Article
Chemistry, Analytical
Lili Sun, Zejiang Wang, Juan Hou, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: Heterocyclic amines (HCA) are mutagenic factors in cooked meat products and pose a hazard to food safety. This study presents a new technique for detecting 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) using the molecular cavities of cucurbit[7]uril (CB[7]) for guest recognition. The method involves three steps: oxidation of regenerated cellulose (RC) membrane, trapping of PhIP molecules using amine-aldehyde conjugation chemistry, and quantification of PhIP through host-guest interaction with dansyl chloride-labelled CB[7] dye.
Review
Cell Biology
Bipul Ray, Arehally M. Mahalakshmi, Sunanda Tuladhar, Abid Bhat, Asha Srinivasan, Christophe Pellegrino, Anbarasu Kannan, Srinivasa Rao Bolla, Saravana Babu Chidambaram, Meena Kishore Sakharkar
Summary: Parkinson's disease is characterized by the aggregation of α-synuclein protein, forming Lewy bodies, with several mutations in α-synuclein identified as potential causes. The spread of pathological α-synuclein between cells is believed to play a significant role in the development of the disease. It has been suggested that the pathology of Parkinson's disease may originate in the gastrointestinal tract and spread to the brain via the vagus nerve.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Xinyang Li, Lu Dong, Huaning Yu, Yan Zhang, Shuo Wang
Summary: The study identified five gene modules related to HCAs exposure in PBMC, with functions in mRNA transcriptional regulation, mitochondrial function, RNA catabolic process, protein targeting, and immune function. Additionally, specific genes MIER1, NDUFA4, MLL3, CD53, and CSF3 were recognized as feature genes in these modules. The expression of these feature genes showed significant differences between PhIP/IQ exposed samples and other samples.
Article
Multidisciplinary Sciences
Robin Fertig, Felix Leowsky-Kuenstler, Torsten Irrgang, Rhett Kempe
Summary: Introducing unknown compound classes is crucial for expanding the chemical space. The authors propose a rational design concept and synthesis of unknown classes of N-heterocyclic compounds. The discovery of reactions is a central topic in chemistry, and the ability to synthesize unexplored compound classes is particularly fascinating. N-Heterocyclic compounds are highly important due to their wide applications in life and material sciences. The authors introduce a sequential three-component reaction, classes of N-heterocyclic compounds, and the regenerative cyclisation synthesis concept.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Medicinal
Eun-Joo Shin, Ji Hoon Jeong, Yeonggwang Hwang, Naveen Sharma, Duy-Khanh Dang, Bao-Trong Nguyen, Seung-Yeol Nah, Choon-Gon Jang, Guoying Bing, Toshitaka Nabeshima, Hyoung-Chun Kim
Summary: Methamphetamine (MA) intoxication can cause neurological deficits similar to Parkinson's disease (PD), and anti-Parkinsonian medications have been shown to mitigate the motor impairments induced by MA. Various mechanisms such as mitochondrial dysfunction, oxidative stress, and neuroinflammation play important roles in MA neurotoxicity, sharing commonalities with PD pathogenesis. Rodent models of neurotoxic binge administration of MA have been suggested as a valid tool for studying the neuropathogenesis of PD.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Chemistry, Physical
Elena Castellini, Fabrizio Bernini, Beatrice Bighi, Daniele Malferrari, Adele Mucci, Ignacio Sainz Diaz, Giulio Gorni, Maria Franca Brigatti, Marco Borsari
Summary: The capture of amines known as widespread pollutants, including aliphatic (APAs) and heterocyclic (HCAs), by Cu2+-exchanged montmorillonite (Mt-Cu) was studied using various analytical techniques. The study found that the immobilized amount of amines depended on the structure of the molecule for APAs, while it remained constant for HCAs. The coordination of Cu2+ ions to the amino groups was confirmed through spectroscopic and X-ray studies. The results supported the potential of Cu2+-modified layered silicates as an efficient air/gas purification system.
APPLIED CLAY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shofiul Azam, Md. Ezazul Haque, Duk-Yeon Cho, Joon-Soo Kim, Md. Jakaria, In-Su Kim, Dong-Kug Choi
Summary: Dioscin treatment can protect neuronal cells by inducing autophagy and suppressing the mitochondrial apoptosis pathway, reducing apoptosis and autophagic flux impairment caused by MPP+.
Article
Food Science & Technology
Mohammad Rizwan Khan, Rosa Busquets, Mohammad Azam
Summary: This study demonstrates that berry marinades can reduce the formation of harmful heterocyclic amines in meat during cooking. The reduction of HCAs is associated with marinade time, with longer marinating times (6 hours and above) showing more significant effects. Additionally, marinating for less than 1 hour can lead to an increase in certain HCAs.
Article
Chemistry, Multidisciplinary
Hwajin Yun, Yoonjeong Chae, Eunji Kim, Hong Ki Kim, Sukhyeun Jang, Mu-Hyun Baik, Chi Won Ahn, Yonghee Lee
Summary: This study reports a simple but effective strategy to enhance the stability of delaminated MXenes by passivating vulnerable edges with heterocyclic aromatic amines. The functionalized pyrrole MXenes exhibit long-term anti-oxidation in aqueous solutions and higher electrochemical performance as a supercapacitor.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Victor Tapias, Paula Gonzalez-Andres, Laura F. Pena, Asuncion Barbero, Lucia Nunez, Carlos Villalobos
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases in the elderly, characterized by abnormal protein aggregates and loss of neurons in specific brain regions. The exact mechanisms of these diseases are unknown, but oxidative stress, mitochondrial dysfunction, and disrupted Ca2+ homeostasis play a crucial role. With an increase in life expectancy, there is a need for preventive strategies and disease-modifying therapies for AD/PD. Modulating Ca2+ homeostasis and signaling, as well as controlling mitochondrial function with heterocyclic compounds, may provide potential neuroprotective treatments for these diseases.
Review
Biochemistry & Molecular Biology
Lady Johanna Forero-Rodriguez, Jonathan Josephs-Spaulding, Stefano Flor, Andres Pinzon, Christoph Kaleta
Summary: Parkinson's Disease is a neurodegenerative disease associated with dysbiosis and exposure to heavy metals, affecting the gut-brain axis. Integrative modeling and modulation of gut microbiota may provide potential treatment options for neurodegeneration.
Article
Chemistry, Applied
Meilin Jing, Qingqing Jiang, Yamin Zhu, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Acrolein increases the formation of PhIP by facilitating the degradation of phenylalanine and reacting with phenylalanine, creatinine, and PhIP. In addition, oxidation of the tilapia fish further increases the formation of PhIP in the roasted fish patties.
Article
Environmental Sciences
Chaoyang Liu, Zehua Liu, Yanyan Fang, Zhen Du, Zhi Yan, Xin Yuan, Lijun Dai, Ting Yu, Min Xiong, Ye Tian, Honghu Li, Fei Li, Jingdong Zhang, Lanxia Meng, Zhihao Wang, Haiqiang Jiang, Zhentao Zhang
Summary: This study revealed the mechanisms underlying the neurotoxicity induced by Maneb, and identified significant changes in proteins and metabolites in the pathways associated with PD. Furthermore, the PD-like phenotype induced by Maneb was attenuated by the inhibitor compound #11. This is the first study to investigate the molecular mechanisms underlying Maneb-induced PD-like phenotypes using multiomics analysis, providing novel therapeutic targets for PD associated with pesticides and environmental pollutants.
Article
Food Science & Technology
Olga Savinova, Mira Yerzhanova
Summary: The study focuses on the amount of heterocyclic aromatic amines in meat products during heat treatment, identifying potential mutagens. Results show that meat products sold in supermarkets contain significantly higher levels of mutagens compared to those grilled in laboratory conditions. Future research will focus on improving analysis methods and developing purification techniques to reduce human consumption of mutagens.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Biochemistry & Molecular Biology
Hui -Hui Gao, Nai-Chang Hou, Xin Gao, Jing-Yang Yuan, Wan-Qing Kong, Chen-Xia Zhang, Zhao Qin, Hua-Min Liu, Xue-De Wang
Summary: In this study, two proanthocyanidins (PAs) with different degrees of polymerization (DP) were extracted from Chinese quince fruits and combined with bovine serum albumin (BSA). The results showed that the complexes formed by PAs and BSA had different secondary structures. Molecular docking studies indicated that hydrogen bonds and hydrophobic interactions were the forces holding the complexes together. The thermal stabilities of PAs were stronger than those of PAs-BSA, and PAs-BSA showed increased antioxidant activity with increasing temperature. Furthermore, PAs-BSA had stronger HCAs inhibition than PAs, suggesting that PAs can be used as natural antioxidants for reducing HCAs in fried foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Zhi-Jie Xia, Xin-Xin Zeng, Mitali Tambe, Bobby G. Ng, P. Duc S. Dong, Hudson H. Freeze
Summary: Saul-Wilson syndrome is a rare skeletal dysplasia caused by a dominant variant in the COG4 gene, leading to disturbances in non-canonical Wnt signaling, which may be a possible pathological mechanism underlying the syndrome.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Medicinal
Tauqeerunnisa Syeda, Jason R. Cannon
Summary: This review summarizes and critically evaluates previous studies on HAAs-induced neurotoxicity and the potential neurotoxic effects of HAAs. The available studies provide strong evidence that HAAs may impact neurological function and addressing the adverse neurological outcomes is crucial.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aswathy Chandran, Jean-Christophe Rochet
Summary: A novel assay using a photoconvertible fusion protein identified autophagy inducers that either alleviated or exacerbated neurotoxicity in different cellular models of amyotrophic lateral sclerosis, challenging the notion that autophagy stimulation can be used as a one-size-fits-all therapy for neurodegenerative diseases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Josephine M. Brown-Leung, Jason R. Cannon
Summary: Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants found in the environment and living organisms, including humans. They have the potential to cause neurotoxicity and have been linked to ADHD, Parkinson's disease, and Alzheimer's disease. Studies suggest that PFAS disrupt neurotransmission in the brain, particularly affecting dopamine and glutamate systems.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Toxicology
Shreesh Raj Sammi, Tauqeerunnisa Syeda, Kendra D. Conrow, Maxwell C. K. Leung, Jason R. Cannon
Summary: Organophosphate (OP) pesticides, like CPF, have irreversible neurotoxic effects on dopaminergic neurons. CPF reduces mitochondrial content and is associated with specific genes, cyp-35A2 and cyp-35A3. Mitochondria may be a common target for all OP pesticide parent compounds.
TOXICOLOGICAL SCIENCES
(2023)
Article
Biochemical Research Methods
Der-Shyang Kao, Yanyan Du, Andrew G. DeMarco, Sehong Min, Mark C. Hall, Jean-Christophe Rochet, W. Andy Tao
Summary: Hyperphosphorylation of the microtubule-associated protein Tau is a major characteristic of Alzheimer's disease and other tauopathies. This study identified 59 Tau kinases, including 23 known kinases and 36 novel candidates, using fluorescence complementation mass spectrometry. Four candidate kinases, OXSR1, DAPK2, CSK, and ZAP70, were found to phosphorylate Tau in vitro and increase its phosphorylation in human neuroglioma cells. This research provides new opportunities for developing therapeutic strategies for Alzheimer's disease.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Neurosciences
Pablo Martinez, Henika Patel, Yanwen You, Nur Jury, Abigail Perkins, Audrey Lee-Gosselin, Xavier Taylor, Yingjian You, Gonzalo Viana Di Prisco, Xiaoqing Huang, Sayan Dutta, Aruna B. Wijeratne, Javier Redding-Ochoa, Syed Salman Shahid, Juan F. Codocedo, Sehong Min, Gary E. Landreth, Amber L. Mosley, Yu-Chien Wu, David L. McKinzie, Jean-Christophe Rochet, Jie Zhang, Brady K. Atwood, Juan Troncoso, Cristian A. Lasagna-Reeves
Summary: This study identified the interaction between the presynaptic protein Bassoon and the tau seed, enhancing its stability and promoting tau toxicity and spreading. Decreasing the expression level of Bassoon can reduce tau propagation and overall disease pathology, improving synaptic and behavioral impairments, and reducing brain atrophy.
NATURE NEUROSCIENCE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Jean-Christophe Rochet
Article
Food Science & Technology
Soyol Enkh-Amgalan, Josephine M. Brown-Leung, Tauqeerunnisa Syeda, Rachel M. Nolan, Jason R. Cannon, Julia A. Chester
Summary: This study investigated the effects of the PD-related neurotoxicant PQ on binge-like alcohol drinking and striatal monoamines in mice bred for high alcohol preference. It found that PQ decreased alcohol drinking and ventral striatal DOPAC levels in male mice but not in females.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Regina F. Fernandez, Emily S. Wilson, Victoria Diaz, Jonatan Martinez-Gardeazabal, Rachel Foguth, Jason R. Cannon, Shelley N. Jackson, Brian P. Hermann, Jeffrey B. Eells, Jessica M. Ellis
Summary: Deleting the 6th isoform of long-chain acyl-CoA synthetase (ACSL6) in mice alters dopamine metabolism and regulation of light entrainment, suggesting that DHA metabolism mediated by ACSL6 plays a crucial role in dopamine neuron biology.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L. Oblak, Cristian A. Lasagna-Reeves
Summary: The study investigated the effects of TREM2 deficiency on tau spreading using a mouse model and found that Trem2(-/-) mice showed attenuated tau pathology in multiple brain regions along with decreased microglial density. The reduced TREM2 signaling impaired microglia activation and their contribution to tau spreading. However, caution should be exercised before targeting TREM2 as a therapeutic entry point for Alzheimer's disease until its involvement in tau aggregation and propagation is better understood.
Article
Cell Biology
Joshua Abbott, Mitali Tambe, Ivan Pavlinov, Atena Farkhondeh, Ha Nam Nguyen, Miao Xu, Manisha Pradhan, Tate York, Matthew Might, Karsten Baumgaertel, Steven Rodems, Wei Zheng
Summary: NGLY1 deficiency is a rare genetic disease caused by mutations in the NGLY1 gene. Patients with NGLY1 deficiency exhibit complex symptoms and abnormal neuronal development. In this study, midbrain organoids derived from patient-specific iPSCs and NGLY1 knockout iPSCs were generated and characterized. The results showed altered neuronal development and reduced neuronal and astrocytic markers in NGLY1 patient-derived midbrain organoids. These findings provide a valuable model to investigate the disease mechanism and evaluate potential treatments for NGLY1 deficiency.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Medjda Bellamri, Kyle Brandt, Kari Cammerrer, Tauqeerunnisa Syeda, Robert J. J. Turesky, Jason R. R. Cannon
Summary: Animal fat and iron-rich diets increase the risk of Parkinson's disease. Heterocyclic aromatic amines (HAAs), including harman and norharman, formed in cooked meats, suggest a connection between red meat consumption and PD.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mitali A. Tambe, Aurelie de Rus Jacquet, Katherine E. Strathearn, Jennifer A. Hensel, Bryce D. Colon, Aswathy Chandran, Gad G. Yousef, Mary H. Grace, Mario G. Ferruzzi, Qingli Wu, James E. Simon, Mary Ann Lila, Jean-Christophe Rochet
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra region of the brain. Anthocyanin (ANC) intake has been associated with a reduced risk of PD. This study found that botanical extracts enriched with ANC and other polyphenols could protect against the death of dopaminergic neurons caused by PD-related toxins, such as paraquat (PQ) and rotenone. These extracts activated cellular antioxidant mechanisms and alleviated mitochondrial dysfunction, suggesting their potential to slow neurodegeneration in individuals exposed to PQ or rotenone.
Article
Biochemistry & Molecular Biology
Aurelie de Rus Jacquet, Abeje Ambaw, Mitali Arun Tambe, Sin Ying Ma, Michael Timmers, Mary H. Grace, Qing-Li Wu, James E. Simon, George P. McCabe, Mary Ann Lila, Riyi Shi, Jean-Christophe Rochet
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by nigrostriatal degeneration and the spreading of aggregated forms of the presynaptic protein alpha-synuclein (aSyn) throughout the brain. Current treatments for PD only target symptoms, but research shows that isoflavones found in soy products and medicinal plants may have neuroprotective effects that could delay onset and slow progression of PD. Further studies are needed to explore the potential of plant-derived isoflavones as dietary supplements for at-risk individuals and patients with PD.