Article
Cell & Tissue Engineering
Eric Stec, Jared Lombardi, Jephte Augustin, Maryellen Sandor
Summary: Comparative studies on the mechanical properties and host tissue integration of ADMs are important for abdominal wall reconstruction procedures. This study compared two commercially available ADMs, Strattice and SurgiMend, and found that Strattice retained greater mechanical strength and exhibited greater fibroblast cell infiltration.
TISSUE ENGINEERING PART A
(2023)
Article
Dermatology
Zhuzhen Zhang, Ilja Kruglikov, Shangang Zhao, Zhenzhen Zi, Christy M. Gliniak, Na Li, May-yun Wang, Qingzhang Zhu, Christine M. Kusminski, Philipp E. Scherer
Summary: Study found that dermal adipocytes can modulate the structure of the dermis through regulating extracellular matrix production in dermal fibroblasts, with involvement of fatty acids released by dermal adipocytes.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cell & Tissue Engineering
Jeffrey L. Van Eps, Christian Boada, Jacob C. Scherba, Dmitry Zavlin, Noemi Arrighetti, Aaron Shi, Xin Wang, Ennio Tasciotti, Joseph F. Buell, Warren A. Ellsworth, Daniel J. Bonville, Joseph S. Fernandez-Moure
Summary: The study examined the potential of using amniotic fluid allograft (AFA) augmentation in improving tissue incorporation of acellular dermal matrix (ADM) in ventral hernia repair (VHR) in an animal model. AFA treatment led to enhanced tissue vascularization and cellularization, resulting in increased histomorphometric scores. The upregulation of pro-regeneration genes and molecular evidence of an anti-inflammatory, M2-polarized macrophage phenotype suggest a therapeutic role of AFA as a VHR adjunct.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jess Pedrina, John Stambas
Summary: Traditional approaches like flu vaccines and antiviral therapies have limitations due to ongoing antigenic drift, leading researchers to explore more sophisticated methods involving host proteins and the extracellular matrix in flu treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Arwa Bafail, Karina Midori Mori Carneiro, Anil Kishen, Anuradha Prakki
Summary: The study evaluated the effect of Odanacatib inhibitor treatment on lipopolysaccharide (LPS) contamination-induced dentin degradation mediated by cathepsin-K. Results showed that LPS contamination significantly increased the release rates of telopeptides from dentin matrix, while Odanacatib treatment significantly reduced the telopeptide release rates in LPS-contaminated dentin.
Article
Multidisciplinary Sciences
Sofie Falkenlove Madsen, Jannie Marie Buelow Sand, Pernille Juhl, Morten Karsdal, Christian S. Thudium, Anne Sofie Siebuhr, Anne-Christine Bay-Jensen
Summary: This study investigated the difference between dermal and pulmonary fibroblasts in a fibrotic setting. The results showed that the fibroblasts exhibit different response profiles to TGF-beta 1 and PDGF-AB, suggesting that drivers of fibrosis are tissue-dependent, which needs to be considered in drug development.
SCIENTIFIC REPORTS
(2023)
Review
Microbiology
Idoia Buldain, Leire Martin-Souto, Aitziber Antoran, Maialen Areitio, Leire Aparicio-Fernandez, Aitor Rementeria, Fernando L. Hernando, Andoni Ramirez-Garcia
Summary: Infections caused by opportunistic pathogens Scedosporium/Lomentospora are increasing, posing challenges in diagnosis and treatment in the clinic. Understanding the immune response against these fungi is crucial for developing effective strategies. While progress has been made, many aspects remain unclear and further research is needed to elucidate the immune response to Scedosporium/Lomentospora.
Editorial Material
Medicine, General & Internal
Eric J. Rubin, Lindsey R. Baden, Penny L. Moore, Stephen Morrissey
Summary: This article discusses the impact of SARS-CoV-2 virus on the host immune system and invites South African virologist Penny Moore to join the discussion.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rui Qin, Lara K. Mahal
Summary: Recent discoveries have shed light on the roles of glycans in infectious diseases, particularly in the host glycome response to infection. While the functions and dynamics of host glycans during infection are still not fully understood, new findings have provided insights into the mechanisms and implications of these interactions in host immunity.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2021)
Article
Microbiology
Sarah K. Wideman, Joe N. Frost, Felix C. Richter, Caitlin Naylor, Jose M. Lopes, Nicole Viveiros, Megan R. Teh, Alexandra E. Preston, Natasha White, Shamsideen Yusuf, Simon J. Draper, Andrew E. Armitage, Tiago L. Duarte, Hal Drakesmith
Summary: This study reveals that host cell iron scarcity inhibits the immune response but prevents excessive hepatic tissue damage during malaria infection. Malaria is a serious and potentially lethal infectious disease that affects nearly 250 million people each year. Iron deficiency is prevalent in malaria endemic areas and there is a complex and incompletely understood relationship between iron and malaria. Assessing the host's iron status may have important implications for the treatment of malaria and iron deficiency in malaria endemic regions.
Article
Microbiology
Qi Wang, Nadia Shakoor, Adam Boyher, Kira M. Veley, Jeffrey C. Berry, Todd C. Mockler, Rebecca S. Bart
Summary: The study used sorghum and Xanthomonas vasicola pv. holcicola as a model pathosystem to investigate plant defense and pathogen virulence responses. The findings show that genes related to plant defense and pathogen virulence are most induced during a resistance interaction. This supports the concept of fluidity between different stages of plant immunity and pathogen virulence.
Article
Engineering, Biomedical
Meng Zhang, Fenghua Zhao, Xue Zhang, Linda A. Brouwer, Janette K. Burgess, Martin C. Harmsen
Summary: This study found that MRC-5 fibroblasts promote collagen fiber remodeling and deposition of fibronectin in the hydrogel, leading to modifications in the ECM microenvironment and promoting vascularization.
MATERIALS TODAY BIO
(2023)
Editorial Material
Immunology
Beatriz Leon
Summary: The invasive fungal pathogen Cryptococcus neoformans promotes type 2 immunity to escape host defenses by unknown mechanisms. In a recent study, researchers identify a secreted fungal protein that triggers TLR4 signaling, supporting a type 2 permissive environment and growth of C. neoformans.
Article
Environmental Sciences
Dongbo Li, Xingjie Li, Yu Tao, Zhenning Yan, Yansong Ao
Summary: This study assessed the impact of Hg contaminated soils on bacterial communities and found a significant positive correlation between bacterial diversity and Hg content. Factors such as land use type, pH, EC, TK, and nitrate-N played important roles in shaping the bacterial communities. Long-term Hg-contaminated soils can be categorized into different types based on land use, with dominant phyla and genera identified.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Biochemistry & Molecular Biology
Marcin Gierek, Wojciech Labus, Diana Kitala, Andrzej Lorek, Gabriela Ochala-Gierek, Karolina Mikus Zagorska, Dariusz Waniczek, Karol Szyluk, Pawel Niemiec
Summary: Reconstructive surgery often deals with large tissue defects and requires materials that are both immunogenic but offer tissue filling. ADM, an acellular dermal matrix, is a commonly used biological collagen matrix without immunogenicity. This literature review examines the use of human ADM in reconstructive surgery across different fields, emphasizing the need for further research in this area.
Article
Engineering, Biomedical
Abigail E. Loneker, Denver M. Faulk, George S. Hussey, Antonio D'Amore, Stephen F. Badylak
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Engineering, Biomedical
Jenna L. Dziki, Derek S. Wang, Catalina Pineda, Brian M. Sicari, Theresa Rausch, Stephen F. Badylak
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Editorial Material
Multidisciplinary Sciences
Stephen Badylak
Meeting Abstract
Surgery
Crisanto M. Torres, Janet E. Reing, Catalina Pineda Molina, George S. Hussey, Stephen F. Badylak
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2017)
Article
Cell & Tissue Engineering
Keisuke Takanari, Yi Hong, Ryotaro Hashizume, Alexander Huber, Nicholas J. Amoroso, Antonio D'Amore, Stephen F. Badylak, William R. Wagner
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2016)
Editorial Material
Peripheral Vascular Disease
Vineet Agrawal, Jonathan D. Mosley
Letter
Cardiac & Cardiovascular Systems
Kaushik Amancherla, Juan Qin, Michelle L. Hulke, Ryan D. Pfeiffer, Vineet Agrawal, Quanhu Sheng, Yaomin Xu, Kelly H. Schlendorf, JoAnn Lindenfeld, Ravi V. Shah, Jane E. Freedman, Nathan R. Tucker, Javid Moslehi
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Vineet Agrawal, Jonathan A. Kropski, Jason J. Gokey, Elizabeth Kobeck, Matthew B. Murphy, Katherine T. Murray, Niki L. Fortune, Christy S. Moore, David F. Meoli, Ken Monahan, Yan Ru Su, Thomas Blackwell, Deepak K. Gupta, Megha H. Talati, Santhi Gladson, Erica J. Carrier, James D. West, Anna R. Hemnes
Summary: This study investigates whether a well-accepted murine model of HFpEF displays features of PH, and identifies potential pathways driving early remodeling of the pulmonary vasculature in HFpEF.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Minoo Bagheri, Vineet Agrawal, Jeffrey Annis, Mingjian Shi, Jane F. Ferguson, Matthew S. Freiberg, Jonathan D. Mosley, Evan L. Brittain
Summary: This study used genetic approaches to identify clinical conditions associated with increased pulmonary pressure and right ventricular dysfunction, and found that diabetes was significantly associated with genetic risk for increased pulmonary pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Vineet Agrawal, Anna R. Hemnes, Nicholas J. Shelburne, Niki Fortune, Julio L. Fuentes, Dan Colvin, Marion W. Calcutt, Megha Talati, Emily Poovey, James D. West, Evan L. Brittain
Summary: This study found that a relative carnitine deficiency contributes to decreased fatty acid oxidation and increased lipid accumulation in right ventricular failure in pulmonary arterial hypertension (PAH). Supplementation of L-carnitine reversed RV failure by increasing fatty acid oxidation, improving cardiac output and decreasing lipid accumulation. This suggests that correcting carnitine deficiency through L-carnitine supplementation may reverse RV failure in PAH.
PULMONARY CIRCULATION
(2022)
Letter
Cardiac & Cardiovascular Systems
Vineet Agrawal, Anna R. Hemnes
PULMONARY CIRCULATION
(2020)
Article
Cardiac & Cardiovascular Systems
Vineet Agrawal, Niki Fortune, Sheeline Yu, Julio Fuentes, Fubiao Shi, David Nichols, Linda Gleaves, Emily Poovey, Thomas J. Wang, Evan L. Brittain, Sheila Collins, James D. West, Anna R. Hemnes
PULMONARY CIRCULATION
(2019)
Review
Cardiac & Cardiovascular Systems
Vineet Agrawal, Benjamin F. Byrd, Evan L. Brittain
PULMONARY CIRCULATION
(2019)
Article
Engineering, Biomedical
Tao Jin, Francesca J. Nicholls, William R. Crum, Harmanvir Ghuman, Stephen F. Badylak, Michel Modo
Article
Engineering, Biomedical
Lisa J. White, Adam J. Taylor, Denver M. Faulk, Timothy J. Keane, Lindsey T. Saldin, Janet E. Reing, Ilea T. Swinehart, Neill J. Turner, Buddy D. Ratner, Stephen F. Badylak
ACTA BIOMATERIALIA
(2017)