Article
Immunology
Jason T. Patregnani, Michimasa Fujiogi, Carlos A. Camargo, Bonnie A. Brooks, Claire E. Hoptay, Jonathan M. Mansbach, Stephen J. Teach, Robert J. Freishtat, Kohei Hasegawa
Summary: Serum sRAGE levels are inversely associated with acute and chronic morbidities of bronchiolitis, including recurrent wheeze. Higher presenting sRAGE levels are associated with lower risk of intensive care and significantly lower rate of recurrent wheeze. The effect of sRAGE on development of recurrent wheeze is potentially driven through pathways other than acute severity of bronchiolitis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Critical Care Medicine
Michelle J. Lim, Matt S. Zinter, Lucia Chen, Kayley Man Yee Wong, Anoopindar Bhalla, Kinisha Gala, Mona Guglielmo, Mustafa Alkhouli, Leanna L. Huard, Mark R. Hanudel, Sitaram Vangala, Andreas Schwingshackl, Michael Matthay, Anil Sapru
Summary: This study investigates the relationship between plasma soluble receptor for advanced glycation end products (sRAGE) and primary pulmonary dysfunction, extrapulmonary organ dysfunction, and mortality in pediatric acute respiratory distress syndrome (ARDS) patients. The results show that sRAGE is associated with extrapulmonary organ dysfunction and markers of inflammation in ARDS patients, and is also related to mortality in children with indirect lung injury.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Julio A. Lamprea-Montealegre, Alice M. Arnold, Robyn L. McCLelland, Kenneth J. Mukamal, Luc Djousse, Mary L. Biggs, David S. Siscovick, Russell P. Tracy, Paul J. Beisswenger, Bruce M. Psaty, Joachim H. Ix, Jorge R. Kizer
Summary: This study found that alpha-dicarbonyl-derived AGEs are associated with CVD in an older cohort, but not in a healthier middle-aged/older cohort. The results suggest that AGEs may exert detrimental cardiovascular effects only under conditions of marked dicarbonyl and oxidative stress. Further investigation of alpha-dicarbonyl derivatives could lead to potential new strategies for CVD prevention in high-risk older populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Critical Care Medicine
Jehan Alladina, Sean D. Levy, Josalyn L. Cho, Kelsey L. Brait, Sowmya R. Rao, Alexander Camacho, Kathryn A. Hibbert, R. Scott Harris, Benjamin D. Medoff, James L. Januzzi, B. Taylor Thompson, Ednan K. Bajwa
Summary: The study suggests that elevations in sST2 concentrations in patients with AHRF may indicate ongoing lung injury and better predict patient outcomes. IL-6 concentrations did not correlate with outcomes. Therefore, using sST2 concentrations to guide ventilator management may be more accurate than traditional measures.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Matthieu Jabaudon, Bruno Pereira, Erwan Laroche, Laurence Roszyk, Raiko Blondonnet, Jules Audard, Thomas Godet, Emmanuel Futier, Jean-Etienne Bazin, Vincent Sapin, Julie A. Bastarache, Lorraine B. Ware, Jean-Michel Constantin
Summary: Plasma soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury in acute respiratory distress syndrome (ARDS). Changes in plasma sRAGE over time are associated with 90-day survival in ARDS patients. This suggests that plasma sRAGE could be helpful as a surrogate outcome in ARDS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Xiaoxia Huang, Bingyu Li, Jiaqing Hu, Zhuanhua Liu, Dongping Li, Zhenfeng Chen, Hang Huang, Yanjia Chen, Xiaohua Guo, Yun Cui, Qiaobing Huang
Summary: This study reveals that AGEs mediate kidney injury with characteristic patterns by binding with RAGE and inducing moesin phosphorylation. AGE-BSA stimulation in mice resulted in distinct abnormal angiogenesis, glomerular hypertrophy, mesangial expansion, glomerular atrophy, and fibrosis at different time points. Moesin phosphorylation was accompanied by these AGE-induced alterations, and moesin deficiency attenuated AGE-BSA-induced fibrosis. The phosphorylation of moesin T558 was critical in AGE-induced tube formation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Plant Sciences
Stefaniya Velichkova, Kenn Foubert, Luc Pieters
Summary: Protein glycation, a post-translational modification, is linked to glucose metabolism defects and the progression of various diseases. Research on antiglycation agents is lacking sufficient clinical data and approved drugs. Scientists are increasingly exploring natural compounds as potential inhibitors of advanced glycation endproduct formation.
Article
Multidisciplinary Sciences
Christian M. Jensen, Junia C. Costa, Jens C. Norgaard, Adrian G. Zucco, Bastian Neesgaard, Carsten U. Niemann, Sisse R. Ostrowski, Joanne Reekie, Birgit Holten, Anna Kalhauge, Michael A. Matthay, Jens D. Lundgren, Marie Helleberg, Kasper S. Moestrup
Summary: The existing chest X-ray (CXR)-based scoring systems for COVID-19 pneumonia have low spatial resolution, which needs to be increased for better evaluation of lung anatomy and severity. In this study, the MBrixia score was developed by modifying the Brixia score to improve spatial resolution. The MBrixia score, based on a rule-based quantification of CXR severity in 12 anatomical zones, was applied to CXR images of COVID-19 patients. The results showed a positive correlation between the MBrixia score and the level of respiratory support at the time of CXR imaging. The MBrixia score has the potential to serve as a quantitative surrogate measurement of COVID-19 pneumonia severity, and further research should investigate its validity and predictive capabilities for clinical outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Vaishali Rana, Ahana Mukherjee, Yogita Basnal, Deepak Kushwaha, Jaydeep Bhattacharya, Ranjita Ghosh Moulick
Summary: The elevated blood sugar in Type II diabetes leads to the formation of Advanced Glycation Endproducts (AGEs), which cause severe pathogenic complications. Previous research has shown that AGEs generated from Hemoglobin A0 (HbA0) can synthesize gold nanoparticles (AuNPs). In this study, it was found that these AGEs can also reduce silver ions and synthesize silver nanoparticles (AgNPs) with a different plasmonic response. The research demonstrates that AGEs can be detected by deploying metal salts in solution.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Biomedical
Julia Kamml, Claire Acevedo, David S. Kammer
Summary: Advanced-Glycation-Endproducts (AGEs) are a major cause of impaired tissue material properties, particularly in collagen fibrils. The mechanical properties of collagen fibrils are altered when AGEs accumulate, which is commonly caused by diabetes and aging. However, the relationship between nano-scale cross-link properties, AGEs density in collagen fibrils, and the mechanical properties at larger scales is not well understood. This study uses molecular dynamics simulations and destructive tensile tests to evaluate the effect of different cross-link densities and mechanical properties on collagen fibril deformation and fracture behavior. It is found that increasing the AGEs density or loading energy capacity leads to stiffening of the collagen fibril. The absorbed energy is stored rather than dissipated through friction, resulting in brittle fracture upon fibrillar failure. The study emphasizes the importance of understanding AGEs properties for a better understanding of impaired tissue behavior and suggests further investigation into the loading energy capacity of AGEs.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Food Science & Technology
Qian Wu, Yingna Feng, Yu Ouyang, Yinggang Liang, Kuoquan Zhao, Ying Wang, Qing Luo, Juan Xiao, Nianjie Feng, Mengzhou Zhou
Summary: The study demonstrated that LSOPC inhibited AGEs formation, alleviated AGEs-induced liver injury by suppressing NF-kappa B nuclear translocation and MAPK signaling pathway activation. Additionally, LSOPC also inhibited the expression of TNF-alpha and IL-6. In conclusion, LSOPC treatment potentially modulated liver injury caused by long-term dietary AGEs by suppressing the RAGE-MAPK-NF-kappa B pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Ana-Lucia Mayen, Elom K. Aglago, Viktoria Knaze, Reynalda Cordova, Casper G. Schalkwijk, Karl-Heinz Wagner, Krasimira Aleksandrova, Veronika Fedirko, Pekka Keski-Rahkonen, Michael F. Leitzmann, Verena Katzke, Bernard Srour, Matthias B. Schulze, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Bas Bueno-de-Mesquita, Magritt Brustad, Antonio Agudo, Maria Dolores Chirlaque Lopez, Pilar Amiano, Bodil Ohlsson, Stina Ramne, Dagfinn Aune, Elisabete Weiderpass, Mazda Jenab, Heinz Freisling
Summary: The study found that higher dietary intake of AGEs was inversely associated with the risk of hepatocellular carcinoma and positively associated with the risk of gallbladder cancer. No associations were observed for cancers of the intra and extrahepatic bile ducts.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Orthopedics
Zachary S. Gallate, Danielle N. D'Erminio, Philip Nasser, Damien M. Laudier, James C. Iatridis
Summary: Back and neck pain are major causes of disability, with intervertebral disc degeneration being a contributing factor. Accumulation of advanced glycation endproducts (AGEs) is associated with oxidative stress and collagen damage in the intervertebral disc. The receptors for AGEs (RAGE) and Galectin 3 (Gal3) play important roles in the response to AGEs in the intervertebral disc.
Article
Ophthalmology
Johanna Rankenberg, Stefan Rakete, Brandie D. Wagner, Jennifer L. Patnaik, Christian Henning, Anne Lynch, Marcus A. Glomb, Ram H. Nagaraj
Summary: The levels of AGEs in human lens capsules during cataract surgery were found to be similar between diabetic and non-diabetic patients, except for significantly higher levels of glucosepane in diabetic patients, which may explain the similar incidence of posterior capsule opacification between the two groups.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jyh-Gang Leu, Wei-Hsiang Su, Yu-Cheng Chen, Yao-Jen Liang
Summary: The research suggests that Hydralazine has the potential to reduce oxidative stress and inflammation in AGEs-induced kidney injury in diabetic patients, showing promising therapeutic effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Letter
Rheumatology
Maria De Santis, Antonio Voza, Victor Savevski, Salvatore Badalamenti, Maurizio Cecconi, Alberto Mantovani, Carlo Selmi
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Paolo Corradini, Chiara Agrati, Giovanni Apolone, Alberto Mantovani, Diana Giannarelli, Vincenzo Marasco, Veronica Bordoni, Alessandra Sacchi, Giulia Matusali, Carlo Salvarani, Pier Luigi Zinzani, Renato Mantegazza, Fabrizio Tagliavini, Maria Teresa Lupo-Stanghellini, Fabio Ciceri, Silvia Damian, Antonio Uccelli, Daniela Fenoglio, Nicola Silvestris, Fausto Baldanti, Giulia Piaggio, Gennaro Ciliberto, Aldo Morrone, Franco Locatelli, Valentina Sinno, Maria Rescigno, Massimo Costantini
Summary: This study investigated the immune response to the SARS-CoV-2 vaccine in patients with tumors and immune disorders. The results showed that immunosuppressive treatment was a risk factor for a low humoral response, while the booster dose improved both humoral and T-cell responses.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Davit Pipoyan, Seda Stepanyan, Meline Beglaryan, Alberto Mantovani
Summary: This study aimed to assess the dietary exposure of the adult population in Yerevan, Armenia to nickel. Based on a total diet study and analysis, fruits, vegetables, and bread were identified as the main sources of nickel intake. The estimated chronic dietary exposure was below the safety standards for both age and gender groups, suggesting low health risks. However, acute oral exposure to nickel may pose potential health concerns for sensitized individuals.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Medicine, General & Internal
Alberto Mantovani, Cecilia Garlanda
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Giovanni Mistraletti, Armando Lancioni, Gabriele Bassi, Francesca Nespoli, Michele Umbrello, Silvia Salini, Alberto Zangrillo, Federico Pappalardo, Anna Mara Scandroglio, Giuseppe Foti, Leonello Avalli, Nicolo Patroniti, Ferdinando Raimondi, Elena Costantini, Emanuele Catena, Davide Ottolina, Claudia Ruffini, Maurizio Migliari, Giovanni Sesana, Roberto Fumagalli, Antonio Pesenti
Summary: A study found that mechanical chest compression (mechCPR) can improve the rate of return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA) patients. MechCPR, combined with extracorporeal circulation life support (ECLS), offers a chance of survival to refractory OHCA patients, and also provides opportunities for organ donation.
Review
Immunology
Alberto Mantovani, Maria Rescigno, Guido Forni, Francesca Tognon, Giovanni Putoto, Jerry Ictho, Peter Lochoro
Summary: This article reviews the modes of action of COVID-19 vaccines, including innate immunity, trained innate immunity, and mucosal responses. It also discusses the inequality in access to vaccines and vaccine-related immunological research in Africa. The authors argue that strengthening immunology research in Africa can provide insights into fundamental aspects of vaccination, including the relevance of genetics, trained innate immunity, and microbiome diversity.
TRENDS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Marco Erreni, Francesca D'Autilia, Roberta Avigni, Evangelia Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cecile Vincke, Fijs W. B. van Leeuwen, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter
Summary: Nanobodies (Nbs) have been identified as an elegant alternative to conventional monoclonal antibodies for cancer therapy, but there is a lack of detailed microscopic insight into the in vivo pharmacokinetics of different Nb formats in tumor-bearers, especially for the targeting of pro-tumoral tumor-associated macrophages (TAMs) located in less penetrable tumor regions.
Article
Oncology
Nina Cortese, Roberta Carriero, Marialuisa Barbagallo, Anna Rita Putignano, Guido Costa, Fabio Giavazzi, Fabio Grizzi, Fabio Pasqualini, Clelia Peano, Gianluca Basso, Sergio Marchini, Federico Simone Colombo, Cristiana Soldani, Barbara Franceschini, Luca Di Tommaso, Luigi Terracciano, Matteo Donadon, Guido Torzilli, Paolo Kunderfranco, Alberto Mantovani, Federica Marchesi
Summary: Two M4 markers associated with opposite clinical relevance were identified through single-cell analysis, indicating the importance of improved classification and prognostic classifiers for patients with colorectal liver metastasis.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Mattia Loppini, Marco Di Maio, Roberta Avigni, Roberto Leone, Antonio Inforzato, Guido Grappiolo, Alberto Mantovani, Barbara Bottazzi
Summary: This study evaluated the diagnostic potential of synovial and plasmatic PTX3 in hip and knee periprosthetic joint infections (PJIs). The results showed that synovial PTX3 had high sensitivity and specificity in diagnosing PJI, while plasmatic PTX3 failed to differentiate infected from non-infected patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Antonio Pesenti, Douglas Slobod, Sheldon Magder
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Immunology
Diletta Di Mitri, Fabio Conforti, Alberto Mantovani
Summary: In the microenvironment of prostate bone metastasis, macrophages activate a cascade involving Activin A, the extracellular matrix, and SRC kinase, leading to resistance against anti-androgen therapy. These findings have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Jonathan Muri, Valentina Cecchinato, Andrea Cavalli, Akanksha A. A. Shanbhag, Milos Matkovic, Maira Biggiogero, Pier Andrea Maida, Jacques Moritz, Chiara Toscano, Elaheh Ghovehoud, Raffaello Furlan, Franca Barbic, Antonio Voza, Guendalina De Nadai, Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Lilly A. Murray, Gabriela Danelon-Sargenti, Simone Moro, Tao Gong, Pietro Piffaretti, Filippo Bianchini, Virginia Crivelli, Lucie Podesvova, Mattia Pedotti, David Jarrossay, Jacopo Sgrignani, Sylvia Thelen, Mario Uhr, Enos Bernasconi, Andri Rauch, Antonio Manzo, Adrian Ciurea, Marco B. L. Rocchi, Luca Varani, Bernhard Moser, Barbara Bottazzi, Marcus Thelen, Brian A. Fallon, Onur Boyman, Alberto Mantovani, Christian Garzoni, Alessandra Franzetti-Pellanda, Mariagrazia Uguccioni, Davide F. Robbiani
Summary: We found that antibodies against specific chemokines are commonly present in COVID-19 convalescents and are associated with favorable disease outcomes and a decreased risk of long COVID development at 1 year post-infection. These chemokine antibodies are also found in HIV-1 infection and autoimmune disorders, but target different chemokines compared to COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bind to the chemokine N-loop impair cell migration. Naturally occurring chemokine antibodies may modulate the inflammatory response and have therapeutic potential.
Review
Endocrinology & Metabolism
Damiano Chiari, Barbara Pirali, Vittoria Perano, Roberto Leone, Alberto Mantovani, Barbara Bottazzi
Summary: This article investigates the role of long pentraxin 3 (PTX3) in immune dysregulation, tissue remodeling, and oncogenesis, and finds that PTX3 may be a common factor underlying nodular thyroid disease, thyroid cancer, and autoimmune thyroid disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Elena Azzolini, Maximiliano Mollura, Chiara Pozzi, Leonardo Ubaldi, Alberto Mantovani, Carlo Selmi, Riccardo Barbieri, Maria Rescigno
Summary: An important issue often ignored is the discrepancy in medical treatment response between male and female genders. COVID-19 vaccine administration has revealed that females tend to experience more adverse events compared to males despite following identical protocols. Through logistic regression analysis of adverse events in 2385 healthcare workers receiving the Comirnaty vaccine, we found that age, sex, COVID-19 history, and BMI may contribute to the development of adverse events, particularly in young subjects, females, and individuals with a BMI below 25 kg/m(2). Furthermore, partial dependence plots indicate a 50% probability of mild adverse events lasting for a long period (>= 7 days) or any duration of severe adverse events in women below 40 years old with a BMI < 20 kg/m(2). Given that this effect is more prominent after the second vaccine dose, we propose adjusting the vaccine dosage for additional booster doses based on age, sex, and BMI to reduce adverse events without compromising vaccine efficacy.
Article
Urology & Nephrology
Simone Sforza, Valeria Emma Palmieri, Maria Rosaria Raspollini, Giandomenico Roviello, Alberto Mantovani, Umberto Basso, Maria Carmen Affinita, Alberto D'Angelo, Lorenzo Antonuzzo, Marco Carini, Andrea Minervini, Lorenzo Masieri
Summary: This study reviewed the literature on robotic surgery in Wilms' tumor and reported the first case of adult WT management using both neoadjuvant chemotherapy and robotic strategy.
ASIAN JOURNAL OF UROLOGY
(2023)