Article
Pharmacology & Pharmacy
Guo Yang, Yangyang Tian, Chao Li, Jiarui Xia, Yuanmeng Qi, Wu Yao, Changfu Hao
Summary: This study observed the changes and effects of UCA1 and miR-204-5p in silica-induced mouse silicosis model and in vitro EMT model of A549 cells. It was found that both models showed the presence of EMT process, and UCA1 was upregulated in the in vitro model. Silencing UCA1 inhibited EMT process, while intervention of miR-204-5p regulated EMT.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Suresh L. Mehta, Anil K. Chokkalla, Saivenkateshkomal Bathula, Vijay Arruri, Bharath Chelluboina, Raghu Vemuganti
Summary: Reconstitution of CDR1as is neuroprotective after stroke, possibly by protecting miR-7 and preventing a-Syn-mediated neuronal death.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Medicine, Research & Experimental
Xiaoyan Liu, Yongjun Li, Zhuo Li, Tian Hou
Summary: The study revealed that miR-155 may serve as a potential diagnostic and therapeutic target for breast cancer. High levels of miR-155 were found in breast cancer tissues and were associated with tumor size, TNM stage, and metastasis status. Inhibitors of miR-155 reduced cell proliferation and suppressed the epithelial-mesenchymal transition process in MCF-7 cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Food Science & Technology
Haoming Chen, Xinrong Tao, Hangbing Cao, Bing Li, Qixian Sun, Wenyang Wang, Yuanjie Zou, Min Mu, Huihui Tao, Yehong Zhao, Deyong Ge
Summary: Nicotine accelerates the progression of silica-induced pulmonary fibrosis in mice through the activation of the STAT3-BDNF-TrkB pathway. It also induces an increase in Fgf7 expression and alveolar type II cell proliferation, but fails to promote regeneration of alveolar structure and release of pro-fibrotic factor IL-33 in newborn AT2 cells.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Toxicology
Chao Li, Jiarui Xia, Wu Yao, Guo Yang, Yangyang Tian, Yuanmeng Qi, Changfu Hao
Summary: This study reveals that LncRNA XIST can regulate the expression of miR-101-3p and up-regulate ZEB1, thereby promoting the EMT process of alveolar epithelial cells in silicosis-related pulmonary fibrosis EMT.
TOXICOLOGY LETTERS
(2022)
Article
Cell & Tissue Engineering
Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong, Zhi Zheng
Summary: This study revealed that exosomal miR-27b derived from hucMSCs could reverse the EMT process induced by TGF-beta 2 by inhibiting HOXC6, suggesting the potential therapeutic role of the exosomal miR-27b/HOXC6 axis in ameliorating subretinal fibrosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jingjing Wei, Qiuyan Zhao, Guo Yang, Ruoxuan Huang, Chao Li, Yuanmeng Qi, Changfu Hao, Wu Yao
Summary: The study revealed that bone marrow-derived mesenchymal stem cells can exhibit an anti-fibrotic effect in a rat silicosis model by inhibiting inflammation and reversing epithelial-mesenchymal transition through the inhibition of the TGF-beta/Smad signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Environmental Sciences
Zhihao Lv, Hao Xu, Xuezhe Si, Shushuo Xu, Xinxiao Li, Ning Li, Qiang Zhou, Meiyu Chang, Sanqiao Yao, Haibin Li
Summary: Silicosis is an occupational lung disease caused by long-term inhalation of free silica dust. The Wnt signaling pathway has been found to be associated with the development of silicosis fibrosis, suggesting it as a potential target for treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mei-Chuan Kuo, Wei-An Chang, Ling-Yu Wu, Yi-Chun Tsai, Ya-Ling Hsu
Summary: Hypoxia-induced epithelial-to-mesenchymal transition (EMT) in proximal tubular epithelial cells (PTECs) is modulated by miR-545-3p-TNFSF10 interaction. TNFSF10 attenuates EMT induced by hypoxia in PTECs. These findings provide new insights into the unique regulation of miR-545-3p-TNFSF10 interaction and their potential therapeutic effect in kidney injury induced by hypoxia.
Article
Oncology
Xin Zhao, Xiaoshi Zhang, Xinxue Zhang, Tao Jiang, Jialei Zhai, Huaguang Wang, Mengxiu Huang, Ren Lang, Qiang He
Summary: This study revealed that miR-374b-5p is downregulated in pancreatic cancer (PC) and its overexpression can inhibit the proliferation, migration, and invasion of PC cells by suppressing the expression of KDM5B, thereby reducing epithelial-mesenchymal transition (EMT) in PC. The findings suggest that miR-374b-5p could potentially serve as a prognostic biomarker and therapeutic target for EMT induced by KDM5B in PC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Environmental Sciences
Jiarui Xia, Yangyang Tian, Zheng Shao, Chao Li, Mingcui Ding, Yuanmeng Qi, Xiao Xu, Kai Dai, Chenchen Wu, Wu Yao, Changfu Hao
Summary: The study reveals that miR-30c-5p can inhibit the epithelial-mesenchymal transition (EMT) in alveolar type II epithelial cells by targeting CTGF and ATG5-mediated autophagy, thereby slowing down the progression of silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Ning Li, Zhang Lin, Qiang Zhou, Meiyu Chang, Yongheng Wang, Yi Guan, Haibin Li, Yingzheng Zhao, Nan Liu, Yulan Jin, Sanqiao Yao
Summary: This study found that Metformin enhanced autophagy, suppressed EndoMT, and alleviated silica-induced inflammation and collagen deposition in the lungs. Metformin also protected vascular endothelial cells from morphological damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoqiang Hu, Junzhe Zhang, Junfeng Bu, Kaini Yang, Sunwang Xu, Mengqiao Pan, Dongxi Xiang, Wei Chen
Summary: This study identified the upregulation of miR-4733-5p and the downregulation of KLF7 in GBC, and demonstrated that miR-4733-5p promotes GBC cell proliferation by directly binding to the 3'UTR of KLF7. The downregulation of KLF7 inhibited GBC cell proliferation and migration.
Review
Oncology
Ilaria Cavallari, Francesco Ciccarese, Evgeniya Sharova, Loredana Urso, Vittoria Raimondi, Micol Silic-Benussi, Donna M. D'Agostino, Vincenzo Ciminale
Summary: MicroRNAs of the miR-200 family play crucial roles in regulating gene expression in cancer cells, potentially serving as biomarkers for cancer detection. The mature miR-200 family microRNAs are abundantly expressed in epithelial cells, contributing to maintaining the epithelial phenotype and inhibiting cancer development. These microRNAs exhibit both tumor suppressor and pro-metastatic functions, showing promise as biomarkers for epithelial cancers.
Article
Biochemistry & Molecular Biology
Yi Liu, Yan Li, Qi Xu, Wenxi Yao, Qiuyun Wu, Jiali Yuan, Weiwen Yan, Tiantian Xu, Xiaoming Ji, Chunhui Ni
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Pharmacology & Pharmacy
Qi Xu, Yi Liu, Honghong Pan, Tiantian Xu, Yan Li, Jiali Yuan, Ping Li, Wenxi Yao, Weiwen Yan, Chunhui Ni
Article
Oncology
Emily S. Reardon, Vivek Shukla, Sichuan Xi, Sudheer K. Gara, Yi Liu, David Straughan, Mary Zhang, Julie A. Hong, Eden C. Payabyab, Anju Kumari, William G. Richards, Assunta De Rienzo, Raffit Hassan, Markku Miettinen, Liqiang Xi, Mark Raffeld, Lisa T. Uechi, Xinmin Li, Ruihong Wang, Haobin Chen, Chuong D. Hoang, Raphael Bueno, David S. Schrump
Summary: The study revealed the significant role of UHRF1 in malignant pleural mesothelioma (MPM), with its overexpression affecting patient survival. Experiments such as RNA sequencing showed that inhibiting UHRF1 can reduce DNA hypomethylation, inhibit the growth and spread of MPM cells, and correspond with certain chemotherapeutic agents.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Demin Cheng, Qi Xu, Yi Liu, Guanru Li, Wenqing Sun, Dongyu Ma, Chunhui Ni
Summary: Silicosis is a common occupational disease caused by long-term exposure to crystalline silica. Recent studies have shown the important role of miR-490-3p in silica-induced pulmonary fibrosis by regulating TGFBR1 gene. The results suggest that the SNHG20/miR-490-3p/TGFBR1 axis may serve as a new therapeutic target for pulmonary fibrosis.
Article
Cell Biology
Qi Xu, Demin Cheng, Yi Liu, Honghong Pan, Guanru Li, Ping Li, Yan Li, Wenqing Sun, Dongyu Ma, Chunhui Ni
Summary: The dysregulation of non-coding RNAs, particularly lncRNA-ATB and its downstream targets miR-29b-2-5p and miR-34c-3p, plays a crucial role in regulating EMT and fibrosis in pulmonary diseases. Overexpression of miR-29b-2-5p or miR-34c-3p can inhibit EMT progression and counteract the pro-fibrotic effects of lncRNA-ATB, providing potential therapeutic targets for pulmonary fibrosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han, Chunhui Ni
Summary: The study found that metformin significantly reduced lung inflammation and fibrosis in silica-induced lung fibrosis model. Metformin reversed silica-induced cell toxicity, oxidative stress, and epithelial-mesenchymal transition process in epithelial cells and macrophages, as well as alleviated TGF-beta 1-stimulated fibroblast activation in lung fibroblasts via an AMPK-dependent pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Weiwen Yan, Dongyu Ma, Yi Liu, Wenqing Sun, Demin Cheng, Guanru Li, Siyun Zhou, Yue Wang, Huanqiang Wang, Chunhui Ni
Summary: This study investigates the pathogenesis and pathological process of hard metal-induced acute lung injury. WC-Co treatment damaged the lungs of mice, resulting in inflammation and apoptosis. In vitro experiments showed similar results. Furthermore, PTX3 was identified as an important mediator in inflammation regulation and its promotion of macrophage efferocytosis was confirmed.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Toxicology
Huanqiang Wang, Siyun Zhou, Yi Liu, Yihan Yu, Sha Xu, Lan Peng, Chunhui Ni
Summary: This study aimed to characterize the serum metabolic profile of pneumoconiosis and artificial stone silicosis patients. Differential metabolites were identified that could predict the stages of pneuomoconiosis and serve as potential biomarkers for artificial stone silicosis. Tryptophan metabolism was found to be closely related to pneumoconiosis and may play a role in disease progression.
TOXICOLOGY LETTERS
(2022)
Article
Toxicology
Guanru Li, Qi Xu, Demin Cheng, Wenqing Sun, Yi Liu, Dongyu Ma, Yue Wang, Siyun Zhou, Chunhui Ni
Summary: This study found that the expression of caveolin-1 (CAV1) was decreased in silica-induced fibrotic mouse lung tissues and confirmed that the functional peptide CSP7 of CAV1 could attenuate pulmonary fibrosis in vivo. Further experiments revealed that CAV1 suppressed fibroblast activation by reducing the expression of Yes-associated protein 1(YAP1).
TOXICOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Demin Cheng, Yue Wang, Ziwei Li, Haojie Xiong, Wenqing Sun, Sichuan Xi, Siyun Zhou, Yi Liu, Chunhui Ni
Summary: This study indicates that UHRF1 plays a crucial role in pulmonary fibrosis by repressing beclin 1 through methylation, leading to fibroblast activation and lung fibrosis both in vitro and in vivo. Knockdown of UHRF1 reverses this process and protects against experimental pulmonary fibrosis when administered intravenously using liposomes loaded with UHRF1 siRNA.
Article
Medicine, Research & Experimental
Demin Cheng, Ziwei Li, Yue Wang, Haojie Xiong, Wenqing Sun, Siyun Zhou, Yi Liu, Chunhui Ni
Summary: This study investigated the expression and function of matrix stiffness-regulated ZNF416 in pulmonary fibrotic lung fibroblasts. The results showed that ZNF416 can regulate fibroblast differentiation, proliferation, and contraction by promoting the nuclear accumulation of p-Smad2/3. ZNF416 siRNA-loaded liposomes selectively targeted the fibrotic area in the lung and co-administration with SB431542 protected mice against lung injury and fibrosis induced by silica or BLM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yi Liu, Demin Cheng, Yue Wang, Sichuan Xi, Ting Wang, Wenqing Sun, Guanru Li, Dongyu Ma, Siyun Zhou, Ziwei Li, Chunhui Ni
Summary: This study identified the involvement of Uhrf1 in mediating ferroptosis of chemically injured AEC2 cells through de novo promoter-specific methylation of GPX4 and FSP1 genes, thus accelerating the process of pulmonary fibrosis. Inhibition of Uhrf1 can prevent the formation of ferroptosis and block the progression of pulmonary fibrosis.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Siyun Zhou, Yue Wang, Chen Yu, Chunguang Ding, Jiayu He, Yi Liu, Huanqiang Wang, Chunhui Ni
Summary: This cross-sectional study aimed to assess the potential risk of haemal and urinary metal content in welder's pneumoconiosis and its effects on lung function parameters. The results showed that haemal Cr and Zn are risk factors for welder's pneumoconiosis, while Cd and Pb may worsen lung function in welder's pneumoconiosis. Welders were exposed to higher levels of respirable dust, total dust, and six kinds of metals compared to non-welders.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Sichuan Xi, Shakirat Oyetunji, Haitao Wang, Said Azoury, Yi Liu, Shih-Hsin Hsiao, Mary Zhang, Shamus R. Carr, Chuong D. Hoang, Haobin Chen, David S. Schrump
Summary: This study investigates the mechanisms by which cigarette smoke affects the initiation and progression of esophageal adenocarcinomas (EAC). The results show that cigarette smoke inhibits the expression of miR-145 and upregulates the expression of LOXL2, leading to increased proliferation, invasion, and tumorigenicity of EAC cells. The findings highlight the role of the miR-145-LOXL2 axis in EAC and suggest its potential as a therapeutic target for these malignancies.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Qi Xu, Demin Cheng, Guanru Li, Yi Liu, Ping Li, Wenqing Sun, Dongyu Ma, Chunhui Ni
Summary: Glycolysis is associated with pulmonary fibrosis, and the circHIPK3/miR-30a-3p/FOXK2 regulatory pathway plays a crucial role in promoting fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)