Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations

Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes

(2012) Christine Götz et al.   EXPERIMENTAL DERMATOLOGY

Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)

(2012) Christine Götz et al.   EXPERIMENTAL DERMATOLOGY

Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

(2012) Marilyn J. Aardema et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Elucidation of Xenobiotic Metabolism Pathways in Human Skin and Human Skin Models by Proteomic Profiling

(2012) Sven van Eijl et al.   PLoS One

Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models

(2011) Christine Götz et al.   XENOBIOTICA

Genetic factors in contact allergy-review and future goals

(2010) Axel Schnuch et al.   CONTACT DERMATITIS

Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes

(2010) P. Upadhyaya et al.   DRUG METABOLISM AND DISPOSITION

International prevalidation studies of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility

(2010) Marilyn J. Aardema et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Exposure of human skin to benzo[a]pyrene: Role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation

(2010) C. Costa et al.   TOXICOLOGY

Xenobiotic metabolism gene expression in the EpiDerm™ in vitro 3D human epidermis model compared to human skin

(2010) T. Hu et al.   TOXICOLOGY IN VITRO

Further development of the NCTC 2544 IL-18 assay to identify in vitro contact allergens

(2010) V. Galbiati et al.   TOXICOLOGY IN VITRO

Cutaneous Metabolic Activation of Carvoxime, a Self-Activating, Skin-Sensitizing Prohapten

(2009) Hagen Ott et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of HuR and p38MAPKin Ultraviolet B-induced Post-transcriptional Regulation of COX-2 Expression in the Human Keratinocyte Cell Line HaCaT

(2009) Niklas S. Fernau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin™ and full thickness model from Episkin™

(2009) Van Luu-The et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes

(2009) Wei Wei et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

(2009) Ting Hu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Further development of the EpiDerm™ 3D reconstructed human skin micronucleus (RSMN) assay

(2009) Greg C. Mun et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Skin irritation

(2009) Martin Macfarlane et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A comparative study of leukaemia inhibitory factor and interleukin-1α intracellular content in a human keratinocyte cell line after exposure to cosmetic fragrances and sodium dodecyl sulphate

(2009) Alessandro Parodi et al.   TOXICOLOGY LETTERS

Cyclooxygenase-2 Expression during Immortalization and Breast Cancer Progression

(2008) X. Zhao et al.   CANCER RESEARCH

Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens

(2008) Lina Hagvall et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

(2007) Daphnee S. Pushparajah et al.   TOXICOLOGY IN VITRO