy metal stress. The findings suggest that superoxide dismutase (SOD) is the dominant antioxidant enzyme activity during low cadmium toxicity, while peroxidase (POD) is the dominant enzyme activity during higher cadmium toxicity. In addition, cadmium stress affects the chlorophyll content and cell structure of Sesuvium portulacastrum.
Article
Biochemistry & Molecular Biology
Gui-Li Yang, Lei Huang, Xiao Yang, Zhu Li, Hai-Min Liao, Kang Mao, Zhao-Ju Liu, He-Yan Geng, Qin Cao, Ai-Juan Tan
Summary: In this study, the growth, Cd enrichment, and antioxidant enzyme activity of duckweed were investigated under Cd stress. The results showed that both high-Cd-tolerance duckweed (HCD) and low-Cd-tolerance duckweed (LCD) strains hyper-enriched with Cd. Transcriptome analysis revealed significant differences in gene expression between HCD and LCD, with antioxidant system being significantly expressed in HCD but not in LCD. Alpha-linolenic acid metabolism likely plays an important role in Cd detoxification in duckweed. These findings contribute to the understanding of Cd tolerance mechanisms in hyperaccumulator plants and lay the foundation for future phytoremediation studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Dejan Beukovic, Marko Vukadinovic, Sasa Krstovic, Miroslava Polovinski-Horvatovic, Igor Jajic, Zoran Popovic, Vukan Lavadinovic, Milos Beukovic
Summary: This study investigated the occurrence of lead and cadmium in the liver samples of hares in the agricultural biotope of Vojvodina, Serbia. The results showed that lead was more common and present at higher concentrations in the samples.
Review
Biochemistry & Molecular Biology
Lea Clusan, Francois Ferriere, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer, the most common and deadliest cancer among women worldwide, is closely associated with estrogen signaling. Hormone therapy using antiestrogens is the standard treatment, but resistance inevitably occurs through various biological mechanisms. Understanding the estrogen pathway is crucial for the development of new therapies for hormone-dependent breast cancer. This mini-review summarizes the current literature on estrogen receptors in breast cancer, including their signalization, mechanisms of action, and clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Jiahui Xu, Canyang Hu, Maolin Wang, Zongsheng Zhao, Xiaoxue Zhao, Liu Cao, Yifu Lu, Xiyun Cai
Summary: The effects of coexisting heavy metals on the transfer of Cd in wheat grains were found to be changeable, with zinc showing a stronger inhibitory effect than lead and copper. A predictive model of grain Cd using soil zinc, along with other factors, was constructed and validated with good accuracy levels.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Muhammad Riaz, Muhammad Kamran, Yizeng Fang, Guoling Yang, Muhammad Rizwan, Shafaqat Ali, Yaoyu Zhou, Qianqian Wang, Lulu Deng, Youjuan Wang, Xiurong Wang
Summary: This study investigated the alleviative role of boron on cadmium toxicity in rice seedlings, demonstrating that boron can mitigate cadmium stress by decreasing cadmium uptake and encouraging cadmium adsorption on cell walls, as well as activating protective mechanisms.
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
