Article
Environmental Sciences
Alexander M. Rubin, Frank Seebacher
Summary: Bisphenols, including the commonly known bisphenol A (BPA) and its alternatives, have strong effects on circulating hormone levels in non-human animals, particularly in laboratory rats. However, the ecological impacts of bisphenols are still uncertain due to incomplete knowledge and limited data.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Karla Lara Lopes, Hanna Leijoto de Oliveira, Jessica Aparecida Silva Serpa, Juliana Arriel Torres, Francisco Guilherme Esteves Nogueira, Victor Augusto Araujo de Freitas, Keyller Bastos Borges, Maria Cristina Silva
Summary: Endocrine disruptors (EDs) are exogenous compounds that alter the endocrine system's normal functioning, raising environmental concerns. The use of a magnetic nanosorbent for extraction and detection of pollutants in water samples proved to be efficient and convenient, showing high specific surface area and good recovery rates.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
Lili Wang, Anjie Li
Summary: This study investigates the molecular mechanism of EE2 degradation by AOB and AMO using a combination of experimental and computational simulation methods. The results reveal that ammonia nitrogen is essential for the co-metabolism of EE2 by AOB, and NH3 binds with CuC to induce a conformational change in AMO, enabling EE2 to bind with CuB and undergo biological transformation. These findings provide a theoretical basis and a novel research perspective on the removal of ammonia nitrogen and emerging contaminants in wastewater treatment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Oluwakemi D. Samuel, Joseph A. Adeyemi, Olufemi S. Bamidele, Fernando Barbosa Jr, Chris O. Adedire
Summary: This study aimed to investigate the toxicities and immune dysfunction of African catfish exposed to bisphenol A (BPA) and its analogues. The results showed that the exposure to BPA and its analogues caused cytotoxicity, oxidative stress, and immune dysfunction in the African catfish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Carolina G. Moreira, Larissa C. de Souza, Thayanne C. Castor Neto, Giselle Gomes, Daniele M. Bila, Fabiana Fonseca
Summary: Bisphenol-A (BPA) and 17 alpha-ethinylestradiol (EE2) are harmful endocrine disrupting compounds. This study used a combination of reverse osmosis (RO) membrane and UV/H2O2 process to successfully remove BPA and EE2 from low concentration solutions. The removal efficiency increased with higher H2O2 dosage and the reduction in estrogenic activity after UV/H2O2 treatment was significant.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Edmund Charles Jenkins, Gabriella Casalena, Maria Gomez, Dazhi Zhao, Timothy C. Kenny, Nagma Shah, Giovanni Manfredi, Doris Germain
Summary: Dysfunctions in proteasome and protein aggregation are key features of several neurodegenerative disorders. The study found distinct effects of different selective estrogen receptor modulators (SERMs) on gene expression in the spinal cord, with raloxifene showing significant regulation of deubiquitinating enzymes, proteasome subunits and assembly factors. In a mouse model of amyotrophic lateral sclerosis, even a low dose of raloxifene reduced mutant SOD1 aggregates in females and delayed muscle strength decline. These results highlight the importance of considering sex-specific and SERM-selective effects in clinical trials for neurodegenerative diseases.
Article
Ecology
Shanshan Qin, Tian Xia, Gongzheng Li, Lei Gu, Yunfei Sun, Zhou Yang
Summary: Herbicide pollution has negative impacts on individual organisms and can alter population dynamics and stability of interspecific relationships. Cladocerans, a key part of zooplankton, are often exposed to both environmental pollutants and predation risk in aquatic environments. This study evaluated the combined effects of atrazine and fish predation risk on cladoceran population traits. The findings emphasized the importance of considering the combined impact of environmental pollutants and predation risks on zooplankton populations.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Medicine, General & Internal
Andrea Lucia Bastos Carneiro, Ana Paula Curi Spadella, Fabiola Amaral de Souza, Karen Borelli Ferreira Alves, Joaquim Teodoro De Araujo-Neto, Mauro Abi Haidar, Rita de Cassia de Maio Dardes
Summary: The study compared the effects of low-dose conjugated estrogen (CE), raloxifene, and their combination on the endometrium of postmenopausal women. The results showed that combined raloxifene and low-dose CE reduced menopausal symptoms to a similar extent as CE alone, and had similar effects on the endometrium as raloxifene alone.
Article
Environmental Sciences
Gerardo Heredia-Garcia, Gustavo Axel Elizalde-Velazquez, Leobardo Manuel Gomez-Olivan, Hariz Islas-Flores, Sandra Garcia-Medina, Marcela Galar-Martinez, Octavio Dublan-Garcia
Summary: This study aimed to assess the neurotoxic effects of acute BPA exposure at environmentally relevant concentrations in adult zebrafish. Results showed that exposure to 1500 ng/L of BPA reduced swimming distance and increased freezing time. Biomarker evaluation revealed the production of reactive oxygen species and increased acetylcholinesterase activity in the zebrafish brain. Gene expression analysis also indicated overexpression of mbp, alpha 1-tubulin, and manf. Based on these findings, it can be concluded that environmentally relevant concentrations of BPA can cause anxiety-like behavior and neurotoxic effects in adult zebrafish.
Review
Medicine, General & Internal
Karel Dandurand, Dalal S. Ali, Aliya A. Khan
Summary: Primary hyperparathyroidism is the most common cause of hypercalcemia in outpatient settings, with most patients being asymptomatic or presenting with non-specific signs. Recent guidelines recommend surgery for patients under 50 years old with significant hypercalcemia, impaired renal function, renal stones, or osteoporosis. Medical interventions, such as optimizing calcium and vitamin D intake and using cinacalcet, can be considered for patients not undergoing surgery. The impact of medical treatment on fracture risk reduction should be a focus of future research.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Refaat A. Eid, Muhammad Alaa Edeen, Mohamed A. Soltan, Mubarak Al-Shraim, Mohamed Samir A. Zaki, Saleh M. Al-Qahtani, Eman Fayad, Eman T. Salem, Waleed K. Abdulsahib, Hebatallah Emam, Hesham M. Hassan
Summary: This study investigated the protective effects of astaxanthin (ATX) against bisphenol A (BPA)-induced nephrotoxicity. The results showed that ATX protected the kidney by inhibiting the activity of Cytochrome P450 CYP2C9 and preventing excessive production of reactive oxygen species (ROS). ATX also restored mitochondrial function and maintained the balance of oxidant-antioxidant levels. These findings suggest that ATX could be a potential treatment or preventive agent for BPA-induced kidney damage.
Article
Environmental Sciences
Xifa Yang, Yuhao He, Bin Liu, Hui Guo, Lu Xue, Yiwen Duan, Hao Hu, Fei Gao, Lin Zhou, Jing Jing Zhang
Summary: The study showed that alfalfa has a certain tolerance to ATZ and is capable of accumulating the compound. Analysis using metabolomic and transcriptomic techniques revealed significant changes in specific genes and metabolites of alfalfa under ATZ stress, providing potential pathways for using alfalfa as an engineering plant to remediate ATZ-contaminated soil.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Psychiatry
Zijia Li, Yucheng Wang, Zhe Wang, Lingtao Kong, Linzi Liu, Liu Li, Yanqing Tang
Summary: This meta-analysis evaluated the efficacy and safety of estrogen and selective estrogen receptor modulators as adjunctive treatment for women with schizophrenia. The results showed that adjunctive estradiol and raloxifene have positive effects on improving symptoms of schizophrenia in women. Further research is needed to explore the differences in timing and dosage of these treatments.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Engineering, Environmental
Xiaoyun Wu, Xiaowen Yang, Xilin Geng, Xiaotong Ji, Xiaozheng Zhang, Huifeng Yue, Guangke Li, Nan Sang
Summary: This study used the adverse outcome pathway (AOP) approach to explore the toxic mechanisms of BPA and its analogs towards placental thyroid hormone receptors. The findings suggest that they interfere with the structure and function of TRs, potentially leading to adverse outcomes in the placenta.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Richa Mishra, Lalita Mohan Behera, Soumendra Rana
Summary: hC5a, as a pro-inflammatory glycoprotein, plays an important role in drug research. Recent studies have shown that hC5a can cooperatively accommodate drugs at multiple sites, suggesting exploration of polypharmacology for targeting inflammatory diseases related to the "cytokine storm".
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)