Review
Biochemistry & Molecular Biology
Marcela Valko-Rokytovska, Peter Ocenas, Aneta Salayova, Zuzana Kostecka
Summary: Metabolomics is a promising analytical method for the diagnosis and prognosis of breast cancer, offering a comprehensive non-invasive approach. Targeted metabolomics of steroid hormones play a crucial role in the classification and development of breast cancer, with high potential for effective diagnosis and monitoring of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Jason J. Northey, Valerie M. Weaver
Summary: Mechanical forces and steroid hormones play important roles in regulating cell fate and tissue development. Aberrant steroid hormone action is associated with tumor origin, while prolonged perturbations to mechanical forces may lead to tumor progression and the development of aggressive metastatic diseases.
Article
Cell Biology
Maira S. Rodrigues, Aldo Tovo-Neto, Ivana F. Rosa, Lucas B. Doretto, Hamideh P. Fallah, Hamid R. Habibi, Rafael H. Nobrega
Summary: Thyroid hormones play a critical role in controlling various physiological processes in vertebrates, including development, growth, and metabolism. This study investigates the effects of methimazole-induced hypothyroidism on testicular function in adult zebrafish. The results demonstrate that the inhibition of thyroid hormone significantly alters spermatogenesis and decreases the number of spermatozoa in zebrafish. Moreover, the study suggests that thyroid hormones not only affect the brain-pituitary-peripheral axis but also exert a direct action on the testis. These findings indicate the essential role of thyroid hormones in the multifactorial control of reproduction and testicular function in zebrafish and possibly other vertebrate species.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Biology
Noor M. Kotb, Prashanth Rangan
Summary: Experiments on female fruit flies provide insights into the molecular mechanisms underlying the transition of germline stem cells into egg cells.
Review
Environmental Sciences
J. O. Ojoghoro, M. D. Scrimshaw, J. P. Sumpter
Summary: Steroid hormones are crucial natural hormones that regulate physiological processes in vertebrates; both natural and synthetic steroid hormones have been identified as widespread aquatic contaminants; experiments have shown that even at extremely low concentrations, steroid hormones can adversely affect reproduction in aquatic vertebrates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Valentin Rousson, Daniel Ackermann, Belen Ponte, Menno Pruijm, Idris Guessous, Claudia H. d'Uscio, Georg Ehret, Genevieve Escher, Antoinette Pechere-Bertschi, Michael Groessl, Pierre-Yves Martin, Michel Burnier, Bernhard Dick, Murielle Bochud, Bruno Vogt, Nasser A. Dhayat
Summary: In this study, diagnostic ratios calculated from urinary steroid hormone metabolites were used to evaluate relative enzyme activity, with most ratios showing sex- and age-specific relationships. Reference curves and intervals were established to aid in distinguishing between health and disease, with daytime enzyme activity generally higher than nighttime activity. This suggests a circadian rhythm for enzymes involved in human steroid hormone metabolism.
Article
Environmental Sciences
Jing Ding, Hongwei Sun, Aiping Liang, Jin Liu, Lehui Song, Min Lv, Dong Zhu
Summary: The exposure to testosterone significantly altered the bacterial community structure and metabolic profiles in soils in Ningbo and Kunming, China. This resulted in a decrease in the abundance of bacterial taxa associated with nutrient cycling and downregulation of metabolites related to amino acid metabolism. The close connection between bacterial taxa and specific metabolites was confirmed by Procrustes tests and a co-occurrence network analysis.
ENVIRONMENTAL POLLUTION
(2021)
Review
Cell Biology
Zigang Cao, Qifen Yang, Lingfei Luo
Summary: Germ cells play a crucial role in genetic information transfer and species evolution, with their regeneration being a potential treatment for infertility. Zebrafish's strong regenerative capacity makes it an attractive model for studying germ cell development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaojun Ren, Jianqing Liang, Yiming Zhang, Ning Jiang, Yuhui Xu, Mengdi Qiu, Yiqin Wang, Bing Zhao, Xiaojun Chen
Summary: This study used single-cell transcriptomics to characterize the development of endometrioid endometrial cancers (EEC) and revealed potential cells of origin. The findings provide important insights for EEC research and diagnosis.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Tae-Kyung Hong, Jae-Hoon Song, So-Been Lee, Jeong-Tae Do
Summary: Assisted reproductive technologies (ARTs) have limitations in rectifying germ cell aplasia such as non-obstructive azoospermia (NOA) and oocyte maturation failure syndrome. In vitro gametogenesis shows promise in overcoming infertility, with research focusing on deriving male and female germ cells from pluripotent stem cells (PSCs). This technique not only helps understand the biological mechanism of gamete development but also offers insights into its application in infertility treatments.
Article
Oncology
Angela Alonso-Diez, Sara Caceres, Laura Pena, Belen Crespo, Juan Carlos Illera
Summary: Inflammatory breast cancer is an aggressive type of breast cancer associated with exacerbated angiogenesis, lymphangiogenesis, and lymphangiotropism. Current antiangiogenic therapies have limited effects on the overall survival of IBC patients. Steroid hormones play a significant role in tumor development, angiogenesis regulation, and metastasis. Sex steroid hormones can influence the production of angiogenic factors and may offer insights into developing personalized therapeutic strategies to manage IBC.
Article
Agriculture, Dairy & Animal Science
Jing Li, Xue-Jie Ma, Xing Wu, Su-Jin Si, Chong Li, Peng-Kun Yang, Guo-Xi Li, Xiao-Jun Liu, Ya-Dong Tian, Xiang-Tao Kang
Summary: The study reveals that adiponectin and its receptors play a significant role in regulating steroid synthesis and secretion in ovarian granulosa cells of laying hens. Treatment with AdipoRon can influence hormone levels and key gene expression, indicating its impact on reproductive processes. Additionally, the interaction between AdipoRon and AdipoR2 may lead to a significant decrease in E2 secretion.
Article
Biochemistry & Molecular Biology
Soghra Bahmanpour, Zia Moasses, Nehleh Zarei-Fard
Summary: This study compared the effects of forskolin, retinoic acid (RA), and granulosa cell-conditioned medium on germ cell differentiation from embryonic stem cells (ESCs). The results showed that granulosa cell-conditioned medium and RA effectively induced germ cell differentiation, and the combined application of granulosa cell-conditioned medium and co-culturing with granulosa cells had a synergic effect on germ cell development in vitro.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Endocrinology & Metabolism
Jose Cipolla-Neto, Fernanda Gaspar Amaral, Jose Maria Soares-Jr, Camila Congentino Gallo, Andre Furtado, Jose Eduardo Cavaco, Isabel Goncalves, Cecilia Reis Alves Santos, Telma Quintela
Summary: This study reviews the various effects of melatonin on biological functions, discusses the interactions between melatonin and sex hormones, and highlights the impact of melatonin on female gonadal steroidogenesis and hormonal control. It suggests that there is ambiguity in the influence of sex differences on the circadian rhythms of melatonin, and the debate surrounding the reciprocal relationship between melatonin and reproductive hormones remains inconclusive.
NEUROENDOCRINOLOGY
(2022)
Review
Cell Biology
Wenjiao Liu, Ting Gong, Fangxiong Shi, Houqiang Xu, Xiang Chen
Summary: This article explores the signaling mechanisms through which taste receptor factors influence testosterone synthesis in male reproduction and discusses their potential role in regulating male fertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)