Article
Marine & Freshwater Biology
Hanna Niemikoski, Kari K. Lehtonen, Aino Ahvo, Ilse Heiskanen, Paula Vanninen
Summary: This study investigated the metabolism and cytotoxicity of diphenylarsinic acid (DPA) and its major metabolite, diphenylarsine glutathione conjugate (DPA-SG), finding that DPA-SG is significantly more toxic than DPA itself. Results provide insights into the biological effects of dumped chemical munitions in marine environments and help assess the environmental and health risks associated with the continued presence and deterioration of marine munitions at the sea bottom.
AQUATIC TOXICOLOGY
(2021)
Article
Oncology
Yu Zheng, Yuan-Fei Mao, Hui-Jin Zhao, Li Chen, Li-Ning Wang, Yun-Xiang Zhang, Jiong Hu, Jun-Min Li, Xiao-Yang Li, Hong-Ming Zhu
Summary: This study investigated the arsenic metabolism in APL patients who completed ATO treatment and found a decreased arsenic methylation capacity after treatment. The increased proportion of iAs(III) in urine was associated with chronic liver toxicity, highlighting the importance of monitoring urine PMI and considering SNPs of the AS3MT gene in determining ATO dosage.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mahmoud A. El-Ghiaty, Ayman O. S. El-Kadi
Summary: Arsenic, a naturally occurring hazardous element, is widely distributed in various chemical forms. Biomethylation, a pathway in which arsenic is progressively methylated, has been considered as a detoxification mechanism. However, the emergence of toxic trivalent species has raised debate about whether arsenic methylation is a detoxifying or bioactivating mechanism. This review provides a comprehensive understanding of arsenic metabolism in relation to various arsenic-related pathologies.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Review
Environmental Sciences
Yihui Ruan, Xin Fang, Tingyue Guo, Yiting Liu, Yu Hu, Xuening Wang, Yuxin Hu, Lanyue Gao, Yongfang Li, Jingbo Pi, Yuanyuan Xu
Summary: Chronic exposure to arsenic is associated with various cancers, with metabolic reprogramming being a key mechanism. Research has primarily focused on glucose reprogramming induced by arsenic exposure. Apart from enhanced glycolysis, arsenic may also disrupt lipid deposition and induce one-carbon metabolism pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Rajbinder K. Virk, Roobee Garla, Naveen Kaushal, Mohinder P. Bansal, Mohan L. Garg, Biraja P. Mohanty
Summary: Long term exposure to arsenic through consumption of contaminated groundwater is a global issue, but arsenic compounds are also emerging as potential chemotherapeutic drugs. Arsenic speciation studies have significantly contributed to our understanding of the biological behavior of arsenic in humans, but there are limitations and challenges in interpreting arsenic metabolism. Various technologies have identified hundreds of metabolic arsenic conjugates, but the relationship between these species and the metabolic pathway of arsenic remains unclear. New experimental methodologies have revealed novel biorelevant arsenic species, but there is still a need to focus on identifying and characterizing different types of arsenicals in a comprehensive manner.
Article
Engineering, Environmental
Shuai Wang, Kai Zheng, Heping Li, Xiaonan Feng, Luying Wang, Qingyou Liu
Summary: Arsenopyrite, a common metal sulfide mineral, weathers readily in the presence of humic acid (HA) and is influenced by factors such as temperature and acidity. Research findings showed that HA can form complexes with arsenic and iron ions, affecting the weathering behavior and mechanism of arsenopyrite. Electrochemical techniques were used to investigate the weathering process of arsenopyrite, providing valuable insights for understanding the fate and transport of arsenic in acidic conditions.
Article
Environmental Sciences
Guangren Qian, Lu Xu, Nuo Li, Kaili Wang, Yangwei Qu, Yunfeng Xu
Summary: The study found that humus has a significant impact on the release of arsenic in tailing soil, and sulfur-modified HA could greatly improve the release capacity of As, with 2% modification showing the best effect.
Article
Marine & Freshwater Biology
Michal Czub, Jakub Nawala, Stanislaw Popiel, Tomasz Brzezinski, Piotr Maszczyk, Hans Sanderson, Edmund Maser, Diana Gordon, Daniel Dziedzic, Barbara Dawidziuk, Joanna Pijanowska, Jacek Fabisiak, Marta Szubska, Thomas Lang, Paula Vanninen, Hanna Niemikoski, Tine Missiaen, Kari K. Lehtonen, Jacek Beldowski, Lech Kotwicki
Summary: The study reveals the presence of abandoned chemical warfare agents in the oceans worldwide during the 20th century, posing a potential threat to marine ecosystems. Experimental results demonstrate that arsenic-based chemical warfare agents have severe toxic effects on aquatic organisms.
AQUATIC TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shengqiang Fan, Genevieve H. Dennison, Nicholas FitzGerald, Paul L. Burn, Ian R. Gentle, Paul E. Shaw
Summary: Fluorescent sensing materials commonly used for detecting chemical warfare agents and simulants may give false positives in the presence of acids due to the nitrogen-based groups' basicity. This study examines the response of pyridyl-containing sensing materials to acid-containing and acid-free Sarin and simulants.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Environmental Sciences
Jennifer L. Griggs, Liang Chi, Nancy M. Hanley, Michael Kohan, Karen Herbin-Davis, David J. Thomas, Kun Lu, Rebecca C. Fry, Karen D. Bradham
Summary: Arsenic exposure can alter the gut microbiome in mice, and the composition of the microbiome can affect arsenic bioaccessibility. This study used a simulated gastrointestinal model to assess the effects of exposure to arsenic-contaminated soils on the gut microbiome and its impact on arsenic bioaccessibility. The results showed that exposure to arsenic did not change the gut microbiome composition in the colon phase, but it led to a decline in bacteria in the cecum phase. The variability in arsenic bioaccessibility may be influenced by the physicochemical properties of different soil types.
ENVIRONMENTAL POLLUTION
(2022)
Review
Toxicology
Miroslav Styblo, Abhishek Venkatratnam, Rebecca C. Fry, David J. Thomas
Summary: Methylation of inorganic arsenic is both a detoxification pathway and a mechanism for initiating disease.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Chemistry, Analytical
B. Krasnodebska-Ostrega, A. Drwal, E. Biadun, J. Kowalska
Summary: This paper presents a simple and quick procedure for the separation and analysis of As(iii) species in water systems. By using a C18 column saturated with APDC and acidified water samples, As(iii) anions can be effectively separated and the influence of other metal cations can be limited.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Environmental Sciences
Shurui Guo, Mingqin Jiang, Jiajiang Lin, Nasreen Islam Khan, Gary Owens, Zuliang Chen
Summary: This study found that the availability of arsenic (As) in soil is closely related to the presence of iron (Fe) oxides and humic acid (HA). However, the relationship between Fe oxides and HA and As species is not well understood. The experiment showed that As(V) is mainly distributed to certain bound forms of Fe and Al oxides, while As(III) is mainly found in the residual fraction. The addition of HA and green synthesized Fe oxide nanoparticles (FeNPs) affected the distribution of As species in the soil, with HA/FeNPs treatment increasing As(V) in certain bound forms and decreasing As(III) in the residual fraction. The study proposed a mechanism involving the combination of HA and FeNPs to explain the redistribution of As species in the soil.
Article
Food Science & Technology
Lena Ruzik, Malgorzata Jakubowska
Summary: The popularity of plant-based food products has grown in response to the increasing demand for plant foods. This study analyzed the total arsenic content and its species in plant-based beverages purchased in Poland. The research validated a method for analyzing arsenic using high-performance liquid chromatography combined with inductively coupled plasma mass spectrometry.
Article
Environmental Sciences
I. Cunha-Lopes, K. Lehtoranta, S. M. Almeida, M. Evtyugina, A. Vicente, E. Vicente, H. Kuutti, F. Amato, C. A. Alves
Summary: Particulate matter (PM) produced by vehicle emissions is the deadliest form of air pollution, but the detailed chemical speciation of PM is still poorly understood. In this study, different heavy-duty vehicles were tested and the PM emission factors were determined. The study found that major and trace elements accounted for a significant fraction of PM mass, and the composition of PM varied depending on the vehicle and fuel used. Various organic compounds, including n-alkanes and acids, were detected in the exhaust particulates. The study provides important insights into the composition and sources of PM emissions from heavy-duty vehicles, contributing to a better understanding of air pollution.
ATMOSPHERIC ENVIRONMENT
(2023)
Letter
Hematology
Qian Qian Wang, Hua-Feng Wang, Jian-Zhi Zhao, Hua Naranmandura, Jie Jin, Hong-Hu Zhu
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Letter
Oncology
Huafeng Wang, Chang Yang, Ting Shi, Yi Zhang, Jiejing Qian, Yungui Wang, Yongxian Hu, Liping Mao, Xiujin Ye, Fang Liu, Zhenfang Xi, Lihong Shou, Caiyun Fu, Hua Naranmandura, Jie Jin, Hong-Hu Zhu
BLOOD CANCER JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Yasen Maimaitiyiming, Linyan Ye, Tao Yang, Wenjuan Yu, Hua Naranmandura
Summary: Non-coding RNAs, including linear and circular long non-coding RNAs, play significant roles in the etiology, maintenance, and progression of Acute Lymphoblastic Leukemia (ALL). They can modulate gene expression and protein functions, contributing to the classification, diagnosis, risk stratification, and treatment of ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yasen Maimaitiyiming, Tao Yang, Qian Qian Wang, Yan Feng, Zhi Chen, Mikael Bjorklund, Fudi Wang, Chonggao Hu, Chih-Hung Hsu, Hua Naranmandura
Summary: Research has discovered that mild heat treatment can disrupt the RNA polymerase of the SARS-CoV-2 virus, leading to a decrease in viral replication. This heat-induced NSP12 degradation could potentially be a novel approach to combatting SARS-CoV-2.
Review
Chemistry, Medicinal
Yi Ming Shao, Bold Sharavyn, Ping Huang, Hua Naranmandura, Qian Qian Wang
Summary: Metals are naturally present in soil and rocks, playing a vital role in living systems. Metal-based drugs have made significant advancements in cancer treatment, although further research is needed to optimize their side effects.
NATURAL PRODUCTS JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Qian-qian Wang, Liaqat Hussain, Pei-han Yu, Chang Yang, Chen-ying Zhu, Ya-fang Ma, Si-chun Wang, Tao Yang, Yuan-yuan Kang, Wen-juan Yu, Yasen Maimaitiyiming, Hua Naranmandura
Summary: This study demonstrates that hyperthermia can effectively destabilize and degrade the ZBTB16/RAR alpha fusion protein, providing a potential thermal-based therapeutic strategy for refractory ZBTB16/RAR alpha-driven APL.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Pharmacology & Pharmacy
Tao Yang, Si Chun Wang, Linyan Ye, Yasen Maimaitiyiming, Hua Naranmandura
Summary: Emergence of highly infectious SARS-CoV-2 variants requires constant updates in antiviral approaches. The virus encodes structural and nonstructural proteins that play important roles in viral replication and transcription, virion assembly and release, cellular entry, and compromising host defenses. Non-spike viral proteins should be targeted for developing novel drugs to overcome resistance of SARS-CoV-2 variants to preexisting vaccines and antibody-based treatments.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Chemistry, Analytical
Yoshikazu Yamagishi, Go Inokuchi, Yumi Hoshioka, Sayaka Nagasawa, Hirotaro Iwase, Yasumitsu Ogra
Summary: Paliperidone, a widely used antipsychotic agent, was found to be decomposed by hemoglobin through the Fenton reaction, resulting in the formation of the metabolite PM1. The detection of PM1 in the blood can serve as a biomarker to correct for the concentration of paliperidone at the time of death in forensic cases.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Chemistry, Organic
Yasumasa Hara, Teruhisa Manome, Wataru Suehiro, Shinji Harada, Yoshikazu Yamagishi, Akiko Takaya, Yasumitsu Ogra, Masami Ishibashi
Summary: Two new octadeca-peptibols, trichorzin PAX and XI (1 and 2), were isolated from the fungus Trichoderma harzianum IFM 66736, obtained from the soil in Aobanomori Park, Chiba City, Japan. The structures of the compounds were determined through spectral studies, X-ray crystallographic analysis, and MS/MS analysis. Compound 1 and 2 exhibited cytotoxicity against human colon cancer cell lines HCT116.
TETRAHEDRON LETTERS
(2023)
Article
Food Science & Technology
Kazuaki Takahashi, Sakie Horiai, Yoshikazu Yamagishi, Sayaka Nagasawa, Hirotaro Iwase, Yasumitsu Ogra
Summary: This study reveals the biotransformation of a common vegetable selenium compound by gut microbe Morganella morganii, which provides efficient metabolic support for animals.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Analytical
Ryu Mochizuki, Akane Kobayashi, Hiromitsu Takayama, Toshihiko Toida, Yasumitsu Ogra
Summary: The Konig reaction is a useful method for detecting cyanide and its derivatives. In this study, we found that it can also be used to quantify glutathione and applied it to determine the levels of reduced and oxidized glutathiones. The method showed good sensitivity and was successfully applied to measure GSH and GSSG levels in cells exposed to oxidative stress.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Yoshinari Suzuki, Midori Kondo, Masae Harimoto, Yusuke Okamoto, Yu-ki Tanaka, Yasumitsu Ogra, Hiroshi Akiyama
Summary: Single-particle ICP-MS is a method for determining the mass distribution and particle number concentration of inorganic nanoparticles. Researchers developed a Bayesian estimation method to analyze the data obtained from spICP-MS analysis of silver and silica nanoparticles. The Bayesian method provided better estimation results, especially for samples with high particle number concentration, compared to conventional criteria-based methods.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Physics, Fluids & Plasmas
Yu-ki Tanaka, Taiki Osawa, Yoshikazu Yamagishi, Akitoshi Okino, Yasumitsu Ogra
Summary: This study demonstrates that cold atmospheric pressure plasma jet irradiation can effectively degrade methicillin and vancomycin, providing a powerful and environmentally friendly method for antibiotic treatment.
Article
Biochemistry & Molecular Biology
Shohei Takada, Yu-ki Tanaka, Kazuhiro Kumagai, Keita Kobayashi, Akiko Hokura, Yasumitsu Ogra
Summary: This study investigates the mechanism of tellurium (Te) nanorod formation in Chlamydomonas reinhardtii. It is found that the alga initially metabolizes tellurate to form soluble Te compounds, and excess tellurate is then transformed into low-toxicity Te nanorods.
Review
Nutrition & Dietetics
Yasumitsu Ogra, Yu-ki Tanaka, Noriyuki Suzuki
Summary: This review highlights recent advances in analytical techniques such as speciation, imaging, and single-cell analysis to understand copper metabolism.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2022)