Article
Engineering, Environmental
Hua Meng, Guyanan Li, Wei Wei, Yansen Bai, Yue Feng, Ming Fu, Xin Guan, Mengying Li, Hang Li, Chenming Wang, Jiali Jie, Xiulong Wu, Meian He, Xiaomin Zhang, Sheng Wei, Yangkai Li, Huan Guo
Summary: This study identified 15 CpG sites associated with BPDE-Alb adducts, with methylation levels at 5 sites mediating the association between BPDE-Alb adducts and lung cancer risk. The addition of these CpG sites improved the discrimination for lung cancer compared to traditional factors. These results highlight DNA methylation alterations as potential mediators in lung tumorigenesis induced by B[a]P exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Helena Dracinska, Radek Indra, Sandra Jelinkova, Vera Cerna, Volker Manfred Arlt, Marie Stiborova
Summary: In rats, co-exposure to the industrial azo dye Sudan I increases the formation of BaP-derived DNA adducts and enhances the expression and activity of hepatic CYP enzymes when exposed to Sudan I prior to BaP treatment, which exacerbates the genotoxicity of BaP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Angela L. Caipa L. Garcia, Jill E. E. Kucab, Halh Al-Serori, Rebekah S. S. Beck, Franziska Fischer, Matthias Hufnagel, Andrea Hartwig, Andrew Floeder, Silvia Balbo, Hayley Francies, Mathew Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M. M. Arlt, David H. H. Phillips
Summary: Human organoids derived from different tissues have the ability to metabolize the environmental carcinogen benzo[a]pyrene. The response and metabolite formation of the organoids varied between tissue types. This study demonstrates the potential of organoids for studying environmental carcinogenesis and genetic toxicology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Mustafa Abbass, Yuzhi Chen, Volker M. Arlt, Stephen R. Sturzenbaum
Summary: The study found that exposure to high concentrations of BaP significantly impacted life cycle endpoints of C. elegans, such as reduced reproductive output and shortened lifespan, despite the absence of the classical CYP1A1 bioactivation pathway. DNA damage increased dose-dependently, but no bulky DNA adducts were observed. Transcriptomic analysis identified changes in gene expression related to xenobiotic metabolism, suggesting the involvement of parallel pathways in BaP metabolism in C. elegans.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Ye Fu, Xuejing Li, Baolong Pan, Yingying Niu, Bin Zhang, Xinyu Zhao, Jisheng Nie, Jin Yang
Summary: This study investigates the mechanisms of long noncoding RNA (lncRNA) H19 binding to S-adenosylhomocysteine hydrolase (SAHH) and how it regulates DNA damage caused by polycyclic aromatic hydrocarbons (PAHs). The results show that urinary levels of 1-hydroxypyrene (1-OHP) are positively associated with blood H19 RNA expression but inversely correlated with plasma SAHH activity in coke oven workers. Furthermore, the study reveals that H19 binding to SAHH exaggerates DNMT1 expression and activity, leading to increased oxidative DNA damage and cell cycle arrest.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Gentile, Valeria Vezzoli, Sara Martone, Maria Grazia Totaro, Marco Bonomi, Luca Persani, Federica Marelli
Summary: In this study, we investigated the effects of BaP on the HPG axis in zebrafish embryos. The results showed that BaP compromised the neuronal architecture of the GnRH3 network and upregulated antioxidant activity, oxidative DNA damage, and apoptosis pathways. These findings suggest that short-term exposure to BaP can adversely affect GnRH3 development in zebrafish embryos through a neurotoxic mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Bartosz Kazimierz Slowikowski, Maurycy Jankowski, Pawel Piotr Jagodzinski
Summary: Lung cancer is one of the most frequently diagnosed tumor types globally, with increasing mortality rates and incidences observed in recent years, especially among nonsmokers. The mechanisms of lung cancer formation and progression remain unclear due to their complexity involving environmental, genetic, and molecular factors. Besides the undeniable association with cigarette smoke exposure, the presence of estrogens and their interaction with tobacco smoke components can also affect lung cancer development.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Qianyong Shen, Ranran Liu, Jingyi Chen, Guiying Li, Shengtao Ma, Yingxin Yu, Taicheng An
Summary: Occupational workers and residents near petrochemical industry facilities are exposed to multiple contaminants on a daily basis. However, little is known about the co-exposure effects of different pollutants based on biotransformation. This study investigated the changes in toxicity and co-exposure mechanism associated with different monoaromatic hydrocarbons (MAHs) when co-exposed with benzene, toluene, chlorobenzene, or nitrobenzene. The results showed that co-exposure to MAHs negatively affected the detoxification process of benzo[a]pyrene (BaP) and disturbed its metabolic pathways.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Amina Amadou, Delphine Praud, Thomas Coudon, Floriane Deygas, Leny Grassot, Elodie Faure, Florian Couvidat, Julien Caudeville, Bertrand Bessagnet, Pietro Salizzoni, John Gulliver, Karen Leffondre, Gianluca Severi, Francesca Romana Mancini, Beatrice Fervers
Summary: The study found a significant association between cumulative airborne Benzo[a]pyrene (BaP) exposure and breast cancer risk. This association varied depending on menopausal status, hormone receptor status, and grade of differentiation of breast cancer.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Claudio Luparello, Ilenia Cruciata, Andreas C. Joerger, Cory A. Ocasio, Rhiannon Jones, Raysa Khan Tareque, Mark C. Bagley, John Spencer, Martin Walker, Carol Austin, Tiziana Ferrara, Pietro D' Oca, Rossella Bellina, Rossella Branni, Fabio Caradonna
Summary: Carbazole compounds PK9320 and PK9323, as second-generation analogues of PK083, have been shown to restore p53 signaling in cancer cells by binding to mutation-induced surface crevices. The study demonstrates that small modifications in carbazole substitution patterns can significantly impact their genotoxic and epigenetic properties, with PK9320 and PK9323 being potential candidates for anticancer and epi-compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Olga A. Sukocheva, Dong Gui Hu, Robyn Meech, Anupam Bishayee
Summary: Breast cancer MCF-7 cell-line-derived mammospheres exhibit enriched CD44+/CD24- cells resembling breast cancer stem cells, expressing high levels of S1P3. Growth-promoting agents induce SphK1 and S1P3 translocation to the nucleus, while TNF alpha inhibits their nuclear translocation and promotes apoptosis in mammospheres. The study suggests inhibiting SphK1 and S1P3 nuclear translocation as a novel approach to prevent BCSC proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Bozena Bukowska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Benzo[a]pyrene (B[a]P) is a representative polycyclic aromatic hydrocarbon (PAH) that is commonly found in the environment and human surroundings. It has been shown to have toxic effects on DNA, reproduction, neurology, and development. The metabolism of B[a]P is mediated by cytochrome P450 (CYP P450) and its polymorphism determines the sensitivity to B[a]P. Additionally, B[a]P may facilitate the replication of viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Nan Zhao, Weiwei Wu, Shiwei Cui, Haibin Li, Yongliang Feng, Ling Guo, Yawei Zhang, Suping Wang
Summary: This study found a significant association between high levels of maternal PAHs exposure and increased risk of preterm birth. Additionally, the study suggests that dietary intake levels of vitamins, carotene, and folate during pre- and post-conception may modify this association.
ENVIRONMENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Giuditta Rurale, Ilaria Gentile, Camilla Carbonero, Luca Persani, Federica Marelli
Summary: In this study, the effects of BaP on thyroid development and function were tested using zebrafish as a model system. The results showed that exposure to BaP significantly affects thyroid function in zebrafish, with the primary toxic effects occurring at the hypothalamic-pituitary level, creating a model of central hypothyroidism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Vladimir Kodzhahinchev, Kamran Shekh, Lynn P. Weber, Som Niyogi
Summary: The study revealed a significant increase in tissue accumulation and modulation of gene expression when two environmental toxicants were co-exposed. However, this did not result in additive or more-than-additive toxic effects (oxidative stress) in zebrafish.
ENVIRONMENTAL POLLUTION
(2021)