Article
Biochemistry & Molecular Biology
Yixiang Fan, Xin Yu, Biao Yu, Xinmiao Ji, Xiaofei Tian, Chao Song, Xin Zhang
Summary: Living organisms, including mice, can benefit from long-term exposure to a moderate static magnetic field (SMF) by improving lifespan and healthspan. The experiments showed that SMFs significantly enhanced exploratory and locomotive activities in aged mice, as well as their spatial learning ability and memory. Additionally, SMFs reduced oxidative stress in the brain of aged mice, suggesting their potential as an adjuvant physical therapy to reduce aging-related health risks in animals and humans.
Article
Biochemistry & Molecular Biology
Fan Fei, Peng Zhang, Xinyu Li, Shun Wang, Erhui Feng, Yinglang Wan, Can Xie
Summary: This study examined the effects of magnetic fields on offshore molluscs by analyzing the changes in metabolism and transcriptome of Elysia leucolegnote exposed to either the geomagnetic field or a 1.1 T static magnetic field. The results showed that prolonged exposure to the high static magnetic field led to increased blood glucose and lipid levels, as well as increased activities of antioxidant enzymes. Furthermore, enzymes related to digestive performance and liver functions were found to have decreased activity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Huanhuan Lv, Yijia Wang, Junyu Liu, Chenxiao Zhen, Xinyi Zhang, Yuetong Liu, Chenge Lou, Huijie Guo, Yunpeng Wei
Summary: Static magnetic fields have significant effects on hepatic metabolism and function in obesity and diabetes, including improving glycolipid metabolism, reducing inflammation and fibrosis, regulating iron metabolism, balancing redox level, and activating autophagy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Shuangquan Wen, Li Wang, Hui Zou, Jianhong Gu, Ruilong Song, Jianchun Bian, Yan Yuan, Zongping Liu
Summary: This study evaluated the neuroprotective potential of Puerarin against cadmium-induced neuronal injury for the first time, showing that Puerarin ameliorated neuronal injury and oxidative stress induced by cadmium. Additionally, Puerarin stimulated cadmium excretion, thereby reducing apoptosis in cerebral cortical neurons.
Article
Cell Biology
Jacopo J. Branca, Donatello Carrino, Ferdinando Paternostro, Gabriele Morucci, Claudia Fiorillo, Claudio Nicoletti, Massimo Gulisano, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Matteo Becatti, Alessandra Pacini
Summary: Cadmium is a well-known toxic pollutant that can accumulate in the brain and increase the permeability of the blood-brain barrier. Zinc, on the other hand, has antioxidant properties. This study aimed to investigate the role of zinc in preventing cadmium-induced blood-brain barrier alterations. The results showed that zinc protected cells from cadmium-induced damage and prevented blood-brain barrier impairment.
Article
Biotechnology & Applied Microbiology
Liyuan Zhang, Mengqiao Chi, Yue Cheng, Zhongrong Chen, Yunxia Cao, Gang Zhao
Summary: This study proposes a new method to improve the antioxidant capacity of whole ovaries during cryopreservation, static magnetic field assisted thawing. The results show that the antioxidant capacity of ovarian tissue was significantly improved by static magnetic field treatment. In addition, successful vascular regeneration and follicular development were achieved through ovarian tissue allograft transplantation.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Aiguo Dong, Junfeng Huo, Juanjuan Yan, Ailing Dong
Summary: The research found that cadmium caused oxidative stress on the liver of turtle Mauremys reevesii, with significant differences between the control group and Cd-treated group as Cd concentration increased and exposure time prolonged.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
L. Makinistian, L. Zastko, A. Tvarozna, L. E. Dias, I Belyaev
Summary: Research suggests that the static magnetic field generated by the use of earphones can have a wide range of exposure and potential biological effects on the human body. With no scientific consensus on the possible mechanisms of interaction with living tissues, caution in using earphones may be advisable.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Haodong Li, Runnan Xie, Xiang Xu, Xingru Liao, Jiaxin Guo, Yanwen Fang, Zhicai Fang, Jirong Huang
Summary: Magnetic fields have been shown to affect the growth and virulence of Escherichia coli. The application of a static magnetic field reduces the size of bacterial colonies but has no effect on colony numbers. The inhibitory effect is due to differential gene expression related to carbon source utilization. The addition of specific compounds restores the bacterial phenotype, and mutants lacking glycolate oxidase are no longer sensitive to the magnetic field. Furthermore, the magnetic field inhibits long-chain fatty acid degradation, leading to oxidative stress and growth inhibition.
Article
Environmental Sciences
Utsav N. Patel, Urvesh D. Patel, Aniket Khadayata, Rahul K. Vaja, Harshad B. Patel, Chirag M. Modi
Summary: This study evaluated the behavior, oxidative stress, gene expressions, and histopathological changes in the brain of zebrafish following exposure to cadmium chloride and mercury chloride alone and in combination. The results showed anxiety-like behavior in all toxicity groups, significant downregulation of Nrf2 in the brain, and changes in glutathione and malondialdehyde levels. Additionally, significant pathological changes were observed in various brain regions of zebrafish, with the Cd + Hg group showing severe changes in the periventricular gray zone of the optic tectum.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Chemistry, Medicinal
Genesis Serrano, Carol Miranda-Ostojic, Pablo Ferrada, Cristian Wulff-Zotelle, Alejandro Maureira, Edward Fuentealba, Karem Gallardo, Manuel Zapata, Mariella Rivas
Summary: Research on magnetic fields in biological systems shows potential, but their application in microalgae remains underexplored. This study measured enzymatic and non-enzymatic activity in response to static magnetic fields-induced stress in two microalgae species, revealing different responses in SOD and CAT activity, as well as carotenoid production. The results varied between continuous and pulse exposure, with significant increases observed in antioxidant pigment production for N. gaditana.
Article
Pharmacology & Pharmacy
Di Guoqing, Xiang Junli, Dong Li, Wu Jiahong
Summary: The exposure to non-time-varying electric field caused by direct current transmission lines did not significantly affect testosterone synthesis in male mice, but prolonged exposure resulted in testicular oxidative stress, leading to mitochondrial structural damage and inhibition of testosterone synthesis.
Article
Agriculture, Dairy & Animal Science
Chunlin Yu, Mohan Qiu, Zengrong Zhang, Xiaoyan Song, Huarui Du, Han Peng, Qingyun Li, Li Yang, Xia Xiong, Bo Xia, Chenming Hu, Jialei Chen, Xiaosong Jiang, Chaowu Yang
Summary: The study revealed that cadmium induction may trigger oxidative stress and pathological changes in the chicken heart, leading to differential gene expression related to this process. This enhances our understanding of cadmium toxicity in the chicken heart.
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Magdalena Kozlowska, Joanna Rogalska, Malgorzata Galazyn-Sidorczuk, Alicja Roszczenko, Nazar M. Smereczanski
Summary: This research showed that increasing zinc intake can alleviate oxidative stress and damage caused by cadmium in the brain. The interaction between zinc and cadmium can effectively prevent the imbalance in oxidative/antioxidative status and protect against injury to cellular macromolecules in the nervous system.
Article
Biochemistry & Molecular Biology
Hironobu Ikehata, Toshio Mori, Yasuhiro Kamei, Thierry Douki, Jean Cadet, Masayuki Yamamoto
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2020)
Correction
Biochemistry & Molecular Biology
Marius Pollet, Siraz Shaik, Melina Mescher, Katrin Frauenstein, Julia Tigges, Stephan A. Braun, Kevin Sondenheimer, Mana Kaveh, Anika Bruhs, Stephan Meller, Bernhard Homey, Agatha Schwarz, Charlotte Esser, Thierry Douki, Christoph F. A. Vogel, Jean Krutmann, Thomas Haarmann-Stemmann
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Biotechnology & Applied Microbiology
Willie Taylor, Emily Camilleri, D. Levi Craft, George Korza, Maria Rocha Granados, Jaliyah Peterson, Renata Szczpaniak, Sandra K. Weller, Ralf Moeller, Thierry Douki, Wendy W. K. Mok, Peter Setlow
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Toxicology
Anne von Koschembahr, Antonia Youssef, David Beal, Etienne Bourgart, Alex Rivier, Marie Marques, Marie-Therese Leccia, Jean-Philippe Giot, Anne Maitre, Thierry Douki
ARCHIVES OF TOXICOLOGY
(2020)
Article
Biochemical Research Methods
Marie Roser, David Beal, Camille Eldin, Leslie Gudimard, Fanny Caffin, Fanny Gros-Desormeaux, Daniel Leonco, Francois Fenaille, Christophe Junot, Christophe Pierard, Thierry Douki
Summary: This study aimed to identify new biomarkers of exposure to sulfur mustard (SM) and validate their detectability in various models and body fluids. The results demonstrated that N7Gua-CEES, glutathione, and cysteine conjugates of 2-chloroethyl ethyl sulfide (CEES) were easily quantifiable in different models and plasma, showing promising potential for application in toxicological studies related to SM.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kazuki Nishimura, Hironobu Ikehata, Thierry Douki, Jean Cadet, Shigeki Sugiura, Toshio Mori
Summary: Sunlight can generate three types of DNA photolesions, with differences in efficiency between summer and winter attributed to seasonal variations in the UVA/UVB ratio. The conversion of 6-4PPs to DewarPPs is more efficient in winter than in late summer, indicating a significant influence of seasonal UVA/UVB ratio on photoisomerization.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Oncology
Damilola Fajuyigbe, Thierry Douki, Arjan van Dijk, Robert P. E. Sarkany, Antony R. Young
Summary: This study found the presence of dark CPD in human skin, which may be influenced by melanin location and concentration. Repair kinetics of different skin types show no significant differences in CPD formation and repair post-exposure.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Thierry Douki
Summary: Photobiological events depend on the wavelength of radiation, with action spectra used to describe efficiency at different wavelengths. Consideration of synergistic or inhibitory effects of photons on photochemical processes and cellular responses is necessary for a full understanding of the biological effects of complex light sources.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thierry Douki, Arnaud Buhot
Summary: Photobiological effects greatly depend on incident photon wavelength, and the effects of complex light sources cannot simply be summed up as monochromatic exposures. Similar to nonadditivity effects in chemical toxicology, photobiological processes can exhibit additive, antagonistic, and synergistic effects. The combination index can be applied to study the nonadditive effects in photobiological processes, but further research is needed to evaluate the error in its determination.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
D. Bacqueville, C. Jacques-Jamin, H. Dromigny, F. Boyer, Y. Brunel, P. J. Ferret, D. Redoules, T. Douki, S. Bessou-Touya, H. Duplan
Summary: Comprehensive sun protection is crucial in preventing skin damage, with the innovative sunfilter TriAsorB shown to effectively protect the skin from harmful effects of UV and visible light.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Marie Gilardoni, Daniel Leonco, Fanny Caffin, Fanny Gros-Desormeaux, Camille Eldin, David Beal, Sadia Ouzia, Christophe Junot, Francois Fenaille, Christophe Pierard, Thierry Douki
Summary: The study demonstrates that exposure to CEES causes significant systemic impact, confirmed by the presence of specific biomarkers in plasma and alkylation damage in brain. These results provide additional evidence of vesicants' ability to induce internal damage after dermal exposure.
Article
Biochemical Research Methods
Noemie Reynaud, Laura Belz, David Beal, Daniel Bacqueville, Helene Duplan, Camille Genies, Emmanuel Questel, Gwendal Josse, Thierry Douki
Summary: UV-induced formation of photoproducts in DNA is a major initiating event of skin cancer, and many analytical tools have been developed for their quantification. In this study, a liquid chromatography-mass spectrometry method was extended to quantify short DNA fragments containing photoproducts released from cells. The method was validated with a robust protocol and showed high sensitivity and specificity. Proof of concept for the use of excreted DNA repair products as biomarkers of UV genotoxicity was obtained through in vitro and ex vivo studies.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marouane Libiad, Thierry Douki, Marc Fontecave, Mohamed Atta
Summary: Post-transcriptional modifications of tRNA nucleotide play a crucial role in determining their folding, structure, and function. We have discovered and characterized a novel modified base called 2-methylthio-methylenethio-N-6-(cis-4-hydroxyisopentenyl)adenosine, which is found at position 37 in specific tRNAs. Furthermore, we have identified the catalytic cycle of the tRNA-diiron monooxygenase, MiaE, in Salmonella typhimurium, which converts the known 2-methylthio-methylenethio-N-6-(isopentenyl)adenosine nucleoside into this newly identified modified adenosine.
Article
Chemistry, Organic
Jouda Jakhlal, Clement Denhez, Stephanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Summary: In this study, it is experimentally demonstrated that the presence of furanose in a southern conformation in oligonucleotides is necessary for the formation of (6-4) photoproduct. The location of the southern sugar conformation, particularly at the 5'-end, is more favorable for the formation of the (6-4) adduct in thymine dinucleotide. The flexibility of the southern pucker at the 3'-end has little influence on the formation of the (6-4) adduct.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Laure Bobyk, Adeline Tarantini, David Beal, Giulia Veronesi, Isabelle Kieffer, Sylvie Motellier, Eugenia Valsami-Jones, Iseult Lynch, Pierre-Henri Jouneau, Karin Pernet-Gallay, Catherine Aude-Garcia, Sylvie Sauvaigo, Thierry Douki, Thierry Rabilloud, Marie Carriere
Summary: Silver nanoparticles are commonly used as biocides, but studies have shown that acute exposure to these nanoparticles can have a stronger impact on DNA integrity compared to repeated exposure. Both exposure regimens were found to alter cellular metabolism, induce intracellular ROS accumulation, and disrupt cell cycle progression, indicating detrimental effects on cells.
ENVIRONMENTAL SCIENCE-NANO
(2021)
