Article
Green & Sustainable Science & Technology
Lucas Schmeling, Patrik Schoenfeldt, Peter Klement, Lena Vorspel, Benedikt Hanke, Karsten von Maydell, Carsten Agert
Summary: The optimal combination of energy conversion and storage technologies with local energy demand is a key challenge of distributed energy. The choice of technology and operational strategy have a decisive influence on the optimality.
Article
Management
Jerry Anunrojwong, Krishnamurthy Iyer, Vahideh Manshadi
Summary: Information design is an effective tool in reducing congestion in social services by persuading users to choose their outside options, leading to improved service quality.
MANAGEMENT SCIENCE
(2023)
Article
Management
Jerry Anunrojwong, Krishnamurthy Iyer, Vahideh Manshadi
Summary: This study examines the effectiveness of information design in reducing congestion in social services catering to users with different levels of need. The research shows that information design can improve social welfare and sometimes achieve optimal welfare when the population is sufficiently heterogeneous.
MANAGEMENT SCIENCE
(2023)
Review
Materials Science, Multidisciplinary
Priyambada Nayak, Amir Armani
Summary: This paper reviews the development of methods for optimizing material composition distribution in additive manufacturing processes. Various components such as homogenization approaches, material representation techniques, finite element analysis approaches, and optimization algorithms are discussed and compared. Manufacturing techniques for producing functionally graded materials with complex material distribution are also reviewed.
Article
Mathematics, Applied
Azhar Iqbal Kashif Butt, Kinza Mumtaz, Edgar O. Resendiz-Flores
Summary: This study implements space mapping technique to optimize the geometry of a glass tube during production, aligning the optimizer of a coarse model with a fine model to find an optimal solution using adjoint variable approach and the aggressive space mapping (ASM) algorithm.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2021)
Article
Engineering, Civil
Yicong Zhou, Qiyin Lin, Jun Hong, Nan Yang
Summary: The distribution of Young's modulus in functionally graded materials was investigated to reduce stress concentration. An evolutionary optimization algorithm was developed to control the Young's modulus evolution process. Finite element analysis was used to verify the effectiveness of the Young's modulus design in reducing stress concentration.
Article
Physics, Fluids & Plasmas
Paulo H. dos Santos, Igor D. S. Siciliani, M. H. R. Tragtenberg
Summary: This study proposes a method based on theoretical and numerical optimization scheme to determine the crossover income, temperature, and index of income distribution. By analyzing Brazilian income distribution data, the study explores economic differences among different subsets and discusses the implications of income inequality on Brazil. The study also presents a measure of inequality that relies on the Pareto index and the percentage of people in the high-income region.
Article
Computer Science, Interdisciplinary Applications
Aytac Arikoglu
Summary: Optimal design of two-dimensional functionally graded thick flywheels was achieved using GDQM and NSGA II, with results compared to open literature and ANSYS solutions showing good agreement. Pareto optimal solutions for minimum mass and maximum energy storage capability were obtained, leading to the determination of optimal cross-section geometry and material distribution of FG flywheels.
STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
(2021)
Article
Engineering, Electrical & Electronic
Zi He, Yu-Sheng Li, Peng-Fei Gu, Kwok Wa Leung, Ru-Shan Chen
Summary: An efficient electromagnetic optimization technique for radar cross section reduction is proposed in this study. By constructing coarse and fine models and using different methods to solve them, the optimal solution is found using the trust region aggressive space-mapping algorithm, significantly improving optimization efficiency and reducing RCS.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2021)
Article
Gastroenterology & Hepatology
Fabienne Kurt, Gabriel E. Leventhal, Marianne Rebecca Spalinger, Laura Anthamatten, Philipp Rogalla von Bieberstein, Carmen Menzi, Markus Reichlin, Marco Meola, Florian Rosenthal, Gerhard Rogler, Christophe Lacroix, Tomas de Wouters
Summary: By selecting nine strains and continuous co-culturing, a stable microbial consortium that emulates the central metabolic pathways of carbohydrate fermentation in the healthy human gut microbiota was constructed. The function-based consortium showed an efficacy comparable to FMT in counteracting acute colitis, while an equivalent mix of strains failed to match FMT. The approach of combining a bottom-up functional design with continuous co-cultivation is proposed as a powerful strategy to produce robust functionally designed synthetic consortia for therapeutic use.
Article
Green & Sustainable Science & Technology
Sara Carcangiu, Alessandra Fanni, Augusto Montisci
Summary: This paper formalizes the optimization of an inductive Magneto-Hydro-Dynamic (MHD) electric generator as a multi-objective optimization problem. The proposal uses pulsed discharges to ionize the working fluid and applies a DC electrical field to create a neutral plasma that induces an electromotive force into a magnetically coupled coil. A tailored multi-objective optimization algorithm based on Tabu Search meta-heuristics is implemented to find Pareto optimal solutions.
Article
Energy & Fuels
Seong-Tae Jo, Woo-Hyeon Kim, Young-Keun Lee, Yong-Joo Kim, Jang-Young Choi
Summary: In this study, a multi-objective optimal design method for the SPMSM of an EV air conditioner system compressor was proposed and applied using NSGA-II and an analytical method. The validity of the proposed method was confirmed by comparing the characteristics of the optimal design model with those of the initially designed model.
Article
Green & Sustainable Science & Technology
F. Cruz-Peragon, F. J. Gomez-de la Cruz, J. M. Palomar-Carnicero, R. Lopez-Garcia
Summary: This work presents the optimal design of a hybrid ground source heat pump (GSHP) that takes into account thermal imbalance and space limitation for the ground heat exchanger field (GHE) in an official building. The study utilizes experiments and modeling to simulate the behavior of the GHE and seeks to find a balance between energy savings and internal rate of return through design optimization.
Article
Construction & Building Technology
Ugur Acar, Onder Kaska
Summary: There is currently no widely accepted definition or specific design standard to achieve zero energy buildings (NZEB). This study proposes a complete design methodology for NZEB, divided into two stages of analysis and optimization. The results show that NZEB can be achieved under different climatic conditions, with the integration of renewable energy systems significantly influencing both net energy balance and cost reduction. The payback period for integrating renewables into NZEB is around 3.5 years if the proposed methodology is followed.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Energy & Fuels
Mohamad Saleh Sanjari Nia, Pourya Shamsi, Mehdi Ferdowsi
Summary: This paper analyzes and optimizes a high voltage pulsed power system to improve its electromagnetic compatibility (EMC) by focusing on the design of high voltage pulse transformers. The new generation of pulsed power systems using SiC and GaN fast switches face more EMI challenges, requiring a novel energy distribution model to optimize parasitic parameters and reduce EMI propagation. Three pareto-optimal techniques are investigated for cost function optimization, verified through 3D finite element method (FEM) simulations and experimental results. The optimized system shows reduced EMI noise levels compared to the IEC61800-3 standard.
CSEE JOURNAL OF POWER AND ENERGY SYSTEMS
(2021)
Article
Biochemistry & Molecular Biology
Yoonjoo Choi, Christian Ndong, Karl E. Griswold, Chris Bailey-Kellogg
PROTEIN ENGINEERING DESIGN & SELECTION
(2016)
Article
Biology
Casey K. Hua, Albert T. Gacerez, Charles L. Sentman, Margaret E. Ackerman, Yoonjoo Choi, Chris Bailey-Kellogg
Article
Chemistry, Multidisciplinary
Woosung Heu, Jung Min Choi, Hyun-Ho Kyeong, Yoonjoo Choi, Hee Yeon Kim, Hak-Sung Kim
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Biochemical Research Methods
Yoonjoo Choi, Jacob M. Furlon, Ryan B. Amos, Karl E. Griswold, Chris Bailey-Kellogg
Article
Chemistry, Medicinal
Tae-Geun Yu, Hak-Sung Kim, Yoonjoo Choi
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2019)
Article
Biotechnology & Applied Microbiology
Yoo-Kyoung Sohn, Sumin Son, Yoonjoo Choi, Da-Eun Hwang, Hyo-Deok Seo, Joong-jae Lee, Hak-Sung Kim
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Biochemistry & Molecular Biology
Sukyo Jeong, Yoo-Kyoung Sohn, Yoonjoo Choi, Jinho Park, Hak-Sung Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biotechnology & Applied Microbiology
Dain Kim, Jisu Hong, Yoonjoo Choi, Jemin Han, Sangkyu Kim, Gyunghee Jo, Jun-Yeol Yoon, Heesu Chae, Hyeseon Yoon, Chankyu Lee, Hyo Jeong Hong
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Biochemical Research Methods
Yoonjoo Choi, Sukyo Jeong, Jung-Min Choi, Christian Ndong, Karl E. Griswold, Chris Bailey-Kellogg, Hak-Sung Kim
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Chemistry, Medicinal
Dong-Gun Kim, Yoonjoo Choi, Hak-Sung Kim
Summary: The preference for a binding site by protein binders is strongly related to the structural flexibility of a target protein surface, and the relatedness of epitopes to the structural flexibility of a target protein surface is dependent on the secondary structure elements of paratopes. Monobody and repebody, whose binding sites are composed of beta-strands, distinctively prefer to bind to a relatively more rigid region of a target protein.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Immunology
Koemchhoy Khim, Yong Jun Bang, Sao Puth, Yoonjoo Choi, Youn Suhk Lee, Kwangjoon Jeong, Shee Eun Lee, Joon Haeng Rhee
Summary: In this study, immunogenic regions in Vibrio vulnificus flagellin B were computationally identified and deimmunized by removing a B cell epitope region. The resulting deimmunized FlaB maintained stable TLR5-stimulating activity and did not induce specific B cell responses after multiple immunizations. Co-administration of deimmunized FlaB with influenza vaccine enhanced strong antigen-specific immune responses without inducing specific antibody production.
Article
Immunology
Jisu Hong, Youngjin Choi, Yoonjoo Choi, Jiwoo Lee, Hyo Jeong Hong
Summary: By conducting experiments and structural analysis, it was found that 1A8 can effectively block HBV infection of different genotypes, making it a promising candidate for the prevention and treatment of HBV infection.
Article
Biochemistry & Molecular Biology
Youn Hee Jung, Yoonjoo Choi, Hyo-Deok Seo, Moon-Hyeong Seo, Hak-Sung Kim
Summary: This study reports the development of conformation-selective protein binders for a KRAS mutant. The protein binders were selected from a repebody scaffold composed of LRR modules using phage display and modular engineering. The binders were shown to effectively block the interaction between active KRAS and the RAS-binding domain of BRAF, thereby suppressing KRAS-mediated downstream signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Tae Yoon Kim, Jeong Seok Cha, Hoyoung Kim, Yoonjoo Choi, Hyun-Soo Cho, Hak-Sung Kim
Summary: This study describes the computationally-guided design and affinity improvement of a protein binder recognizing a specific site on domain IV of HER2. The binding affinity of the selected lead was significantly increased through mutual feedback between computational and experimental methods. The utility and potential of this approach was demonstrated by determining the binding interface of the developed protein binder through crystal structure analysis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemical Research Methods
Hyun-Ho Kyeong, Yoonjoo Choi, Hak-Sung Kim