Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2

Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies inCyp1a1(−/−),Cyp1a2(−/−), andCyp1a1/1a2(−/−)Mice

(2011) Volker M. Arlt et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

(2011) Marie Stiborová et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

(2011) Kateřina Levová et al.   TOXICOLOGICAL SCIENCES

Cytochrome P450 1A2 Detoxicates Aristolochic Acid in the Mouse

(2010) T. A. Rosenquist et al.   DRUG METABOLISM AND DISPOSITION

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice

(2010) Volker M. Arlt et al.   INTERNATIONAL JOURNAL OF CANCER

The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease

(2010) Imari Mimura et al.   Nature Reviews Nephrology

Late Onset of Bladder Urothelial Carcinoma After Kidney Transplantation for End-Stage Aristolochic Acid Nephropathy: A Case Series With 15-Year Follow-up

(2008) Anne Lemy et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Generation of a ‘humanized’ hCYP1A1_1A2_Cyp1a1/1a2(−/−)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor

(2008) Zhanquan Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aristolochic acid nephropathy: A worldwide problem

(2008) Frédéric D. Debelle et al.   KIDNEY INTERNATIONAL

A review of human carcinogens—Part A: pharmaceuticals

(2008) Yann Grosse et al.   LANCET ONCOLOGY

Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury

(2008) X. Xue et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy

(2007) Marie Stiborová et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH