Catalysis of Selective Hydrogen/Deuterium Exchange at Allylic Positions Using Deuterium Oxide

Deuterated organic compounds can be prepared efficiently and cost effectively by the direct exchange of a hydrogen atom by a deuterium atom on a carbon center rather than classical synthetic procedures. H/D exchange is achieved at allylic positions of alkenes catalyzed by alkene isomerization catalyst 1. An outstanding degree of deuteration is achieved at positions accessible by isomerization in homogeneous and biphasic reaction settings.