Article
Psychology, Multidisciplinary
Fabienne E. M. Willemen, Mirjam van Zuiden, Jasper B. Zantvoord, Susanne R. de Rooij, Bert-Jan H. van den Born, A. Elisabeth Hak, Kathleen Thomaes, Menno Segeren, Leonie K. Elsenburg, Anja Lok
Summary: The study found that child maltreatment was significantly associated with an increased risk for depressed mood, but not with an increased risk for metabolic syndrome. No significant moderating effects by gender were observed.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Mengmeng Song, Tong Liu, Hai Liu, Qi Zhang, Qingsong Zhang, Yiming Wang, Xiangming Ma, Liying Cao, Hanping Shi
Summary: The co-occurrence of MetS and high hs-CRP levels is associated with an elevated risk of PLC.
Article
Biochemistry & Molecular Biology
Roisin Hambly, Niamh Kearney, Rosalind Hughes, Jean M. Fletcher, Brian Kirby
Summary: Hidradenitis suppurativa (HS) is an inflammatory disease that affects both the skin and the whole body, causing significant impact on mental health and quality of life. Metformin is commonly used for HS treatment and has shown effectiveness for certain patients, although its mechanism of action is not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jing Li, Bingru Nan, Zehua Xu, Hao Chang, Song Xu, Miaomiao Ren, Yike Zhang, Yaru Wu, Yujie Chen, Dongbei Guo, Heqing Shen
Summary: Arsenic exposure can lead to male infertility by damaging sperm, resulting in decreased female pregnancy rate. DHA in sperm may be related to the rate of unsuccessful pregnancies, suggesting dietary intervention to improve sperm quality.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Endocrinology & Metabolism
Ophelia Godin, Geraud Gaube, Emilie Olie, Raoul Belzeaux, Frank Bellivier, Josephine Loftus, Philippe Courtet, Caroline Dubertret, Pierre-Michel Llorca, Sebastien Gard, Chantal Henry, Raymund Schwan, Christine Passerieux, Mircea Polosan, Ludovic Samalin, Marion Leboyer, Bruno Etain
Summary: Research has shown a link between childhood maltreatment and Metabolic Syndrome in individuals with bipolar disorders, particularly in men and younger individuals. However, this association was not significant in the early onset subgroup after adjusting for recruitment site and education level. Confirmation in independent and large samples is needed to further explore these potential links.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Qianlei Yang, Rui Yan, Jie Zhang, Ting Zhang, Qi Kong, Xiaoyun Zhang, Haixuan Xia, Aojun Ye, Xinhua Qiao, Koichi Kato, Chang Chen, Yan An
Summary: Our study investigated the role of NRF2 in malignant transformation using NaAsO2-induced HaCaT cells. We found that oxidative stress levels increased at the early stage, and the NRF2 pathway was continuously activated. Additionally, glucose metabolism indicators and related enzyme expression levels increased. However, after transfection with NRF2 or G6PD siRNA, both cellular and mitochondrial reductive stress levels decreased.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, Research & Experimental
James Reigle, Dina Secic, Jacek Biesiada, Collin Wetzel, Behrouz Shamsaei, Johnson Chu, Yuanwei Zang, Xiang Zhang, Nicholas J. Talbot, Megan E. Bischoff, Yongzhen Zhang, Charuhas V. Thakar, Krishnanath Gaitonde, Abhinav Sidana, Hai Bui, John T. Cunningham, Qing Zhang, Laura S. Schmidt, W. Marston Linehan, Mario Medvedovic, David R. Plas, Julio A. Landero Figueroa, Jarek Meller, Maria F. Czyzyk-Krzeska
Summary: The study identified a TS-related metabolic subtype of ccRCC with vulnerabilities that can be targeted for precision medicine. A gene expression signature based on this subtype provided prognostic stratification of ccRCC tumors independent of genomic alterations. Metallomic analysis revealed disrupted metal homeostasis in ccRCC, emphasizing the importance of studying effects of metals from e-cigarettes and environmental exposures.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Environmental Sciences
Jing Sun, Meng Wu, Li Wang, Peiwen Wang, Tian Xiao, Suhua Wang, Qizhan Liu
Summary: This study reveals that arsenic exposure may induce Th2 polarization of CD4+ T cells and promote hepatic fibrosis. miR-21 regulates the metabolism of CD4+ T cells and affects cell cycle and proliferation, leading to the release of fibrogenic factor IL-13. Inhibition of Th2 polarization of CD4+ T cells or miR-21 expression may be a therapeutic strategy to combat arsenic-induced hepatic fibrosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nutrition & Dietetics
Mi Joung Kim, In Woo Kim
Summary: The study found that self-rated health is related to metabolic syndrome and high-sensitivity C-reactive protein levels, and can serve as an independent predictor in healthy adults for the development of a health promotion program.
NUTRITION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Wade M. Sanders, Sioban D. Harlow, Kelly R. Ylitalo, Brittney S. Lange-Maia, Aleda M. Leis, Daniel S. McConnell, Carrie A. Karvonen-Gutierrez
Summary: Cardiometabolic factors and inflammation are significantly associated with peripheral neuropathy (PN), independent of diabetes and obesity. C-reactive protein (CRP) mediates the relationship between obesity and MetS with PN.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Rafael Y. Brzezinski, Ariel Melloul, Shlomo Berliner, Ilana Goldiner, Moshe Stark, Ori Rogowski, Shmuel Banai, Shani Shenhar-Tsarfaty, Yacov Shacham
Summary: Elevated concentrations of C-reactive protein (CRP) early during an acute coronary syndrome (ACS) may indicate the severity of myocardial damage-induced inflammatory response and are associated with worse outcomes. The combined measurement of CRP and cardiac troponin in ST-segment myocardial infarction (STEMI) patients can help identify individuals prone to an inflammatory response and predict their short- and long-term prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Karl Kochanowski, Hiroyuki Okano, Vadim Patsalo, James Williamson, Uwe Sauer, Terence Hwa
Summary: This study identifies the regulatory mechanisms that coordinate catabolism and anabolism in Escherichia coli, showing that a simple global gene regulatory program mainly implemented by the transcription factor Crp plays a crucial role in allocating proteomic resources and adjusting metabolic fluxes. In addition, passive changes in local metabolite concentrations contribute to the robust coordination of individual metabolic reactions.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Zahra Tabibi, Jafar Massah, Keyvan Asefpour Vakilian
Summary: An electrochemical biosensor using arsenite oxidase (ArOx) for arsenite concentration determination was developed in this study, with gold nanoparticles (AuNP) used to enhance the analytical characteristics. The biosensor showed a linear measurement range from 10(1) to 10(4) nM and a detection limit of 5 nM. It was found that an enzyme concentration of 7 µM at physiological pH resulted in the highest biosensor response, and the biosensor exhibited excellent reproducibility and minimal interference from heavy metals.
Article
Engineering, Environmental
Jian Chen, Barry P. Rosen
Summary: In this study, the broad diversity of structural domains in ArsMs was revealed through comparative analysis. The differences in the ArsM structure lead to variations in methylation efficiency and substrate selectivity. The C-terminal domain was found to play a role in modulating the rate of catalysis. Additionally, the relationship between arsenite efflux systems and methylation was examined.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Rodrigo de Lima Brum, Lisiane Martins Volcao, Livia da Silva Freitas, Jessica El Koury Santos, Mariana Vieira Coronas, Juliane Ventura-Lima, Daiane Dias, Bruno Meira Soares, Erico Kunde Correa, Ng Haig They, Daniela Fernandes Ramos, Flavio Manoel Rodrigues da Silva Junior
Summary: This study evaluated the microbial metabolic profile in soil samples containing different forms of inorganic arsenic (As) and found that the microbial community's metabolic activity decreased in short-term exposure to arsenate, while in long-term exposure to arsenite, the microbial community's consumption of nitrogen-rich substrates decreased.
WATER AIR AND SOIL POLLUTION
(2022)
Article
Chemistry, Multidisciplinary
Derrick Broka, Eric Ditzel, Stephanie Quach, Todd D. Camenisch
DRUG AND CHEMICAL TOXICOLOGY
(2016)
Article
Environmental Sciences
Eric J. Ditzel, Thu Nguyen, Patricia Parker, Todd D. Camenisch
ENVIRONMENTAL HEALTH PERSPECTIVES
(2016)
Article
Cell Biology
Patrick Allison, Daniella Espiritu, Todd D. Camenisch
CELL ADHESION & MIGRATION
(2016)
Article
Toxicology
Aram B. Cholanians, Andy V. Phan, Eric J. Ditzel, Todd D. Camenisch, Serrine S. Lau, Terrence J. Monks
TOXICOLOGICAL SCIENCES
(2016)
Article
Gastroenterology & Hepatology
John D. Clarke, Petr Novak, April D. Lake, Rhiannon N. Hardwick, Nathan J. Cherrington
LIVER INTERNATIONAL
(2017)
Review
Oncology
Hani M. Babiker, Ali McBride, Michael Newton, Leigh M. Boehmer, Adrienne Goeller Drucker, Mollie Gowan, Manouchkathe Cassagnol, Todd D. Camenisch, Faiz Anwer, James M. Hollands
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2018)
Article
Pharmacology & Pharmacy
April D. Lake, Rhiannon N. Hardwick, Christopher P. Leamon, Philip S. Low, Nathan J. Cherrington
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Biochemical Research Methods
Marine P. M. Letertre, Nyasha Munjoma, Kate Wolfer, Alexandros Pechlivanis, Julie A. K. McDonald, Rhiannon N. Hardwick, Nathan J. Cherrington, Muireann Coen, Jeremy K. Nicholson, Lesley Hoyles, Jonathan R. Swann, Ian D. Wilson
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Environmental Sciences
Sasha Harris-Lovett, Kara L. Nelson, Paloma Beamer, Heather N. Bischel, Aaron Bivins, Andrea Bruder, Caitlyn Butler, Todd D. Camenisch, Susan K. De Long, Smruthi Karthikeyan, David A. Larsen, Katherine Meierdiercks, Paula J. Mouser, Sheree Pagsuyoin, Sarah M. Prasek, Tyler S. Radniecki, Jeffrey L. Ram, D. Keith Roper, Hannah Safford, Samendra P. Sherchan, William Shuster, Thibault Stalder, Robert T. Wheeler, Katrina Smith Korfmacher
Summary: Wastewater surveillance for SARS-CoV-2 is an emerging approach to identify COVID-19 outbreak risks, especially for institutions like colleges, prisons, and nursing homes. Considerations in wastewater monitoring include local information needs, resources, result interpretation, and follow-up actions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Editorial Material
Cell & Tissue Engineering
Peter Loskill, Rhiannon N. Hardwick, Adrian Roth
Summary: This commentary presents a thought experiment on starting a new drug discovery program that prioritizes human and disease-relevant models throughout the entire process, challenging traditional methods in the field.
Article
Toxicology
Rhiannon N. Hardwick, Patrick Brassil, Ilaria Badagnani, Kimberly Perkins, Glenmar P. Obedencio, Andrea S. Kim, Michael W. Conner, David L. Bourdet, Eric B. Harstad
Summary: Izencitinib, an oral JAK inhibitor, has been developed for the treatment of inflammatory bowel diseases with a focus on optimal efficacy in the gastrointestinal tract and minimal systemic exposures. Nonclinical studies demonstrated that izencitinib had minimal systemic findings and low systemic concentrations in rats and dogs, suggesting the potential for reduced systemic safety concerns. The gut-selective approach of izencitinib highlights the importance of organ-selective drugs in reducing systemic side effects.
TOXICOLOGICAL SCIENCES
(2022)
Review
Toxicology
Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N. Hardwick, Stephen S. Ferguson, Jason P. Stanko, Piyush Bajaj, Karissa Adkins, Nisha S. Sipes, E. Sidney Hunter, Maria T. Baltazar, Paul L. Carmichael, Kritika Sadh, Richard A. Becker
Summary: This article provides a detailed account of a public-private collaboration in testing various microphysiological systems and offers considerations for their practical application in decision-making processes. The authors argue that the success of these systems depends more on the cells, reagents, and research staff's technical expertise rather than the devices themselves. Difficulties in extrapolating concentration-response effects in microphysiological systems to human blood or oral exposures, replicating whole organs, and maintaining long-term functionality are identified as critical challenges.
TOXICOLOGICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Xiaoting Wang, Anna K. Kopec, Mark Collinge, Rhiannon David, Christian Grant, Rhiannon N. Hardwick, Aaron Navratil, Nirav Patel, Wendy Rowan, Nikki B. Marshall
Summary: Immune responses play a crucial role in the regulation and pathogenesis of various human diseases. The immune system can act as a defense mechanism against infection and cancer, but it can also cause tissue damage when the response becomes excessive or uncontrolled. One challenge in drug development is the lack of suitable preclinical human models to study the efficacy and toxicity of immunomodulatory drugs. Recent advancements in human microphysiological systems (MPS) provide a promising platform to evaluate immune responses and reduce reliance on animal models.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2023)
Review
Biochemical Research Methods
Rhiannon N. Hardwick, Catherine J. Betts, Jessica Whritenour, Radhakrishna Sura, Maike Thamsen, Elad H. Kaufmanf, Kristin Fabre
Article
Pharmacology & Pharmacy
R. N. Hardwick, C. Viergever, A. E. Chen, D. G. Nguyen
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2017)