期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 263, 期 3, 页码 315-322出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2012.07.003
关键词
Polygonum cuspidatum; Carbamazepine; Carbamazepine-10,11-epoxide; Herbal-drug interaction; CYP 3A; MRP 2
资金
- National Science Council, Taiwan [NSC 99-2320-B-039-017-MY3, NSC99-2320-B-039-009-MY3]
- China Medical University, Taichung, Taiwan [CMU99-S-33, CMU98-S-34]
Carbamazepine (CBZ), an antiepileptic with narrow therapeutic window, is a substrate of CYP 3A which metabolizes CBZ to carbamazepine-10,11-epoxide (CBZE), an active metabolite. This study investigated the acute and chronic effects of Polygonum cuspidatum (PC), a resveratrol-rich nutraceutical, on the pharmacokinetics of CBZ in rats and the underlying mechanisms. Rats were orally administered CBZ (200 mg/kg) alone and coadministered with a single dose and the 7th dose of PC (2 g/kg) in a crossover design. The concentrations of CBZ and CBZE in serum and various tissues were determined by HPLC method. The results showed that PC significantly increased the AUC(0-t) of CBZ and CBZE, whereas the formation rate of CBZE was decreased. Tissue analysis showed that the concentrations of CBZ and CBZE in brain, liver and kidney were significantly increased by PC. Cell studies indicated that the efflux function of MRP 2 was inhibited by the serum metabolites of PC. In conclusion, PC markedly increased the systemic exposure and brain concentration of CBZ and CBZE through inhibiting the activities of CYP 3A and MRP 2. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
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