Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD

Paradoxical Role of DNA Methylation in Activation of FoxA2 Gene Expression during Endoderm Development

(2014) Keren Bahar Halpern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome Analysis Reveals Differential Splicing Events in IPF Lung Tissue

(2014) Tracy Nance et al.   PLoS One

Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD

(2014) Poornima Gopal et al.   RESPIRATORY RESEARCH

MODMatcher: Multi-Omics Data Matcher for Integrative Genomic Analysis

(2014) Seungyeul Yoo et al.   PLoS Computational Biology

DNA Methylation Is Globally Disrupted and Associated with Expression Changes in Chronic Obstructive Pulmonary Disease Small Airways

(2013) Emily A. Vucic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression

(2013) Lauren J. Buro-Auriemma et al.   HUMAN MOLECULAR GENETICS

Molecular Signature of Smoking in Human Lung Tissues

(2012) Y. Bosse et al.   CANCER RESEARCH

Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony

(2012) Aibek E Mirrakhimov   Cardiovascular Diabetology

Surfactant Protein D as a Biomarker for Chronic Obstructive Pulmonary Disease

(2012) Russell P. Bowler   COPD-Journal of Chronic Obstructive Pulmonary Disease

Gene promoter methylation is associated with lung function in the elderly: The normative aging study

(2012) Johanna Lepeule et al.   Epigenetics

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

(2012) S. A. Selamat et al.   GENOME RESEARCH

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA

(2012) Veronika Reiter et al.   NUCLEIC ACIDS RESEARCH

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype

(2012) Claire M Robinson et al.   RESPIRATORY RESEARCH

Updates on the COPD gene list

(2012) Yohan Bosse   International Journal of Chronic Obstructive Pulmonary Disease

Tobacco-Smoking-Related Differential DNA Methylation: 27K Discovery and Replication

(2011) Lutz P. Breitling et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variable DNA Methylation Is Associated with Chronic Obstructive Pulmonary Disease and Lung Function

(2011) Weiliang Qiu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non-Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy

(2011) F. Yang et al.   CANCER RESEARCH

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Statistical approaches for the analysis of DNA methylation microarray data

(2011) Kimberly D. Siegmund   HUMAN GENETICS

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13

(2011) M. H. Cho et al.   HUMAN MOLECULAR GENETICS

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter

(2011) Han Han et al.   HUMAN MOLECULAR GENETICS

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing

(2011) Fabienne Brenet et al.   PLoS One

Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction

(2011) Hiroe Tabara et al.   PLoS One

Hypoxia-inducible factor 2  (HIF-2 ) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

(2011) Y.-J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population

(2011) DAISUKE KINOSE et al.   RESPIROLOGY

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

(2011) Jordana T Bell et al.   GENOME BIOLOGY

Accurate genome-scale percentage DNA methylation estimates from microarray data

(2010) M. J. Aryee et al.   BIOSTATISTICS

Redefining CpG islands using hidden Markov models

(2010) H. Wu et al.   BIOSTATISTICS

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

Genomic and Genic Deletions of the FOX Gene Cluster on 16q24.1 and Inactivating Mutations of FOXF1 Cause Alveolar Capillary Dysplasia and Other Malformations

(2009) Paweł Stankiewicz et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Disentangling molecular relationships with a causal inference test

(2009) Joshua Millstein et al.   BMC GENETICS

Generation of an epigenetic signature by chronic hypoxia in prostate cells

(2009) J. A. Watson et al.   HUMAN MOLECULAR GENETICS

The COPD genetic association compendium: a comprehensive online database of COPD genetic associations

(2009) Peter J. Castaldi et al.   HUMAN MOLECULAR GENETICS

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

(2009) Xia Yang et al.   NATURE GENETICS

Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease

(2009) F.L. Fimognari et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

(2009) Sreekumar G. Pillai et al.   PLoS Genetics

Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages

(2008) Lauren Kent et al.   CYTOKINE

Tumour necrosis factor gene polymorphisms are associated with COPD

(2008) M. R. Gingo et al.   EUROPEAN RESPIRATORY JOURNAL

Comprehensive high-throughput arrays for relative methylation (CHARM)

(2008) R. A. Irizarry et al.   GENOME RESEARCH

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer

(2008) Malcolm V. Brock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predictors of Survival in COPD: More than Just the FEV1

(2008) Bartolome R. Celli et al.   RESPIRATORY MEDICINE

Review: Surfactant protein D: A lung specific biomarker in COPD?

(2008) Don D. Sin et al.   Therapeutic Advances in Respiratory Disease