Article
Biochemistry & Molecular Biology
Itzel Pamela Zavala-Guevara, Manolo Sibael Ortega-Romero, Juana Narvaez-Morales, Tania Libertad Jacobo-Estrada, Wing-Kee Lee, Laura Arreola-Mendoza, Frank Thevenod, Olivier Christophe Barbier
Summary: The study evaluated the uptake of CdMT complex through 24p3R after proximal tubule injury. Findings showed increased uptake of CdMT complex and 24p3R expression in the distal tubules after proximal tubule injury, potentially compensating for protein losses associated with AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chikage Mori, Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh
Summary: Cadmium, a toxic heavy metal widely present in the environment, causes renal proximal tubule disorder in chronic poisoning. This study reveals that PPAR delta plays a critical role in modifying susceptibility to Cd renal toxicity, possibly through the apoptosis pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Chen-Xi Li, Milton Talukder, Ya-Ru Xu, Shi-Yong Zhu, Ying-Xin Zhao, Jin- Long Li
Summary: Cadmium is a non-biodegradable environmental pollutant that can cross the blood-brain barrier and cause cerebral toxicity. However, its effect on the blood-brain barrier remains unclear.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell Biology
Shaista Anwer, Emily Branchard, Qinghong Dan, Angela Dan, Katalin Szaszi
Summary: Claudins are crucial for tight junction formation and paracellular transport. TNFa can impact epithelial permeability through modulating the expression of specific claudins, including claudin-3. The effect of TNFa on claudin-3 is mediated by ERK-dependent activation of NF-kappa B and PKA-induced activation of CREB1 pathways, both of which are necessary for the upregulation of claudin-3.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Maria Angeles Avila-Galvez, Daniela Marques, Ines Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Claudia Nunes dos Santos
Summary: Sesquiterpene lactones, such as those found in chicory, have shown potential as bioactive compounds with health benefits for brain disorders. In this study, researchers investigated the ability of six sesquiterpene lactones to cross the blood-brain barrier (BBB) and their effects on brain microvascular endothelial cells. They found that different lactones had varying capacities to be transported through the BBB, with costunolide showing the highest transport rate. Additionally, costunolide and parthenolide were found to improve barrier tightness by affecting the expression of specific proteins. These findings suggest that costunolide and parthenolide could be promising compounds for brain therapies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Yuan Zhao, Zi-Fa Li, Dong Zhang, Zhen-Yong Wang, Lin Wang
Summary: Autophagy dysregulation is a key factor in cadmium-induced nephrotoxicity, and Quercetin has a protective effect by restoring lysosomal function, which is dependent on TFEB activity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Kongdong Li, Chuanzhi Guo, Jiacheng Ruan, Bo Ning, Chris Kong-Chu Wong, Haifeng Shi, Jie Gu
Summary: Cadmium (Cd2+) exposure-induced cytotoxicity and renal injury can be protected against by activating the calcium-sensing receptor (CaSR) to restore the intracellular Ca2+ homeostasis through the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) channel. SERCA2 degradation caused by Cd2+ can be inhibited by the proteasome inhibitor MG132, indicating the involvement of the proteasomal protein degradation pathway in maintaining SERCA2 stability. Targeting SERCA2 and the associated proteasome may provide a new therapeutic approach for preventing Cd2+-induced cytotoxicity and renal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Monica Nordberg, Gunnar F. Nordberg
Summary: This review summarizes the adverse effects of cadmium on human and animal health and emphasizes the importance of preventive measures. It specifically focuses on the role of metallothionein (MT) in cadmium toxicology and highlights the binding of cadmium to MT and the importance of the Cd/Zn ratio in kidney toxicity. The review calls for the application of these findings in risk assessment and preventive measures against cadmium exposures.
Article
Environmental Sciences
Wenxuan Dong, Gang Liu, Kanglei Zhang, Yun Tan, Hui Zou, Yan Yuan, Jianhong Gu, Ruilong Song, Jiaqiao Zhu, Zongping Liu
Summary: Cd exposure induces kidney cell injury by inhibiting autophagic flux leading to p62 accumulation and Nrf2 nucleus translocation. Nrf2 nucleus translocation inhibits AMPK phosphorylation, activates the AKT/mTOR signaling, and ultimately results in rPT cell injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Patrick Carius, Annemarie Jungmann, Marco Bechtel, Alexander Grissmer, Annette Boese, Gilles Gasparoni, Abdulrahman Salhab, Ralf Seipelt, Klaus Urbschat, Clementine Richter, Carola Meier, Denisa Bojkova, Jindrich Cinatl, Joern Walter, Nicole Schneider-Daum, Claus-Michael Lehr
Summary: The study describes a novel monoclonal cell line called Arlo, derived from a polyclonal human alveolar epithelium cell line. Arlo cells exhibit enhanced barrier properties and express genes relevant to barrier integrity and homeostasis, similar to primary human alveolar epithelial cells. Additionally, Arlo cells have been successfully infected with SARS-CoV-2, suggesting potential applications beyond biopharmaceutical experimentation.
Article
Environmental Sciences
Yue Liu, Chengfei Yang, Le Sun, Aoming Wang, Xinhui Lan, Wei Xu, Yan Liang, Sanyuan Ma, Qingyou Xia
Summary: Heavy metal pollution is a major global issue affecting ecosystems. Silkworms are poisoned by heavy metals and a new metallothionein has been identified as a potential factor in improving heavy metal tolerance. Transcriptome sequencing revealed the toxicological mechanism of cadmium and a transgenic silkworm strain overexpressing metallothionein showed enhanced larval viability under cadmium exposure.
Article
Medicine, Research & Experimental
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John Hartman, Damian Fermin, Christopher L. O'Connor, Lalita Subramanian, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius III, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
Summary: This study analyzed kidney biopsies from type 2 diabetes patients and healthy controls, and found that SGLT2 inhibitor treatment mitigates diabetes-induced metabolic perturbations through suppression of the mTORC1 signaling pathway in kidney tubules. The treatment with SGLT2 inhibitors also affected transcriptional processes in different segments of the renal tubules.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Mojtaba Malekinejad, Mohammad Reza Pashaee, Hassan Malekinejad
Summary: The effects of Glycyrrhizin and its metabolites on intestinal epithelial cells were investigated. The results suggest that 18 beta-GA may cause cellular damage at higher concentrations, which is of significant importance to the nutraceutical and pharmaceutical industries.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Hematology
Joanna Kim, John A. Cooper
Summary: Septin 2 localization at cell junctions is essential for organizing cell-cell adhesion proteins, and there are common pathways in gene expression and biological pathways with inflammatory cytokine treatment.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Environmental Sciences
Shi-Long Ruan, Lei Xie, Jun-Wei Ou, Xue-Song Sun, Yong-Pu Zhang, Jian-Rao Hu
Summary: Cd is an environmental toxicant that can affect multiple organs in vertebrates, with the testis being particularly sensitive. Metallothionein (MT) and catalase (CAT) show distinct expression patterns in response to different concentrations of Cd, suggesting CAT may be a better indicator of Cd pollution than MT.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
A. Reeder, M. Attar, L. Nazario, C. Bathula, A. Zhang, D. Hochbaum, E. Roy, K. L. Cooper, S. Oesterreich, N. E. Davidson, C. A. Neumann, M. S. Flint
BRITISH JOURNAL OF CANCER
(2015)
Article
Oncology
Maureen A. Soh, Scott H. Garrett, Seema Somji, Jane R. Dunlevy, Xu Dong Zhou, Mary Ann Sens, Chandra S. Bathula, Christina Allen, Donald A. Sens
CANCER CELL INTERNATIONAL
(2011)
Article
Environmental Sciences
Seema Somji, Chandra S. Bathula, Xu Dong Zhou, Mary Ann Sens, Donald A. Sens, Scott H. Garrett
ENVIRONMENTAL HEALTH PERSPECTIVES
(2008)
Article
Multidisciplinary Sciences
Andrea Slusser, Chandra S. Bathula, Donald A. Sens, Seema Somji, Mary Ann Sens, Xu Dong Zhou, Scott H. Garrett
Article
Immunology
Brandon W. Lewis, Thao Vo, Ishita Choudhary, Allison Kidder, Chandra Bathula, Camille Ehre, Nobuko Wakamatsu, Sonika Patial, Yogesh Saini
JOURNAL OF IMMUNOLOGY
(2020)
Article
Materials Science, Biomaterials
Girdhari Rijal, Chandra Bathula, Weimin Li
INTERNATIONAL JOURNAL OF BIOMATERIALS
(2017)