Article
Microbiology
A. E. Marriott, J. L. Dagley, S. Hegde, A. Steven, C. Fricks, U. DiCosty, A. Mansour, E. J. Campbell, C. M. Wilson, F. Gusovsky, S. A. Ward, W. D. Hong, P. O'Neill, A. Moorhead, S. McCall, J. W. McCall, M. J. Taylor, J. D. Turner
Summary: We demonstrated that lymphopenic mouse strains like NSG and RAG2 are susceptible to the larval development phase of heartworm disease. These mouse models can provide a refined alternative for preclinical drug research and reduce the need for experimental use of cats or dogs.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Veronika Wess, Paula Schuster-Winkelmann, Yasemin Hazal Karatekin, Simge Malik, Florian Beigel, Florian Kuehn, Roswitha Gropp
Summary: Animal models, such as NSG-UC and NSG-CD mice, can partially mimic the pathologies of ulcerative colitis (UC) and Crohn's disease (CD) in humans. NSG-UC mice exhibit a strong inflammatory response when challenged with ethanol, while NSG-CD mice develop pathological manifestations without challenge.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Stefan D. Heinze-Milne, Shubham Banga, Susan E. Howlett
Summary: Persistent low-grade inflammation in aging individuals is associated with frailty, with interleukin-6 being a key pro-inflammatory cytokine linked to frailty progression. The relationship between other cytokines/chemokines and frailty remains uncertain, highlighting the need for further research to identify common inflammatory biomarkers for frailty in both humans and mice.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Review
Immunology
Mahelat Tesfamariam, Picabo Binette, Carrie Mae Long
Summary: This article reviews the animal models used in Q fever vaccine development, describes recent advances in this field, discusses the limitations and strengths of these models, and summarizes the requirements and criteria for future modeling efforts. Overall, while there are already useful models for Q fever vaccine development, there is still room for growth and expansion, which will enhance our understanding of C. burnetii host interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Clinical Neurology
Sarinnapha M. Vasunilashorn, Nadia Lunardi, John C. Newman, Gregory Crosby, Leah Acker, Ted Abel, Seema Bhatnagar, Colm Cunningham, Rafael de Cabo, Laura Dugan, Joseph A. Hippensteel, Yumiko Ishizawa, Shouri Lahiri, Edward R. Marcantonio, Zhongcong Xie, Sharon K. Inouye, Niccolo Terrando, Roderic G. Eckenhoff
Summary: Delirium is a common, morbid, and costly syndrome closely associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). While human studies have improved our understanding of delirium in terms of incidence, risk factors, outcomes, and management, limited knowledge exists about the neurobiology of delirium. This article discusses the use of preclinical and translational animal models to advance our understanding of delirium neurobiology and develop new prevention and treatment strategies. Recommendations for the development and validation of these models are provided to enhance awareness in this important field.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Tae Hoon Kim, Nayoung Bae, Taeho Kim, Albert L. Hsu, Mark Hunter, Jung-Ho Shin, Jae-Wook Jeong
Summary: Endometriosis is positively associated with obesity, but negatively associated with low BMI. High-fat diet-induced obesity can increase the development of endometriosis, while obesity with leptin deficiency and leptin receptor deficiency can suppress the development of endometriosis. These findings suggest that leptin and its receptor play a critical role in the development of endometriosis.
Review
Immunology
Yinxi Zhou, Jinghua Xia, Shuonan Xu, Tao She, Yanning Zhang, Ying Sun, Miaomiao Wen, Tao Jiang, Yanlu Xiong, Jie Lei
Summary: The development and growth of tumors pose a significant and ongoing threat to human life globally. Despite the remarkable progress achieved by advanced therapeutic strategies such as immune checkpoint therapy and CAR-T in treating solid and hematological malignancies, the malignant initiation and progression of cancer remains controversial and requires further research. Experimental animal models not only have great advantages in simulating tumor occurrence, development, and malignant transformation mechanisms, but also can be used to evaluate the therapeutic effects of diverse clinical interventions, gradually becoming indispensable in cancer research. This paper reviews recent research progress in mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, aiming to provide guidance for future studies on malignant mechanisms and tumor prevention.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ying He, Bo Liang, Sze Wan Hung, Ruizhe Zhang, Hui Xu, Jacqueline Pui Wah Chung, Chi Chiu Wang
Summary: This study compared the effects of different methods of establishing endometriosis models in mice on pathology and immunology. The results showed that models established using ovariectomy with estrogen supplement, solely endometrium fragments, and intraperitoneal injection are more suitable for studying the pathology and immunology of endometriosis in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hasan Slika, Ziya Karimov, Paolo Alimonti, Tatiana Abou-Mrad, Emerson De Fazio, Safwan Alomari, Betty Tyler
Summary: Glioblastoma is a common and debilitating malignant tumor of the central nervous system. The prognosis for patients with glioblastoma remains poor, and current management methods are not optimal. This review explores the evolution of preclinical models for glioblastoma and discusses commonly used in vitro and in vivo models, as well as advancements in humanized mouse models, genetically engineered animal models, 3D in vitro models, and microfluidics. The review highlights the importance of developing suitable preclinical models to advance glioblastoma research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Suryapriya Ulaganathan, Arunkumar Pitchaimani
Summary: Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder, and understanding its underlying mechanisms is still a challenge. Current animal models fail to accurately mimic the pathology of AD, both in familial and sporadic variants. This review highlights the gaps in AD models and discusses recent advancements in in vitro and chimeric AD models.
Review
Oncology
Lorena Landuzzi, Francesca Ruzzi, Pier-Luigi Lollini, Katia Scotlandi
Summary: Synovial sarcoma is a rare malignant tumor characterized by t(X;18) translocation encoding the SS18-SSX fusion gene, which interacts with BAF enhancer and polycomb repressor complexes to regulate gene transcription. Different experimental in vivo models for synovial sarcoma research include transgenic mouse models, patient-derived xenografts, and cell lines. These models have contributed to identifying vulnerabilities and developing new therapies for synovial sarcoma.
Article
Biochemistry & Molecular Biology
Naoto Watamura, Kaori Sato, Takaomi C. Saido
Summary: This review describes the development and future prospects of Alzheimer's disease mouse models in terms of their scientific properties and therapeutic perspectives in the context of preclinical study of Alzheimer's disease.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Kurinchi S. Gurusamy, David Moher, Marilena Loizidou, Irfan Ahmed, Marc T. Avey, Carly C. Barron, Brian Davidson, Miriam Dwek, Christian Gluud, Gavin Jell, Kiran Katakam, Joshua Montroy, Timothy D. McHugh, Nicola J. Osborne, Merel Ritskes-Hoitinga, Kees van Laarhoven, Jan Vollert, Manoj Lalu
Summary: The study developed a tool to assess the clinical relevance of preclinical studies and refined and developed it using a modified Delphi consensus. The tool consists of eight domains and 28 signaling questions, providing a framework for researchers, journal editors, grant funders, and regulatory authorities to assess the potential clinical relevance of preclinical animal research.
Article
Ophthalmology
Dominique Geoffrion, Marie-Claude Robert, James Chodosh, Adriana Di Polo, Mona Harissi-Dagher
Summary: The study aimed to determine the feasibility of establishing a reproducible mouse model of glaucoma after KPro surgery, finding that removing the lens during surgery can reduce the incidence of loss of ocular tone and retinal detachment. Successful mouse KPro surgery may require practice to be a useful and reproducible model, and animal KPro models should be further pursued in future studies.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Immunology
Hailan He, Hui Luo, Hui Xu, Biao Qian, Xiaofeng Zou, Guoxi Zhang, Fei Zeng, Junrong Zou
Summary: Prostatitis is a common urological condition that affects almost half of all men at some point in their life. It can cause frequent urination, pelvic pain, and even infertility. This review aims to summarize and compare preclinical models of prostatitis to provide a comprehensive understanding and advance basic research.
FRONTIERS IN IMMUNOLOGY
(2023)
