Review
Immunology
Thais Teixeira Oliveira, Leonam Gomes Coutinho, Laysa Ohana Alves de Oliveira, Ana Rafaela de Souza Timoteo, Guilherme Cavalcanti Farias, Lucymara Fassarella Agnez-Lima
Summary: APE1 is a multifunctional enzyme that is essential for maintaining cellular homeostasis and regulating immune response. It plays important roles in cell signaling, senescence, and inflammatory pathways, and is involved in the pathogenesis of various diseases, including cancer and neurological disorders. APE1 inhibitors have potential therapeutic uses, particularly in infectious and immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Razan Alhazmi, Shirley Tong, Shaban Darwish, Elina Khanjani, Bharti Khungar, Swati Chawla, Zhonghui Zheng, Richard Chamberlin, Keykavous Parang, Sun Yang
Summary: A novel APE/Ref-1 inhibitor was synthesized and found to significantly inhibit tumor growth in a mouse model of melanoma. No significant systemic toxicity was observed. Compound 11, an analog of the inhibitor, exhibited potent anti-melanoma activities and improved water solubility compared to its parental compound 2. Targeting APE/Ref-1-mediated signaling using pharmaceutical inhibitors is a novel and effective strategy for melanoma treatment with potentially high impact.
Article
Chemistry, Organic
Agustina La-Venia, Lucas Passaglia, Lucia Gurgone, Vincent Gandon, Martin J. Riveira
Summary: This article presents a synthetic strategy for constructing 2-cyclopentenones through acid-promoted cyclization of all-trans linearly conjugated dienones and dienals.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yingli Han, Yuehua Wang, Fangyu Zhou, Yuyang Jiang, Feng Liu
Summary: This article introduces a new tetrahedral molecular beacon (TMB) probe for the detection of APE 1 activity. The probe has the advantages of being able to enter cells, simple operation, and low cost. The extracellular detection limit of the probe is very low and it has successfully distinguished cancer cells overexpressing APE 1 from normal cells. Additionally, the probe can be used as an effective means for screening APE 1 inhibitors and monitoring the response of APE 1 to different drugs.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Pharmacology & Pharmacy
Ksenia Drozd, Alex N. Manin, Denis E. Boycov, German L. Perlovich
Summary: This study demonstrates that the preparation method of multicomponent crystals significantly affects the solid-state characteristics and physicochemical properties of miconazole. Lyophilization promotes partial amorphization and allows the formation of a new polymorph, but stability issues are observed. In vivo studies show that multicomponent crystals enhance the oral bioavailability of miconazole.
Article
Pharmacology & Pharmacy
Maryam Rasool, Danish Mazhar, Iqra Afzal, Ahmad Zeb, Salman Khan, Hussain Ali
Summary: This study aimed to develop Miconazole Nitrate transethosomes (MCZN TESs) embedded in chitosan-based gel for the treatment of Cutaneous Candidiasis. The optimized MCZN TESs showed small particle size, high entrapment efficiency, sustained drug release, and improved penetration and deposition capabilities compared to MCZN TESs alone. The in vitro and in vivo experiments demonstrated the superior antifungal activity and reduced treatment duration of MCZN TESs Gel. This study highlights the potential of MCZN TESs as an effective drug delivery system for topical treatment of Cutaneous Candidiasis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Juana Suarez-Garcia, Ma-Angeles Cano-Herrera, Alejandra Ramirez-Villalva, Aydee Fuentes-Benites, Nieves Zavala-Segovia, Marco A. Garcia-Eleno, M. Basavanag Unnamatla, Erick Cuevas-Yanez
Summary: A series of 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivatives, synthesized via copper catalyzed azide-alkyne cycloaddition, showed potential antimicrobial activity against Candida genus strains and filamentous fungi. One derivative exhibited remarkable selectivity comparable to that of Itraconazole against Rhizopus oryzae.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Article
Chemistry, Medicinal
Hang Xu, Zhong-zuo Yan, Meng-bi Guo, Ran An, Xin Wang, Rui Zhang, Yan-hua Mou, Zhuang Hou, Chun Guo
Summary: By optimizing selenium-containing miconazole derivatives, compound B17 was discovered to have good antifungal activity against Candida albicans and showed promising in vivo efficacy after administration. This compound also exhibited significant effects on the treatment of resistant Candida albicans infections and could inhibit biofilm formation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Syed Sarim Imam, Sadaf Jamal Gilani, Ameeduzzafar Zafar, May Nasser Bin Jumah, Sultan Alshehri
Summary: The present study aimed to develop MZBSo bilosomes and MZBSo gel. MZBSo presented nano-sized vesicles with high entrapment efficiency and suitable ζ potential, while MZBSoG2 showed good pH, viscosity, spreadability, and a slower drug release. MZBSoG2 was non-irritant and exhibited significant antifungal activity. Stability study results showed no significant changes. MZ-loaded gels could improve therapeutic efficacy.
Article
Pharmacology & Pharmacy
Dalal Y. Tayah, Ahmad M. Eid
Summary: This study aimed to develop an innovative technique to improve the permeability and efficacy of topical miconazole nitrate. A nanoemulgel formulation of miconazole nitrate was developed by incorporating a nanoemulsion and a hydrogel. The formulation with 0.4% Carbopol showed the highest release profile and exhibited superior antifungal activity compared to the commercial product.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Evolutionary Biology
Martin Kuhlwilm, Claudia Fontsere, Sojung Han, Marina Alvarez-Estape, Tomas Marques-Bonet
Summary: Modern human contamination is a common issue in ancient DNA studies, and it is also present in studies on great apes. A simple method called HuConTest has been proposed to detect human contamination in short-read sequencing data from different species. This method is particularly useful for more complex samples with smaller amounts of endogenous DNA.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Infectious Diseases
Yufeng Wang, Haiwen Zhou, Wenmei Wang, Ning Duan, Zhixiao Luo, Hongbo Chai, Lu Jiang, Qianming Chen, Jinli Liu, Hong Hua, Zhimin Yan, Yuan Fan, Juanyong Xu, Xiaobing Guan, Hongjian Wang, Hongzhou Lu, Wenhui Lun, Wei Fei, Tong Zhang, Jizhi Zhao, Chunling Jia, Hui Kong, Xuemin Shen, Qing Liu, Weizhi Wang, Guoyao Tang
Summary: The study found that once-daily treatment with miconazole buccal tablets is as effective as systemic itraconazole capsules in Chinese patients with oropharyngeal candidiasis, and it has minimal side effects.
Editorial Material
Oncology
Robert S. Benjamin, Giorgio Minotti
Summary: Doxorubicin cardiac toxicity is widely misunderstood but largely preventable. Dexrazoxane cardioprotection can be safely initiated on day 1, minimizing the risk of doxorubicin cardiac toxicity.
CLINICAL CANCER RESEARCH
(2021)
Article
Toxicology
Yanru Zhao, Yang Li, Dachuan Fan, Jinxiao Hou, Yunpeng Bai, Chenguang Dai, Xue Cao, Hai Qi, Bingchen Liu
Summary: Cyclosporin A (CsA) induces cardiotoxicity in rats, with differential expression patterns of circRNAs potentially playing crucial roles in this process, possibly related to autophagy or the Hippo signaling pathway.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Mohammed Safi, Hyat Ahmed, Mahmoud Al-Azab, Yun-long Xia, Xiu Shan, Mohammed Al-radhi, Abdullah Al-danakh, Abdullah Shopit, Jiwei Liu
Summary: Immunotherapy drugs for cancer have been approved by the FDA, increasing response rates but also leading to cardiac toxicity in some patients. Clinicians need to carefully evaluate the risks and benefits of using PD-1/PDL-1 inhibitors to reduce morbidity and mortality in cancer patients. Awareness of the etiology and management of cardiovascular adverse events is crucial for comprehensive cancer treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ikjun Lee, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Byeong Hwa Jeon, Shuyu Piao, Cuk-Seong Kim
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Se Yeong Jeon, Mi Ran Kim, Eun Ok Lee, Byeong Hwa Jeon, Jeong Jun Lee, Young Chul Lee
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seon-Ah Jin, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: Deletion of CRIF1 in endothelial cells leads to impaired cardiac function, likely due to mitochondrial dysfunction, oxidative stress, inflammation, and decreased expression of SIRT1. The SIRT1 inducer SRT1720 improves cardiac dysfunction by activating endothelial nitric oxide synthase, reducing oxidative stress, and inhibiting inflammation.
Article
Medicine, General & Internal
In Seol Yoo, Yu-Ran Lee, Seong Wook Kang, Jinhyun Kim, Hee-Kyoung Joo, Su-Jin Yoo, Chan Keol Park, Ha-Reum Lee, Ji Ah Park, Byeong-Hwa Jeon
Summary: The study demonstrates that the levels of APE1/Ref-1 are significantly elevated in the serum and synovial fluid of rheumatoid arthritis patients, and are positively correlated with disease activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-Jeong Choi, Byeong Hwa Jeon, Sang-Ha Oh, Kaikobad Irani, Cuk-Seong Kim
Summary: The deletion of CRIF1 in endothelial cells led to increased homocysteine accumulation, decreased levels of folate cycle intermediates, and disrupted DHFR expression and activity. Supplementation with folic acid could not reverse this effect, but overexpression of DHFR reduced homocysteine accumulation in CRIF1 knockdown cells.
Editorial Material
Biochemistry & Molecular Biology
Byeong Hwa Jeon
Article
Biochemistry & Molecular Biology
Yu-Ran Lee, Eun Young Bae, Hong Ryang Kil, Byeong-Hwa Jeon, Geena Kim
Summary: This study investigated the association between APE1/Ref-1 and Kawasaki disease (KD). The results showed that APE1/Ref-1 levels were significantly higher in KD patients, especially in refractory KD. APE1/Ref-1 could be a beneficial biomarker for the diagnosis and prognosis of KD.
Article
Biochemistry & Molecular Biology
Su-jeong Choi, Harsha Nagar, Jun Wan Lee, Seonhee Kim, Ikjun Lee, Shuyu Piao, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: This study found that IDH2 deficiency induced increased expression of SDC2 in endothelial cells, with MMP7 and TGF-beta signaling playing regulatory roles. UTI could reverse the increase in SDC2, MMP7, and TGF-beta signaling caused by IDH2 deficiency.
Article
Biochemistry & Molecular Biology
Sunga Choi, Yu-Ran Lee, Ki-Mo Kim, Euna Choi, Byeong-Hwa Jeon
Summary: The regulation of inflammatory signaling in the tumor microenvironment using adenoviral-mediated PPTLS-APE1/Ref-1 can inhibit the activity of inflammatory immune cells and cancer cells, providing a potential therapeutic strategy for treating triple-negative breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sungmin Kim, Yu-Ran Lee, Eun-Ok Lee, Hao Jin, Yeon-Hee Choi, Hee-Kyoung Joo, Byeong-Hwa Jeon
Summary: This study found that dietary capsanthin has anti-inflammatory and anti-vascular inflammation effects on atherosclerotic mice, reducing plaque formation and inflammatory marker levels.
Article
Biochemistry & Molecular Biology
Eun-Ok Lee, Hee-Kyoung Joo, Yu-Ran Lee, Sungmin Kim, Kwon-Ho Lee, Sang-Do Lee, Byeong-Hwa Jeon
Summary: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is involved in DNA repair and redox regulation. It inhibits adipocyte differentiation by regulating adipogenic transcription factors, suggesting it as a potential therapeutic target for regulating adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seonhee Kim, Hyewon Park, Harsha Nagar, Su-Jeong Choi, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong-Hwa Jeon, Dong Woon Kim, Youngduk Seo, Cuk-Seong Kim
Summary: This study investigates the role of CRIF1 deficiency in modulating mitochondrial oxidative phosphorylation (OXPHOS) system dysfunction and its antitumor effects in MCF-7 breast cancer cells. CRIF1 silencing decreases the assembly of mitochondrial OXPHOS complexes, leading to mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels. Inhibition of CRIF1 suppresses cell proliferation and inhibits cell migration in MCF-7 cells, and intratumoral injection of CRIF1 siRNA nanoparticles inhibits tumor growth in MCF-7 xenograft mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Minsoo Kim, Giang-Huong Vu, Byeong-Hwa Jeon, Cuk-Seong Kim
Summary: Endothelial senescence impairs vascular function and is a major factor in age-related vasculature diseases. IDH2 is involved in the production of alpha-ketoglutarate and preservation of mitochondrial function. However, the mechanism and regulation of IDH2 in endothelial senescence have not been fully understood.
Article
Medicine, General & Internal
Yumin Jo, Yeojung Kim, Eunhye Park, Yuran Lee, Jiyeon Kim, Minwoong Kang, Jaesung Lim, Insang Song, Chaeseong Lim, Byeonghwa Jeon
Summary: The study found that the plasma APE1/Ref-1 level of patients undergoing cancer surgery increases and is related to the degree of lymph node invasion, but is not affected by the choice of different anesthetics.
MEDICINA-LITHUANIA
(2021)
Article
Nutrition & Dietetics
Ki Mo Kim, Joo Young Lee, Byeong Hwa Jeon, Khong Trong Quan, MinKyun Na, Kung-Woo Nam, Sungwook Chae
Summary: The study showed that dietary intake of Curcuma zedoaria extract reduced atherosclerosis in mice, along with decreasing serum triglyceride and high-density lipoprotein levels, and reducing inflammatory molecule expression.
NUTRITION RESEARCH AND PRACTICE
(2021)