Article
Public, Environmental & Occupational Health
Chuan Shao, Hui Tang, Xiaoya Wang, Jiaquan He, Pan Wang, Nan Wu
Summary: This study provides evidence of a nonlinear, inverse association between oral contraceptive (OC) use and glioma risk. Larger studies in the future are necessary to validate this finding.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Zhongfu Chang, Dandan Jiang, Shikun Zhang, Dongdong Pei, Zhirong Zhang, Lihua Zhang, Jianying Cai, Jun Cao
Summary: This study explored the genetic association between epidermal growth factor (EGF) gene polymorphisms and peri-implantitis risk in a Chinese Han population. Results showed that the GG genotype and G allele of rs2237051 in the EGF gene may serve as protective factors for the onset of peri-implantitis. There was no significant association found with rs4444903 genotype distributions.
Review
Oncology
Yaqi Wu, Jun Zhou, Jun Zhang, Zhijian Tang, Xi Chen, Lulu Huang, Shengwen Liu, Hong Chen, Yu Wang
Summary: This study conducted a meta-analysis and found that certain polymorphisms in TERT, CCDC26, CDKN2A/B, and RTEL1 genes may increase the risk of glioma in Caucasian populations, but not in Asian populations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Xu Han, Lai Zheng, Yi-Yang Mu, Hong-Zhuo Li, Xiao-Feng He
Summary: The meta-analysis investigated the association between OPG gene polymorphisms and osteoporosis risk, finding a significant correlation in certain subgroups but overall pointing to false-positive results. This suggests that previous studies may not have accurately assessed the true association between OPG gene variants and osteoporosis risk.
FRONTIERS IN GENETICS
(2022)
Review
Genetics & Heredity
Lin Zhao, Xiang-Xiongyi Yin, Jun Qin, Wei Wang, Xiao-Feng He
Summary: Based on a comprehensive analysis of a large number of studies, this meta-analysis found no significant association between TP53 codons 72, IVS3 16 bp, and IVS6+62A > G polymorphisms and breast cancer risk. The previous results suggesting an association may be false-positive results due to confounding factors.
FRONTIERS IN GENETICS
(2022)
Review
Obstetrics & Gynecology
Yuxi Li, Lanlan Fang, Yang Yan, Zhen Wang, Ze Wu, Qiongqiong Jia, Jung-Chien Cheng, Ying-Pu Sun
Summary: The presence of a polymorphism of eight or more SHBG (TAAAA)n may be a predictive factor for the risk of PCOS, as it is associated with PCOS risk and low serum SHBG concentrations in women with PCOS. Other SHBG gene polymorphisms were not significantly associated with either PCOS risk or serum SHBG concentrations.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Hematology
Soon Khai Low, Zauraiz Anjum, Amir Mahmoud, Utsav Joshi, Peter Kouides
Summary: This meta-analysis finds that IDH mutation is significantly associated with a lower risk of VTE in patients with high-grade glioma, but the effect is not significant in grade II glioma.
THROMBOSIS RESEARCH
(2022)
Article
Cell Biology
Xue-Feng Li, Guang-Bin Jiang, Shi-Yan Cheng, Ya-Feng Song, Cai Deng, Yu-Ming Niu, Jun-Wei Cai
Summary: The meta-analysis on the association between PPAR-gamma 2 gene polymorphisms and diabetic retinopathy risk did not find a significant relationship between the two factors. Subgroup analyses also failed to reveal any significant associations.
Article
Cell Biology
Chuankun Zhou, Shutao Gao, Xi Yuan, Zixing Shu, Song Li, Xuying Sun, Jun Xiao, Hui Liu
Summary: CTLA-4 gene polymorphisms may be associated with the risk of Rheumatoid arthritis (RA), with rs3087243 and rs231775 polymorphisms showing significant associations, while rs5742909 polymorphism is not associated with RA risk. Meta-analysis confirms the relationship between CTLA-4 gene polymorphisms and RA risk in different populations.
Review
Multidisciplinary Sciences
Shing Cheng Tan, Teck Yew Low, Hafiz Muhammad Jafar Hussain, Mohamad Ayub Khan Sharzehan, Hilary Sito, Hamed Kord-Varkaneh, Md Asiful Islam
Summary: This study conducted a systematic review and meta-analysis to investigate the association between the XRCC3 p.Thr241Met polymorphism and glioma risk. The results showed that this polymorphism is significantly associated with increased glioma risk in the homozygous and recessive models, particularly in the Asian population.
Review
Oncology
Ke Zhu, Aiqun Xu, Wanli Xia, Pulin Li, Binbin Zhang, Huihui Jiang, Sijing Zhou, Ran Wang
Summary: The NAT2 slow + intermediate phenotype is significantly associated with an increased risk of lung cancer, while the NAT2 rapid phenotype is associated with a reduced risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Behavioral Sciences
Fan Cheng, Xiao-Min Si, Gong-Li Yang, Lan Zhou
Summary: This meta-analysis investigated the association between PPAR-gamma gene polymorphisms and ischemic stroke risk. The results suggested that rs1801282 C/G polymorphism may be associated with an increased risk for ischemic stroke, while rs3856806 C/T polymorphism showed no significant association with ischemic stroke risk.
BRAIN AND BEHAVIOR
(2021)
Article
Oncology
Aiqiao Zhang, Shangren Wang, Fujun Zhang, Wei Li, Qian Li, Xiaoqiang Liu
Summary: The meta-analysis showed that the LEP G19A polymorphism may decrease the risk of cancer, especially in Asians, but not significant in Caucasians. Furthermore, the LEP G19A polymorphism may decrease the risk of colorectal cancer, esophageal cancer, digestive system cancer, and urinary system cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Kun Zhao, Liuyan Nie, Grace Min Jun Chin, Xiangming Ye, Peng Sun
Summary: This study evaluated FTO gene expression in different OA sequencing datasets and performed a meta-analysis to assess the association between FTO polymorphism and OA risk. The results showed a significant association between FTO polymorphisms and increased OA risk in Caucasian populations. However, the causality between FTO polymorphisms and OA risk remains unclear, and further studies with larger sample sizes are needed to validate their contribution to OA susceptibility.
FRONTIERS IN MEDICINE
(2022)
Review
Clinical Neurology
Yongchao Zhang, Shichao Chen, Hualei Chen, Shanshan Chen, Zhen Li, Enshan Feng, Wei Li
Summary: This meta-analysis examined the risk and impact of lymphopenia in patients with glioma. It found that lymphopenia was associated with decreased survival, and risk factors for lymphopenia included brain receiving radiation dose, gender, age, baseline lymphocyte count, and dexamethasone dose. Optimization of treatment regimens, especially in patients with concurrent risk factors, may reduce lymphopenia and improve survival in the era of immunotherapy.
FRONTIERS IN NEUROLOGY
(2022)