Review
Immunology
Shen-ping Tang, Xin-li Mao, Ya-hong Chen, Ling-ling Yan, Li-ping Ye, Shao-wei Li
Summary: Liver transplantation is the ultimate method for treating end-stage liver disease. The increasing prevalence of obesity and non-alcoholic fatty liver has led to a rise in the number of patients who may require liver transplantation. Ischemia-reperfusion injury and oxidative stress play key roles in the pathogenesis of non-alcoholic fatty liver and its sensitivity to transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jin-yu Yang, Min Li, Cheng-liang Zhang, Dong Liu
Summary: Baicalin, the main active component of Scutellaria baicalensis, has shown various pharmacological effects, particularly in protecting the liver from different diseases, making it a promising candidate for clinical applications in the treatment of liver diseases.
PHARMACOLOGICAL REPORTS
(2021)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Review
Cell Biology
Hyejin Kim, Chaewon Park, Tae Hyun Kim
Summary: Non-alcoholic fatty liver disease (NAFLD) is a group of conditions characterized by excessive accumulation of lipids in the liver, resulting in serious hepatic manifestations. Despite its global prevalence and impact on liver disease, there is no approved medication for NAFLD treatment. Liver X receptors alpha/beta (LXRα and LXRβ) are key regulators of lipid homeostasis and play critical roles in metabolic processes. Dysregulated LXR signaling is strongly associated with NAFLD progression. Targeting LXRs may offer promising therapeutic strategies for NAFLD treatment. However, modulating LXR activity can have varying metabolic consequences depending on cell type. Understanding how LXRs integrate signaling pathways and regulate metabolic homeostasis in the liver may provide new insights into NAFLD and associated metabolic diseases.
Article
Biochemistry & Molecular Biology
Chin-Feng Tsai, Hui-Wen Lin, Jiuan-Miaw Liao, Ke-Min Chen, Jen-Wei Tsai, Chia-Sung Chang, Chia-Yu Chou, Hsing-Hui Su, Pei-Hsun Liu, Ya-Chun Chu, Yi-Hsin Wang, Meilin Wang, Shiang-Suo Huang
Summary: This study found that D. salina extract can alleviate myocardial ischemia/reperfusion (I/R) injury and exert anti-inflammatory and anti-apoptotic effects through inhibiting TLR4-mediated signaling pathway, while reducing autophagy activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Junhua Weng, Xin Wang, Baohong Xu, Wen Li
Summary: ALR protects against IRI in steatotic liver by inhibiting inflammation and downregulating the TLR4/NF-κB pathway, thereby preserving liver function, reducing hepatic injury, and suppressing the inflammatory response.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Immunology
Niloofar Deravi, Mohadeseh Poudineh, Marzieh Pirzadeh, Hanie Yavarpour-Bali, Hoda Mehrabi, Gisou Erabi, Amene Saghazadeh, Nima Rezaei
Summary: Endothelial cells play a critical role in innate immune and inflammatory responses, and Toll-like receptors (TLRs) are key in activating innate mechanisms in ECs. Endothelial dysfunction may lead to tissue damage in various diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Desislava Germanova, Jiri Keirsse, Arnaud Kohler, Jean-Francois Hastir, Peter Demetter, Sandrine Delbauve, Yvon Elkrim, Laurine Verset, Lionel Larbanoix, Nicolas Preyat, Sophie Laurent, Sergei Nedospasov, Vincent Donckier, Jo A. Van Ginderachter, Veronique Flamand
Summary: Liver ischemia-reperfusion injury following hepatic resection in patients with metastases can lead to tumor relapse, with the death of Kupffer cells and recruitment of monocytes possibly playing key roles.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Lu-Yuan Peng, Hai-Tao Shi, Yue-Rong Tan, Si-Yang Shen, Peng-Fei Yi, Hai-Qing Shen, Ben-Dong Fu
Summary: The study found that baicalin protected against APEC infection by modulating gut microbiota, increasing short chain fatty acid (SCFA) production, especially acetate. Acetate may circulate to the lungs to activate FFAR2 to defend against APEC infection.
Review
Biochemistry & Molecular Biology
Saahithh Redddi Patlola, Gary Donohoe, Declan P. McKernan
Summary: Toll-like receptors (TLRs) are pattern recognition receptors that protect the brain from self and foreign antigens/pathogens and can elicit a harmful or beneficial immune response. TLR activation has been associated with neurodegenerative diseases and cytokine imbalance in schizophrenia. This review explores the current literature on TLRs, their potential role in schizophrenia pathogenesis, factors affecting TLR activity and their impact on cognitive performance in schizophrenia.
Article
Plant Sciences
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng
Summary: Baicalin exhibits positive effects on myocardial ischemia diseases, achieved by regulating key pathological indicators and various signaling pathways. In animal models of myocardial ischemia, reperfusion injury, and myocardial infarction, baicalin can reduce myocardial infarction size, improve cardiac pathological condition, and enhance heart function indicators.
Article
Cell Biology
Nicolas Melin, Daniel Sanchez-Taltavull, Rene Fahrner, Adrian Keogh, Michel Dosch, Isabel Buechi, Yitzhak Zimmer, Michaela Medova, Guido Beldi, Daniel M. Aebersold, Daniel Candinas, Deborah Stroka
Summary: The study found that CBLB502 reduces liver damage in ischemia-reperfusion injury and ConA-induced immuno-hepatitis by activating NF-kappa B and STAT3 signaling pathways. IL-22 enhances CBLB502's protective effects through cooperation, increasing hepatocyte resistance to acute liver injury.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yu-Qiong Lei, Yan-Tong Wan, Guang-Tao Liang, Yu-hao Huang, Peng Dong, Si-dan Luo, Wen-juan Zhang, Wei-Feng Liu, Ke-Xuan Liu, Xi-Yang Zhang
Summary: This study evaluated the effects of extracellular RNAs/TLR3 signaling in intestinal I/R injury. The results showed that extracellular RNAs, especially double-stranded RNAs, were significantly increased and TLR3 knockout attenuated intestinal I/R injury. The extracellular RNAs/TLR3 signaling is a key mechanism that regulates intestinal I/R injury in adult mice.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Miguel D. Ferrer, Clara Reynes, Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Silvia Garcia, David Mateos, Miguel Casares, Cristina Gomez, Lucia Ugarriza, Josep A. Tur, Antoni Sureda, Antoni Pons
Summary: Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of hepatic fat. This study investigated the plasma levels of oxylipins, free polyunsaturated fatty acids (PUFA), and markers of lipid peroxidation in NAFLD patients. The results showed that severe NAFLD patients had higher levels of oxylipins, saturated oxylipins, and free PUFA, suggesting an association between inflammation, fatty acid oxidation dysregulation, and NAFLD progression.
Article
Plant Sciences
Seok-Joo Kim, Hyo-Sun Choi, Hong-Ik Cho, Young-Woo Jin, Eun-Kyong Lee, Jeung Youb Ahn, Sun-Mee Lee
JOURNAL OF GINSENG RESEARCH
(2015)
Review
Immunology
Seok-Joo Kim, Craig N. Jenne
SEMINARS IN IMMUNOLOGY
(2016)
Article
Pharmacology & Pharmacy
Jeong-Min Hong, Seok-Joo Kim, Sun-Mee Lee
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Min-Jong Seo, Jeong-Min Hong, Seok-Joo Kim, Sun-Mee Lee
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Cell Biology
Seok-Joo Kim, Sun-Mee Lee
Article
Integrative & Complementary Medicine
Jung-Woo Kang, Seok-Joo Kim, Hyo-Yeon Kim, Soon Hyun Cho, Kyung Nam Kim, Sin Gu Lee, Sun-Mee Lee
AMERICAN JOURNAL OF CHINESE MEDICINE
(2012)
Article
Pharmacology & Pharmacy
Seok-Joo Kim, Hong-Ik Cho, So-Jin Kim, Jin-Hyun Park, Joon-Sung Kim, Young Ho Kim, Sang Kook Lee, Jong-Hwan Kwak, Sun-Mee Lee
EUROPEAN JOURNAL OF PHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Hyo-Yeon Kim, Seok-Joo Kim, Sun-Mee Lee
Article
Biochemistry & Molecular Biology
Seok-Joo Kim, Sun-Mee Lee
FREE RADICAL BIOLOGY AND MEDICINE
(2013)
Article
Plant Sciences
So-Jin Kim, Hong-Ik Cho, Seok-Joo Kim, Joon-Sung Kim, Jong-Hwan Kwak, Dong-Ung Lee, Sang Kook Lee, Sun-Mee Lee
JOURNAL OF NATURAL PRODUCTS
(2014)
Article
Medicine, Research & Experimental
Seok-Joo Kim, Jin Gu Park, Sun-Mee Lee
Letter
Critical Care Medicine
Seok-Joo Kim, Sun-Mee Lee
Article
Critical Care Medicine
Seok-Joo Kim, Hyun-Ae Eum, Timothy R. Billiar, Sun-Mee Lee
Article
Hematology
Braedon McDonald, Rachelle P. Davis, Seok-Joo Kim, Mandy Tse, Charles T. Esmon, Elzbieta Kolaczkowska, Craig N. Jenne
Meeting Abstract
Critical Care Medicine
H. Cho, S. Kim, H. Choi, J. Shin, S. Lee