Metabolomics-on-a-Chip of Hepatotoxicity Induced by Anticancer Drug Flutamide and Its Active Metabolite Hydroxyflutamide Using HepG2/C3a Microfluidic Biochips

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

(2012) Laetitia Shintu et al.   ANALYTICAL CHEMISTRY

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells

(2012) Djomangan Adama Ouattara et al.   Molecular BioSystems

Improvement of HepG2/C3a cell functions in a microfluidic biochip

(2011) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

(2011) Jean-Matthieu Prot et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Integrated Proteomic and Transcriptomic Investigation of the Acetaminophen Toxicity in Liver Microfluidic Biochip

(2011) Jean Matthieu Prot et al.   PLoS One

Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor

(2010) Régis Baudoin et al.   BIOCHEMICAL ENGINEERING JOURNAL

A robust high-throughput sandwich cell-based drug screening platform

(2010) Shufang Zhang et al.   BIOMATERIALS

The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping

(2010) Judith M. Fonville et al.   JOURNAL OF CHEMOMETRICS

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

(2010) Olaf Beckonert et al.   Nature Protocols

Global metabolic profiling procedures for urine using UPLC–MS

(2010) Elizabeth J Want et al.   Nature Protocols

α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population

(2010) Walter E. Gall et al.   PLoS One

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic 3D hepatocyte chip for drug toxicity testing

(2009) Yi-Chin Toh et al.   LAB ON A CHIP

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

(2009) Rohini Kashimshetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bioactivation of Flutamide Metabolites by Human Liver Microsomes

(2008) P. Kang et al.   DRUG METABOLISM AND DISPOSITION