Article
Multidisciplinary Sciences
Fabian Cuypers, Alexander Schaefer, Sebastian B. Skorka, Surabhi Surabhi, Lea A. Toelken, Antje D. Paulikat, Thomas P. Kohler, Saskia A. Otto, Thomas C. Mettenleiter, Sven Hammerschmidt, Ulrike Blohm, Nikolai Siemens
Summary: The study shows that IAV challenge of healthy mice does not automatically result in severe co-infection, but a general local inflammatory response was noted at the asymptomatic stage of infection regardless of the infection type.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Beryl Mazel-Sanchez, Chengyue Niu, Nathalia Williams, Michael Bachmann, Helena Choltus, Filo Silva, Veronique Serre-Beinier, Wolfram Karenovics, Justyna Iwaszkiewicz, Vincent Zoete, Laurent Kaiser, Oliver Hartley, Bernhard Wehrle-Haller, Mirco Schmolke
Summary: Using proximity ligation and mass spectrometry, transferrin receptor 1 (TfR1) was identified as a candidate entry protein for influenza A virus (IAV). Genetic and chemical inhibition experiments confirmed TfR1's functional involvement in IAV entry, with recycling being essential for this function. Even without its head, TfR1 promotes IAV particle uptake, confirming its role as a directly acting entry factor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Randall C. Gunther, Vanthana Bharathi, Stephen D. Miles, Lauryn R. Tumey, Clare M. Schmedes, Kohei Tatsumi, Meagan D. Bridges, David Martinez, Stephanie A. Montgomery, Melinda A. Beck, Eric Camerer, Nigel Mackman, Silvio Antoniak
Summary: Global Par2 or myeloid cell deficiency, but not lung epithelial cell deficiency, was associated with reduced BALF inflammatory markers and reduced IAV-induced mortality in mice. This study suggests that PAR2 may be a therapeutic target to reduce IAV pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hyejin Park, Un-Ho Jin, Gregory Martin, Robert S. Chapkin, Laurie A. Davidson, Kyongbum Lee, Arul Jayaraman, Stephen Safe
Summary: Unsubstituted flavone can induce gene expression in Caco2 cells and acts as an AhR agonist. The addition of hydroxyl groups can determine the activity of flavones, but the affinity of mono- and dihydroxyflavones to AhR is similar and cannot accurately predict their activity. Most AhR-inactive flavones also function as AhR antagonists.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Virology
Zhibin Yan, Meijing Chen, Dong Tang, Xiaoyan Wu, Xiaobo Ren, Hui Pan, Yanhua Li, Qiuyun Ji, Yongwen Luo, Huiying Fan, Chunmei Ju
Summary: The study found that the inactivated vaccine of rPRV-AH-gI(-)/gE(-)/gC(+) had higher levels of neutralizing antibodies in mice and weaned pigs, providing better protection against PRV-AH challenge.
Article
Immunology
Wei Zhang, Eun-Koung An, Juyoung Hwang, Jun-O Jin
Summary: The study found that LPS can directly stimulate pDCs via the TLR4/MD2 pathway and promote the activation of pDCs and cDCs. cDCs may contribute to the enhancement of IFN-alpha production in pDCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Tao Qin, Yulian Chen, Dandan Huangfu, Yinyan Yin, Xinyu Miao, Yuncong Yin, Sujuan Chen, Daxin Peng, Xiufan Liu
Summary: The PA-X protein of H9N2 subtype avian influenza virus enhances its pathogenicity in mammals and inhibits its infection to dendritic cells. The PA-X protein also suppresses immune cell activation and inflammatory cytokine expression, as well as reduces the migration ability of mucosal and draining DCs, hindering immune response. These findings highlight the significance of PA-X protein in the pathogenicity and immune evasion of H9N2 subtype avian influenza virus.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Hanna Abberger, Romy Barthel, Jasmin Bahr, Jacqueline Thiel, Sina Luppus, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: The study found that in activated CD4(+) non-Tregs, Nrp-1 expression has an activating role, while in CD4(+) non-Tregs from naive mice, Nrp-1 expression leads to dysfunction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Karolina Ondrova, Iveta Zuvalova, Barbora Vyhlidalova, Kristyna Krasulova, Eva Mikova, Radim Vrzal, Petr Nadvornik, Binod Nepal, Sandhya Kortagere, Martina Kopecna, David Kopecny, Marek Sebela, Fraydoon Rastinejad, Hua Pu, Miroslav Soural, Katharina Maria Rolfes, Thomas Haarmann-Stemmann, Hao Li, Sridhar Mani, Zdenek Dvorak
Summary: The researchers identified carvones as noncompetitive antagonists of the human aryl hydrocarbon receptor (AhR) and demonstrated their ability to inhibit AhR's interaction with its canonical partner ARNT, as well as its binding to CYP1A1. They also showed the protective effects of carvones against UV skin damage in female mice, providing potential opportunities for disease treatment modified by AhR.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Qin Hao, Suman Kundu, Sreerama Shetty, Torry A. Tucker, Steven Idell, Hua Tang
Summary: This study reveals that the knockout of transcription factor Runx3 has a significant impact on the numbers of CD8(+) cytotoxic T cells in the lungs during influenza A virus (IAV) infection. However, it does not significantly affect viral clearance and animal survival. Interestingly, the knockout of Runx3 increases the numbers of pulmonary innate immune cells and the production of pro-inflammatory cytokines during IAV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Denise van Uden, Thomas Koudstaal, Jennifer A. C. van Hulst, Ingrid M. Bergen, Chelsea Gootjes, Nicholas W. Morrell, Geert van Loo, Jan H. von der Thusen, Thierry P. P. van den Bosch, Maria-Rosa Ghigna, Frederic Perros, David Montani, Mirjam Kool, Karin A. Boomars, Rudi W. Hendriks
Summary: The involvement of dendritic cells in the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) was studied in depth, showing a unique role of cDC1s independent of general immune activation or a mutation in the Bmpr2 gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Stefanie Deinhardt-Emmer, Laura Jaeckel, Clio Haering, Sarah Boettcher, Janine J. Wilden, Brigitte Glueck, Regine Heller, Michaela Schmidtke, Mirijam Koch, Bettina Loeffler, Stephan Ludwig, Christina Ehrhardt
Summary: The PI3K inhibitor Pictilisib has been identified as a potent inhibitor of IV propagation, showing reduced viral titers and inflammatory response in the lungs, making it a promising candidate for anti-IV therapies. Repurposing previously approved substances is a cost-effective and efficient way for the development of novel antiviral strategies.
Article
Microbiology
Jian Lin, Yanan Cao, Jinjiao Zuo, Shuai Zhang, Qinghua Yu, Qian Yang, Abid Ullah Shaha, Mark M. W. Chong
Summary: This study found that the Non-structural protein 2 (NS2) of Influenza A viruses (IAV) inhibits the maturation and antigen-presenting ability of dendritic cells (DCs). NS2 impairs miRNA biogenesis pathway by binding to exportin 5 (Xpo5), and also interacts with interferon regulatory factor 3 to further inhibit the antigen-presenting ability of DCs.
VETERINARY MICROBIOLOGY
(2022)
Article
Microbiology
Weigang Ren, Shuli Pei, Wenming Jiang, Meixia Zhao, Le Jiang, Honggang Liu, Yongxiang Yi, Mizhou Hui, Junwei Li
Summary: A replication-deficient recombinant influenza virus was developed in this study, which stimulated robust immune response and conferred complete protection against H5N1 or H9N2 influenza virus infections in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Ning Ma, Xingjie Li, Hongyu Jiang, Yulong Dai, Guofeng Xu, Zongde Zhang
Summary: Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. The study has shown that influenza virus neuraminidase unmasked CD83 protein in the lung and contributed to high cytokine levels. Anti-CD83 treatment could alleviate lung injury caused by influenza virus.
JOURNAL OF VIROLOGY
(2021)