☆ 4.5 Article

Anti-inflammatory effect of leaves of Eriobotrya japonica correlating with attenuation of p38 MAPK, ERK, and NF-κB activation in mast cells

TOXICOLOGY IN VITRO (2009)

期刊

TOXICOLOGY IN VITRO

卷 23, 期 7, 页码 1215-1219

出版社

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.tiv.2009.07.036

关键词

Eriobotrya japonica; Mast cell; Allergic inflammation; Pro-inflammatory cytokines; NF-kappa B; Mitogen-activated protein kinase

类别

Toxicology

资金

Woosuk University

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Protocol

Reagent

摘要

Mast cell-mediated allergic inflammation is involved in many diseases such as asthma and sinusitis Mast. cells induce synthesis and production of pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 with immune regulatory properties. In the present study, we investigate the effect an unspecified aqueous extract from leaves of Eriobotrya japonica Lindl. (Rosaceae) (LEJL) on the expression of pro-inflammatory cytokines and its possible mechanisms of action in human mast cells (HMC-1). LEJL dose-dependently inhibited phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI)-induced gene expression and secretion of TNF-alpha, IL-6, and IL-8. LEJL attenuated PMACI-induced activation of nuclear factor (NF)-kappa B, and specifically blocked activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) but not that of c-jun N-terminal kinase. The inhibitory effect of LEJL on the pro-inflammatory cytokines was likely NF-kappa B p38, MAPK, and ERK dependent. Our in vitro studies provide evidence that LEJL might contribute to the treatment of mast cell-derived allergic inflammatory diseases. (C) 2009 Published by Elsevier Ltd.

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