Article
Endocrinology & Metabolism
Angela Fraga, Eva Rial-Pensado, Ruben Nogueiras, Johan Ferno, Carlos Dieguez, Emilio Gutierrez, Miguel Lopez
Summary: The study investigated the effects of activity-based anorexia (ABA) on whole body energy homeostasis in rats under different housing temperatures. Results showed that ABA rats exhibited hyperactivity and hypophagia, leading to weight loss and muscle cachexia. Increasing the housing temperature reversed these effects without impacting key hypothalamic pathways involved in energy metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Milan Rezac, Nela Glorikova, Shawn M. Wilder, Petr Heneberg
Summary: The study found that while spider behavior was affected by exposure to neonicotinoid insecticides, their lipid and protein reserves were not impacted, and dietary treatments did not show any synergy with acute exposure to neonicotinoid insecticides.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Klaus Abraham, Iris Trefflich, Fabian Gauch, Cornelia Weikert
Summary: Following a strict raw food diet may lead to undersupply of energy and essential nutrients. In this study, strict raw food eaters had lower body fat percentage and lower intake of certain nutrients compared to non-raw food eaters. They also had lower levels of HDL cholesterol, triglycerides, zinc, and vitamin D3.
Letter
Medicine, General & Internal
Arie R. Gafson, Xiaotong Jiang, Changyu Shen, Raj Kapoor, Henrik Zetterberg, Robert J. Fox, Shibeshih Belachew
Summary: This cohort study examines the serum neurofilament light concentration as a biomarker in relation to disability progression in multiple sclerosis, without considering the presence of acute inflammation.
Article
Materials Science, Multidisciplinary
Sungjae Lee, Bowon Ryu, Inho Kim, Yong-Won Song
Summary: This article demonstrates a fiber-optic hydrogen sensor with high sensitivity, selectivity, and reliability. It can accurately monitor hydrogen in liquid fluid and operates independently of temperature and pressure.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Endocrinology & Metabolism
Pavlos Fanis, Maria Morrou, Marios Tomazou, Kyriaki Michailidou, George M. M. Spyrou, Meropi Toumba, Nicos Skordis, Vassos Neocleous, Leonidas A. A. Phylactou
Summary: Makorin RING finger protein 3 (MKRN3) is an important factor associated with Prader-Willi syndrome. It is expressed in the hypothalamus and mutations in the gene have been found in patients with central precocious puberty. The methylation status of the Mkrn3 promoter was investigated in female mice and differential methylation patterns were observed between pre-pubertal and pubertal/post-pubertal stages.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Plant Sciences
Jose A. Abelenda, Noemi Trabanco, Ivan del Olmo, Jenifer Pozas, Maria del Mar Martin-Trillo, Jessica Gomez-Garrido, Anna Esteve-Codina, Monica Pernas, Jose A. Jarillo, Manuel Pineiro
Summary: The flowering response of oilseed rape (OSR) to high ambient temperature is diverse, with one variety exhibiting opposite behavior. BnaFTA2 plays a key role in temperature-dependent flowering initiation in OSR, and additional molecular mechanisms are involved in its repression under high ambient temperature. The presence of H3K4me3 in BnaFTA2 is reduced at high temperature, suggesting a role for this active chromatin marker in the flowering response of OSR to warming.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Environmental Sciences
Bin Pan, Minjie Chen, Xuan Zhang, Shuai Liang, Xiaobo Qin, Lianglin Qiu, Qi Cao, Renzhen Peng, Shimin Tao, Zhouzhou Li, Yaning Zhu, Haidong Kan, Yanyi Xu, Zhekang Ying
Summary: This study found that ambient PM2.5 exposure can activate the HPA axis and mediate PM2.5-induced pulmonary inflammation, providing insights into the contribution of central neurohormonal mechanisms in modulating adverse health effects caused by exposure to PM2.5.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Angshuman Ray Chowdhuri, B. K. Spoorthi, Biswajit Mondal, Paulami Bose, Sandeep Bose, Thalappil Pradeep
Summary: Ambient electrospray can quickly convert preformed polydisperse nanoparticles into monodisperse particles, which then spontaneously self-assemble to form organized films within seconds. Uniform nanoparticles can be obtained without the need for additional chemicals or templates, and this method shows potential for creating advanced materials.
Article
Family Studies
Dharmendra P. Singh, Rajeshwari A. Biradar, Shiva S. Halli, Laxmi Kant Dwivedi
Summary: The study highlights the relationship between maternal and children nutritional status in India, showing that anaemic women are more likely to have anaemic children, and underweight mothers are more likely to have stunted, underweight, and wasted children. Targeting interventions towards anaemic women and children is crucial for achieving Sustainable Development Goals in the country.
CHILDREN AND YOUTH SERVICES REVIEW
(2021)
Article
Oncology
Minami Une, Masaya Ito, Hiroaki Suzuki, Masahiro Toide, Shuichiro Kobayashi, Hiroshi Fukushima, Fumitaka Koga
Summary: In this study, the mutual relationship between the controlling nutritional status (CONUT) score and sarcopenia as prognostic factors in patients with advanced urothelial carcinoma (aUC) was comprehensively examined. The study found that the CONUT score and sarcopenia were significant and independent prognostic biomarkers and incorporating them into established prognostic models increased their predictive accuracy. These objective indices of a patient's general condition may assist in treatment decision-making for patients with aUC.
Article
Engineering, Marine
So-Sun Kim, Gyeong-Sik Han, Hae-Kyun Yoo, Ki-Tae Kim, Soon-Gyu Byun, Min-Min Jung, Woo-Jin Kim, Sung-Don Hwang
Summary: The study revealed that 27 degrees Celsius is the upper limit of tolerable water temperature for starry flounders, and survival was not affected when the water temperature dropped to below 27 degrees Celsius after starvation and feeding.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Public, Environmental & Occupational Health
S. M. Manzoor Ahmed Hanifi, Nidhiya Menon, Agnes Quisumbing
Summary: This study examines the impact of climate change on the nutritional status of young children in rural coastal Bangladesh. The findings indicate that temperatures exceeding 25 degrees Celsius have negative effects on children's nutritional status, while humidity has a positive impact. Exposure to changing climate during the fetal period also plays a significant role.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Endocrinology & Metabolism
Rachel Morano, Emily Yates, Rachel Barnes, Eric S. Wohleb, Diego Perez-Tilve
Summary: The study found that chronic calorie restriction or in db/db mice may alter the co-expression levels of Agrp and Pomc in POMC and AGRP neurons, suggesting an additional mechanism to further suppress melanocortin signaling under conditions of severely reduced leptin action.
NEUROENDOCRINOLOGY
(2022)
Article
Cell Biology
Anne Petzold, Hanna Elin van den Munkhof, Rebecca Figge-Schlensok, Tatiana Korotkova
Summary: By studying freely behaving mice using calcium imaging, optogenetics, and chemogenetics, researchers found that two neuronal populations in the lateral hypothalamus guide hungry animals to make behavioral choices between nutritional and social rewards. One population of neurons increased food consumption by inhibiting hunger signals, while the other population limited feeding and drinking and promoted social interaction despite hunger or thirst. These findings shed light on the neuronal mechanisms of balancing competing needs and provide insights into the flexible fulfillment of essential needs in animals.
Article
Endocrinology & Metabolism
Hui Wang, Monja Willershaeuser, Yongguo Li, Tobias Fromme, Katharina Schnabl, Andrea Bast-Habersbrunner, Samira Ramisch, Sabine Mocek, Martin Klingenspor
Summary: While UCP1 is essential for cold-induced thermogenesis, its presence alone does not protect mice from diet-induced obesity. A new mouse model with low UCP1 levels demonstrates that impaired cold-induced thermogenic capacity does not increase susceptibility to diet-induced obesity. Pharmacological activation of brown fat is necessary to promote negative energy balance in diet-induced obese mice.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Thomas Gantert, Fiona Henkel, Christine Wurmser, Josef Oeckl, Lena Fischer, Mark Haid, Jerzy Adamski, Julia Esser-von Bieren, Martin Klingenspor, Tobias Fromme
Summary: The study found that fibroblast growth factors can upregulate Ucp1 expression in both brown and white adipocyte precursor cells independent of adipogenesis, involving prostaglandin and glucose metabolism and dependent on transcription factors such as Nrf1 and Hes1.
Article
Biochemistry & Molecular Biology
Michal Trela, Olga Witkowska-Pilaszewicz, Dominika Domanska, Monika M. Kaczmarek, Bartosz Pawlinski, Zdzislaw Gajewski, Malgorzata Domino
Summary: This study evaluated the effectiveness of vaginal progesterone inserts therapy in cows with anestrus type II. The expression of progesterone and estrogen receptors in the endometrium was assessed, and blood levels of estradiol and progesterone were evaluated. The results showed a decrease in mRNA expression of certain receptors in both treated and untreated animals. However, treated animals showed an increase in the expression of specific receptors compared to untreated animals. In addition, the recurrence of ovarian cyclicity and pregnancy rates were higher in the treated group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Julia Jaroslawska, Emilia Gospodarska, Agnieszka Korytko
Summary: Negative energy balance induced through either lower ambient temperature or exercise resulted in substantial and similar improvements in markers of inflammation and mitochondrial damage in the hypothalamus of mice with diet-induced obesity, potentially by reducing oxidative stress.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Joanna Szuszkiewicz, Anna Nitkiewicz, Klaudia Drzewiecka, Monika M. Kaczmarek
Summary: Embryo implantation is the most critical stage of pregnancy, dependent on the synchronized developmental capacity of the embryo and uterine receptivity. In early pregnancy, both the conceptus and uterus release various factors to facilitate successful implantation and placenta formation. MicroRNAs, which regulate gene expression, are considered important regulators of early pregnancy events.
BIOLOGY OF REPRODUCTION
(2022)
Review
Medicine, Research & Experimental
Magdalena Wit, Jonathan Trujillo-Viera, Akim Strohmeyer, Martin Klingenspor, Mohammed Hankir, Grzegorz Sumara
Summary: Overconsumption of energy-dense foods can lead to increased intestinal nutrient absorption and excessive lipid accumulation, resulting in obesity and obesity-associated diseases. Targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential.
EMBO MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Andrzej Ciereszko, Mariola A. Dietrich, Mariola Slowinska, Joanna Nynca, Michal Ciborowski, Monika M. Kaczmarek, Kamil Myszczynski, Joanna Kisluk, Anna Majewska, Anna Michalska-Falkowska, Natalia Kodzik, Joanna Reszec, Ewa Sierko, Jacek Niklinski
Summary: Proteomics was used to study non-small cell lung cancer and investigate the differences in proteins between the tumor center and tumor margin. Several important proteins related to lung cancer development and molecular specificity were identified, which could potentially serve as biomarkers and targets for anticancer therapy.
Article
Biology
Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G. Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad
Summary: The study identifies GPR183/EBI2 as the most highly expressed inhibitory G-protein-coupled receptor in brown adipose tissue, which decreases energy expenditure. Loss of Ebi2 in mice results in increased brown adipocyte energy expenditure in response to cold exposure, providing potential insights into modulating energy expenditure in humans.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joanna Szuszkiewicz, Kamil Myszczynski, Zaneta P. Reliszko, Yael Heifetz, Monika M. Kaczmarek
Summary: Research has shown that during early pregnancy, communication between the embryo and uterus occurs through the exchange of extracellular vesicles carrying miRNAs. These vesicles impact embryonic development and trophoblast cell function and interactions, playing a crucial role in successful embryo implantation and pregnancy.
Article
Biochemistry & Molecular Biology
Pawel Likszo, Katarzyna Gromadzka-Hliwa, Jan Klos, Monika M. Kaczmarek, Adam J. Ziecik
Summary: This study focuses on the routine procedure of estrous cycle synchronization in pigs and the use of gonadotropins to stimulate ovarian activity. The research reveals the importance of sexual maturity in maintaining the estrogenic environment and the moderate role of eCG and FSH in activating steroidogenic enzymes in preovulatory follicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria M. Guzewska, Joanna Szuszkiewicz, Monika M. Kaczmarek
Summary: The establishment of cell-to-cell communication is crucial for successful mammalian pregnancy. Extracellular vesicles (EVs) carrying unique molecular cargo have been identified as mediators of this communication during early pregnancy. However, the mechanism of EV-mediated crosstalk between early embryos and the endometrium needs further investigation. Understanding the role of EVs in mammalian reproduction can greatly enhance our knowledge of successful reproductive performance.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Article
Cell Biology
Cecilia Colson, Pierre-Louis Batrow, Sebastian Dieckmann, Laura Contu, Christian H. Roux, Laurence Balas, Claire Vigor, Baptiste Fourmaux, Nadine Gautier, Nathalie Rochet, Nathalie Bernoud-Hubac, Thierry Durand, Dominique Langin, Martin Klingenspor, Ez-Zoubir Amri
Summary: Obesity is a complex disease associated with diet and lifestyle, and it is related to a low amount of thermogenic adipocytes. Recent studies suggest that lipokines, fatty acids and their metabolites, play a role in the control of thermogenesis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Sanna Laurila, Minna Lahesmaa, Eleni Rebelos, Kirsi A. Virtanen, Katharina Schnabl, Martin Klingenspor, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study reveals that secretin can induce satiation by modulating the metabolic communication between brown adipose tissue and the brain. Secretin regulates the brain response to appetite-inducing stimuli and improves inhibitory control, leading to increased feelings of fullness.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Severin Lechner, Raphael R. Steimbach, Longlong Wang, Marshall L. Deline, Yun-Chien Chang, Tobias Fromme, Martin Klingenspor, Patrick Matthias, Aubry K. Miller, Guillaume Medard, Bernhard Kuster
Summary: Lipoic acid is a cofactor in central metabolic pathways and is investigated for its potential as a pharmaceutical in clinical trials. It has been found that lipoic acid inhibits certain histone deacetylases, which explains its various effects on cells.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jolanta Kiewisz, Tomasz Wasniewski, Jacek Kiezun, Agnieszka Skowronska, Monika M. Kaczmarek, Blazej Szostak, Anna E. Kowalczyk, Zbigniew Kmiec
Summary: This study aimed to evaluate the alterations of WNT4 gene expression and protein immunoreactivity in endometrial cancer (EC) and their association with tumor characteristics, clinicopathological factors, and estrogen dependence. The results showed that WNT4 gene expression was decreased in EC samples, particularly in endometrioid EC, and was associated with tumor characteristics. However, there was no statistical difference in WNT4 protein immunoreactivity or estrogen receptor alpha immunoreactivity between EC and control group. The study also found that alterations in WNT4 gene expression tended to be mutually exclusive with alterations in ESR1 gene expression. Overall, this study highlights the importance of evaluating the molecular background of EC, and suggests that WNT4 gene may be a marker of functional estrogen signaling in endometrioid EC.
