Article
Environmental Sciences
Laura Ruiz-Azcona, Bohdana Markiv, Andrea Exposito, Ana Pozueta, Maria Garcia-Martinez, Ignacio Fernandez-Olmo, Miguel Santibanez
Summary: This study aimed to investigate the manganese exposure of residents near a ferromanganese alloy plant in northern Spain, and determine its association with poorer cognitive function. The results showed that higher manganese exposure was associated with lower cognitive test scores in various tests and biomarker analyses.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Lu Du, Mengying Zhang, Lingyao Qi, Senwei Liu, Tao Ren, Qing Tan, Yonghua Chen
Summary: This study explores the Mn tolerance ability and physiological and biochemical response of P. fortunei to Mn. Results show that a low concentration of Mn exposure is favorable for P. fortunei growth, while high Mn exposure inhibits its growth. P. fortunei shows high tolerance to Mn. The microstructure of P. fortunei organs reveals that its Mn tolerance is related to cell wall compartmentalization.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Xinye Guo, Yankui Tang, Juanjuan Yin, Rugui Li, Binting Qin, Lu Jiang, Xuemin Chen, Zhining Huang
Summary: Benthic diatoms were investigated in a stream impacted by manganese-mining and smelting activities, revealing their distribution, abundances, diversities, and habitat preferences. Navicula, Diatoma, Nitzschia, and Gomphonema were found to be dominant diatom genera. The even distribution of diatoms on plant roots and the tolerance of diatom strains to high concentrations of manganese were observed.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Environmental Sciences
Brad A. Racette, Gill Nelson, Wendy W. Dlamini, Pradeep Prathibha, Jay R. Turner, Mwiza Ushe, Harvey Checkoway, Lianne Sheppard, Susan Searles Nielsen
Summary: This study suggests that environmental manganese exposure may be associated with clinical parkinsonism, with higher PM2.5-Mn concentrations and poorer motor function performance observed in residents of Meyerton compared to those in Ethembalethu.
ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Shixuan Zhang, Luli Wu, Junrou Zhang, Xueting Wang, Xin Yang, Ye Xin, Li Chen, Jie Li, Piye Niu
Summary: This study utilized single-cell RNA sequencing to identify 10 cell types in zebrafish brain and revealed the critical role of dopamine neurons in manganese-induced neurological damage. Long-term manganese exposure impaired amino acid and lipid metabolic processes in the brain and disrupted the ferroptosis signaling pathway in zebrafish dopamine neurons. This study provided insights into a novel potential mechanism of manganese neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Physical
Beibei Wang, Chao Wang, Ya Chu, Haoyue Zhang, Mengjiao Sun, Hui Wang, Shiping Wang, Guangjiu Zhao
Summary: In this study, a pair of lead-free manganese-based metal halide enantiomers were successfully prepared, exhibiting bright green emission, high decay lifetimes, and notable circular dichroism signals. These findings make them promising materials for the development of chiral optoelectronic devices.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Toxicology
Natalia Shilnikova, Nataliya Karyakina, Nawal Farhat, Siva Ramoju, Brandon Cline, Franco Momoli, Donald Mattison, Natalie Jensen, Rowan Terrell, Daniel Krewski
Summary: A critical review on biomarkers of environmental manganese exposure found that blood and urine levels of manganese are not useful biomarkers of manganese exposure in non-occupational settings, while the association between manganese in saliva and environmental media is variable. The utility of hair manganese as a biomarker of environmental manganese exposure has inconsistent findings. Measurements of manganese in teeth are technically challenging, and there is large uncertainty in bone manganese measurements. Manganese in nails may reflect manganese in environmental media and discriminate between different levels of environmental manganese exposure, but more research is needed.
CRITICAL REVIEWS IN TOXICOLOGY
(2022)
Article
Water Resources
Monika Lukasiewicz, Jan Czerniecki, Donata Ponikwicka-Tyszko, Maria Sztachelska, Marta Hryniewicka, Edyta Nalewajko-Sieliwoniuk, Wieslaw Wiczkowski, Beata Banaszewska, Robert Milewski, Jorma Toppari, Ilpo Huhtaniemi, Nafis A. Rahman, Slawomir Wolczynski
Summary: The study found that pregnant women and male newborns exposed to BPA had lower concentrations, and there was no significant correlation between the BPA levels and hormone levels or anthropometric parameters measured. The placenta may play a protective role in reducing fetal exposure to environmental BPA.
EXPOSURE AND HEALTH
(2021)
Article
Environmental Sciences
Bruna Moreira Freire, Roberta Granja Gonzaga, Tatiana Pedron, Lucilena Rebelo Monteiro, Camila Neves Lange, Walter dos Reis Pedreira Filho, Bruno Lemos Batista
Summary: The study found that industrial foundry workers are exposed to multiple potentially toxic elements, with some workers having high concentrations of arsenic and cadmium. The concentration of these elements in different biological samples is significantly influenced by work tasks and employment years. This occupational exposure is associated with both carcinogenic and noncarcinogenic risks.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Brad A. Racette, Gill Nelson, Wendy W. Dlamini, Tamara Hershey, Pradeep Prathibha, Jay R. Turner, Harvey Checkoway, Lianne Sheppard, Susan Searles Nielsen
Summary: Residence in a community near a high manganese emission source is associated with cognitive dysfunction, including aspects of cognitive control as assessed by the Go-No-Go test.
Article
Environmental Sciences
Nai-Chia Fan, Hsin-Yi Huang, Shih-Ling Wang, Yu-Lun Tseng, Ju Chang-Chien, Hui-Ju Tsai, Tsung-Chieh Yao
Summary: This study found that exposure to vanadium and manganese had negative effects on lung function among young children in the general population. Children exposed to environmental tobacco smoke were more susceptible to the adverse effects of vanadium and manganese exposure on lung function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
B. Markiv, A. Exposito, L. Ruiz-Azcona, M. Santibanez, I. Fernandez-Olmo
Summary: Manganese, a trace element necessary for the body's functioning, can cause health disorders at higher concentrations. This study assessed the individual health risk of exposure to manganese through different media and routes of entry. It was found that individuals living near the main manganese source had a higher potential risk for health issues, and residents in the capital city located further away may also face some risk under certain wind conditions.
ENVIRONMENTAL RESEARCH
(2023)
Review
Physiology
Sachi D. Wong, Kenneth P. Wright, Robert L. Spencer, Celine Vetter, Laurel M. Hicks, Oskar G. Jenni, Monique K. LeBourgeois
Summary: In humans, the circadian system begins development in utero and continues throughout the first few years of life. Understanding the role of external factors in the development of stable circadian rhythms during this critical period is still limited.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2022)
Article
Environmental Sciences
Xiaohui Liu, Hong Shen, Mingfeng Chen, Jun Shao
Summary: The study revealed that higher blood manganese concentrations were positively associated with liver stiffness and steatosis, primarily in females, in races other than Non-Hispanic White, and in obese subjects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Rodrigo X. Armijos, M. Margaret Weigel, Emmanuel Obeng-Gyasi, Marcia Racines-Orbe
Summary: The study identified elevated levels of lead and other metals/metalloids in mothers and children from low-resource households in Quito, Ecuador, indicating urgent public health concern. Traffic-related exposures and other environmental sources were found to contribute significantly to metal/metalloid exposures in urban Ecuadorian populations. Future biomonitoring studies are needed to confirm these findings and develop effective intervention strategies.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Medicine, Legal
Honesty Tohon, Mathieu Valcke, Rocio Aranda-Rodriguez, Andy Nong, Sami Haddad
Summary: This study used a reverse dosimetry PBPK modeling approach to estimate toluene atmospheric exposure from urinary measurements of S-benzylmercapturic acid. Results showed that estimating toluene exposure based on spot measurements generated more variability and uncertainty compared to 24-h urine samples. Toluene levels estimated were well below Health Canada's maximum chronic air guidelines, suggesting low health risks.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Toxicology
Andrea Rowan-Carroll, Anthony Reardon, Karen Leingartner, Remi Gagne, Andrew Williams, Matthew J. Meier, Byron Kuo, Julie Bourdon-Lacombe, Ivy Moffat, Richard Carrier, Andy Nong, Luigi Lorusso, Stephen S. Ferguson, Ella Atlas, Carole Yauk
Summary: This study focused on four model PFAS and found that they may have common molecular targets and toxicities, with PFOS and PFDS being the most similar. The data from the study provide baseline toxicity levels for comparison with other known PFAS.
TOXICOLOGICAL SCIENCES
(2021)
Review
Environmental Sciences
Melvin E. Andersen, Pankajini Mallick, Harvey J. Clewell III, Miyoung Yoon, Geary W. Olsen, Matthew P. Longnecker
Summary: The translation discusses the assessment of biomarkers in human populations and the issue of PK bias, emphasizing the factors that need to be considered when studying health effects at low levels of exposure.
ENVIRONMENTAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Melvin E. Andersen, Bruno Hagenbuch, Udayan Apte, J. Christopher Corton, Tony Fletcher, Christopher Lau, William L. Roth, Bart Staels, Gloria L. Vega, Harvey J. Clewell, Matthew P. Longnecker
Summary: The study showed a positive correlation between serum cholesterol concentrations and exposure to PFOA and PFOS in humans, with only a small impact. Animal studies have not yet identified a mechanism that explains this association, and further research is needed to determine whether there is a causal relationship.
Article
Pharmacology & Pharmacy
Alina Efremenko, Pergentino Balbuena, Rebecca A. Clewell, Michael Black, Linda Pluta, Melvin E. Andersen, P. Robinan Gentry, Janice W. Yager, Harvey J. Clewell
Summary: Evidence shows that long-term exposure to arsenite results in significant changes in gene expression, including reversals in the direction of expression change in key regulatory genes. Cells treated with arsenic initially exhibit upregulation of oxidative stress responses and down-regulation of immune/inflammatory responses, followed by increased inflammatory and proliferative signaling, evidence of epithelial-to-mesenchymal transition, and alterations in DNA damage responses. The changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling, leading to inhibition of P53 function.
Correction
Biochemistry & Molecular Biology
Lijuan Zhan, Hao Zhang, Qiang Zhang, Courtney G. Woods, Yanyan Chen, Peng Xue, Jian Dong, Erik J. Tokar, Yuanyuan Xu, Yongyong Hou, Jingqi Fu, Kathy Yarborough, Aiping Wang, Weidong Qu, Michael P. Waalkes, Melvin E. Andersen, Jingbo Pi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Toxicology
Byron Kuo, Marc A. Beal, John W. Wills, Paul A. White, Francesco Marchetti, Andy Nong, Tara S. Barton-Maclaren, Keith Houck, Carole L. Yauk
Summary: Risk assessments are increasingly relying on in vitro assays for genotoxicity testing. This study evaluated 292 chemical datasets using the in vitro micronucleus test (MNvit) for hazard identification. The results identified 157 clastogenic chemicals, 25 negatives, and 110 inconclusive substances. In vitro to in vivo extrapolation (IVIVE) was used to convert concentrations into administered equivalent doses (AEDs), which were generally lower than points of departure (PODs) based on in vivo endpoints. Exposure estimates were utilized to calculate bioactivity exposure ratio (BER) values, identifying chemicals that may require additional testing.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Engineering, Environmental
Lei Dong, Zhiqiang Jiang, Lili Yang, Fen Hu, Weiwei Zheng, Peng Xue, Songhui Jiang, Melvin E. Andersen, Gengsheng He, M. James C. Crabbe, Weidong Qu
Summary: The study evaluated the health effects of nitrosamine mixtures in drinking water, revealing that mixed nitrosamines had greater genotoxic potential compared to individual compounds, while N-acetylcysteine could protect cells from chromosome damage.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Toxicology
Melvin E. Andersen
Summary: Octamethylcyclotetrasiloxane (D4) is a lipophilic compound that is highly volatile and has low water solubility. Animal studies have shown that D4 is toxic to several tissues when exposed to near saturating vapor concentrations or administered orally in vegetable oil vehicles. The toxicity of D4 is mediated through various mechanisms, including direct contact with epithelial cells in the lungs, interaction with nuclear receptor signaling pathways in the liver leading to hypertrophy and hepatocyte proliferation, and binding with alpha-2u globulin in the kidneys causing nephropathy.
TOXICOLOGY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Peng Xue, Huihui Wang, Lili Yang, Zhiqiang Jiang, Hongliang Li, Qinxin Liu, Qiang Zhang, Melvin E. Andersen, M. James C. Crabbe, Lipeng Hao, Weidong Qu
Summary: Humans are exposed to disinfection by-products called HANs, which can lead to various health problems. In this study, it was found that NRF2-ARE activity plays a protective role against the cytotoxicity caused by HANs.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Amy J. Stefanowicz, Leslie Recio, Michael B. Black, Tyler Beames, Melvin E. Andersen, R. Allysa Stern, Rebecca A. Clewell, Patrick D. McMullen, Jessica K. Hartman, Aarati Ranade
Summary: Liver responses are commonly used as the basis for exposure standards, and the development of in vitro models is important to reduce reliance on animal models. This paper presents the development and evaluation of 2-D hepatocyte monoculture and 2-D liver cell co-culture systems using rat liver cells. The co-culture model showed more representative transcriptomic responses compared to intact rat models.
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2023)
Article
Toxicology
Jerry L. Campbell, Harvey J. Clewell III, Cynthia Van Landingham, P. Robinan Gentry, Athena M. Keene, Michael D. Taylor, Melvin E. Andersen
Summary: An updated PBPK model for manganese has been developed and successfully described the kinetics of manganese in tissues in both monkeys and humans. This model eliminates the need for relying solely on cadaver data and whole-body tracer studies to calibrate a human model, increasing the biological relevance and confidence in using the manganese PBPK models for risk assessment.
TOXICOLOGICAL SCIENCES
(2023)
Article
Toxicology
Rory B. Conolly, Jeffry Schroeter, Julia S. Kimbell, Harvey Clewell, Melvin E. Andersen, P. Robinan Gentry
Summary: Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC), and the development of a biologically based dose-response (BBDR) model has provided dose-response conclusions for several international regulatory agencies. However, uncertainties prevented its use for cancer risk assessment by USEPA. This study presents an updated BBDR model that addresses uncertainties through refined dosimetry modeling and an extended dataset considering both exogenous and endogenous formaldehyde.
TOXICOLOGICAL SCIENCES
(2023)
Article
Toxicology
Malek Jomaa, Guillaume Pelletier, Denis Dieme, Jonathan Cote, Hamadi Fetoui, Andy Nong, Michele Bouchard
Summary: We conducted a study on rats to assess the effects of dose and co-exposure with other rare earth elements (REEs) on the toxicokinetics of praseodymium (Pr) and cerium (Ce). The study showed that dose and mixture exposure are important factors determining the toxicokinetics of REEs.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
J. L. Campbell Jr, H. J. Clewell III, C. Van Landingham, P. R. Gentry, M. E. Andersen
Summary: The PBPK model is used to correlate predicted tissue exposure to reactive metabolites with toxicity and carcinogenicity of CP.
FRONTIERS IN PHARMACOLOGY
(2023)
