Review
Biochemistry & Molecular Biology
Marco Zuin, Valentina Rosta, Alessandro Trentini, Cristina Bosi, Giovanni Zuliani, Carlo Cervellati
Summary: Cumulative evidence suggests a link between environmental toxicants, particularly organophosphate pesticides, and the development of Alzheimer's disease (AD). The enzyme Paraoxonase 1 (PON1) plays a role in neutralizing these toxicants and protecting against their harmful effects. Previous studies have shown a partial association between PON1 activity and AD, but a comprehensive examination is lacking. In this meta-analysis, data from seven studies comparing PON1 activity in AD patients and healthy controls were analyzed, revealing a significant reduction in PON1 activity in the AD group.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biology
Hazael Ramiro Ceja-Galvez, Erandis Dheni Torres-Sanchez, Juan Heriberto Torres-Jasso, Emmanuel Reyesuribe, Joel Salazar-Flores
Summary: The activity of the PON-1 enzyme is influenced by genetic variants such as Q192R, as well as alcohol consumption, which may impact the susceptibility of populations to organophosphate poisoning.
Article
Chemistry, Multidisciplinary
Amanpreet Singh, Sanjeev Saini, Mayank, Navneet Kaur, Ajnesh Singh, Narinder Singh, Doo Ok Jang
Summary: An anion-mediated preorganization approach was used to design and synthesize a benzimidazolium-based calix compound R1.2 ClO4-, which was able to encapsulate DMF molecules. A nanoreactor was fabricated by using R1.2 ClO4- and l-histidine as components, showing detoxification ability for paraoxon within 30 minutes, with l-His playing a vital role in the process. The nanoreactor inhibited AChE activity, as determined by Ellman's reagent.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Genetics & Heredity
Marija Vavlukis, Ana Vavlukis, Katerina Krsteva, Sonja Topuzovska
Summary: Paraoxonase 1 (PON1) is an enzyme with multiple functions, and several PON1 gene polymorphisms related to cardiovascular diseases have been proven in clinical studies. Different polymorphisms affect the concentration and activity of PON1, thus influencing atherosclerosis. PON1 genotyping may be reasonable in patients with high and very high cardiovascular risk.
FRONTIERS IN GENETICS
(2022)
Review
Clinical Neurology
Nader Salari, Shna Rasoulpoor, Amin Hosseinian-Far, Nazanin Razazian, Kamran Mansouri, Masoud Mohammadi, Aliakbar Vaisi-Raygani, Rostam Jalali, Shervin Shabani
Summary: PON1 plays a crucial role in the pathogenesis of multiple sclerosis by protecting antioxidants in the blood. Oxidative stress and lipid peroxidation are key factors in the development of MS. Inflammatory cytokines and oxidative stress can have negative effects on PON1, but reducing its activity may help in treating the disease.
NEUROLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Zahra Najafi Arab, Danial Khayatan, Seyed Mehrad Razavi, Kimia Zare, Elnaz Kheradkhah, Saeideh Momtaz, Gianna Ferretti, Tiziana Bacchetti, Thozhukat Sathyapalan, Seyed Ahmad Emami, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
Summary: Chronic diseases such as cardiovascular disease, atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality, with oxidative stress and free radicals playing important roles in their development. Antioxidants, including paraoxonases (PONs), can scavenge free radicals and mitigate their adverse effects. Modulating the expression of PON1, an important antioxidant enzyme, can have beneficial effects in various diseases by regulating inflammatory and oxidative stress signaling pathways. Dietary factors can influence PON1 expression and activity, making them important for disease prevention and treatment.
Review
Cardiac & Cardiovascular Systems
Paul N. N. Durrington, Bilal Bashir, Handrean Soran
Summary: PON1 is an esterase mainly found on HDL, with hydrolytic activity towards organophosphates and other substrates. It plays a critical role in protecting LDL and outer cell membranes against oxidative damage, and its activity is inversely related to the occurrence of atherosclerotic cardiovascular disease. More specific medications targeting PON1 need to be developed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Stefania Sedda, Arduino A. Mangoni
Summary: The presence of a pro-oxidant state in patients with schizophrenia may contribute to the higher risk of atherosclerosis and cardiovascular disease in this group. This study investigated the associations between paraoxonase-1 levels and oxidative stress in schizophrenia patients. The results suggest that alterations in paraoxonase-1 may reflect a pro-oxidant state in specific subgroups of patients with schizophrenia.
Article
Food Science & Technology
Quynh-Anh Bui, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Summary: Vitamin E and paraoxonase 1 (PON1) are linked to cancer development, but their combined effect on colorectal cancer (CRC) risk is unclear. In a case-control study of 1,351 CRC patients and 2,670 controls, vitamin E intake was associated with reduced CRC risk. Individuals carrying the CC genotype of the PON1 rs662 polymorphism had lower CRC risk compared to those carrying the T allele. The interaction between vitamin E intake and PON1 rs662 variants was strongest among individuals with the CC genotype.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Sana Ashiq, Kanwal Ashiq
Summary: This study analyzed the association of PON1 gene polymorphisms with CAD and found that the Q192R polymorphism increased the risk of CAD while the L55M polymorphism showed no significant association. More studies with larger sample sizes are needed for a more definitive conclusion in the future.
BIOCHEMICAL GENETICS
(2021)
Article
Medicine, General & Internal
Shaowei Jiang, Yang Wang, Liang Chen, Honghua Mu, Connor Meaney, Yiwen Fan, Janesh Pillay, Hairong Wang, Jincheng Zhang, Shuming Pan, Chengjin Gao
Summary: This study investigates the associations among serum levels of PAI-1, PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients. The results suggest that genetic polymorphisms of PAI-1 can affect serum levels of PAI-1, which in turn may influence mortality by affecting neutrophil activity.
CHINESE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Bostjan Petric, Sara Redensek Trampuz, Vita Dolzan, Milica Gregoric Kramberger, Maja Trost, Nikola Marakovic, Marko Golicnik, Aljosa Bavec
Summary: Cognitive impairment is a common symptom of Parkinson's disease (PD), and researchers have investigated the potential biomarker PON1 in PD patients. However, no significant correlation was found between PON1 genetic and enzyme-kinetic parameters and cognitive impairment in PD patients, although some associations were observed.
Article
Hospitality, Leisure, Sport & Tourism
Oya Yigitturk, Faruk Turgay, Servet Kizildag, Dua Ozsoylu, Gorkem Aybars Balci
Summary: This study aimed to investigate the effects of hypoxic underwater rugby training on PON1 enzyme activity and oxLDL levels, as well as the role of PON1-Q192R and PON1-L55M polymorphisms. The results showed that hypoxic training led to significant oxidative stress and antioxidant response, resulting in increased PON1 and PON3 activity. The activity of PON1 and ARE was affected by PON1-Q192R and PON1-L55M polymorphisms, and improvements in PON1 activity were observed in QQ and LL genotype groups. However, hypoxic training had a detrimental effect on ARE activity in LL and Rc groups.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Kazuhiko Kotani, Jun Watanabe, Kouichi Miura, Alejandro Gugliucci
Summary: PON1 activity, particularly paraoxonase, is lower in patients with NAFLD, while arylesterase activity shows no significant difference. Patients with biopsy-proven NAFLD have lower activity, whereas those diagnosed by ultrasonography or laboratory data have similar activity to non-NAFLD patients. Further studies are needed to confirm the relevance of PON1 measurements in NAFLD patients.
Article
Biochemistry & Molecular Biology
Milosz Jasinski, Dorota Olszewska-Slonina
Summary: The study showed that the activity of PON1 in patients with prostate cancer undergoing radiotherapy is associated with the risk of recurrence. PON1 activity could be a predictor of prostate cancer recurrence risk.
Article
Biochemical Research Methods
Judit Marsillach, Jessica O. Becker, Tomas Vaisar, Bevra H. Hahn, John D. Brunzell, Clement E. Furlong, Ian H. de Boer, Maureen A. McMahon, Andrew N. Hoofnagle
JOURNAL OF PROTEOME RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Jacqueline M. Garrick, Khoi Dao, Rian de Laat, John Elsworth, Toby B. Cole, Judit Marsillach, Clement E. Furlong, Lucio G. Costa
CHEMICO-BIOLOGICAL INTERACTIONS
(2016)
Article
Biochemistry & Molecular Biology
Clement E. Furlong, Judit Marsillach, Gail P. Jarvik, Lucio G. Costa
CHEMICO-BIOLOGICAL INTERACTIONS
(2016)
Review
Public, Environmental & Occupational Health
Judit Marsillach, Lucio G. Costa, Clement E. Furlong
ANNALS OF GLOBAL HEALTH
(2016)
Article
Biochemistry & Molecular Biology
Judit Marsillach, Edward J. Hsieh, Rebecca J. Richter, Michael J. MacCoss, Clement E. Furlong
CHEMICO-BIOLOGICAL INTERACTIONS
(2013)
Article
Medical Laboratory Technology
Natalia Ferre, Albert Feliu, Anabel Garcia-Heredia, Judit Marsillach, Neus Paris, Marta Zaragoza-Jordana, Bharti Mackness, Michael Mackness, Joaquin Escribano, Ricardo Closa-Monasterolo, Jorge Joven, Jordi Camps
CLINICAL BIOCHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Daniel Seung Kim, David R. Crosslin, Paul L. Auer, Stephanie M. Suzuki, Judit Marsillach, Amber A. Burt, Adam S. Gordon, James F. Meschia, Mike A. Nalls, Bradford B. Worrall, W. T. Longstreth, Rebecca F. Gottesman, Clement E. Furlong, Ulrike Peters, Stephen S. Rich, Deborah A. Nickerson, Gail P. Jarvik
JOURNAL OF LIPID RESEARCH
(2014)
Meeting Abstract
Neurosciences
J. Marsillach, E. J. Hsieh, R. J. Richter, M. J. Maccoss, A. N. Hoofnagle, C. E. Furlong
NEUROTOXICOLOGY AND TERATOLOGY
(2014)
Review
Pharmacology & Pharmacy
Daniel Seung Kim, Judit Marsillach, Clement E. Furlong, Gail P. Jarvik
Article
Multidisciplinary Sciences
Judit Marsillach, Stephanie M. Suzuki, Rebecca J. Richter, Matthew G. McDonald, Peter M. Rademacher, Michael J. MacCoss, Edward J. Hsieh, Allan E. Rettie, Clement E. Furlong
Article
Multidisciplinary Sciences
Wynn K. Meyer, Jerrica Jamison, Rebecca Richter, Stacy E. Woods, Raghavendran Partha, Amanda Kowalczyk, Charles Kronk, Maria Chikina, Robert K. Bonde, Daniel E. Crocker, Joseph Gaspard, Janet M. Lanyon, Judit Marsillach, Clement E. Furlong, Nathan L. Clark
Article
Pharmacology & Pharmacy
Judit Marsillach, Lucio G. Costa, Clement E. Furlong
Review
Medicine, General & Internal
Carlo Cervellati, Giuseppe Valacchi, Veronica Tisato, Giovanni Zuliani, Judit Marsillach
Article
Environmental Sciences
Clement E. Furlong, Judit Marsillach, Michael J. MacCoss, Rebecca J. Richter, Thomas R. Bukowski, Andrew N. Hoofnagle, Matthew G. McDonald, Allan E. Rettie
JOURNAL OF HEALTH AND POLLUTION
(2019)