期刊
TOXICOLOGY
卷 254, 期 3, 页码 136-146出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2008.08.003
关键词
Endothelium; Liver; Hepatitis; Chemokines; Adhesion molecules; Lymphocyte; Trafficking
资金
- Biotechnology and Biological Sciences Research Council [BB/D523151/1] Funding Source: Medline
- Medical Research Council [G0400496, G0300101] Funding Source: Medline
- NIAAA NIH HHS [R01 AA014257-01A2, R01 AA014257-02, R01 AA014257-04, R01 AA014257, R01 AA014257-03] Funding Source: Medline
- BBSRC [BB/D523151/1] Funding Source: UKRI
- MRC [G0300101, G0400496] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D523151/1] Funding Source: researchfish
- Medical Research Council [G9818340B, G0400496, G0300101] Funding Source: researchfish
Recirculation of blood lymphocytes through the liver occurs under normal conditions as part of the process of immune surveillance. In response to injury or infection recruitment from blood increases and the nature and distribution of the infiltrate will determine the type and outcome of the resulting hepatitis. Recruitment from blood occurs via the hepatic sinusoids and is controlled by interactions between circulating lymphocytes and the highly specialised sinusoidal endothelial cells. This is a low flow vascular bed and the molecular basis of recruitment differs from other tissues. In this review we outline the molecular basis of lymphocyte recruitment to the liver and the effect on it of the local tissue microenvironment and how dysregulation of these processes can lead to uncontrolled inflammation and liver damage. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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