Article
Physiology
Sukanta S. S. Bhattacharya, Brijesh Yadav, Ekta Yadav, Ariel Hus, Niket Yadav, Perminder Kaur, Lauren Rosen, Roman Jandarov, Jagjit S. Yadav
Summary: The understanding of biomarkers and their underlying mechanisms for toxic chemicals and particulates, such as engineered nanoparticles and chlorine gas, is limited. This study focused on the regulation of aquaporins (AQPs), also known as water channels, in lung injuries caused by different toxicity models. The results showed toxicity model-specific regulation of AQPs, indicating their potential as predictive markers for toxicant-specific pulmonary injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Farnoosh Haghighi, Leah Andriasian, Nini Chaichanasakul Tran, Renate Lux
Summary: The study suggests that nicotine from different sources may affect the pathogenic characteristics of C. albicans, including hyphal growth, biofilm formation, and particularly the expression of virulence-related genes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cell Biology
Jamila H. Siamwala, Jim A. Mossman, Christoph Schorl, Diana Borgas, Pavlo Sakhatskyy, David M. Rand, Qing Lu, Sharon Rounds
Summary: Cigarette smoking increases the risk of acute respiratory distress syndrome (ARDS) and causes emphysema. Smoke-exposed AKR mice were found to be more susceptible to LPS-induced acute lung injury (ALI) than C57BL/6 mice. Therefore, we investigated strain-dependent lung transcriptomic responses to cigarette smoke (CS).
PHYSIOLOGICAL GENOMICS
(2023)
Article
Chemistry, Analytical
Tim Axelrod, Evgeni Eltzov, Merav Lerman, Dorin Harpaz, Robert S. Marks
Summary: This study demonstrates that cigarette filters can reduce the harmful effects of cigarette smoke, but they cannot completely eliminate the impact on the human body. Smoking also affects quorum sensing and increases the risk of pulmonary infections.
Article
Cell Biology
P. P. S. J. Khedoe, W. A. A. M. van Schadewijk, M. Schwiening, J. P. Ng-Blichtfeldt, S. J. Marciniak, J. Stolk, R. Gosens, P. S. Hiemstra
Summary: The study finds that cigarette smoke exposure may interfere with Wnt/beta-catenin signaling in lung fibroblasts through induction of cellular stress responses, resulting in inadequate lung repair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Respiratory System
Simon D. Pouwels, Valerie R. Wiersma, Immeke E. Fokkema, Marijn Berg, Nick H. T. Ten Hacken, Maarten Van Den Berge, Irene Heijink, Alen Faiz
Summary: Cigarette smoking leads to significant transcriptional changes in lung epithelial cells, and a novel smoking-related inducible eQTL was identified that is associated with altered expression of FPR genes.
Article
Biochemistry & Molecular Biology
Paul Bigot, Simon Chesseron, Ahlame Saidi, Damien Sizaret, Christelle Parent, Agnes Petit-Courty, Yves Courty, Fabien Lecaille, Gilles Lalmanach
Summary: Chronic obstructive pulmonary disease (COPD) is an irreversible disease mainly caused by smoking. The protein occludin, involved in the cohesion of epithelial tight junctions, is found to be decreased in lung biopsies of smokers and correlates with smoking history, COPD grades, and cathepsin S (CatS) activity. Cigarette smoke-elicited CatS induces an alteration of epithelial integrity via the proteolytic injury of occludin, highlighting the emerging role of CatS in smoking-related lung diseases and the relevance of targeting CatS in the treatment of emphysema and COPD.
Article
Biochemistry & Molecular Biology
Pritam Saha, Sneha Durugkar, Siddhi Jain, P. A. Shantanu, Samir R. Panda, Aishwarya Jala, Sharad Gokhale, Pawan Sharma, V. G. M. Naidu
Summary: The study found that PIP treatment can protect cells from CSE-induced lung epithelial cell death. PIP treatment can restore epithelial markers and reduce mesenchymal and inflammatory markers in both in vitro and in vivo models. PIP treatment can improve altered lung function in mice induced by CS exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ryan H. Nguyen, Laura B. Vater, Lava R. Timsina, Gregory A. Durm, Katelin Rupp, Keylee Wright, Miranda H. Spitznagle, Brandy Paul, Shadia Jalal, Lisa Carter-Harris, Karen S. Hudmon, Nasser H. Hanna, Patrick J. Loehrer, DuyKhanh P. Ceppa
Summary: The study found that counties with stronger smoke-free air ordinances had lower smoking rates and fewer new lung cancer cases per year. Therefore, strengthening smoke-free air ordinances is crucial for reducing lung cancer incidence.
Article
Biochemistry & Molecular Biology
Maria Ferraro, Serena Di Vincenzo, Valentina Lazzara, Paola Pinto, Bernardo Patella, Rosalinda Inguanta, Andreina Bruno, Elisabetta Pace
Summary: This study found that long-acting beta 2-agonist formoterol (FO), commonly used for COPD treatment, may exert anti-cancer effects by reversing oxidative stress, inflammation, and epithelial-mesenchymal transition (EMT) processes induced by cigarette smoke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Michal Mastalerz, Elisabeth Dick, Ashesh Chakraborty, Elisabeth Hennen, Andrea C. Schamberger, Andreas Schroppel, Michael Lindner, Rudolf Hatz, Jurgen Behr, Anne Hilgendorff, Otmar Schmid, Claudia A. Staab-Weijnitz
Summary: This study investigated the effects of different cigarette smoke extract (CSE) exposure protocols on human bronchial epithelial cells and compared them with whole cigarette smoke (wCS) exposure. The results showed that different exposure protocols had differing effects on gene expression, with chronic CSE exposure, acute submerged CSE exposure, and wCS exposure of differentiated phBECs resulting in significant upregulation of smoke-induced genes. These findings provide guidance for the design of in vitro cigarette smoke exposure models in lung research.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Eun-Jung Park, Seung-Woo Jin, Hyun-Ji Lim, Hyeon-Young Kim, Min-Sung Kang, Siyoung Yang
Summary: The study found that smoking may lead to dysfunction of astrocytes, which in turn may contribute to the occurrence of Alzheimer's disease.
Review
Physiology
Marta Schiliro, Elizabeth R. Vogel, Lucia Paolini, Christina M. Pabelick
Summary: The detrimental effects of tobacco exposure on children's health are well known, and the prevalence of secondhand or direct cigarette smoke exposure in the pediatric population has not significantly decreased over time. Additionally, the rapid increase in e-cigarette use among adolescents has raised public health concerns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Lilan Wang, Yao Wang, Jianwen Chen, Xue-Min Yang, Xing-Tao Jiang, Peiqing Liu, Min Li
Summary: This study compared the effects of cigarette smoke condensate (CSC) to electronic cigarette smoke condensate (ECSC) on human lung epithelial cells (BEAS-2B) at equivalent nicotine levels. The results showed that compared to CSC, ECSC did not significantly impact cell effects and gene expression profile at equimolar nicotine concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Xiaoyun Wang, Joselyn Rojas-Quintero, Duo Zhang, Takahiro Nakajima, Katherine H. Walker, Hong Yong Peh, Yuhong Li, Quynh-Anh Fucci, Yohannes Tesfaigzi, Caroline A. Owen
Summary: The study found that ADAM15 plays a significant role in the pathogenesis of COPD. In a mouse model, deficiency in ADAM15 leads to more severe emphysema, small airway fibrosis, and lung inflammation.
MUCOSAL IMMUNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Yohannes A. Mebratu, Yohannes Tesfaigzi
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Hematology
Peter G. Miller, Dandi Qiao, Joselyn Rojas-Quintero, Michael C. Honigberg, Adam S. Sperling, Christopher J. Gibson, Alexander G. Bick, Abhishek Niroula, Marie E. McConkey, Brittany Sandoval, Brian C. Miller, Weiwei Shi, Kaushik Viswanathan, Matthew Leventhal, Lillian Werner, Matthew Moll, Brian E. Cade, R. Graham Barr, Adolfo Correa, L. Adrienne Cupples, Sina A. Gharib, Deepti Jain, Stephanie M. Gogarten, Leslie A. Lange, Stephanie J. London, Ani Manichaikul, George T. O'Connor, Elizabeth C. Oelsner, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Vasan Ramachandran, Bing Yu, Lynette Sholl, Donna Neuberg, Siddhartha Jaiswal, Bruce D. Levy, Caroline A. Owen, Pradeep Natarajan, Edwin K. Silverman, Peter van Galen, Yohannes Tesfaigzi, Michael H. Cho, Benjamin L. Ebert
Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.
Article
Critical Care Medicine
Catherine John, Anna L. Guyatt, Nick Shrine, Richard Packer, Thorunn A. Olafsdottir, Jiangyuan Liu, Lystra P. Hayden, Su H. Chu, Jukka T. Koskela, Jian'an Luan, Xingnan Li, Natalie Terzikhan, Hanfei Xu, Traci M. Bartz, Hans Petersen, Shuguang Leng, Steven A. Belinsky, Aivaras Cepelis, Ana I. Hernandez Cordero, Ma'en Obeidat, Gudmar Thorleifsson, Deborah A. Meyers, Eugene R. Bleecker, Lori C. Sakoda, Carlos Iribarren, Yohannes Tesfaigzi, Sina A. Gharib, Josee Dupuis, Guy Brusselle, Lies Lahousse, Victor E. Ortega, Ingileif Jonsdottir, Don D. Sin, Yohan Bosse, Maarten van den Berge, David Nickle, Jennifer K. Quint, Ian Sayers, Ian P. Hall, Claudia Langenberg, Samuli Ripatti, Tarja Laitinen, Ann C. Wu, Jessica Lasky-Su, Per Bakke, Amund Gulsvik, Craig P. Hersh, Caroline Hayward, Arnulf Langhammer, Ben Brumpton, Kari Stefansson, Michael H. Cho, Louise Wain, Martin D. Tobin
Summary: This study identified genetic variants associated with asthma-COPD overlap and discovered shared genetic influences that may predispose individuals to type 2 inflammation and serious long-term consequences of asthma.
Article
Critical Care Medicine
Charles R. Esther, Wanda K. O'Neal, Wayne H. Anderson, Mehmet Kesimer, Agathe Ceppe, Claire M. Doerschuk, Neil E. Alexis, Annette T. Hastie, R. Graham Barr, Russell P. Bowler, J. Michael Wells, Elizabeth C. Oelsner, Alejandro P. Comellas, Yohannes Tesfaigzi, Victor Kim, Laura M. Paulin, Christopher B. Cooper, MeiLan K. Han, Yvonne J. Huang, Wassim W. Labaki, Jeffrey L. Curtis, Richard C. Boucher
Summary: This study identified altered physiologic pathways associated with COPD airway pathophysiologic features through the analysis of sputum samples. Several biomarkers were found to be correlated with disease severity and predicted exacerbations in COPD patients.
Article
Respiratory System
Akshay Sood, Hans Petersen, Congjian Liu, Orrin Myers, Xin Wang Shore, Bobbi A. Gore, Rodrigo Vazquez-Guillamet, Linda S. Cook, Paula Meek, Yohannes Tesfaigzi
Summary: Racial and ethnic disparities in COPD are not well-studied. This study found that all minority groups had a lower prevalence of airflow obstruction but a higher level of self-reported dyspnea compared to non-Hispanic Whites.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Environmental Sciences
Dereje Tassew, Susan Fort, Yohannes Mebratu, Jacob McDonald, Hong Wei Chu, Hans Petersen, Yohannes Tesfaigzi
Summary: Exposure to wood smoke (WS) increases mucin expression more efficiently than exposure to cigarette smoke (CS), especially in a p53 pathway-dependent manner. The WS constituent oxalate can enhance mucin expression, particularly in individuals with a p53 arginine genotype, revealing potential mechanisms for increased risk of chronic bronchitis. Identifying responsible compounds and genetic variations could help estimate pollutant-related risks and improve lung disease management strategies.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Cell Biology
Yohannes A. Mebratu, Jewel Imani, Jane T. Jones, Yohannes Tesfaigzi
Summary: The study shows that Bik can reduce epithelial and mucous cell hyperplasia in the airways by inducing apoptosis in a cell cycle-specific manner, but more research is needed to fully understand the mechanisms.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Dilpreet Singh, Dereje Damte Tassew, Jordan Nelson, Marie-Cecile G. Chalbot, Ilias G. Kavouras, Philip Demokritou, Yohannes Tesfaigzi
Summary: Wood burning parameters such as moisture content and combustion conditions significantly influence the composition, organic and inorganic elemental characteristics, and bioactivity of particulate matter. The study suggests that PM generated from the flaming combustion of low-moisture pine contains abundant oxygenated saturated aliphatic functional groups and exhibits the highest biological potency in stimulating mucin gene expression.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Environmental Sciences
Mizanur Rahman, Hans Petersen, Hammad Irshad, Congjian Liu, Jacob McDonald, Akshay Sood, Paula M. Meek, Yohannes Tesfaigzi
Summary: Replacing old wood stoves with new ones can reduce personal exposure to household air pollution, but cleaning the flue may be more important than stove age in reducing pollution.
Article
Engineering, Environmental
Dilpreet Singh, Dereje Damte Tassew, Jordan Nelson, Marie-Cecile G. Chalbot, Ilias G. Kavouras, Yohannes Tesfaigzi, Philip Demokritou
Summary: The physicochemical and biological properties of particulate matter emitted during wood burning were investigated. Different wood types and combustion conditions were found to have significant effects on the emissions. The particulate matter from flaming combustion stimulated gene expression associated with mucus production in pulmonary diseases, while smoldering and incomplete combustion did not show any biological activity. Further research is needed to identify the specific compounds responsible for these biological responses.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Medicine, Research & Experimental
Joselyn Rojas-Quintero, Maria Eugenia Laucho-Contreras, Xiaoyun Wang, Quynh-Anh Fucci, Patrick R. . Burkett, Se-Jin Kim, Duo Zhang, Yohannes Tesfaigzi, Yuhong Li, Abhiram R. . Bhashyam, Li Zhang, Haider Khamas, Bartolome Celli, Aprile L. . Pilon, Francesca Polverino, Caroline A. Owen
Summary: Low Club Cell 16 kDa protein (CC16) plasma levels are associated with accelerated lung function decline in chronic obstructive pulmonary disease (COPD) patients. CS-exposed Cc16-/- mice exhibit exaggerated COPD-like disease with increased NF-KB activation in their lungs. RhCC16 treatment limits COPD progression in CS-exposed Cc16-/- mice by reducing pulmonary inflammation, alveolar septal cell apoptosis, and NF-KB activation, as well as rescuing reduced Foxj1 expression. It represents a potentially novel therapeutic approach for COPD.
Article
Biochemistry & Molecular Biology
Yohannes Tesfaigzi, Jeffrey L. Curtis, Irina Petrache, Francesca Polverino, Farrah Kheradmand, Ian M. Adcock, Stephen I. Rennard
Summary: The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current approaches to define distinct disease phenotypes are lacking. This perspective discusses the role of different cell types in COPD pathogenesis and the application of new technologies in understanding the pathophysiology and clinical heterogeneity of COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Respiratory System
Miguel J. Divo, Congjian Liu, Francesca Polverino, Peter J. Castaldi, Bartolome R. Celli, Yohannes Tesfaigzi
Summary: A predictive model consisting of FEV1/FVC, smoking history, BMI, and symptoms of chronic bronchitis can help identify middle-aged smokers at high risk of developing chronic airflow limitation.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Shuguang Leng, Maria A. Picchi, Paula M. Meek, Menghui Jiang, Samuel H. Bayliss, Ting Zhai, Ruslan Bayliyev, Yohannes Tesfaigzi, Matthew J. Campen, Huining Kang, Yiliang Zhu, Qing Lan, Akshay Sood, Steven A. Belinsky
Summary: This study investigated the impact of wood smoke (WS) exposure on lung health and mortality in adults over the age of 40 who were ever smokers. The findings suggest that WS exposure accelerates decline in lung function, increases the risk of developing chronic obstructive pulmonary disease (COPD) and lung cancer (LC), and shortens lifespan. WS exposure also worsens overall health and quality of life.
RESPIRATORY RESEARCH
(2022)