Article
Environmental Sciences
Mahdi Banaee, Amir Zeidi, Reshma Sinha, Caterina Faggio
Summary: The study aimed to evaluate the impact of the interaction between polyethylene microplastics (PE-MPs) and zinc oxide nanoparticles (ZnO-NPs) on mosquito fish. The results showed that the combination of ZnO-NPs and PE-MPs induced oxidative stress and toxicity in fish.
Article
Environmental Sciences
Hsin Her Yu, Yi-Chun Chen, Han-Pang Su, Liliang Chen, Hung-Hsiang Chen, Kun-Yi Andrew Lin, Chia-Hua Lin
Summary: This study evaluated the toxic risk of tungsten trioxide (WO3) nanoparticles and explored their mechanism of toxicity. The results showed that these nanoparticles have cytotoxic effects on lung cells and are associated with an increased risk of developing chronic obstructive pulmonary disease.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Adriel Ekozin, Chiagoziem A. Otuechere, Adewale Adewuyi
Summary: This study synthesized silver nanoparticles coated with Apocynin (Apo-AgNPs) and investigated their antioxidant and liver protective effects on pyrogallol-induced toxicity in rats. The results showed that Apo-AgNPs exhibited potent antioxidant and membrane stability activities in vitro. In rats, Apo-AgNPs prevented liver damage caused by pyrogallol and restored the activities of liver antioxidant enzymes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Jaqueline P. Souza, Adrislaine S. Mansano, Francine P. Venturini, Valeria S. Marangoni, Paula M. P. Lins, Barbara P. C. Silva, Barbara Dressler, Valtencir Zucolotto
Summary: This study evaluated the toxic effects of gold nanorods (AuNRs) on aquatic organisms, finding decreases in neonate production and filtration rate in cladocerans after exposure. The toxic mechanism in cladocerans was attributed to increased reactive oxygen species (ROS) generation. Enzymatic biomarkers in fish showed recovery after exposure to AuNRs, indicating the impacts of this novel nanomaterial on aquatic biota.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Jacky Bhagat, Liqing Zang, Hiroko Nakayama, Norihiro Nishimura, Yasuhito Shimada
Summary: The study found that co-exposure to polystyrene nanoplastics (PS NP) and ketoconazole (KCZ) or fluconazole (FCZ) increased oxidative stress and apoptosis-related gene expression, exacerbating the toxicity of azoles. This highlights the need for caution in releasing azole fungicides in the environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Edgardo Cruces, Ana C. Barrios, Yaritza P. Cahue, Brielle Januszewski, Leanne M. Gilbertson, Francois Perreault
Summary: The study compared the toxicity of oxidized multi-walled CNTs and GO in the cyanobacterium Microcystis aeruginosa. The results showed that both CNMs induced indirect toxicity through physical mechanisms associated with light shading and cell aggregation, without causing oxidative stress or membrane damage. This indirect toxicity explained why the intrinsic differences in shape, size, and surface properties between CNTs and GO did not result in differences in how they induce toxicity to cyanobacteria.
Article
Biochemistry & Molecular Biology
Ewa Florek, Marta Witkowska, Marta Szukalska, Magdalena Richter, Tomasz Trzeciak, Izabela Miechowicz, Andrzej Marszalek, Wojciech Piekoszewski, Zuzanna Wyrwa, Michael Giersig
Summary: Multi-walled carbon nanotubes (MWCNTs) can be toxic when in contact with the biological system due to their size, causing oxidative stress and the production of reactive oxygen species (ROS). This study evaluated the oxidative stress of MWCNTs in male rats using various parameters. The results showed that higher concentrations of nanotubes led to decreased TEAC levels in the liver, increased NO levels in the kidneys, and lower GSH levels in the serum. Therefore, analyzing oxidative stress parameters can be a key indicator of the toxic potential of MWCNTs.
Article
Chemistry, Multidisciplinary
Sonia Martel Martin, Rocio Barros, Brixhilda Domi, Carlos Rumbo, Matteo Poddighe, Santiago Aparicio, Maria Suarez-Diez, Juan Antonio Tamayo-Ramos
Summary: This study assessed the toxicity of commercial pristine multi-walled carbon nanotubes on Saccharomyces cerevisiae and found that cell proliferation was negatively affected at a high concentration of 800 mg L-1, while oxidative stress was induced at a lower concentration of 160 mg L-1. The transcriptome analysis showed limited biological response of the yeast cells exposed to the selected MWCNTs, with only a small number of genes showing significant transcriptional changes, most of which were downregulated.
Review
Environmental Sciences
Philippe J. Thomas, Genevieve Perono, Franca Tommasi, Giovanni Pagano, Rahime Oral, Petra Buric, Ines Kovacic, Maria Toscanesi, Marco Trifuoggi, Daniel M. Lyons
Summary: The widespread presence of microplastics and nanoplastics in aquatic and terrestrial environments has raised concerns about their toxicity to plants, wildlife, and human health, potentially leading to severe outcomes such as increased mortality rates and genetic damage. While there is abundant literature on the effects of MP and NP in aquatic biota, reports on terrestrial environments are still limited. Comparative studies on different types of MPs and NPs are necessary to understand their respective effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Xiaokang Wu, Ming Li, Shengao Yang, Jiaxin Dong, Wenhao Pan, Yang Ning, Xiuyi Hua, Deming Dong, Dapeng Liang
Summary: Understanding the molecular-level metabolic disorders induced by nano-and microplastics in aquatic organisms can provide insights into their potential toxicity and contribute to the regulation of plastic products.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Ting Li, Zhou Li, Jianfei Fu, Chunlan Tang, Liya Liu, Jin Xu, Jinshun Zhao, Zhen Li
Summary: This study investigated the cytotoxicity of nickel nanoparticles on HTR-8/SVneo cells in vitro. The results showed that nickel nanoparticles treatment reduced cell viability, increased oxidative stress, and impaired mitochondrial respiratory capacity. Additionally, it induced cell cycle arrest and apoptosis.
ENVIRONMENTAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Tapan A. Patel, Bhavesh D. Kevadiya, Neha Bajwa, Preet Amol Singh, Hong Zheng, Annet Kirabo, Yu-Long Li, Kaushik P. Patel
Summary: Oxidative stress is a deteriorating condition caused by an imbalance between reactive oxygen species and the body's antioxidant defense system. The high utilization of oxygen in the nervous system makes it particularly susceptible to oxidative stress, leading to neurodegeneration and inflammation-related disorders. The use of nanoparticles with antioxidant properties and nanotheranostics as therapeutic tools shows promise in treating such conditions.
Article
Plant Sciences
Runqiang Liu, Jingchong Li, Lei Zhang, Ta Feng, Zhiyong Zhang, Baohong Zhang
Summary: Difenoconazole exposure inhibits plant growth by reducing root and shoot development, decreasing chlorophyll biosynthesis, and inducing oxidative stress, ultimately leading to impaired wheat plant growth and development.
Article
Food Science & Technology
Robin Mesnage, Scarlett Ferguson, Inger Brandsma, Nynke Moelijker, Gaonan Zhang, Francesca Mazzacuva, Anna Caldwell, John Halket, Michael N. Antoniou
Summary: The co-formulant POE-15 tallow amine (POE-15) and the active ingredient glyphosate in herbicides have been found to be cytotoxic, causing cell necrosis and oxidative stress. The study highlights the importance of comprehensive testing of both co-formulants and active ingredients of commercial pesticides to ensure better regulation and protection of public health and the environment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Xiuge Gao, Xiaoxiao Liu, Xinhao Song, Pei Teng, Hui Ji, Lin Peng, Yawei Qiu, Dawei Guo, Shanxiang Jiang
Summary: The study found that maduramicin has lethal toxicity to crayfish, affecting their biochemical parameters and tissue structure. After exposure, crayfish developed a certain degree of resistance to maduramicin.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Paramita Sarkar, Sandip Samaddar, Veena Ammanathan, Venkateswarlu Yarlagadda, Chandradhish Ghosh, Manjulika Shukla, Grace Kaul, Ravi Manjithaya, Sidharth Chopra, Jayanta Haldar
ACS CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Uttam Ghosh, Isha Soni, Grace Kaul, Priyanka Trivedi, Vinita Chaturvedi, Sidharth Chopra, Tushar Kanti Chakraborty
Article
Toxicology
A. Hussain, S. Kumar, G. Kaul
HUMAN & EXPERIMENTAL TOXICOLOGY
(2020)
Article
Chemistry, Physical
Satyaveni Malasala, Md Naiyaz Ahmad, Jitendra Gour, Manjulika Shukla, Grace Kaul, Abdul Akhir, Srikanth Gatadi, Y. V. Madhavi, Sidharth Chopra, Srinivas Nuri
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Chemistry, Medicinal
Vitthal B. Makane, Eruva Vamshi Krishna, Uattam B. Karale, Dattatraya A. Babar, Saradhi Kalari, Estharla M. Rekha, Manjulika Shukla, Grace Kaul, Dharmarajan Sriram, Sidharth Chopra, Sunil Misra, Haridas B. Rode
ARCHIV DER PHARMAZIE
(2020)
Article
Toxicology
S. Kumar, A. Hussain, B. Bhushan, G. Kaul
HUMAN & EXPERIMENTAL TOXICOLOGY
(2020)
Correction
Chemistry, Medicinal
Vitthal B. Makane, Eruva Vamshi Krishna, Uattam B. Karale, Dattatraya A. Babar, Saradhi Kalari, Estharla M. Rekha, Manjulika Shukla, Grace Kaul, Dharmarajan Sriram, Sidharth Chopra, Sunil Misra, Haridas B. Rode
ARCHIV DER PHARMAZIE
(2020)
Article
Biotechnology & Applied Microbiology
Karmveer Yadav, Syed Azmal Ali, Ashok Kumar Mohanty, Eshwarmoorthy Muthusamy, Kesavan Subaharan, Gautam Kaul
Summary: The study suggests that different types of nanoparticles have varied effects on CHO-K1 cells, with MSN helping prevent protein aggregation, MWCNT causing elongated cell appearance and cytoskeleton remodeling, and ZnO resulting in rounded cell morphology and activation of endocytic, ubiquitination, and proteasomal pathway proteins.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Genetics & Heredity
Mahesh Kumar, Noyonika, Anjali Aggarwal, Gautam Kaul
Summary: The study identified 387 known and 77 novel miRNAs from TH and KF cattle under HS condition, with miR-2284 being the most abundant. Pathway analysis revealed the involvement of target genes in various signaling pathways. Differential gene expression showed significant changes in miRNAs between control and HS conditions.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2021)
Article
Biochemistry & Molecular Biology
Mohd Akram, Syed Azmal Ali, Pradip Behare, Gautam Kaul
Summary: Probiotics have been shown to have beneficial effects on weight loss and endogenous testosterone in male diet-induced obesity (DIO) models, with significantly improved sperm motility. Fermented milk supplementation may be an alternative treatment for preventing obesity and related metabolic syndromes.
Article
Biochemistry & Molecular Biology
Kavita Rani, Syed Azmal Ali, Gautam Kaul, Pradip Behare
Summary: This study demonstrates that oral delivery of indigenous probiotic Lactobacillus fermentum NCDC 400 and prebiotic fructo-oligosaccharide (FOS) can reduce obesity-associated hepatic steatosis and improve antioxidant and anti-inflammatory properties.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Karmveer Yadav, Syed Azmal Ali, Noyonika Kaul, Ashok Kumar Mohanty, Gautam Kaul
Summary: The study found that nanoparticles have a negative impact on the ovarian function of female rats, leading to reduced body weight, smaller ovaries, decreased follicle count, and follicular cyst development. The distribution of nanoparticles in the body directly affects ovarian function and alters the expression of critical proteins.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Pharmacology & Pharmacy
G. Kaul, D. Saxena, A. Dasgupta, S. Chopra
Article
Chemistry, Inorganic & Nuclear
Payal Srivastava, Manjulika Shukla, Grace Kaul, Sidharth Chopra, Ashis K. Patra
DALTON TRANSACTIONS
(2019)
Article
Chemistry, Multidisciplinary
Apurva Panjla, Grace Kaul, Manjulika Shukla, Shubhandra Tripathi, Nisanth N. Nair, Sidharth Chopra, Sandeep Verma
CHEMICAL COMMUNICATIONS
(2019)