Article
Chemistry, Multidisciplinary
Kuo-Cheng Lan, Te- Weng, Wei-Che Chiang, Chen-Yuan Chiu, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: DEHP and its metabolite MEHP have been found to inhibit myogenesis in vitro, suggesting their potential role as environmental risk factors affecting muscle differentiation.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiuzhen Liu, Ana M. Adamo, Patricia I. Oteiza
Summary: The study found that gestational exposure to DEHP could cause secondary zinc deficiency and impaired neurogenesis, which may have long-term consequences on the brain structure and function of adult offspring.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Immunology
Hsin-Han Tseng, Chia-Yang Li, Shin-Ting Wu, Hsiang-Han Su, Tzu-Hsuan Wong, Hsin-En Wu, Yu-Wei Chang, Shau-Ku Huang, Eing Mei Tsai, Jau-Ling Suen
Summary: This study found that chronic exposure to DEHP may lead to allergic lung inflammation. Following DEHP exposure, mice showed a decrease in CD8α(+) dendritic cells and its metabolite MEHP hindered dendritic cell differentiation by modulating PPARγ activity. These findings have important implications for the interaction between environmental pollutants and innate immunity in the development of allergic asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Wing Sum Kwan, Vellaisamy A. L. Roy, Kwan Ngok Yu
Summary: DEHP, widely used as a plasticizer in consumer products, has been linked to adverse health effects, prompting the need for toxicological assessment. Zebrafish embryos have become a popular in vivo model for studying DEHP toxicity, aiming to assess both acute and chronic effects on different developmental stages.
Article
Environmental Sciences
Abibe Useini, Felipe Engelberger, Georg Kuenze, Norbert Straeter
Summary: Di-2-ethylhexyl phthalate (DEHP) and its substitute 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) are plasticizers that can hydrolyze in the human body to form metabolites that bind to PPARγ and induce adipogenesis. This study characterized the binding modes of these metabolites using X-ray crystallography and molecular dynamics simulations. The metabolites bind to the AF-2 binding site of PPARγ and stabilize the AF-2 helix in an upward conformation, promoting the formation of the active complex for transcription. Comparisons with other species suggest similar effects of these plasticizer metabolites.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Jing Leng, Hongyi Li, Yuequn Niu, Kelie Chen, Xiaoyu Yuan, Hanwen Chen, Zhiqin Fu, Lihuan Zhang, Fang Wang, Chaoyi Chen, Paul Heroux, Jun Yang, Xinqiang Zhu, Weiguo Lu, Dajing Xia, Yihua Wu
Summary: Low-dose MEHP promotes ovarian cancer progression through activating the PI3K/Akt/NF-kappa B pathway in a PPAR alpha-dependent manner.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Respiratory System
Clarus Leung, Min Hyung Ryu, Anette Kocbach Bolling, Danay Maestre-Batlle, Christopher F. Rider, Anke Huls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor, Chris Carlsten
Summary: This study investigates how SNPs in PPARG and oxidative stress genes modify the impact of DBP exposure on lung function and immune responses. The results suggest that variants in PPARG play a greater role in airway allergic responses to DBP than oxidative stress-related genes.
RESPIRATORY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Article
Agriculture, Multidisciplinary
Wei-Chih Su, Yi-Chen Tsai, Tsung-Kun Chang, Tzu-Chieh Yin, Hsiang-Lin Tsai, Ching-Wen Huang, Yen-Cheng Chen, Ching-Chun Li, Po-Jung Chen, Jaw-Yuan Wang
Summary: Exposure to di-(2-ethylhexyl) phthalate (DEHP) is significantly correlated with the development of colorectal cancer (CRC). Detection of urinary monoethylhexyl phthalate (MEHP) may serve as a noninvasive indicator for increased CRC risk.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Enrico D'Aniello, Pietro Amodeo, Rosa Maria Vitale
Summary: This review provides an overview of discovery, optimization, and structure-activity relationship studies on PPAR modulators from marine sources, as well as the structural and computational studies that led to their identification and/or elucidation, and rationalization of their mechanisms of action.
Article
Environmental Sciences
Yuezhu Zhang, Honghao Qian, Jia Wang, Ying Zhu, Xiaohan Miao, Xu Li, Jianli Yin, Ruxuan Zhang, Jiaming Ye, Chuanyi Huo, Weisen Zhao, Lin Ye
Summary: This study aimed to explore the molecular mechanism of DEHP/MEHP-induced hepatic lipid metabolism disorders. The results showed that DEHP/MEHP promoted the expression of Notch pathway molecules and led to lipid accumulation. Inhibiting the Notch pathway reversed the inflammation and lipid accumulation caused by MEHP. This study revealed that DEHP/MEHP induced lipid accumulation by up-regulating the Notch pathway, with inflammation playing a key role in the process.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Medicine, General & Internal
Iason Psilopatis, Kleio Vrettou, Eleni Nousiopoulou, Kostas Palamaris, Stamatios Theocharis
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, causing severe menstrual irregularities, skin conditions, and insulin resistance-associated health problems. Peroxisome proliferator-activated receptors (PPARs) have been investigated for their role in PCOS, but studies have reached contradictory conclusions about PPAR expression in PCOS. However, natural agents have shown promise as alternative treatments for PCOS. Overall, PPARs appear to play a significant role in PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)