Article
Multidisciplinary Sciences
Visarut Buranasudja, Dolly Rani, Ashwini Malla, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: Formation of oxidative stress in dermal fibroblasts is crucial for skin aging, and using phytochemicals to enhance the cells' ability to combat oxidative stress is a promising strategy to prevent skin aging. Callus culture of Centella asiatica produces unique antioxidant compounds that exhibit anti-skin-aging activities, including upregulation of cellular antioxidant enzymes and inhibition of matrix metalloprotease-9 induction. This highlights the potential of C. asiatica callus extract as an effective anti-skin-aging agent in cosmeceutical preparations.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Mi Yang, Xiaofei Zhou, Xi Tan, Xincheng Huang, Lu Yuan, Zipeng Zhang, Yan Yang, Min Xu, Ying Wan, Zezhi Li
Summary: Alcohol dependence leads to oxidative stress in the body, as evident from the changes observed in the levels of oxidative stress biomarkers. This meta-analysis highlights the decreased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes and lower levels of albumin, along with increased levels of malondialdehyde (MDA), vitamin B12, homocysteine, and bilirubin in patients with alcohol dependence.
Article
Biochemistry & Molecular Biology
Lara Rouco, Rebeca Alvarino, Amparo Alfonso, Maria J. Romero, Rosa Pedrido, Marcelino Maneiro
Summary: This study investigates the antioxidant properties of four manganese(II) complexes with fluorescent dyes and their protective effects on SH-SY5Y neuroblastoma cells. The complexes showed significant antioxidant activity and improved cell survival by reducing reactive oxygen species release. The incorporation of the fluorescent label allowed the study of their cellular uptake in the neuroblastoma cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Medicine, General & Internal
Teresa Cunha-Oliveira, Daniela Franco Silva, Luis Segura, Ines Baldeiras, Ricardo Marques, Tatiana Rosenstock, Paulo J. Oliveira, Filomena S. G. Silva
Summary: Distinct redox signatures were found in lymphoblasts from mutSOD1, undSOD1, and healthy controls, which can serve as therapeutic targets for ALS drug development. High heterogeneity in redox profiles between cohorts was observed, but clustering analysis successfully segregated healthy controls from ALS samples based on specific parameters. These findings provide valuable insights for understanding oxidative stress profiles in different forms of ALS and potential treatment strategies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Longyan Chen, Yang Liu, Yonggang Zhang, Yanmin Zhang, Wei Wang, Hongyu Han, Chunyu Yang, Xueqian Dong
Summary: This study verified the oxidative stress remediation effects of exogenous superoxide dismutase and its therapeutic role against hepatic inflammation. The supplementation significantly restored the hepatic parameters and inhibited the expression of interleukin 1β and interleukin 6 in mice with hepatic inflammation. Transcriptomic analysis showed that superoxide dismutase regulated the expression of specific genes, alleviating oxidative stress damage and mediating liver cell apoptosis. These findings lay a foundation for further investigating the mechanism by which superoxide dismutase alleviates hepatic disease.
Article
Biochemistry & Molecular Biology
Chia-Chu Liu, Chia-Fang Wu, Yung-Chin Lee, Tsung-Yi Huang, Shih-Ting Huang, Hsun-Shuan Wang, Jhen-Hao Jhan, Shu-Pin Huang, Ching-Chia Li, Yung-Shun Juan, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chu-Chih Chen, Ming-Tsang Wu
Summary: Environmental exposure to melamine increases the risk of oxidative stress and early kidney injury. The single-nucleotide polymorphisms (SNPs) of MnSOD, rs4880 and rs5746136, influence the risk of oxidative stress and renal tubular injury, respectively, in patients with calcium urolithiasis.
Article
Biochemistry & Molecular Biology
Matic Broz, Veronika Furlan, Samo Lesnik, Marko Jukic, Urban Bren
Summary: A mutation in the MnSOD gene (rs4880, Ala16Val) has been linked to various types of cancer and autoimmune diseases. This study shows that this mutation disrupts the secondary structure of MnSOD and reduces its activity.
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Arduino Aleksander Mangoni, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro Giuseppe Fois, Pietro Pirina, Angelo Zinellu
Summary: The study found that whole blood SOD concentrations were significantly lower in patients with obstructive sleep apnoea, while serum/plasma SOD concentrations did not show a significant difference. This suggests an impaired antioxidant defence in OSA patients.
Article
Cell Biology
Aushia Tanzih Al Haq, Hong-Yu Tseng, Li-Mei Chen, Chien-Chia Wang, Hsin-Ling Hsu
Summary: Triple-negative breast cancer (TNBC) and the aggressive subtypes of HER2(+) breast cancer are associated with high expression levels of mitochondrial superoxide dismutase (MnSOD). The oncoprotein MCT-1 induces MnSOD in TNBC cells by stabilizing the transcription factor Nrf2. High expression of MnSOD correlates with poor prognosis in breast cancer patients.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Mario Inclan, Maria Teresa Albelda, Salvador Blasco, Carolina Serena, Javier Ugarte Chicote, Antonio Garcia-Espana, Enrique Garcia-Espana
Summary: Superoxide dismutase (SOD) is important for protecting living organisms from harmful effects, but its therapeutic use is limited. This study found three low-molecular-weight compounds that can form complexes with Mn2+, showing a protective effect in vitro and restoring the growth of SOD-deficient E. coli.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Mengli Zheng, Yating Liu, Guanfeng Zhang, Zhikang Yang, Weiwei Xu, Qinghua Chen
Summary: Superoxide dismutase (SOD) is an enzyme that can respond to cellular oxidative stress and has shown effectiveness in anti-tumor, anti-radiation, and anti-aging studies. This research summarizes the types, biological functions, and applications of SODs, and highlights the challenges of membrane permeability and enzyme persistence.
Article
Chemistry, Multidisciplinary
Gwang-Bum Im, Young Geon Kim, Tae Yong Yoo, Yeong Hwan Kim, Kang Kim, Jiyu Hyun, Min Soh, Taeghwan Hyeon, Suk Ho Bhang
Summary: Copper-deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects and therapeutic performance through the upregulation of specific biological factors, scavenging reactive oxygen species, and promoting anti-inflammation and M2 polarization of macrophages. In ischemic vascular diseases, CuCe NPs afford increased perfusion and alleviate tissue damage.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Pengfei Zhai, Yinyan Ma, Huan Xu, Ling Lu
Summary: This study demonstrates that MtmA is involved in responding to oxidative stress by activating mitochondrial SodB activity in A. fumigatus. MtmA, especially for the first Mito-carr domain, is essential for colony growth by regulating cellular Zn2+ equilibrium and responses to oxidative stress. This study reveals the vital and unique role of the MtmA protein in pathogenic fungi, suggesting its potential as a target for antifungal drugs.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Namrata Singh, Somanathapura K. NaveenKumar, Motika Geethika, Govindasamy Mugesh
Summary: The study demonstrates that CeVO4 nanozyme can substitute the function of SOD1 and SOD2 in neuronal cells even when the natural enzymes are down-regulated. The nanozyme prevents mitochondrial damage by regulating superoxide levels and restores physiological levels of anti-apoptotic proteins. Additionally, it effectively prevents mitochondrial depolarization and improves cellular ATP levels under oxidative stress.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, Research & Experimental
Ken-Ichiro Tanaka, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Masahiro Kawahara, Tohru Mizushima
Summary: Lecithinized superoxide dismutase (PCSOD) effectively ameliorates renal ischemia/reperfusion (I/R) injury by inhibiting ROS production, reducing markers of renal damage and fibrosis, and preventing the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This suggests that PCSOD could be a promising therapeutic agent for I/R-induced renal injury.
Article
Nutrition & Dietetics
Simon Bucher, Karima Begriche, Daniel Catheline, Viviane Trak-Smayra, Francois Tiaho, Cedric Coulouarn, Gregory Pinon, Dominique Lagadic-Gossmann, Vincent Rioux, Bernard Fromenty
EUROPEAN JOURNAL OF NUTRITION
(2020)
Review
Gastroenterology & Hepatology
Issam Tout, Dimitri Loureiro, Abdellah Mansouri, Vassili Soumelis, Nathalie Boyer, Tarik Asselah
JOURNAL OF HEPATOLOGY
(2020)
Article
Cell Biology
Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty
Summary: In addition to severe mitochondrial dysfunction, drug-induced steatosis may also be triggered by mild-to-moderate inhibition of mitochondrial fatty acid oxidation, increased de novo lipogenesis, and impairment of very low-density lipoprotein (VLDL) secretion. Among these mechanisms, impairment of VLDL secretion seems to be more frequently involved, possibly as a consequence of endoplasmic reticulum stress.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Julie Massart, Karima Begriche, Bernard Fromenty
Summary: Increased CYP2E1 activity exacerbates APAP-induced liver injury, associated with inflammation. Insulin deficiency and ketosis may lead to hepatic CYP2E1 induction in rodents treated with STZ.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Review
Oncology
Camille Houron, Marie Danielou, Olivier Mir, Bernard Fromenty, Gabriel Perlemuter, Cosmin Sebastian Voican
Summary: Multikinase inhibitors (MKI) have revolutionized cancer management, but there is a lack of data on MKI-related liver injury risk and clinical guidelines. Liver toxicity from MKI typically occurs one to two months after treatment initiation, with hepatocellular toxicity being more common. Early detection and monitoring of liver function are crucial for managing MKI-induced liver injury.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Julie Massart, Karima Begriche, Anne Corlu, Bernard Fromenty
Summary: Metabolic-associated fatty liver disease (MAFLD), often associated with obesity, is a disease that encompasses a range of liver lesions. In addition to nutritional and genetic factors, pharmaceuticals and environmental toxicants are suspected to worsen MAFLD in obese individuals. The mechanisms by which xenobiotics can aggravate MAFLD are still poorly understood, but previous studies have indicated the involvement of different metabolic pathways and cellular events associated with reactive oxygen species overproduction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pierre-Jean Ferron, Brendan Le Dare, Julie Bronsard, Clara Steichen, Elodie Babina, Romain Pelletier, Thierry Hauet, Isabelle Morel, Karin Tarte, Florian Reizine, Bruno Clement, Bernard Fromenty, Thomas Gicquel
Summary: The study investigated the effects of using hydroxychloroquine (HCQ) to treat COVID-19 patients, especially obese patients, and its impact on drug metabolism and hepatotoxicity. In vitro experiments on HepaRG and RPTEC cells showed that HCQ metabolism was altered in conditions of hepatic steatosis in HepaRG cells, leading to the detection of a new metabolite (carboxychloroquine). Furthermore, HepaRG cells exposed to exogenous fatty acids exhibited increased cytotoxicity of HCQ and enhanced neutral lipid accumulation. These in vitro findings were compared with clinical data from COVID-19 patients treated with HCQ, suggesting that steatosis may increase the risk of altered drug metabolism and potential toxicity of HCQ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Laetitia L. Lecante, Sabrina Leverrier-Penna, Thomas Gicquel, Frank Giton, Nathalie Costet, Christele Desdoits-Lethimonier, Laurianne Lesne, Bernard Fromenty, Vincent Lavoue, Antoine D. Rolland, Severine Mazaud-Guittot
Summary: The study found that APAP can impact the development of fetal human ovaries, especially during the 10-12 week window of heightened sensitivity. APAP reduced the total cell number in ovaries, induced cell death, and decreased KI67-positive cell density independently of fetal age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Gastroenterology & Hepatology
Jose C. Fernandez-Checa, Pierre Bagnaninchi, Hui Ye, Pau Sancho-Bru, Juan M. Falcon-Perez, Felix Royo, Carmen Garcia-Ruiz, Ozlen Konu, Joana Miranda, Oleg Lunov, Alexandr Dejneka, Alistair Elfick, Alison McDonald, Gareth J. Sullivan, Guruprasad P. Aithal, M. Isabel Lucena, Raul J. Andrade, Bernard Fromenty, Michel Kranendonk, Francisco Javier Cubero, Leonard J. Nelson
Summary: DILI is a major cause of ALF and a leading indication for liver transplantation in Western societies. Lack of concordance between human and animal DILI and absence of models that faithfully recapitulate human DILI pathophysiological features have hindered our understanding and predictive capabilities of DILI.
JOURNAL OF HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Florian Reizine, Murielle Gregoire, Mathieu Lesouhaitier, Valentin Coirier, Juliette Gauthier, Celine Delaloy, Elise Dessauge, Florent Creusat, Fabrice Uhel, Arnaud Gacouin, Frederic Dessauge, Cecile Le Naoures, Caroline Moreau, Claude Bendavid, Yoann Daniel, Kilian Petitjean, Valerie Bordeau, Claire Lamaison, Caroline Piau, Vincent Cattoir, Mikael Roussel, Bernard Fromenty, Christian Michelet, Yves Le Tulzo, Jaroslaw Zmijewski, Ronan Thibault, Michel Cogne, Karin Tarte, Jean-Marc Tadie
Summary: Severe sepsis can lead to sustained immune dysfunction, resulting in organ failure, secondary infections, and late mortality. Supplementation with arginine or citrulline can restore T cell function and reduce immunosuppression induced by sepsis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Julie Massart, Karima Begriche, Jessica H. Hartman, Bernard Fromenty
Summary: CYP2E1 plays a pivotal role in hepatotoxicity induced by alcohol abuse and different xenobiotics, generating reactive metabolites that induce oxidative stress, mitochondrial dysfunction, and cell death. Increased CYP2E1 activity in nonalcoholic fatty liver disease (NAFLD) leads to reactive oxygen species overproduction, triggering oxidative stress, necroinflammation, and fibrosis. Mitochondrial CYP2E1 (mtCYP2E1) has been found in different experimental models and may contribute to alcohol-associated liver disease, xenobiotic-induced hepatotoxicity, and NAFLD.
Article
Cell Biology
Muhammad Imran, Frederic Chalmel, Odile Sergent, Bertrand Evrard, Helene Le Mentec, Antoine Legrand, Aurelien Dupont, Maelle Bescher, Simon Bucher, Bernard Fromenty, Laurence Huc, Lydie Sparfel, Dominique Lagadic-Gossmann, Normand Podechard
Summary: The study reveals that the combined exposure of the environmental carcinogen benzo[a]pyrene (B[a]P) and ethanol can induce the transition of fatty liver to steatohepatitis. Using zebrafish and human hepatocyte models, the research identifies the involvement of mitochondrial dysfunction, alterations in heme and iron homeostasis, aryl hydrocarbon receptor (AhR) signaling, and oxidative stress in this process.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Annaig Lan, Thomas Guerbette, Mireille Andriamihaja, Benjamin Magnin, Martin Bordet, Pierre-Jean Ferron, Agnes Burel, Roselyne Viel, Bernard Fromenty, Anne Corlu, Francois Blachier, Guillaume Bouguen
Summary: Mucosal healing is important in the treatment of ulcerative colitis, and the involvement of mitochondrial activity in epithelial repair after colitis induction in mouse colonic crypts has been explored. The results show adaptations of colonocyte metabolism to ensure maximal ATP production, despite decreased mitochondrial biogenesis, during inflammation and recovery phases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Julien Allard, Simon Bucher, Pierre-Jean Ferron, Youenn Launay, Bernard Fromenty
Summary: This study aimed to determine whether busulfan could induce steatosis in primary human hepatocytes (PHH) and differentiated HepaRG cells. The results showed that busulfan induced lipid accumulation in HepaRG cells but not in six different batches of PHH. It is suggested that investigations should be carried out in both HepaRG cells and PHH to avoid drawing wrong conclusions on the potential hepatotoxicity of drugs and other xenobiotics.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Meeting Abstract
Toxicology
B. Fromenty
TOXICOLOGY LETTERS
(2021)