Article
Food Science & Technology
Xiaoling Chen, Diaoyun Luo, Gang Jia, Hua Zhao, Guangmang Liu, Zhiqing Huang
Summary: L-theanine, a bioactive component in tea leaves, was found to protect against lipopolysaccharide-induced intestinal tight junction damage in IPEC-J2 cells. It reversed the increase of reactive oxygen species production and lactate dehydrogenase release and decreased the mRNA expression of tight junction proteins related genes. This protective effect was mediated through the inhibition of the p38 MAPK-mediated NLRP3 inflammasome pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Geriatrics & Gerontology
Qiongyan Ma, Xu You, Kaili Zhu, Xueyi Zhao, Ding Yuan, Ting Wang, Yaoyan Dun, Jie Wu, Dongming Ren, Changcheng Zhang, Haixia Zhao
Summary: Impaired tight junction function, reduced autophagy, and the activated p38MAPK/MMP9 pathway in Sertoli cells may be closely associated with age-related testicular dysfunction.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Cell Biology
Matthew Herrera, Patricia Molina, Flavia M. Souza-Smith
Summary: Chronic alcohol consumption increases susceptibility to inflammation, bacterial, and viral infections, while alcohol-induced lymphatic leakage may be attributed to disruption of junctional protein complexes in lymphatic endothelial cells. Phosphorylated p38 may play a key role in regulating alcohol-induced lymphatic endothelial cell permeability.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Lan-Min Wang, Yu-Ting Wang, Wan-Xi Yang
Summary: This review summarizes the influences of four typical metal/metal oxide nanomaterials on the paracellular permeability of biological barriers, including disruptions on tight junctions, adhesion junctions, gap junctions, and desmosomes. Complex signaling pathways, as well as reactive oxygen species and cytokines, play crucial roles in ENP-triggered alterations in paracellular permeability.
Article
Food Science & Technology
Xiaoyu Bao, Jianping Wu
Summary: Ovomucin hydrolysate has been shown to prevent pathogen adhesion to intestinal epithelial cells, and in this study, it was demonstrated to improve intestinal barrier integrity by inhibiting inflammatory responses induced by LPS.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Toxicology
Enkai Li, Nathan Horn, Kolapo M. Ajuwon
Summary: Through the study, it was discovered that deoxynivalenol accelerates the endocytosis and degradation of tight junction proteins, which may be regulated by the activation of p38 MAPK and JNK signaling pathways.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Plant Sciences
Ying Wei, Sichen Ren, Jian Wang, Yanling Wang, Yanfei Cui, Miao Tian, Ruilin Wang, Honghong Liu, Yanling Zhao
Summary: DHE alleviated dyspepsia, inflammatory infiltration, and tissue damage induced by IDO through the ERK and p38 signaling pathways rather than the JNK pathway.
Article
Environmental Sciences
Mengxing Cui, Qianmei He, Ziwei Wang, Yongjiang Yu, Huan Gao, Ziqi Liu, Honghao Peng, Han Wang, Xue Zhang, Daochuan Li, Liping Chen, Xiumei Xing, Yongmei Xiao, Wen Chen, Qing Wang
Summary: Micro/nano-plastics (MPs/NPs) can induce intestinal toxicity by increasing permeability and decreasing tight junction proteins expression. The expression of MUC2 is elevated in response to 20 nm PS-NPs, alleviating their cytotoxicity. HO1/p38/IL-10 pathway plays a role in the regulation of MUC2 expression. This study provides valuable insight into the mechanism and potential risk of intestinal toxicity induced by nanoplastics.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell Biology
Tom Breugelmans, Wout Arras, Baptiste Oosterlinck, Aranzazu Jauregui-Amezaga, Michael Somers, Bart Cuypers, Kris Laukens, Joris G. De Man, Heiko U. De Schepper, Benedicte Y. De Winter, Annemieke Smet
Summary: This study investigates the role of MUC13 in disrupting epithelial barrier integrity and the involvement of MUC1 in inflammatory bowel diseases (IBD). The results demonstrate that MUC13 overexpression affects the expression of junctional proteins and barrier mediators, leading to intestinal barrier dysfunction. Furthermore, MUC13 modulates several signaling pathways, including JAK1/STAT3, SNAI1/ZEB1, and ROCK2/MAPK, in cooperation with MUC1. The findings suggest that aberrant MUC13 signaling plays an active role in inducing intestinal barrier dysfunction during inflammation.
Article
Oncology
Wenping Ding, Yuanyuan Lu, Aibin Zhou, Yihong Chen, Zhaoxia Wang, Limei Wang, Ye Tian
Summary: The study revealed that Mast1 plays a crucial role in radiation-induced gastric injury by negatively regulating P38 activation in gastric epithelial cells. Knockdown of Mast1 inhibited cell growth and promoted apoptosis, while overexpression of Mast1 protected cells from radiation damage. These findings suggest Mast1 as a promising prognostic and therapeutic target for radiation-induced gastric injury.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Huaping Tao, Zhiwei Bao, Zhengwei Fu, Yuanxiang Jin
Summary: Exposure to chlorothalonil (CTL) can induce structural and functional damage to the human IEB, leading to barrier dysfunction through the activation of the mitogen-activated protein kinase pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Medicine, Research & Experimental
Jingyuan Wen, Zhengsheng Bao, Lunxin Li, Yingquan Liu, Bing Wei, Xiaoang Ye, Huihui Xu, Longkang Cui, Xuefei Li, Gaobo Shen, Yuan Fang, Hanbing Zeng, Zhe Shen, Enping Guo, Hongting Jin, Lianguo Wu
Summary: Through network pharmacological analysis, this study found that Qiangguyin (QGY) can reduce fat accumulation in the chondro-osseous junction by activating the mitogen-activated protein kinase (MAPK) signaling pathway, thereby reducing decreased bone density and increased bone fragility in postmenopausal osteoporosis (PMOP) patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Jian Kang, Yanhong Zhou, Chunyang Zhu, Tian Ren, Yong Zhang, Longfei Xiao, Binghu Fang
Summary: Inflammation leads to disruption of intestinal epithelial cell tight junctions, and ginsenoside Rg1 can alleviate this disruption by inhibiting the p38 MAPK-mediated NLRP3 inflammasome pathway induced by lipopolysaccharide (LPS).
Article
Cell Biology
Zhangming Chen, Zhe Jiang, Lei Meng, Ye Wang, Minggui Lin, Zhijian Wei, Wenxiu Han, Songcheng Ying, Aman Xu
Summary: SAMHD1 inhibits the proliferation of gastric cancer cells by negatively regulating the activation of MAPK p38 signaling pathway, and is upregulated by KLF4.
Article
Biochemistry & Molecular Biology
Laura Stein, Nora Brunner, Salah Amasheh
Summary: The epithelial barrier plays a crucial role in gastrointestinal function by preventing the passage of solutes. This study investigates the interaction between claudin-4 and claudin-18.2, two tight junction proteins in the gastric epithelium, and suggests that this interaction is dependent on both mechanical force and pH. The findings highlight the importance of tight junction integrity for proper gastrointestinal function.