Review
Biotechnology & Applied Microbiology
Zeqing Zhao, Jin Liu, Michael D. Weir, Abraham Schneider, Tao Ma, Thomas W. Oates, Hockin H. K. Xu, Ke Zhang, Yuxing Bai
Summary: This review article presents the recent advances in PDLSC-based bone regeneration and periodontal tissue regeneration. By combining PDLSCs with various materials and scaffolds, as well as applying different osteoinductive agents and strategies, PDLSCs demonstrate the potential for bone and periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Yi-Tao Chang, Chuan-Ching Lai, Dan-Jae Lin
Summary: This study aimed to develop an injectable cell-laden hydrogel for periodontal regeneration using LED photo-cross-linking collagen scaffolds. The scaffolds were found to support the differentiation of HPLFs into myofibroblasts and preosteoblasts. Histomorphometric analysis showed that the COL_HPLF_LED group had less epithelial downgrowth and reduced bone defects compared to the control groups. The results suggest that this approach holds promise for regenerating periodontal defects both structurally and functionally.
Article
Biochemistry & Molecular Biology
Lucy Vojtova, Veronika Pavlinakova, Johana Muchova, Katarina Kacvinska, Jana Brtnikova, Martin Knoz, Bretislav Lipovy, Martin Faldyna, Eduard Gopfert, Jakub Holoubek, Zdenek Pavlovsky, Monika Vicenova, Veronika Hefka Blahnova, Vanessa Hearnden, Eva Filova
Summary: The study demonstrates the application of a novel FGF2 variant on collagen/chitosan scaffolds, indicating its positive effects on wound healing and vascularization.
Article
Chemistry, Multidisciplinary
Ik-Hwan Kim, Mijeong Jeon, Kyounga Cheon, Sun Ha Kim, Han-Sung Jung, Yooseok Shin, Chung Min Kang, Seong-Oh Kim, Hyung-Jun Choi, Hyo-Seol Lee, Ko Eun Lee, Je Seon Song
Summary: This study evaluated the use of decellularized human tooth as a scaffold for regeneration of periodontal ligaments (PDL) and pulp tissue with PDLSCs and DPSCs, respectively. The experiment demonstrated successful differentiation and potential for regeneration in both PDLSCs and DPSCs on the decellularized tooth scaffolds. This suggests a novel treatment method for tooth regeneration utilizing decellularized human tooth as a scaffold.
APPLIED SCIENCES-BASEL
(2021)
Article
Biotechnology & Applied Microbiology
Xiongcheng Xu, Ziqin Chen, Long Xiao, Yanmei Xu, Nianqi Xiao, Weiqiu Jin, Yuling Chen, Yanfen Li, Kai Luo
Summary: This study aimed to investigate the effects of nanosilicate-incorporated PCL (PCL/LAP) nanofibrous membranes on periodontal ligament cells (PDLCs) in vitro and periodontal regeneration in vivo. The results showed that the PCL/LAP nanofibrous membrane exhibited good biocompatibility and bioactivity, enhanced the proliferation and osteogenic differentiation of PDLCs, and promoted periodontal regeneration by orchestrating the immunomodulatory effects of PDLCs. Therefore, the PCL/LAP nanofibrous membrane has the potential to be a promising biomaterial for periodontal regeneration therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Orie Adachi, Hideki Sugii, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Masataka Kadowaki, Risa Sugiura, Mhd Safwan Albougha, Hidefumi Maeda
Summary: The study aims to clarify the biological functions of decorin in the healing and regeneration of wounded periodontal tissue. The results demonstrate that decorin promotes osteoblastic differentiation of periodontal ligament stem cells and contributes to bone healing through ERK1/2 signaling pathway.
Article
Chemistry, Multidisciplinary
Fahad Ali Alshehri
Summary: This study investigated whether vitamin C could improve the proliferation and viability of gingival fibroblasts extracted from smoking and non-smoking donors and cultured on collagen membranes. The results showed that vitamin C positively affected the cells from the smoking group, mitigating the adverse effects of smoking on periodontal cells.
APPLIED SCIENCES-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Yongxi Liang, Ajay Shakya, Xiaohua Liu
Summary: This study designed and fabricated a bioinspired tubular 3D matrix to guide the migration and growth of human periodontal ligament stem cells (PDLSCs) and form aligned fiber bundles. The tubular matrix controlled cell migration and alignment through inhibiting osteogenic differentiation. Mechanism study revealed involvement of the Yap1/Twist1 signaling pathway.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Qianyu Liang, Lingqian Du, Rui Zhang, Wenyan Kang, Shaohua Ge
Summary: The combination therapy of SDF-1 and EX-4 synergistically regulated the activities of PDLSCs, promoted periodontal bone formation, and provided a new strategy for periodontal bone regeneration.
CELL PROLIFERATION
(2021)
Article
Pharmacology & Pharmacy
Ioannis Tsamesidis, Anna Theocharidou, Anastasia Beketova, Maria Bousnaki, Iason Chatzimentor, Georgia K. Pouroutzidou, Dimitrios Gkiliopoulos, Eleana Kontonasaki
Summary: The aim of this study was to investigate the osteogenic capacity of human periodontal ligament cells (hPDLCs) in culture with artemisinin (ART)-loaded Ce-doped calcium silicate nanopowders (NPs). The results showed that artemisinin promoted the osteogenic differentiation of hPDLCs in the presence of Ce-doped NPs and also exhibited antioxidant activity.
Article
Cell & Tissue Engineering
Liya Ma, Nanquan Rao, Hui Jiang, Yuzhe Dai, Songtao Yang, Hefeng Yang, Jiangtian Hu
Summary: This study investigates the potential of DFSCs-sEVs in regenerating damaged periodontal tissue. The results show that DFSCs-sEVs promoted the proliferation, migration, and osteogenic differentiation of PDLSCs, potentially through the activation of the p38 MAPK signaling pathway. DFSCs-sEVs provide a novel strategy for periodontal regeneration.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Poranee Banyatworakul, Thanaphum Osathanon, Sujin Chumprasert, Prasit Pavasant, Nopadon Pirarat
Summary: The study showed that PRF derived from Thai buffaloes was more beneficial for the proliferation of canine periodontal ligament cells (cPDLs) compared to PRF derived from Murrah buffaloes, and also promoted cell migration and spreading. Additionally, PRF from Thai buffaloes enhanced mineral deposition in an osteogenic induction medium.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Christian Behm, Michael Nemec, Fabian Weissinger, Marco Aoqi Rausch, Oleh Andrukhov, Erwin Jonke
Summary: The systematic review revealed that orthodontic forces induce increased expression levels of MMPs and TIMPs in the PDL during orthodontic tooth movement. However, the exact effect may vary depending on intervention and sample parameters as well as subject characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Ilaria Roato, Beatrice Masante, Giovanni Putame, Diana Massai, Federico Mussano
Summary: This review provides an overview of recent advancements in periodontal tissue engineering, focusing on the use of PDLSCs and 3D scaffolds. The findings demonstrate the potential of these methods for innovative therapies in the future.
Article
Dentistry, Oral Surgery & Medicine
Byoung-Heon Kim, Bo-Ah Lee, Seong-Ho Choi, Young-Taek Kim
Summary: This study retrospectively evaluated 51 patients who received implant-supported restorations in the anterior region, finding no significant difference in complications among different types of prostheses. Peri-implant mucositis was most frequently observed in the ALIPS type, while mechanical complications were more common in the cement and ALIPS types.
JOURNAL OF PROSTHETIC DENTISTRY
(2021)
Article
Medicine, General & Internal
Jeong-Hwa Kim, Jae-Woon Oh, Young Lee, Jeong-Ho Yun, Seong-Ho Choi, Dong-Woon Lee
Summary: This study found that detecting 18 bacterial species in mouth-rinse samples can be used to diagnose periodontitis, with Treponema denticola, Prevotella nigrescens, and Streptococcus mitis significantly associated with severe periodontitis. Further research is needed to assess the potential of oral-rinsing solutions in indicating oral infection risk and improving oral hygiene.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Physical
Su-Hee Jeon, Young Woo Song, Jae-Kook Cha, Jeong-Won Paik, Sang-Sun Han, Seong-Ho Choi
Summary: This study aimed to compare the internal fit accuracy of 3D-printed BCP block with 3D-milled PMMA block, and found that the internal contact ratio was significantly higher in the BCP group. The internal gap area was similar between the two groups.
Article
Multidisciplinary Sciences
Hye-Min Chung, Jin-Young Park, Kyung-A Ko, Chang-Sung Kim, Seong-Ho Choi, Jung-Seok Lee
Summary: The aim of this study was to compare the supra-alveolar gingival dimension (GD) and the clinical pocket probing depth (PD) using data from an intraoral scanner (IOS) and cone-beam computed tomography (CBCT) and identify the clinical features affecting PD. The results showed a positive correlation between GD and PD, and this correlation was stronger for untreated sites, sites with bleeding on probing (BOP), and sites with a larger PD.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sung-Bae Lee, Bo-Ah Lee, Seong-Ho Choi, Young-Taek Kim
Summary: This study aimed to determine the long-term outcomes after peri-implantitis treatment and the factors affecting these outcomes. The study found that full compliance to recall visits, not smoking, placement of fewer implants, and less bone loss at baseline significantly influenced the treatment outcome.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yu-Seon Park, Bo-Ah Lee, Seong-Ho Choi, Young-Taek Kim
Summary: This study evaluated failed implants and reimplantation survival, identifying the relative risk factors for implant re-failure. The results showed that reimplantation failure was more strongly affected by patient factors than by implant factors, necessitating meticulous control of each patient's specific factors for successful reimplantation.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chena Lee, Yoon Joo Choi, Kug Jin Jeon, Seong Ho Choi, Sang-Sun Han
Summary: This study aimed to introduce the imaging characteristics of cosmetic fillers and grafts shown in dental CBCT and raise awareness of dental considerations. Results revealed diverse shapes and radiopacity of cosmetic materials in CBCT images, and their potential to cause mandibular bone resorption and imaging artifacts.
HEAD & FACE MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiang Jin, Jin-Young Park, Jung-Seok Lee, Ui-Won Jung, Seong-Ho Choi, Jae-Kook Cha
Summary: This study aimed to assess the histomorphometric characteristics of non-crosslinked and crosslinked collagen membranes. The results showed that non-crosslinked membranes were more rapidly biodegraded but fully integrated with the surrounding tissues to form dense periosteum-like connective tissue. The barrier effect of the pseudoperiosteum needs further investigation.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jeong-Woong Kim, Bo-Ah Lee, Yu-Seon Park, Jinho Chung, Seong-Ho Choi, Young-Taek Kim
Summary: The purpose of this study was to determine the efficacy of active noise-canceling (ANC) headphones in reducing the pain and discomfort associated with dental scaling. The study found that the use of ANC headphones can reduce the discomfort caused by noise and pain.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Seungah Lee, In Hye Kim, Junkee Hong, Byung-Ju Jeon, Sung-Su Kim, Ji-Won Lee, Jin-Young Park, Seong-Ho Choi, Tae-Kyeong Lee, Jae-Kook Cha, Moo-Ho Won
Summary: This study provides in vitro and in vivo evidence to support the potential of TEES-10(R) as a treatment for gingivitis and periodontitis, suggesting it could improve dental health.
Article
Chemistry, Multidisciplinary
Min-Woo Baek, Hyun-Chang Lim, Kwantae Noh, Seong-Ho Choi, Dong-Woon Lee
Summary: The study compared digital and conventional impression methods for soft tissue changes after tooth extraction, revealing that digital impressions showed more pronounced tissue surfaces at both time points, with the greatest discrepancy observed immediately post-extraction. Despite small differences, the clinical or scientific implications of these findings may vary.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Kyung-A Ko, Jin-Young Park, Jung-Seok Lee, Byoung Seok Ye, Ui-Won Jung, Seong-Ho Choi, Jae-Kook Cha
Summary: This study investigated the association between changes in masticatory function and cognitive impairment. The results suggest a potential causative relationship between neglected missing teeth and the onset of dementia.
YONSEI MEDICAL JOURNAL
(2022)
Article
Engineering, Biomedical
Young-Wook Seo, Jin-Young Park, Da-Na Lee, Xiang Jin, Jae-Kook Cha, Jeong-Won Paik, Seong-Ho Choi
Summary: This study compared three-dimensionally printed biphasic calcium phosphate (BCP) block bone substitutes with different pore diameters for the regeneration of rabbit calvarial defects. The results showed that the BCP blocks remained unresorbed and new bone formation occurred within the porous structures of the blocks. After 2 weeks, histomorphometric analysis indicated that new bone formation was significantly greater in the BCP groups compared with the control group. However, there were no significant differences between the groups with different pore diameters. At 8 weeks, only the 1.0-mm group presented a significantly larger area of new bone compared with the control group. Among the BCP groups, the 1.0-mm and 1.2-mm groups exhibited significantly larger areas of new bone compared with the 0.8-mm group.
BIOMATERIALS RESEARCH
(2022)
Article
Psychology, Clinical
Shawna J. Lee, Kaitlin P. Ward, Joyce Y. Lee, Christina M. Rodriguez
Summary: The study found that parents' perceived social isolation and recent employment loss were associated with the risk of child maltreatment (including neglect, verbal aggression, and physical punishment), even after controlling for parental depressive symptoms, income, and sociodemographic factors. The results highlight the need for mental health support for parents and children to alleviate the strain caused by COVID-19.
JOURNAL OF FAMILY VIOLENCE
(2022)