Article
Environmental Sciences
Xuan Zhou, Lebin Song, Rong Cong, Jiaochen Luan, Xiang Zhou, Yichun Wang, Liangyu Yao, Xu Zhang, Xiaohan Ren, Tongtong Zhang, Mengchi Yu, Ninghong Song
Summary: This study investigated the effect of the brominated flame retardant BDE-209 on erectile function in rats and identified potential underlying mechanisms. The findings suggest that BDE-209 may impair endothelial function and gene expression, leading to erectile dysfunction.
Article
Environmental Sciences
Ying Wang, Yi-Tong Du, Nora Fung-Yee Tam
Summary: This study investigated the toxic effects of decabromodiphenyl ether (BDE-209) on the antioxidative and non-antioxidative responses of the mangrove species Kandelia obovata. Results showed that BDE-209 did not negatively affect the growth of K. obovata seedlings, but stimulated the activity of certain enzymes only in weeks 1 and 4. The production of reactive oxygen species was induced only at high concentrations of BDE-209, and BDE-209 was taken up, translocated, and accumulated by the plants. These findings highlight the ability of mangrove plants to accumulate PBDEs and the difficulty in removing BDE-209 from mangrove systems.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Environmental Sciences
Rui Wan, Xiaoxiao Li, Yunyi Zha, Xiong Zheng, Haining Huang, Minghui Li
Summary: This study revealed the influence of decabromodiphenyl ether (BDE-209) on denitrification process for the first time. BDE-209 caused a decrease in denitrification efficiency and the production of harmful substances, and these inhibitory effects were enhanced with increasing exposure duration and concentration. However, BDE-209 had insignificant effects on the global abundance of denitrifying bacteria, mainly due to microbial exchange with the overlying water.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Debarshi Sarkar, Shio Kumar Singh
Summary: The study showed that maternal exposure to BDE-209 during lactation significantly affects male reproductive health in adult offspring, leading to altered testicular histoarchitecture, decreased testosterone production, down-regulation of certain steroidogenic markers, as well as interference with germ cell dynamics and oxidative status in testes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Guanghua Mao, Junjie Tang, Taotao Liao, Xiaoxiang Shi, FangYuan Dong, Weiwei Feng, Yao Chen, Ting Zhao, Xiangyang Wu, Liuqing Yang
Summary: This study investigated the effects of BDE-209 on insulin resistance in type 2 diabetes patients. The results showed that BDE-209 could inhibit glucose absorption and disrupt lipid metabolism, leading to cell damage. The IR-BRL cells were found to be more susceptible to the metabolism toxicity induced by BDE-209.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Taifa Zhang, Huan He, Yu Wei, Wenfeng Geng, Jinxia Zhai
Summary: This study investigated the protective effect of vitamin C on meiotic arrest induced by BDE-209 in spermatocytes and its mechanism. The results showed that vitamin C had a protective effect on male reproductive system by reducing testicular damage and abnormal sperm rate. Vitamin C also attenuated the oxidative stress response induced by BDE-209 and restored DNA repair and crossover markers necessary for meiotic division.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Ping-Chi Hsu, Zheng-Kuan Li, Ching-Shu Lai, Li-Ho Tseng, Chia-Wei Lee, Fu-Jen Cheng, Chao-Yu Chang, Jenq-Renn Chen
Summary: The study revealed that BDE-209, an endocrine disrupting chemical, can impact male reproductive function from F1 to F3 generations, leading to changes in DNA methylation levels and alterations in sperm function.
Article
Multidisciplinary Sciences
Kraisiri Khidkhan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M. M. Nakayama, Kei Nomiyama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
Summary: Cats exposed to polychlorinated biphenyls (PCBs) and decabromodiphenyl ether (BDE-209) may experience adverse endocrine effects, such as thyroid hormone dysfunction. Short-term exposure to PCBs resulted in decreased testis weight, serum albumin, and total protein levels in cats. Long-term administration of BDE-209 led to decreased brain weight and albumin levels, increased subcutaneous fat, high-density lipoprotein (HDL) and triglycerides (TG) levels, and down-regulation of stearoyl-CoA desaturase mRNA expression in cats.
Article
Multidisciplinary Sciences
Sobhy M. Yakout, Ahmed M. Isa, Amel A. El-Sayed, Mohamed H. EL-Saeid
Summary: This study presents the temporal changes of decabromodiphenyl ether (decaBDE) in Saudi human breast milk samples for the first time. Through analysis using gas chromatography-mass spectrometry, it was found that the predominant congeners were BDE-209, -28, -138, and -208. BDE-209 was detected in all analyzed samples, indicating recent exposure of mothers to deca-BDE. The study also suggests that eggs may be a source of BDE-28 in the bodies of mothers. Overall, the study highlights the health concerns and the need for further research on the exposure and effects of decaBDE. Rating: 8 out of 10.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Environmental Sciences
Yangyang Ding, Yao Chen, Weiwei Feng, Guijuan Huang, Mingyue Dong, Ting Zhao, Na Chen, Liuqing Yang, Guanghua Mao, Xiangyang Wu
Summary: This study comprehensively investigated the immunotoxicity of BDE-209 on middle-aged mice, revealing that exposure to BDE-209 can lead to oxidative injury to immune organs, impair immune functions, and disturb gene expressions. Furthermore, the study found that middle-aged mice are more susceptible to immune impairment compared to adult mice, and immune impairment in aged mice is more difficult to be self-repaired.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Lin Cheng, Qinxiong Rao, Qicai Zhang, Wei Song, Shuhui Guan, Zhilin Jiang, Tian Wu, Zhihui Zhao, Weiguo Song
Summary: The mechanism through which BDE-209 affects the immune system involves damaging and necrotizing lymphocytes, as well as affecting the activities of immune organs. This leads to suppression of immune functions and atrophy of the spleen.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Jingjing Sha, Xiaoyang Jian, Qingyun Yu, Miao Wei, Xiaoyu Li, Ludan Zhao, Yanping Qi
Summary: This study investigates the effects of PBDEs on Brachionus plicatilis and finds that low concentrations activate antioxidant defense mechanisms, while high concentrations impair antioxidative capacity, leading to the accumulation of free radicals, increased lipid peroxidation, and DNA damage.
Article
Environmental Sciences
Yue Zhang, Xiangyang Li, Li Jing, Guiqing Zhou, Yujian Sang, Leqiang Gao, Shuqin Jiang, Zhixiong Shi, Wei Ge, Zhiwei Sun, Xianqing Zhou
Summary: The study revealed that BDE-209 reduced sperm quality and quantity, which was correlated with glycolipid metabolism dysbiosis of testis. Additionally, BDE-209 exposure activated glycolipid metabolism pathways and the mitochondrial apoptotic pathway, leading to spermatogenic cell apoptosis.
Article
Environmental Sciences
Yao Wang, Jinbao Huang, Hong Wang, Lin Lan, Xin Mu, Weiwei Xu, Shanjin Lv, Xinsheng Li
Summary: This study investigated the thermal degradation mechanism of BDE-209 using density functional theory method and found that the primary degradation reactions involved cleaving the ether bond and the C-Br bond. The formation of hexabromobenzene and low-brominated diphenyl ethers were observed as major products. The results obtained in this study provide valuable information for the treatment and reuse of waste plastics containing BDE-209.
Article
Neurosciences
Yiming Qi
Summary: This study found that exposure to BDE-209 can cause acoustic alterations in isolation USVs, with high-dose exposed pups emitting USVs with shorter duration and lower percentage of frequency-modulated USVs.
NEUROTOXICOLOGY AND TERATOLOGY
(2022)