Article
Biochemistry & Molecular Biology
Bruno Zwingenberger, Corina Vater, Roland L. Bell, Julia Bolte, Elisabeth Mehnert, Ronny Bruenler, Dilbar Aibibu, Stefan Zwingenberger
Summary: The study found that CHS scaffolds exhibited higher osteogenic properties in vitro, but resulted in lower bone-healing outcomes compared to CBA and MCM in vivo. Future improvements on CHS scaffolds are needed for better mechanical stability and osteoconductivity.
Article
Cell Biology
Ulrike Rottensteiner-Brandl, Ulf Bertram, Lara F. Lingens, Katrin Koehn, Luitpold Distel, Tobias Fey, Carolin Koerner, Raymund E. Horch, Andreas Arkudas
Summary: In this study, a critical-sized femoral defect model was combined with an ionizing radiation protocol in rats to support bone healing using a combination of SiHA, MSCs and BMP-2. The implanted osteogenic MSCs survived in vivo for 18 weeks, while irradiation led to impaired bone healing.
Article
Engineering, Biomedical
M. Bouyer, C. Garot, P. Machillot, J. Vollaire, V Fitzpatrick, S. Morand, J. Boutonnat, V Josserand, G. Bettega, C. Picart
Summary: The study suggests that using 3D-printed PLA scaffolds loaded with reduced doses of BMP-2 may be a safe and simple solution for large bone defects in the clinic. The dose of BMP-2 delivered from the scaffold significantly influences the amount of regenerated bone and the repair kinetics, showing good bone repair outcomes.
MATERIALS TODAY BIO
(2021)
Article
Materials Science, Multidisciplinary
Zhiming Zhang, Zijie Rong, Guofeng Wu, Yihan Wang, Zhiwen Tan, Juan Zheng, Yanglei Jin, Zhihao Liang, Chun Liu, Jiasong Guo, Lixin Zhu
Summary: The study introduced a controlled-oxygen-generating composite scaffold to enhance seed cell survival and improve bone defect reconstruction.
APPLIED MATERIALS TODAY
(2021)
Review
Anatomy & Morphology
Antoine Berberi, Mohammad Fayyad-kazan, Sara Ayoub, Rita Bou Assaf, Joseph Sabbagh, Michella Ghassibe-Sabbagh, Bassam Badran
Summary: This paper discusses the use of mesenchymal stem cells obtained from several oral tissues mixed with different types of scaffolds tested in different animal models for bone tissue engineering. It emphasizes the factors that need to be taken into consideration when choosing animals, and highlights the comparisons between human and animal models.
Article
Biochemistry & Molecular Biology
Rene D. Verboket, Nicolas Soehling, Myriam Heilani, Charlotte Fremdling, Alexander Schaible, Katrin Schroeder, Jan C. Brune, Ingo Marzi, Dirk Henrich
Summary: The Masquelet technique is a two-stage procedure used to treat large bone defects. This study tested the effectiveness of demineralized bone matrix and bone marrow mononuclear cells as membrane fillings, and found that they cannot replicate the good results of this material in large, non-membrane coated bone defects. However, they do support the maturation of new bone tissue locally.
Review
Polymer Science
Yaoguang Zhang, Shengjun Jiang, Dongdong Xu, Zubing Li, Jie Guo, Zhi Li, Gu Cheng
Summary: Complex or compromised bone defects often lead to non-union fractures. Nanocellulose aerogels, as biopolymer-based materials, have been widely used in bone tissue engineering. They mimic the extracellular matrix and promote tissue healing and growth. This review summarizes the preparation, modification, composite fabrication, and applications of nanocellulose aerogels in bone tissue engineering, as well as discussing the current limitations and future opportunities.
Article
Orthopedics
Kyeong-Hyeon Park, Chang-Wug Oh, Joon-Woo Kim, Jong-Keon Oh, Yong-Cheol Yoon, Il Seo, Sung-Soo Ha, Seung-Ho Chung
Summary: Both BTON and BTOP showed similar outcomes and complication incidences in treating segmental tibial bone defects. BTOP required less external fixator time, but had similar final outcomes compared to BTON.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Biotechnology & Applied Microbiology
Ru-Lin Huang, Rao Fu, Yuxin Yan, Chuanqi Liu, Jing Yang, Yun Xie, Qingfeng Li
Summary: Developmental engineering of hypertrophic cartilaginous constructs engineered from adipose tissue can effectively heal large bone defects, exhibiting superior regenerative capacity and tissue integration.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Rene D. Verboket, Tanja Irrle, Yannic Busche, Alexander Schaible, Katrin Schroeder, Jan C. Brune, Ingo Marzi, Christoph Nau, Dirk Henrich
Summary: The study found that fibrous demineralized bone matrix (f-DBM) combined with bone marrow mononuclear cells (BMCs) exhibits comparable biomechanical properties and bone healing effects to the gold standard, syngenic cancellous bone. Denser packing of fibers or higher amount of calcium phosphate did not show any positive effects in bone defect regeneration.
Review
Oncology
Luan P. Hatt, Keith Thompson, Jill A. Helms, Martin J. Stoddart, Angela R. Armiento
Summary: Bone tissue engineering has potential for regenerating craniomaxillofacial bones, and 3D printing is a suitable method for creating personalized implants. However, the current clinical implementation of tissue engineering concepts in this field is poor, mainly due to the complexity of the anatomy and biology in the craniomaxillofacial region, as well as the limited relevance of preclinical animal models. There is a lack of appropriate guidelines and standards to address specific craniomaxillofacial pathologies and test the efficacy of biomaterials or tissue engineered constructs. Therefore, it is important to consider critical research aspects in order to develop clinically driven tissue engineered materials for craniomaxillofacial reconstruction.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Materials Science, Biomaterials
Wei Tan, Chengde Gao, Pei Feng, Qing Liu, Congcong Liu, Zhenting Wang, Youwen Deng, Cijun Shuai
Summary: The PLLA/nHA/MET composite scaffold constructed in this study showed improved cell adhesion, appropriate porosity, good biocompatibility, and osteogenic-induced ability in vitro. MET enhanced water solubility and promoted osteogenic differentiation within the scaffold.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Charlotte Garot, Sarah Schoffit, Cecile Monfoulet, Paul Machillot, Claire Deroy, Samantha Roques, Julie Vial, Julien Vollaire, Martine Renard, Hasan Ghanem, Hanane El-Hafci, Adeline Decambron, Veronique Josserand, Laurence Bordenave, Georges Bettega, Marlene Durand, Mathieu Manassero, Veronique Viateau, Delphine Logeart-Avramoglou, Catherine Picart
Summary: A new medical device for bone regeneration is developed by combining a 3D-printed scaffold with a surface coating delivering BMP-2. The internal geometry of the scaffold, particularly the shape of the pores, is found to influence bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Xueqin Gao, Mintai P. Hwang, Nathaniel Wright, Aiping Lu, Joseph J. Ruzbarsky, Matthieu Huard, Haizi Cheng, Michael Mullen, Sudheer Ravuri, Bing Wang, Yadong Wang, Johnny Huard
Summary: This study compared the effectiveness of 5 bone morphogenetic proteins (BMPs) in promoting bone defect healing using a sustained-release platform. BMP2 and BMP7 were found to have the best bone regeneration capabilities.
Article
Materials Science, Multidisciplinary
Yi Fan, Guangkai Ren, Yutao Cui, He Liu, Shaorong Li, Yuhang Tian, Gan Wang, Chuangang Peng, Yanbing Wang, Dankai Wu
Summary: Peptide-based hydrogels are widely studied and applied in bone repair due to their biocompatibility, biodegradability, and designability. By introducing biologically functional groups and adjusting the composition, peptide-based hydrogels can have different properties. They can be used alone to fill bone defects or as sustained-release carriers to enhance bone regeneration. Additionally, peptide-based hydrogels can provide solutions for repairing large bone defects by incorporating other scaffold materials.
MATERIALS & DESIGN
(2023)