Evolutionary Signatures amongst Disease Genes Permit Novel Methods for Gene Prioritization and Construction of Informative Gene-Based Networks

Evolutionary Rate Covariation Identifies New Members of a Protein Network Required for Drosophila melanogaster Female Post-Mating Responses

(2014) Geoffrey D. Findlay et al.   PLoS Genetics

A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk

(2013) David R. Blair et al.   CELL

Targeting the complement system in systemic lupus erythematosus and other diseases

(2013) Maria-Louise Barilla-LaBarca et al.   CLINICAL IMMUNOLOGY

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Noonan syndrome

(2013) Amy E Roberts et al.   LANCET

Evidence for Polygenic Adaptation to Pathogens in the Human Genome

(2013) Josephine T. Daub et al.   MOLECULAR BIOLOGY AND EVOLUTION

Bringing genome-wide association findings into clinical use

(2013) Teri A. Manolio   NATURE REVIEWS GENETICS

The Beginning of the End of the Beginning in Cancer Genomics

(2013) David P. Steensma   NEW ENGLAND JOURNAL OF MEDICINE

UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks

(2013) Ravi Kiran Reddy Kalathur et al.   NUCLEIC ACIDS RESEARCH

Identification of the Causative Gene for Simmental Arachnomelia Syndrome Using a Network-Based Disease Gene Prioritization Approach

(2013) Shihui Jiao et al.   PLoS One

A Novel Null Homozygous Mutation Confirms CACNA2D2 as a Gene Mutated in Epileptic Encephalopathy

(2013) Tommaso Pippucci et al.   PLoS One

Ciliary disorder of the skeleton

(2012) Celine Huber et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

An unbiased evaluation of gene prioritization tools

(2012) Daniela Börnigen et al.   BIOINFORMATICS

Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

(2012) W. Cruz-Munoz et al.   CANCER RESEARCH

Evolutionary Rate Covariation in Meiotic Proteins Results from Fluctuating Evolutionary Pressure in Yeasts and Mammals

(2012) N. L. Clark et al.   GENETICS

Evolutionary rate covariation reveals shared functionality and coexpression of genes

(2012) N. L. Clark et al.   GENOME RESEARCH

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Computational tools for prioritizing candidate genes: boosting disease gene discovery

(2012) Yves Moreau et al.   NATURE REVIEWS GENETICS

BioGPS and MyGene.info: organizing online, gene-centric information

(2012) Chunlei Wu et al.   NUCLEIC ACIDS RESEARCH

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

Combining many interaction networks to predict gene function and analyze gene lists

(2012) Sara Mostafavi et al.   PROTEOMICS

Ciliopathies with Skeletal Anomalies and Renal Insufficiency due to Mutations in the IFT-A Gene WDR19

(2011) Cecilie Bredrup et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis

(2011) Y. Erlich et al.   GENOME RESEARCH

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

(2011) Stuart MacGregor et al.   NATURE GENETICS

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

(2011) Maria N Navarro et al.   NATURE IMMUNOLOGY

Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance

(2011) W Li et al.   ONCOGENE

A Novel Mouse Model for De novo Melanoma

(2010) M. Y. Kumasaka et al.   CANCER RESEARCH

Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease

(2010) Jim Selfridge et al.   DNA REPAIR

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy

(2010) John F. O’Toole et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Method to Detect Proteins Evolving at Correlated Rates: Identifying New Functional Relationships between Coevolving Proteins

(2010) Nathaniel L. Clark et al.   MOLECULAR BIOLOGY AND EVOLUTION

An Integrated View of Molecular Coevolution in Protein-Protein Interactions

(2010) S. C. Lovell et al.   MOLECULAR BIOLOGY AND EVOLUTION

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Recent advances in alveolar biology: Evolution and function of alveolar proteins

(2010) Sandra Orgeig et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Fatal Cardiac Arrhythmia and Long-QT Syndrome in a New Form of Congenital Generalized Lipodystrophy with Muscle Rippling (CGL4) Due to PTRF-CAVIN Mutations

(2010) Anna Rajab et al.   PLoS Genetics

A Pathway-Based View of Human Diseases and Disease Relationships

(2009) Yong Li et al.   PLoS One

Coevolution of Interacting Fertilization Proteins

(2009) Nathaniel L. Clark et al.   PLoS Genetics

fdrtool: a versatile R package for estimating local and tail area-based false discovery rates

(2008) K. Strimmer   BIOINFORMATICS

Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference

(2008) Adrianna Vlachos et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis

(2008) D. B. Sparrow et al.   HUMAN MOLECULAR GENETICS

Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters

(2008) Stefan Bröer et al.   JOURNAL OF CLINICAL INVESTIGATION

McKusick's Online Mendelian Inheritance in Man (OMIM(R))

(2008) J. Amberger et al.   NUCLEIC ACIDS RESEARCH

High-confidence prediction of global interactomes based on genome-wide coevolutionary networks

(2008) D. Juan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The implications of human metabolic network topology for disease comorbidity

(2008) D.- S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA