Article
Food Science & Technology
Caihou Lin, Guifen Liu, Yulong Huang, Shunyi Liu, Binghua Tang
Summary: Continuous exposure to rare-earth nanoparticles in mice can lead to behavioral alterations such as depression, anxiety, and memory impairment, as well as a significant decrease in cell viability. Changes in ATP-citrate lyase and O-linked N-acetylglucosamine transferase play important roles in neurobehavioral disorders induced by rare-earth nanoparticles.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Donglin Yi, Kangmin Kim, Minsu Lee, Eui-man Jung, Eui-Bae Jeung
Summary: D5, a member of the cyclic siloxane family, is widely used in personal care products and as an industrial intermediate. This study found that maternal exposure to D5 resulted in developmental neurotoxicity and behavioral disorders in offspring mice. The offspring showed depression, decreased performance, repetitive activity, cognitive impairment, and social behavior deficits. These findings suggest that the usage of D5 needs to be carefully considered.
Article
Biochemistry & Molecular Biology
Sabrina G. Muller, Natalia S. Jardim, Guilherme Lutz, Gilson Zeni, Cristina W. Nogueira
Summary: This study investigated the anxiolytic-like effect of (m-CF3-PhSe)2 and its modulation of synaptic plasticity and NMDAR-mediated neurotoxicity in young mice exposed to a lifestyle model. The results showed that (m-CF3-PhSe)2 abolished anxiety-like behavior, reversed neurotoxicity, and restored synaptic plasticity-related signaling. These findings suggest that (m-CF3-PhSe)2 may be a potential candidate for anxiolytic drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Lu Peng, Jing Liu, Erqun Song, Yang Song
Summary: This study evaluated the immunotoxic effects of PCB29-pQ, an active quinone-type metabolite of PCBs. The results showed that exposure to PCB29-pQ led to reduced body weight and increased organ index of the spleen and lungs in mice, along with changes in their morphology and structure. Additionally, there was a significant decrease in certain types of lymphocyte subsets in the spleen, indicating immune dysfunction. Furthermore, PCB29-pQ induced apoptosis and an imbalance of Th1/Th2 cytokines. These findings provide new insights into the immunotoxicity mechanism of PCBs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Sarah Thomas Broome, Alessandro Castorina
Summary: Systemic administration of rotenone in mice replicates various pathogenic and behavioral features of Parkinson's disease, and leads to neurochemical alterations at multiple levels of the central nervous system. This study demonstrates the suitability of this pre-clinical model for studying extra-nigral defects in Parkinson's disease.
Article
Neurosciences
Jaini J. Paltian, Angelica S. Dos Reis, Amanda W. S. Martins, Eduardo B. Blodorn, Eduardo N. Dellagostin, Liane K. Soares, Ricardo F. Schumacher, Vinicius F. Campos, Diego Alves, Cristiane Luchese, Ethel Antunes Wilhelm
Summary: Paclitaxel-induced peripheral neuropathy (PIPN) is a common and complex painful condition associated with paclitaxel (PTX) exposure, leading to decreased quality of life, anxiety, and cognitive impairment. However, there are limited treatment options available. In this study, the therapeutic potential of 4-PSQ was assessed for reversing PIPN and its comorbidities. The results showed that 4-PSQ reduced PTX-induced hypersensitivity, anxiety, and cognitive impairment, possibly through modulation of oxidative stress, neuroinflammation, and calcium homeostasis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Analytical
Miao Qi, Rong Liu, Bing Li, Shuai Wang, Runze Fan, Xinyi Zhao, Dehui Xu
Summary: This study investigated the behavioral effects of terahertz radiation on mice, and the results suggest that terahertz waves may enhance anti-anxiety, anti-depression, and social interaction in mice.
Article
Biochemistry & Molecular Biology
Amandia R. Batschauer, Tugstenio L. Souza, Patricia E. Manuitt Brito, Francisco Filipak Neto, Ciro A. Oliveira Ribeiro, Claudia F. Ortolani-Machado
Summary: The study found that chronic perinatal exposure to low doses of manganese in mice can lead to neurotoxic effects, including memory impairment and increased anxiety-like behavior. Manganese exposure also affects biochemical markers in different brain regions, indicating that exposure to low doses of manganese may be harmful to a generation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Environmental Sciences
Jian-Zheng Yang, Kai-Kai Zhang, Yi Liu, Xiu-Wen Li, Li-Jian Chen, Jia-Li Liu, Jia-Hao Li, Long Chen, Clare Hsu, Jia-Hao Zeng, Xiao-Li Xie, Qi Wang
Summary: Polystyrene microplastics (PS-MPs) have become a concerning pollutant due to their widespread production and usage. This study found that PS-MPs exposure activated hippocampal inflammation and induced anxiety-like behavior in mice. PS-MPs also disrupted gut microbiota, impaired the intestinal barrier, and caused peripheral inflammation. Eliminating the gut microbiota protected against the deleterious effects of PS-MPs and green tea's bioactive constituent EGCG showed preventive potential.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ran Ji, Mengqiao Cui, Dongyu Zhou, Xiaoyuan Pan, Yuqi Xie, Xiling Wu, Xin Liang, Hongxing Zhang, Weiyi Song
Summary: BPA exposure during adulthood can lead to sex-specific anxiety-like behaviors in mice, particularly in males. The hyperactivity of glutamatergic neurons in the paraventricular thalamus appears to be a key factor contributing to this anxiety. The down-regulation of alpha-1D adrenergic receptor in the PVT may also play a role in BPA-induced anxiety.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Behavioral Sciences
Melanie P. Leussis, Jessica M. Thanos, Alex Powers, Emalee Peterson, Joshua P. Head, Nathan J. McGovern, Francis J. Malarkey, Anna Drake
Summary: The study showed that prenatal exposure to fluoxetine affects neurodevelopment, mood, social, and repetitive behaviors in mice. High doses of fluoxetine resulted in increased repetitive behaviors and decreased sucrose preference in adult offspring.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Baiba Svalbe, Baiba Zvejniece, Gundega Stelfa, Karlis Vilks, Edijs Vavers, Jose Miguel Vela, Maija Dambrova, Liga Zvejniece
Summary: This study found that the absence of Sig1R significantly influenced metabolic pathways such as amino acids, sphingolipids, and serotonin. Sig1R KO mice had higher levels of serotonin and histamine in their blood and brain tissues, which were correlated with behavioral changes.
Article
Biochemistry & Molecular Biology
Vandana Veenit, Xiaoqun Zhang, Wojciech Paslawski, Ioannis Mantas, Per Svenningsson
Summary: This study reveals the important role of GPR37L1 gene in emotional behaviors and physiological mechanisms in mice, particularly in aversive learning processes. Lack of GPR37L1 also leads to increased body weight and alterations in related biochemical markers, with age- and sex-specific effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kie Shimizu, Rieko Tanaka-Yachi, Kazuaki Nakamura
Summary: This study found that the level of mother preference in mouse pups is associated with anxiety-like behavior and cognition functions in adulthood. Pups with low mother preference exhibit lower anxiety-like behavior and impaired object cognition in adulthood.
NEUROSCIENCE RESEARCH
(2022)
Article
Environmental Sciences
Nour-eddine Kaikai, Saadia Ba-M'hamed, Abderrazzak Ghanima, Mohamed Bennis
Summary: Metam sodium exposure during pregnancy and lactation led to fertility and reproductive issues, as well as alterations in maternal behavior, especially at high doses. The offspring exhibited delayed sensorimotor function development, along with anxiety-like, depression-like behaviors, and learning and memory impairments in adulthood. These effects were associated with oxidative stress, highlighted by changes in enzyme activities in specific brain areas.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Rachid Soulimani, Amadou Dicko, Elie Baudelaire, Jaouad Bouayed
Summary: Rosa canina, Salix alba, Scrophularia nodosa, and Hedera helix have anti-inflammatory effects on LPS-stimulated peripheral blood mononuclear cells. Fine powders with superfine particle sizes have stronger inhibitory effects on inflammatory factors produced by cells, and they contain higher concentrations of phenolic compounds.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nikolai Koehler, Marcus Hoering, Beate Czepukojc, Tim Daniel Rose, Christa Buechler, Tarek Kroehler, Johannes Haybaeck, Gerhard Liebisch, Josch K. Pauling, Sonja M. Kessler, Alexandra K. Kiemer
Summary: This study found that Kupffer cells play an important role in hepatic lipid metabolism and alcoholic liver disease. The accumulation of cytotoxic ceramides and free cholesterol in the liver predispose to disease progression, and the loss of Kupffer cells may accelerate the development of the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Mina Mehanny, Annette Boese, Behnoosh Bornamehr, Jessica Hoppstaedter, Volker Presser, Alexandra K. Kiemer, Claus-Michael Lehr, Gregor Fuhrmann
Summary: This study developed spray-dried gram-positive pneumococcal MVs-loaded vaccine microparticles for enhanced stability and delivery in pulmonary immunization. The optimized microparticles showed excellent flow properties and demonstrated promise as vaccine candidates for pulmonary immunization.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Dimitri Chaussard, Florian Bloch, Arpine Ardzivian Elnar, Yinka Zevering, Jean-Charles Vermion, Remi Moskwa, Jean-Marc Perone
Summary: Difficult surgery is an important factor affecting postoperative endothelial cell density in DMEK, which may be due to endothelial cell loss or the inherent unhealthy properties of the graft.
Article
Medicine, General & Internal
Flora Martin, Nicolas Vautrin, Arpine Ardzivian Elnar, Christophe Goetz, Antoine Becret
Summary: The aim of this study is to assess the impact of an enhanced recovery after surgery (ERAS) programme on patients' well-being after undergoing hysterectomy. The study is an observational, prospective, single-centre before-after clinical trial, recruiting 148 patients. Patients' well-being is measured using a self-questionnaire, and the results will contribute to improving understanding and use of ERAS programmes.
Article
Chemistry, Multidisciplinary
Severine Piutti, Nadine El Wanny, Alexandre Laflotte, Moomen Baroudi, Giovanni Caria, Karen Perronnet, Stefan Jurjanz, Sophie Slezack, Cyril Feidt, Matthieu Delannoy
Summary: This study investigates the use of carbonaceous amendments to reduce the transfer of polychlorobiphenyls (PCBs) to plants. Different types of biochars and activated carbons were tested, and the most effective materials were further studied in historically contaminated soils. The results showed that activated carbons had a significant reduction effect on transfer, while biochars had a lower effect.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Charlotte Dahlem, Shilpee Chanda, Jan Hemmer, Hanna S. Schymik, Michael Kohlstedt, Christoph Wittmann, Alexandra K. Kiemer
Summary: This study investigates the anti-cancer activities of the purple compound violacein and highlights its inhibitory effect on tumor cell proliferation and migration. The study also demonstrates the association between violacein-induced tumor cell death and inflammatory activation of macrophages. The results suggest that violacein may induce immunogenic cell death.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amal Lassoued, Noureddine Khalloufi, Wiem Saidani, Abdelhafidh Khazri, Neziha Ghanem-Boughanmi, Jaouad Bouayed, Mossadok Ben-Attia
Summary: Freshwater salinisation is a threat to the survival of freshwater species. This study investigated the effects of increased water salinity on the bivalve Unio ravoisieri. High salt concentration was found to significantly disrupt oxidative metabolism and increase neurotoxicity in the organism. The findings suggest that cat activity could be used as a sensitive marker to evaluate the impact of freshwater salinisation on freshwater species.
CHEMISTRY AND ECOLOGY
(2023)
Article
Chemistry, Medicinal
Reem K. Fathalla, Wolfgang Froehner, Chantal D. Bader, Patrick D. Fischer, Charlotte Dahlem, Deep Chatterjee, Sebastian Mathea, Alexandra K. Kiemer, Haribabu Arthanari, Rolf Muller, Mohammad Abdel-Halim, Christian Ducho, Matthias Engel
Summary: This study reports a novel class of reversible MurA inhibitors that can inhibit both wild type MurA and fosfomycin-resistant MurA C115D mutant, showing potential for inhibiting cell wall synthesis. The most potent inhibitor 46 exhibits good stability and non-toxicity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sandra Kendzia, Susanne Franke, Tarek Kroehler, Nicole Golob-Schwarzl, Caroline Schweiger, Anna M. Toeglhofer, Christina Skofler, Stefan Uranitsch, Amin El-Heliebi, Julia Fuchs, Andreas Punschart, Philipp Stiegler, Marlen Keil, Jens Hoffmann, David Henderson, Hans Lehrach, Marie-Laure Yaspo, Christoph Reinhard, Reinhold Schaefer, Ulrich Keilholz, Christian Regenbrecht, Rudolf Schicho, Peter Fickert, Sigurd F. Lax, Frank Erdmann, Marcel H. Schulz, Alexandra K. Kiemer, Johannes Haybaeck, Sonja M. Kessler
Summary: By investigating the role of the RNA-binding protein IGF2BP in colorectal cancer chemoresistance, this study found that IGF2BP2 has the highest expression level in primary and metastatic CRC and is associated with tumor stage and growth. IGF2BP2 expression is significantly correlated with resistance to multiple chemotherapeutic drugs, and its knockout enhances sensitivity to certain drugs and affects mitochondrial respiratory chain metabolism. Therefore, IGF2BP2 could be a potential target for overcoming chemoresistance in CRC therapy.
Article
Chemistry, Multidisciplinary
Eilien Heinrich, Olga Hartwig, Christine Walt, Arefeh Kardani, Marcus Koch, Leila Pourtalebi Jahromi, Jessica Hoppstaedter, Alexandra K. Kiemer, Brigitta Loretz, Claus-Michael Lehr, Gregor Fuhrmann
Summary: Recently, researchers introduced two new types of EVs derived from human B-lymphoid cells and non-pathogenic myxobacteria SBSr073 with low immunogenicity. They established a large-scale isolation protocol to reduce plastic waste and cultivation space for sustainable EV research. The biocompatibility of mammalian and bacterial EVs was evaluated comprehensively using in vitro assays and an in vivo zebrafish larvae model. The loaded vesicles showed lower toxicity and were effectively tested on antibiotic-resistant enteropathogenic Shigella.
Article
Medicine, General & Internal
Thomas Maury, Arpine Elnar, Sandra Marchionni, Romain Frisoni, Christophe Goetz, Antoine Becret
Summary: Enhanced recovery after surgery (ERAS) protocols, such as rectus-sheath block (RSB), provide equivalent analgesia compared to thoracic epidural analgesia (TEA), reducing postoperative pain and promoting early rehabilitation. A randomised controlled trial (RCT) will assess the postoperative rehabilitation quality in patients undergoing midline laparotomy after the application of RSB or TEA.
Article
Pharmacology & Pharmacy
Salma Al-Fityan, Britta Diesel, Thorben Fischer, Emmanuel Ampofo, Annika Schomisch, Vida Mashayekhi, Marc Schneider, Alexandra K. Kiemer
Summary: The study aimed to investigate whether loading immune activator poly(I:C) in aspherical silica microrods can repolarize tumour-associated macrophages (TAMs) into M1-like cells. The results showed that even unloaded silica microrods can activate the inflammasome and induce cell death in low concentrations.
Article
Chemistry, Multidisciplinary
Philipp Lapuhs, Eilien Heinrich, Ronald Garcia, Adriely Goes, Nicolas Frank, Lukas Bollenbach, Veronika Stibane, Thomas Kuhn, Marcus Koch, Alexandra K. Kiemer, Rolf Mueller, Kathrin Fuhrmann, Gregor Fuhrmann
Summary: Outer membrane vesicles shed from Gram-negative bacteria play important roles in resistance gene transfer, bacterial virulence, and host cell modulation. This study reports the discovery of autofluorescent vesicles derived from non-pathogenic soil-living myxobacteria, which also exhibit light-regulated antibiotic activity. These findings provide insights into the environmental impact on bacteria-derived vesicles and have implications for future therapeutic design.