Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yuta Semba, Shintaro Yamamoto, Shunsuke Takahashi, Takahisa Shinomiya, Yukitoshi Nagahara
Summary: Masitinib induces apoptosis in c-kit-negative HepG2 cells by targeting the redox balance through the JNK pathway, demonstrating its anticancer effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wei Guo, Yadi Xing, Xiumei Luo, Fuguang Li, Maozhi Ren, Yiming Liang
Summary: Reactive oxygen species (ROS) are crucial regulators in both plant and human cells, serving as messengers in multiple pathways. While they play a beneficial role in growth and development, excessive ROS can cause oxidative stress and damage cellular functions. This review highlights the current research and mechanisms of ROS in both kingdoms, emphasizing their interactions with other substances and proposing potential opportunities for novel therapeutic strategies and agricultural advancements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Marc Herb, Alexander Gluschko, Michael Schramm
Summary: Reactive oxygen species (ROS) play important roles in cellular processes but can also lead to diseases, their effects depending on cell type and ROS production conditions. Cellular redox balance, like cell pH and calcium levels, is tightly controlled, with evidence showing that cells regulate ROS production by controlling activation and localization factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hee Jin Jung, Dong Chan Choi, Sang Gyun Noh, Heejeong Choi, Inkyu Choi, Il Young Ryu, Hae Young Chung, Hyung Ryong Moon
Summary: Thirteen (Z)-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among these compounds, compounds 1-3 displayed stronger tyrosinase inhibitory activity and could inhibit melanin production through different pathways.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Engineering, Environmental
Guoqiang Zhao, Binbin Wu, Xiaoshan Zheng, Baoliang Chen, Andreas Kappler, Chiheng Chu
Summary: We have discovered an unrecognized tidal source of reactive oxygen species (ROS) and demonstrated the generation of ROS in coastal surface soil during tidal processes. The fluctuation of redox potential and dissolved oxygen concentration follows a similar pattern to the production of ROS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Article
Microbiology
Cristina N. Coffman, Matthew G. Varga, Joe Alcock, Amanda Carrol-Portillo, Sudha B. Singh, Xiang Xue, Henry C. Lin
Summary: This study found that norepinephrine promotes the growth of Desulfovibrio vulgaris, and this effect is dependent on iron availability.
Article
Engineering, Environmental
Yunhai Zhang, Xinjie Wang, Ying Li, Hao Wang, Yuexiao Shi, Yang Li, Yongjun Zhang
Summary: The study found that selecting appropriate pH and coagulant concentrations can improve the removal efficiency of polystyrene nanoplastic particles by polyacrylamide, and humic acid has a certain inhibitory effect on this process.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Anlin Xu, Wanqun Liu, Leping Chu, Yunhai Zhang, Yide He, Yongjun Zhang
Summary: This study developed an innovative method to fabricate a cathode with waste-tire carbon and found that it significantly improves the current efficiency and H2O2 yield.
WATER SCIENCE AND TECHNOLOGY
(2022)
Article
Marine & Freshwater Biology
Yide He, Rongwen Zhu, Yujie Cai, Yiqun Zhang, Yunhai Zhang, Shunlong Pan, Rudolf J. Schneider, Yongjun Zhang
Summary: In this study, the degradation pathway of Nebivolol (NEB) under UV radiation was investigated, and zebrafish embryos/larvae were used to evaluate the median lethal concentration (LC50) of NEB. Transcriptomic analysis and protein biomarker analysis revealed that UV radiation could reduce the toxic effects of NEB on the early development of zebrafish by affecting genes and pathways associated with antioxidant, nervous, and immune systems.
AQUATIC TOXICOLOGY
(2022)
Review
Cell Biology
Lavanya Goodla, Xiang Xue
Summary: This brief review discusses the involvement of three representative cytokines (TNF-alpha, IL-6 and IL-1 beta), a lipid molecule PGE2 and two chemokines (CXCL1 and CXCL2) in the process of CRC liver metastases.
Article
Engineering, Chemical
Anlin Xu, Xin Sun, Siyan Fan, Ziyan Yang, Qiqi Zhang, Yunhai Zhang, Yongjun Zhang
Summary: A novel cathode was fabricated using biogenic Fe-Mn oxides and carbon black for heterogeneous electro-Fenton process. The cultivation time of the applied microbes was found to regulate the crystallinity and metal valence of the cathode, affecting the degradation efficiency of ofloxacin. The degradation kinetic constant with the novel cathode was twice that of the chemogenic peer. The cathode showed high stability and efficiency in a broad pH range and its applicability was validated with real livestock wastewater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hyeoncheol Kim, Luke B. Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M. Falcon, David R. Martin, Ho-Joon Lee, Michael K. Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A. Colacino, Costas A. Lyssiotis, Henry C. Lin, Yatrik M. Shah, Xiang Xue
Summary: This study reveals that transferrin receptor (TFRC) is induced by β-catenin activation driven by APC gene loss in colorectal cancer, and TFRC-mediated intratumoral iron accumulation enhances β-catenin signaling through tankyrase activation. Disruption of TFRC reduces colonic iron levels and iron-dependent tankyrase activity, leading to stabilization of AXIN2 and repression of the β-catenin/c-Myc/E2F Transcription Factor 1/DNA polymerase delta1 (POLD1) axis, causing increased DNA replication stress, DNA damage response, apoptosis, and reduced colon tumor growth. Iron chelation combined with DNA damaging agents further increases DNA damage response and reduces colon tumor cell growth. This discovery may offer new strategies for colorectal cancer therapy.
Article
Gastroenterology & Hepatology
Zhaoli Liu, Mariella Arcos, David R. Martin, Xiang Xue
Summary: This study found that myeloid FTH1 is essential for colitis and colitis-associated colorectal cancer through the activation of DMT1/iron-driven STAT3 signaling. Myeloid FTH1-deficient mice fed with a high-iron diet showed reduced susceptibility to DSS-induced acute colitis. The mechanism involves lower expression of DMT1 and active phosphorylated STAT3 in the colon tissues.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Materials Science, Multidisciplinary
Xutong Zheng, Yejie Cao, Yongsheng Liu, Jing Wang, Yunhai Zhang, Ning Dong
Summary: Diamond is widely used in diamond tools and thermal management materials due to its high hardness and thermal conductivity. However, the surface inertness of diamond hinders the bonding with the matrix, resulting in a decline in performance. In this study, Mo2C coatings were successfully prepared using the molten salt method, providing new insights into the growth mechanism. The as-prepared coatings showed good thermal shock resistance and oxidation resistance.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Environmental Sciences
Ning Xu, Lei Jiang, Yunhai Zhang, Yi Shen, Yi Wang, Shangjie Wang, Qingbin Yuan
Summary: This study investigated the pollution and distribution of micro-plastics in the offshore Sea, rivers and wastewater treatment plants (WWTPs) in Jiangsu coastal area in China. The results showed that microplastics were widely present in the offshore area, with higher abundance in rivers and WWTPs. Small-sized microplastics increased from WWTPs to rivers and the offshore area. Various types of microplastics were identified, and both living and industrial sources contributed to their prevalence.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Yunhai Zhang, Zihao Chen, Yuexiao Shi, Qing Ma, Haoran Mao, Ying Li, Hao Wang, Yongjun Zhang
Summary: This study investigated the sorption mechanisms of the popularly occurring carbamazepine (CBZ) on pristine and aged microplastics (MPs). The aging process of MPs increased their sorption capacity and intensified the desorption hysteresis of CBZ. The XDLVO theory was applied to calculate the interfacial free energies and revealed that the hydrophobic interaction was lessened after aging for all MPs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ning Xu, Yi Shen, Lei Jiang, Bin Jiang, Ying Li, Qingbin Yuan, Yunhai Zhang
Summary: To explore antibiotic pollution in the coastal waters of eastern China, the concentrations of 13 antibiotics in representative coastal rivers in Jiangsu and sampling sites in the coastal waters of Jiangsu were analyzed. Antibiotic concentrations in the rivers ranged from 33.14 to 417.78 ng L-1, and in the sampling sites ranged from 0.90 to 86.33 ng L-1. Macrolides exhibited the highest concentrations and detection frequencies. Antibiotic concentrations decreased with distance from the coastline, indicating river inputs as important sources of pollution. Risk assessments identified medium ecological and resistance risks posed by roxithromycin and ofloxacin, respectively. This study emphasizes the importance of monitoring and controlling antibiotic contaminants in the coastal waters of Jiangsu.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Yide He, Yiqun Zhang, Wei Zhou, Rosa Freitas, Yunhai Zhang, Yongjun Zhang
Summary: The reproductive toxicity of polystyrene microplastics (PS MPs) and carbamazepine (CBZ) on Daphnia magna was studied in two consecutive generations (F0, F1). The results showed that a significantly enhanced toxicity was observed in the presence of 5 μm PS MPs and CBZ. Gene expression analysis revealed changes in genes related to reproduction and toxic metabolism in both F0 and F1, indicating serious reproductive damage in aquatic animals caused by long-term exposure to MPs and CBZ.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Anlin Xu, Tong Meng, Siyan Fan, Yunhai Zhang, Qiqi Zhang, Yongjun Zhang
Summary: Fe and Mn were used to synthesize biogenic Fe-Mn oxides (Bio-FeMnOx) via a manganese oxidizing bacterium Pseudomonas sp. The catalytic activity of Bio-FeMnOx was regulated by Fe/Mn ratios, and Cu showed the best doping effect. The optimal Bio-FeMnOx-Cu had a degradation kinetic constant approximately three times that of its chemogenic counterpart.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Lixing Zhang, Xin Miao, Meijia Wang, Aihua Shi, Jingwen Wang, Zhonglin Ma, Yunhai Zhang, Jingzhong Zhang, Shuang Yu
Summary: This study reports the development of a portable reflectance confocal microscope (PRCM) for real-time, noninvasive monitoring of skin wound healing. PRCM allows visualization of cellular and nuclear morphology in mouse and human skin, and its results are consistent with histological evaluations. The study provides new insights into monitoring the effects of topically applied mesenchymal stem cells (MSCs) on wound healing using PRCM.
BIO-DESIGN AND MANUFACTURING
(2023)