Review
Food Science & Technology
Antonio Casas-Rodriguez, Ana M. Camean, Angeles Jos
Summary: Microcystins and cylindrospermopsin can induce toxic effects in various systems and organs, including potential endocrine disruption. However, research on their endocrine disruption activity is limited and existing results are contradictory. Further studies are needed to assess the risks and understand the dose-response relationships.
Article
Environmental Sciences
Maria Florencia Ferreira, Fabiana L. Lo Nostro, Daniel A. Fernandez, Griselda Genovese
Summary: This study utilized gene expression analysis of Patagonotothen tessellata as a bioindicator species to demonstrate the impact of human activities in Ushuaia Bay and surrounding areas. Field surveys showed up-regulation of vtgAb and androgen receptors in fish from sites with higher anthropogenic influence.
MARINE ENVIRONMENTAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Kelsey R. Pool, Faustine Chazal, Jeremy T. Smith, Dominique Blache
Summary: Phytoestrogens have an impact on reproductive health and can influence reproductive capacity in various species. Our understanding of the mechanisms linking phytoestrogens and compromised reproduction in sheep is limited.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Chenyan Hu, Yachen Bai, Jing Li, Baili Sun, Lianguo Chen
Summary: Methylparaben (MeP), commonly used in daily products as a preservative, has become a concerning aquatic pollutant. This study exposed adult zebrafish to different concentrations of MeP to investigate its reproductive toxicity. The results showed that MeP exposure affected gonad development, disrupted hormone balance, and led to developmental deficits in offspring. This study provides insight into the antiestrogenic activity and reproductive toxicity of MeP.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Reproductive Biology
Yuna Lee, Saniya Rattan, Radwa Barakat, Zane Inman, Kathy M. De La Torre, Daryl D. Meling, Marcia H. Monaco, Joseph M. Irudayaraj, Isaac K. Cann, Chemyong J. Ko, Sharon M. Donovan, Jodi A. Flaws, Genoa R. Warner
Summary: DEHP, a commonly used chemical, is found in many consumer products. Research has shown that neonatal exposure to DEHP in pigs leads to sex-specific disruption of the reproductive system, affecting both ovaries and testes.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Marine & Freshwater Biology
Pedro Carriquiriborde, Juan Ignacio Fernandino, Carina G. Lopez, Eduardo de San Benito, Juan Manuel Gutierrez-Villagomez, Diego Cristos, Vance L. Trudeau, Gustavo M. Somoza
Summary: Atrazine (ATZ) is a common contaminant in freshwater ecosystems in agricultural regions. This study evaluated the effects of ATZ on gene expression and early gonadal development in Odontesthes bonariensis larvae during the gonadal differentiation period. Results showed increased fish growth in fish exposed to 7 and 70 mu g ATZ/L at 6 wah, but this effect disappeared at 12 wah. ATZ from 7 mu g ATZ/L upregulated the expression of lhb. However, a dimorphic effect was observed on the expression of cyp19a1a at 70 mu g ATZ/L, upregulating or downregulating mRNA transcription in males and females, respectively. In addition, delayed ovarian development and increased number of testicular germ cells were observed at 7 to 70 mu g ATZ/L, respectively. One larva at 70 mu g ATZ/L also showed sex inversion. Overall, ATZ disrupted HPG axis physiology and normal gonadal development in O. bonariensis larvae at environmentally relevant concentrations.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Anuj Kumar Pandey, Vandana Sharma, Kristipati Ravi Ram
Summary: Insect pollinators, crucial for agriculture and ecosystems, are declining due to human-made chemicals. This study develops an ex vivo assay system using transgenic Drosophila males to evaluate the effects of environmental chemicals on ecdysone receptor activity, crucial for male fertility. The assay demonstrates the specific and sensitive modulation of ecdysone receptor activity by different classes of environmental chemicals, and links the endocrine disruption to reduced fertility in vivo.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nolwenn Adam, Sakina Mhaouty-Kodja
Summary: Phthalates have been shown to have reproductive toxic effects in male rodents, and can also impact the female rodent brain. Research indicates that exposure to phthalates may affect behaviors in female rodents, highlighting the need for further investigation to assess the potential risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tianyi Li, Paraskevi Vazakidou, Pim E. G. Leonards, Anastasios Damdimopoulos, Eleftheria Maria Panagiotou, Catarina Arnelo, Kerstin Jansson, Karin Pettersson, Kiriaki Papaikonomou, Majorie van Duursen, Pauliina Damdimopoulou
Summary: This study aims to identify the mechanisms of endocrine disruption using two EDCs, DES and KTZ. The results show that both chemicals affect the pathways related to folliculogenesis and steroidogenesis. Stearoyl-CoA desaturase (SCD) may serve as a potential biomarker of EDC exposure and effects on ovaries.
Article
Marine & Freshwater Biology
Mackenzie L. Morshead, Kathleen M. Jensen, Gerald T. Ankley, Sara Vliet, Carlie A. LaLone, Alejandro Vidales Aller, Karen H. Watanabe, Daniel L. Villeneuve
Summary: The aim of this study was to explore the potential mechanisms through which exposure to estrogen receptor agonists might lead to reproductive impairment in female fish. The results revealed that exposure to EE2 or BPA, as well as their mixtures with TRB, significantly decreased plasma concentrations of vitellogenin in female fish. In contrast, exposure to TRB alone caused a significant reduction in plasma vitellogenin. Based on these findings, it is hypothesized that the impaired oocyte maturation and ovulation, possibly due to negative feedback or direct inhibitory effects of membrane estrogen receptor activation, could be responsible for the adverse reproductive impacts in female fish exposed to estrogen receptor agonists.
AQUATIC TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ya He, Jie Hou, Yuming Qiu, Kang Ouyang, Dapeng Li, Li Li
Summary: This study reveals the effects of microcystin-LR (MC-LR) on the growth and endocrine of zebrafish during the sex differentiation period. MC-LR inhibits the growth of zebrafish and decreases the expression levels of genes related to the GH/IGF and HPT axes, as well as the levels of T3 and T4 hormones. It also disrupts the HPG axis and leads to a decrease in the T/E2 ratio, resulting in an increase in the percentage of females. The study highlights the key cross-talks among the GHRH, TTR, and GnRH signaling molecules.
Article
Marine & Freshwater Biology
Yan Hu, Dong Li, Xuan Ma, Rongjian Liu, Yongmei Qi, Cong Yuan, Dejun Huang
Summary: The study revealed that 2,4-DCP exposure caused feminization in fish by disrupting sex hormone synthesis, which could be explained by the up-regulation of specific genes and hypomethylation of DNA. The use of fadrozole partially attenuated the feminization effect.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Yan-Qiu Liang, Lishan Zhong, Manli Jiang, Mixue Lu, Chengyong Li, Zhongdian Dong, Zhong Lin
Summary: This study assessed the toxic effects of different concentrations of dexamethasone (DEX) on adult male mosquitofish. The results showed that DEX affected skeleton development, resulting in more masculine characteristics in male fish. DEX also caused damage to testis and liver tissue, and altered mRNA expression of genes related to reproductive and immune system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Loureiro Paschoalini, Lourenco Almeida Savassi, Andre Alberto Weber, Davidson Peruci Moreira, Yves Moreira Ribeiro, Elizete Rizzo, Nilo Bazzoli
Summary: This study compared the effects of estrone and bisphenol-A alone and in combination on spermatogenesis in Astyanax bimaculatus. The results showed that estrone and the estrone + bisphenol-A mixture significantly altered the number of spermatogenic cells, while bisphenol-A exhibited higher cytotoxicity. Analysis suggested that the estrone + bisphenol-A mixture did not have additive or synergistic effects.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Environmental Sciences
Mehwish Faheem, Ramji Kumar Bhandari
Summary: Bisphenol-A is a widely used endocrine-chemical that affects fish reproduction through various mechanisms. Studies suggest that analogs of BPA have similar modes of action and impact fish physiology and reproduction.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Matthew N. Hayek, Helen Harwatt, William J. Ripple, Nathaniel D. Mueller
Summary: The shift in global food production towards plant-based diets by 2050 could sequester 332-547 GtCO(2), equivalent to 99-163% of the CO(2) emissions budget consistent with a 66% chance of limiting warming to 1.5 degrees C. This represents a significant opportunity for carbon sequestration through ecosystem restoration, highlighting the potential benefits of dietary changes for mitigating climate change.
NATURE SUSTAINABILITY
(2021)
Article
Multidisciplinary Sciences
Marc F. Mueller, Gopal Penny, Meredith T. Niles, Vincent Ricciardi, Davide Danilo Chiarelli, Kyle Frankel Davis, Jampel Dell'Angelo, Paolo D'Odorico, Lorenzo Rosa, Maria Cristina Rulli, Nathaniel D. Mueller
Summary: A global systematic analysis found that land acquisitions may lead to a shift towards energy-rich but nutrient-poor crops destined for export markets, affecting access to nutritious foods locally. Specific impacts on food production and access vary substantially across regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Yulin Yan, Sujong Jeong, Chang-Eui Park, Nathaniel D. Mueller, Shilong Piao, Hoonyoung Park, Jaewon Joo, Xing Chen, Xuhui Wang, Junguo Liu, Chunmiao Zheng
Summary: The study found that both extreme heat and cold are significantly reducing tea yields in China, with cold extremes currently affecting more than half of the tea production in the country. However, predictions show that climate change may have a positive net impact on tea yield in the near future, especially in northern regions, but new areas in southern China may face yield reductions due to intensified heat extremes.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Multidisciplinary Sciences
Chaopeng Hong, Jennifer A. Burney, Julia Pongratz, Julia E. M. S. Nabel, Nathaniel D. Mueller, Robert B. Jackson, Steven J. Davis
Summary: Historically, human uses of land have significantly impacted ecosystems, biodiversity, and the atmosphere through greenhouse gas emissions. Despite global efforts to mitigate emissions, land-use emissions have continued to rise, driven by factors such as population growth, agricultural production, and land-use changes. Regional disparities in emissions intensity and the disproportionate impact of certain products, such as beef, emphasize the need for targeted mitigation strategies. Our findings provide insights into the complex drivers of global land-use emissions, offering valuable information for future conservation and sustainability efforts.
Article
Multidisciplinary Sciences
Xuhui Wang, Christoph Mueller, Joshua Elliot, Nathaniel D. Mueller, Philippe Ciais, Jonas Jaegermeyr, James Gerber, Patrice Dumas, Chenzhi Wang, Hui Yang, Laurent Li, Delphine Deryng, Christian Folberth, Wenfeng Liu, David Makowski, Stefan Olin, Thomas A. M. Pugh, Ashwan Reddy, Erwin Schmid, Sujong Jeong, Feng Zhou, Shilong Piao
Summary: The study utilizes a Bayesian framework to analyze the global irrigation contribution to wheat and maize crop yields, finding that at a global scale, ΔY is 349% for wheat and 22% for maize. Comparing irrigation demands with renewable water supply, it is suggested that a significant portion of wheat and maize agriculture may not achieve yield gap closure utilizing current river discharge, raising doubts about the potential of irrigation to mitigate climate change impacts.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Bruno Ringeval, Marko Kvakic, Laurent Augusto, Philippe Ciais, Daniel S. Goll, Nathaniel D. Mueller, Christoph Mueller, Thomas Nesme, Nicolas Vuichard, Xuhui Wang, Sylvain Pellerin
Summary: By calculating the ratio between plant demand and soil supply, researchers conducted a theoretical analysis of nitrogen and phosphorus fertilization experiments to explore interaction formalisms between nutrients. The study revealed that synergistic co-limitation could occur even using Liebig's law of minimum under certain conditions, emphasizing the sensitivity of nutrient interaction categorization to mathematical formulation.
GLOBAL BIOGEOCHEMICAL CYCLES
(2021)
Article
Multidisciplinary Sciences
Lorenzo Rosa, Maria Cristina Rulli, Saleem Ali, Davide Danilo Chiarelli, Jampel Dell'Angelo, Nathaniel D. Mueller, Arnim Scheidel, Giuseppina Siciliano, Paolo D'Odorico
Summary: The study evaluates the multi-dimensional changes in fossil-fuel-based energy demand resulting from the transition from small-holder farming to large-scale commercial agriculture, comparing low-input and high-input agricultural practices. It finds that high-input crop production significantly increases fossil-fuel-based energy consumption, highlighting the need for prioritizing local resource access and incorporating energy-intensity analyses in land use governance.
NATURE COMMUNICATIONS
(2021)
Article
Biodiversity Conservation
Kristell Hergoualc'h, Nathan Mueller, Martial Bernoux, Asa Kasimir, Tony J. Weerden, Stephen M. Ogle
Summary: The research findings show that climate is the major driver of direct N2O emissions from managed soils, with emissions significantly higher in wet climates compared to dry climates. The form of fertilizer also plays a significant role in modulating emissions, with synthetic and mixed forms resulting in higher emissions compared to organic forms in wet climates. Other factors such as land cover, soil texture, carbon content, and pH are also important regulators of emissions. By adopting the 2019 IPCC EF1, countries can improve the accuracy of emissions inventories and better target areas for implementing mitigation strategies.
GLOBAL CHANGE BIOLOGY
(2021)
Article
Environmental Sciences
Lindsey L. Sloat, Marena Lin, Ethan E. Butler, Dave Johnson, N. Michele Holbrook, Peter J. Huybers, Jung-Eun Lee, Nathaniel D. Mueller
Summary: Remote sensing of solar-induced chlorophyll fluorescence (SIF) has shown promise in monitoring global agricultural productivity. In-season relationships between coarse-resolution SIF-based metrics, NDVI, and GPP were analyzed, with NDVI-based metrics showing significantly better yield predictions during drought conditions than SIF-based metrics. Evaluation of the benefits of SIF for crop monitoring should continue as SIF measurements improve.
REMOTE SENSING OF ENVIRONMENT
(2021)
Article
Environmental Sciences
Yi Yang, Stephen Ogle, Stephen Del Grosso, Nathaniel Mueller, Shannon Spencer, Deepak Ray
Summary: This study improves the simulation accuracy of maize yields by calibrating regional types of maize in the DayCent ecosystem model. Regionalization of maize significantly reduces errors and biases compared to using a single maize type globally. The study also finds a positive correlation between optimum parameter values of radiation use efficiency and income level, indicating the impact of breeding on the photosynthetic efficiency of maize in developed countries. The research highlights the importance of representing regional variation in crop types for accurate predictions of crop yields.
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Multidisciplinary Sciences
Davide Danilo Chiarelli, Paolo D'Odorico, Marc F. Mueller, Nathaniel D. Mueller, Kyle Frankel Davis, Jampel Dell'Angelo, Gopal Penny, Maria Cristina Rulli
Summary: Large-scale land acquisitions by transnational agribusinesses exacerbate water scarcity and competition with local users.
NATURE COMMUNICATIONS
(2022)
Article
Food Science & Technology
Hans J. M. van Grinsven, Peter Ebanyat, Margaret Glendining, Baojing Gu, Renske Hijbeek, Shu Kee Lam, Luis Lassaletta, Nathaniel D. Mueller, Felipe S. Pacheco, Miguel Quemada, Tom W. Bruulsema, Brian H. Jacobsen, Hein F. M. ten Berge
Summary: This study develops a generic long-term nitrogen response function for global cereals based on 25 field experiments. The function characterizes the yield impacts, economic benefits, and external costs of changing nitrogen inputs. The study also proposes a new method to assess long-term sustainable nitrogen inputs. The results have important implications for nutrient management practices, policies, and global distribution of cereal production.
Article
Food Science & Technology
Xiaoqing Cui, Feng Zhou, Philippe Ciais, Eric A. Davidson, Francesco N. Tubiello, Xiaoyue Niu, Xiaotang Ju, Josep G. Canadell, Alexander F. Bouwman, Robert B. Jackson, Nathaniel D. Mueller, Xunhua Zheng, David R. Kanter, Hanqin Tian, Wulahati Adalibieke, Yan Bo, Qihui Wang, Xiaoying Zhan, Dongqiang Zhu
Summary: The study finds that the global cropland N2O mitigation potential is limited by uncertainty and variability in direct emission factors (EFs), with most of the potential driven by climatic and edaphic factors and achievable on one-fifth of the global harvested area.
Article
Food Science & Technology
Maria Gisbert-Queral, Arne Henningsen, Bo Markussen, Meredith T. Niles, Ermias Kebreab, Angela J. Rigden, Nathaniel D. Mueller
Summary: This study highlights the significant impact of extreme heat and cold on US dairy systems, with colder regions more sensitive to heat extremes and warmer regions more sensitive to cold extremes. Sensitivity to temperature-humidity index (THI) has decreased over time. Climate trends have modestly contributed to rising yields in most states, but future extreme conditions may offset these benefits.
Article
Food Science & Technology
Xin Zhang, Tan Zou, Luis Lassaletta, Nathaniel D. Mueller, Francesco N. Tubiello, Matthew D. Lisk, Chaoqun Lu, Richard T. Conant, Christopher D. Dorich, James Gerber, Hanqin Tian, Tom Bruulsema, Tai McClellan Maaz, Kazuya Nishina, Benjamin Leon Bodirsky, Alexander Popp, Lex Bouwman, Arthur Beusen, Jinfeng Chang, Petr Havlik, David Leclere, Josep G. Canadell, Robert B. Jackson, Patrick Heffer, Nathan Wanner, Weifeng Zhang, Eric A. Davidson
Summary: Input-output estimates of nitrogen on cropland are essential for improving nitrogen management and understanding the global nitrogen cycle. While most datasets show similar patterns, some annual estimates vary widely, leading to large ranges of uncertainty. The comparison of nitrogen budget terms by country reveals areas for improvement.