Article
Medicine, Research & Experimental
Lilik Duwi Wahyudi, Seon Hui Yu, Min Kyung Cho
Summary: In this study, the effects of curcumin on Cd-induced apoptosis in keratinocytes and the underlying molecular mechanisms were investigated. The results showed that curcumin could inhibit apoptosis caused by Cd in keratinocytes by modulating the expression of MT2A.
Review
Immunology
Wen Xu, Yi Huang
Summary: Cell death is a necessary event to maintain homeostasis in multicellular organisms. Different forms of cell death trigger inflammatory responses and are associated with various human inflammatory diseases. Recent studies suggest that phosphorylation plays a critical role in inflammatory cell death regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Allison K. Tscherner, Angus D. Macaulay, Chyna S. Ortman, Jay M. Baltz
Summary: The period after ovulation is crucial for the healthy development of embryos, as they are sensitive to cell volume perturbations. Early embryos possess unique mechanisms of cell volume control using glycine and betaine, which undergo major changes post-ovulation. These mechanisms are critical for the normal development of embryos.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Carlos Luan A. Passos, Renata Madureira Polinati, Christian Ferreira, Nathalia Alexia Nascimento dos Santos, Daniel Galinis V. Lima, Jerson Lima da Silva, Eliane Fialho
Summary: Curcumin and melphalan combination therapy has anticancer effects on breast cancer cells and represents a promising approach for clinical testing.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Natsumi Fujiwara, Gary M. Whitford, John D. Bartlett, Maiko Suzuki
Summary: Curcumin can mitigate fluoride toxicity by modulating the p53-p21 pathway, inhibiting apoptosis induced by fluoride, and activating Akt to suppress fluoride-induced DNA damage.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Fei Mo, Yinan Xiao, Hao Zeng, Dian Fan, Jinen Song, Xiaobei Liu, Meng Luo, Xuelei Ma
Summary: Curcumin has shown promise as a supplementary therapy in cancer treatment, with our research demonstrating its ability to increase apoptosis rate and downregulate cell cycle-related pathways in human small cell lung cancer cells. Additionally, miRNA-548ah-5p was identified as playing a negative role in curcumin's anticarcinogenic activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Navid Mousazadeh, Mahmoud Gharbavi, Hamid Rashidzadeh, Hamed Nosrati, Hossein Danafar, Behrooz Johari
Summary: The combination of CUR and MTX in niosomal formulation showed enhanced toxicity compared to their free form, indicating the potential of nanocarrier-based approach for codelivery against cancer cells in vitro.
Article
Engineering, Mechanical
Pudi Wang, Qing Zhang, Xu Fang, Feng Lin, Jianyong Huang
Summary: This passage discusses the mechanical mechanisms of cell volume regulation in a 3D microenvironment, revealing a competitive relationship between intracellular cortices and 3D ECM, as well as the joint regulation of cell growth and volume adaption by factors such as initial cell size and ECM stiffness. It also highlights the critical role of prestresses on cell-ECM interfaces in constraining 3D cell growth, and the geometric size-dependent sensitivity of cell volume variation to external stimuli.
EXTREME MECHANICS LETTERS
(2021)
Article
Cell Biology
Yizeng Li, Xiaohan Zhou, Sean X. Sun
Summary: Cells without a stiff cell wall, such as mammalian cells, must actively regulate their volume, with water flow determining cell volume variation. Proton and bicarbonate play significant roles in cell volume regulation, and cells need redundant mechanisms to maintain homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giordana Feriotto, Paolo Marchetti, Riccardo Rondanin, Federico Tagliati, Serena Aguzzi, Simone Beninati, Fabio Casciano, Claudio Tabolacci, Carlo Mischiati
Summary: In this study, the bis-ketone moiety of curcumin (CUR) was replaced to obtain more stable derivatives 2 and 22. The evaluation of their chemical-physical characteristics and cell experiments showed that derivatives 2 and 22 had better bioavailability and stability than CUR, and exhibited significant cytotoxicity and pro-apoptotic effects on chronic myeloid leukemia (CML) cells. Moreover, derivative 22 was able to reverse drug resistance in CML cells resistant to imatinib (IM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Xuelian Gong, Ling Jiang, Wei Li, Qingbin Liang, Zhen Li
Summary: The study showed that curcumin effectively inhibited cell viability of renal cell carcinoma, induced apoptosis and autophagy by suppressing the AKT/mTOR pathway. Using curcumin to target the AKT/mTOR pathway could be a promising alternative treatment for RCC.
Article
Biology
Giordana Feriotto, Riccardo Rondanin, Paolo Marchetti, Federico Tagliati, Simone Beninati, Claudio Tabolacci, Elisa Grusi, Serena Aguzzi, Carlo Mischiati
Summary: By replacing the bis-ketone in Curcumin (CUR) with pyrazole or O-substituted oximes, more stable derivatives were obtained. These derivatives showed improved stability, cytotoxicity, and apoptosis induction compared to CUR in solution and on cancer cell lines. Among them, derivative 1 exhibited the highest cytotoxicity in osteosarcoma (OS) cell lines, suggesting its potential use in future clinical studies for OS treatment.
Article
Environmental Sciences
Kuan-Chun Hsueh, Po-Chung Ju, Yi-Hsien Hsieh, Shih-Chi Su, Chao-Bin Yeh, Chiao-Wen Lin
Summary: HO-3867 triggers cell cycle arrest and apoptotic responses in liver cancer, possibly involving p38-mediated activation of caspase cascades.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Rodrigo Garcia-Tejera, Linus Schumacher, Ramon Grima
Summary: The maintenance and regeneration of adult tissues rely on the self-renewal of stem cells, which requires precise regulation of their proliferation and differentiation rates. A variation of the birth-death process (vBD) that considers volume exclusion effects in the stem cell niche reveals the distribution characteristics of stem cell population.
PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tae Young Ryu, Jinkwon Lee, Yunsang Kang, Mi-Young Son, Dae-Soo Kim, Youn su Lee, Mi-Young Kim, Hyun-Soo Cho
Summary: Through analysis of RNA-seq results in renal cancer patients, we found that SUV420H2 is overexpressed in renal cancer and high SUV420H2 expression is associated with poor prognosis. Knockdown of SUV420H2 using siRNA can inhibit growth and induce apoptosis in the A498 cell line. Further experiments showed that DHRS2 is a direct target of SUV420H2 in the process of apoptosis. Results showed that co-treatment with siSUV420H2 and siDHRS2 could attenuate the growth suppression induced by SUV420H2 knockdown. Additionally, treatment with the SUV420H2 inhibitor A-196 induced apoptosis through upregulation of DHRS2. Taken together, our findings suggest that SUV420H2 may be a potential therapeutic target for the treatment of renal cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sebastian Roesch, Emanuele Bernardinelli, Charity Nofziger, Miklos Toth, Wolfgang Patsch, Gerd Rasp, Markus Paulmichl, Silvia Dossena
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Editorial Material
Cell Biology
Angela Marino, Silvia Dossena, Grazia Tamma, Sandra Donnini
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Review
Biochemistry & Molecular Biology
Simone Vanoni, Giada Scantamburlo, Silvia Dossena, Markus Paulmichl, Charity Nofziger
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Alessia Remigante, Rossana Morabito, Sara Spinelli, Vincenzo Trichilo, Saverio Loddo, Antonio Sarikas, Silvia Dossena, Angela Marino
Article
Cell Biology
Roberta Costa, Alessia Remigante, Davide A. Civello, Emanuele Bernardinelli, Zoltan Szabo, Rossana Morabito, Angela Marino, Antonio Sarikas, Wolfgang Patsch, Markus Paulmichl, Tamas Janaky, Attila Miseta, Tamas Nagy, Silvia Dossena
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Silvia Dossena, Angela Marino
Review
Physiology
Alessia Remigante, Sara Spinelli, Michael Pusch, Antonio Sarikas, Rossana Morabito, Angela Marino, Silvia Dossena
Summary: Bicarbonate, a major anion in mammalian tissues and fluids, plays a critical role in cell and systemic pH homeostasis and is involved in transporting ions and substrates across cell membranes. Chloride/bicarbonate exchangers, abundant in erythrocytes and epithelial cells, are particularly susceptible to oxidative stress. This review focuses on the physiological functions and pathophysiological changes of Cl-/HCO3- exchangers belonging to the SLC4 and SLC26 superfamilies in relation to oxidative stress.
Article
Biochemistry & Molecular Biology
Alessia Remigante, Sara Spinelli, Nancy Basile, Daniele Caruso, Giuseppe Falliti, Silvia Dossena, Angela Marino, Rossana Morabito
Summary: This study aimed to verify the protective role of Quercetin in a d-Galactose-induced model of aging in human erythrocytes. It was found that Quercetin preferentially improved lipid peroxidation rather than protein oxidation and prevented glycated hemoglobin formation. These findings suggest that the Band 3 protein could be a potential target for antioxidant treatments against aging-related disturbances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Alessia Remigante, Sara Spinelli, Elisabetta Straface, Lucrezia Gambardella, Daniele Caruso, Giuseppe Falliti, Silvia Dossena, Angela Marino, Rossana Morabito
Summary: Aging is a decline in physiological functions, closely related to oxidative stress (OS). Functional foods rich in flavonoids are effective in counteracting age-related changes. This study confirmed the protective role of Aca extract in a model of aging in human erythrocytes, reducing OS damage and restoring protein distribution alterations.
Article
Biochemistry & Molecular Biology
Alessia Remigante, Sara Spinelli, Elisabetta Straface, Lucrezia Gambardella, Daniele Caruso, Giuseppe Falliti, Silvia Dossena, Angela Marino, Rossana Morabito
Summary: This study aims to investigate the response of red blood cells to oxidative stress and evaluate the potential beneficial effects of the natural antioxidant quercetin. The results indicate that pre-treatment with quercetin is more effective in protecting red blood cells against oxidative stress and preventing damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Arnoldas Matulevicius, Emanuele Bernardinelli, Zippora Brownstein, Sebastian Roesch, Karen B. Avraham, Silvia Dossena
Summary: The SLC26A4 gene mutation is associated with hearing loss and is particularly common in the Ashkenazi Jewish population. Cell-based assays confirmed that the mutant protein has reduced ion transport function, abnormal subcellular localization, and decreased expression levels, supporting its pathogenicity. Mouse experiments further demonstrated the relevance of this protein variant to Pendred syndrome/DFNB4.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Cell Biology
Alessia Remigante, Paola Gavazzo, Rossana Morabito, Silvia Dossena
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alessia Remigante, Sara Spinelli, Angela Marino, Michael Pusch, Rossana Morabito, Silvia Dossena
Summary: Oxidative stress and immune response are important factors in the development of cancers, including melanoma. Ion channels, which are aberrantly expressed in tumor cells, play a role in neoplastic transformation, malignant progression, and resistance to therapy. These ion channels, located in cellular membranes, are targets of oxidative stress, which is particularly elevated in melanoma. They also represent promising targets for therapeutic intervention in melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Emanuele Bernardinelli, Florian Huber, Sebastian Roesch, Silvia Dossena
Summary: X-linked deafness (DFNX) accounts for up to 2% of hereditary hearing loss cases and can occur in syndromic and non-syndromic forms. POU3F4 is the most common gene associated with X-linked deafness and is responsible for about 50% of non-syndromic cases. It plays a crucial role in the development of the middle and inner ear. This article provides an overview of the pathogenic gene variants of POU3F4, discusses the clinical features, and highlights the importance of further research on its transcriptional targets in the ear and brain.
Review
Audiology & Speech-Language Pathology
Sebastian Roesch, Gerd Rasp, Antonio Sarikas, Silvia Dossena
Summary: Hearing loss is a common sensory deficit in humans, with at least 60% of cases in developed countries being of genetic origin. Enlarged vestibular aqueduct (EVA) is a commonly detected inner ear malformation associated with genetic hearing loss. Genes such as SLC26A4 and FOXI1 play a role in both non-syndromic and syndromic forms of EVA-related hearing loss.
AUDIOLOGY RESEARCH
(2021)