Article
Environmental Sciences
Lidia Caporossi, Paola Vigano, Enrico Paci, Silvia Capanna, Alessandra Alteri, Giovanni Campo, Daniela Pigini, Mariangela De Rosa, Giovanna Tranfo, Bruno Papaleo
Summary: The study revealed significantly higher concentrations of certain phthalates, particularly in women with recurrent pregnancy loss (RPL) and idiopathic infertility. Work environment may have a differential impact on the exposure to these compounds, which warrants further investigation.
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Fisheries
Makito Kobayashi, Mai Kijima, Yuiko Matsuzuka, Youichi Hayakawa, Eri Iwata, Takeji Kimura
Summary: This study clarified the long-term effects of environmental estrogen on male reproductive activity in goldfish, leading to some fish exhibiting active spawning behavior without producing milt. This could result in a substantial decrease in population size of wild fish.
Review
Environmental Sciences
Junchao Ma, Zeming Wang, Chao Qin, Tingting Wang, Xiaojie Hu, Wanting Ling
Summary: The widespread use of consumer products containing benzophenone-type ultraviolet filters has led to their presence in the human body and environment. Increasing evidence shows that these filters are endocrine disruptors, raising concerns about their carcinogenicity and effects on reproduction and development. Due to the varied types of benzophenone-type filters and limited toxicity studies, there is a need for a systematic review to expand knowledge on their health risks and identify safer alternatives.
Article
Engineering, Biomedical
Se-Ra Park, Soo-Rim Kim, Jin Woo Lee, Chan Hum Park, Wook-Joon Yu, Seung-Jin Lee, Seung Joo Chon, Dae Ho Lee, In-Sun Hong
Summary: The research team successfully developed a novel 'dual reproductive organ on a chip' that accurately replicates the bidirectional endocrine crosstalk between the uterine endometrium and the ovary, as well as the complex multicellular structures of these tissues. They identified a reliable reproductive toxicity marker, SERPINB2, and established a luciferase reporter system for detecting and quantifying the toxicity of various substances, ultimately creating an effective tool for predicting reproductive toxicity of hazardous materials.
Article
Environmental Sciences
Minghui Li, Tian Yang, Lixiong Gao, Haiwei Xu
Summary: Endocrine disrupting chemicals (EDCs) can disrupt hormone balance and lead to physiological abnormalities, affecting ocular diseases. Despite EDCs passing through the blood-retinal barrier and accumulating in the neural retina, research on their impact remains limited.
Article
Chemistry, Multidisciplinary
G. Bhanjana, G. R. Chaudhary, N. Dilbaghi, A. Kaushik, K. -h. Kim, S. Kumar
Summary: In this research, the synthesis and utilization of novel-shaped silver oxide nanoblades (Ag2O NBs) for direct electrochemical sensing of 4-hydroxybenzoic acid (HBA) were reported for the first time. The synthesized Ag2O NBs exhibited excellent electrocatalytic competence and oxidation capability towards HBA. A standardized cyclic voltammetry (CV) technique was successfully optimized for the determination of HBA content, and the fabricated sensor showed high sensitivity and selectivity. The practicality of the sensor was demonstrated through analysis of various field samples.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biology
Reka Eszter Sziva, Julia acs, Anna-Maria Tokes, Agnes Korsos-Novak, Gyoergy L. Nadasy, Nandor acs, Peter Gabor Horvath, Anett Szabo, Haoran Ke, Eszter Maria Horvath, Zsolt Kopa, Szabolcs Varbiro
Summary: This study describes a new, accurate, and easy-to-use quantitative computer-based histomorphometric-mathematical image analysis method for evaluating testicular tissue. The method measures quantitatively describable characteristics and immunohistochemical staining intensity on digitized images to improve reproducibility and objectivity in andrological-reproductive medicine research. The technique could be further automated with machine learning and artificial intelligence, and it can be named 'Computer-Assisted or -Aided Testis Histology' (CATHI).
Article
Obstetrics & Gynecology
Kate Devine, Shelley Dolitsky, Inga Ludwin, Artur Ludwin
Summary: The high effectiveness of modern assisted reproductive technology (ART) and the increasing use of ART by noninfertile patients in the United States raise doubts about the relevance of a standard, one-size-fits-all infertility evaluation. This article explores the necessity of uterine cavity and tubal assessment for all patients seeking ART, as well as the most appropriate, efficient, and cost-effective tests in the current times.
FERTILITY AND STERILITY
(2022)
Review
Health Care Sciences & Services
Soyeon Kang, Hagyeong Jo, Mee-Ran Kim
Summary: This study aims to evaluate the effects and safety of menopausal functional health ingredients and medicines as endocrine disruptors on the human body through the literature review and OECD guidelines.
Article
Environmental Sciences
Fei Zhao, Yinfei Hao, Qianru Xu, Zhineng Hao, Xinhui Li, Lihua Cheng, Dong Chen, Xueqing Shi, Yihua Xiao, Penghao Wei, Xuejun Bi
Summary: Reclaimed water from municipal wastewater has the potential to alleviate the water resource crisis, but the presence of organic micropollutants (OMPs) poses a challenge to its safety. Chemical monitoring of two wastewater treatment plants revealed the presence of 31 out of 32 candidate OMPs in reclaimed water, with concentrations ranging from ng/L to μg/L. Using zebrafish as an in vivo model, it was found that exposure to reclaimed water induced endocrine disruption and reproductive impairment. This study contributes to understanding the ecological risks of reclaimed water and the development of control standards for OMPs, highlighting the significance of in vivo biotoxicity tests in water quality evaluation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Fenghua Li, Xianqi Zhao, Yanni Jiao, Xinglan Duan, Lianlong Yu, Fengjia Zheng, Xiaolin Wang, Lin Wang, Jia-Sheng Wang, Xiulan Zhao, Tianliang Zhang, Wei Li, Jun Zhou
Summary: This study analyzed the exposure level and health risks of aflatoxins (AFs) and zearalenone (ZEA) through cooking oil consumption in Shandong, China. The findings showed that children are facing the highest health risk, and liver cancer incidence is associated with exposure to aflatoxins.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Toxicology
Sayed Aliul Hasan Abdi, Abuzer Ali, Shabihul Fatma Sayed, Amena Ali, Shaivad Shabee Hulhasan Abadi, Abu Tahir, Mohd Amir Afjal, Hina Rashid, Omar M. Aly, Sumathi Nagarajan
Summary: Widespread and irrational or long-term use of paracetamol may be harmful to human endocrine homeostasis, especially during pregnancy. Interactions with reproductive hormone receptors can disrupt stability and synthesis of reproductive hormones.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Review
Pathology
Makoto Enomoto, Hijiri Iwata, Mari Iida
Summary: Toxicologic Pathology evaluates toxic chemical exposures and chemically mediated illnesses, with comparative studies playing a crucial role in chemical risk assessment and human health. Studies in this field provide valuable findings on dose levels, exposure times, and effects of specific chemical compounds on different target cells and tissues. Future advancements in toxicological pathology involve molecular pathology and interdisciplinary cooperation for elucidating mechanisms of toxicity.
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2021)
Article
Medicine, Legal
Gina M. Hilton, Catherine Adcock, Gregory Akerman, James Baldassari, Michael Battalora, Warren Casey, Amy J. Clippinger, Rhian Cope, Amber Goetz, A. Wallace Hayes, Sabitha Papineni, Richard C. Peffer, Deborah Ramsingh, Brandy Williamson Riffle, Mitscheli Sanches da Rocha, Natalia Ryan, Edward Scollon, Nicolo Visconti, Douglas C. Wolf, Zhongyu Yan, Anna Lowit
Summary: Rodent cancer bioassays have long been required for assessing human cancer hazard and risk, but new technologies have emerged in the past decade that can effectively evaluate these factors while reducing animal use. To facilitate the adoption of these technologies, a group of scientists developed a framework for waiver rationales for rodent cancer bioassays in agrochemical safety assessment. This framework considers various factors, such as use patterns, exposure scenarios, mode-of-action, and chemical properties, and can be applied to other chemicals and endpoints as well.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)