Article
Materials Science, Multidisciplinary
Austin Worden, Mark J. Uline, Tarek Shazly, Matt Stern, Jay D. Potts
Summary: Developing tissues have complex three-dimensional organizations of cells and extracellular matrix. Researchers have developed a self-assembling cellularized collagen hydrogel model that can rapidly form cell toroids and is sensitive to the composition of the hydrogel. Differences in toroid formation compared to gels with embedded cells were observed, providing new insights into toroid development.
MICROSCOPY AND MICROANALYSIS
(2022)
Article
Multidisciplinary Sciences
Pragya Saxena, Eli Broemer, Gerald M. Herrera, Gerald C. Mingin, Sara Roccabianca, Nathan R. Tykocki
Summary: A balance between stiffness and compliance is important for bladder function, but changes in bladder wall properties occur in many bladder pathologies. These changes are associated with the release of secretagogues that activate mast cells and cause the release of inflammatory mediators. However, the effects of a specific mast cell activator, Compound 48/80, on bladder function were found to be independent of mast cells. Compound 48/80 increased bladder compliance and excitability through activation of Mrgprb2 receptors located outside of mast cells, suggesting that targeting Mrgprb2 could be a potential treatment for lower urinary tract dysfunction.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Yi Cui, Yanyun Yin, Yunlong Zou, Yannan Zhao, Jin Han, Bai Xu, Bing Chen, Zhifeng Xiao, Hongwei Song, Ya Shi, Weiwei Xue, Xu Ma, Jianwu Dai
Summary: This study demonstrated that the expression of NTRK3 was elevated in NSCs cultured on collagen sponge in the RCCS system, and this increased expression was regulated by the downregulation of let-7i-5p. Compared to traditionally cultured NSCs, those cultured on collagen sponge in the RCCS system exhibited better neuronal differentiation and migratory ability, especially in the presence of NT-3.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Xinzhong Xu, Lin Wang, Juehua Jing, Junfeng Zhan, Chungui Xu, Wukun Xie, Shuming Ye, Yao Zhao, Chi Zhang, Fei Huang
Summary: Injectable biomimetic hydrogels with high electrical conductivity and excellent mechanical properties have been developed for potential application in spinal cord injury (SCI) repair. The hydrogel promotes the proliferation and differentiation of neural stem cells, and shows promising prospects in SCI treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Jeong Eun Song, Dae Hoon Lee, Joo Hee Choi, Seong Won Lee, Gilson Khang, Sun-Jung Yoon
Summary: This study focused on collagen extracted from duck's feet as a potential scaffold for bone tissue implantation. The experiment showed that the duck's feet-derived collagen had good cell affinity and low rejection, making it suitable for bone graft materials in tissue engineering applications. Overall, the DC/HAp sponges demonstrated biocompatibility and promising physical properties for bone regeneration.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Biochemistry & Molecular Biology
Behnaz Sadat Eftekhari, Dawei Song, Paul A. Janmey
Summary: Electrical stimulation of human mesenchymal stem cells cultured on soft conductive biodegradable substrates promotes neurite outgrowth and upregulates neuronal markers while downregulating glial markers. The combination of soft conductive substrates and electrical stimulation is a promising tool for enhancing neuronal tissue engineering outcomes.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Gerke H. Schuiringa, Maria Pastrama, Keita Ito, Corrinus C. van Donkelaar
Summary: Cartilage defects are common and can lead to osteoarthritis. Hydrogels are a promising strategy for regenerating tissue, but commonly used hydrogels are too soft for joint load-bearing. To address this, an implant is being developed that uses osmotic pressure generated by a charged hydrogel and restricted swelling to provide mechanical load-bearing function. This study aims to quantify the relationship between hydrogel swelling potential and implant compressive stiffness.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Alex M. Hollenberg, Aric Huber, Charles O. Smith, Roman A. Eliseev
Summary: Research demonstrates that the application of low-intensity constant electromagnetic fields can enhance bone fracture healing by improving biomechanical properties and increasing callus bone mineralization. These effects are mediated through the activation of mitochondrial oxidative phosphorylation.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Bing-Yu Zhang, Pu Xu, Qing Luo, Guan-Bin Song
Summary: By adding TGF-beta 1 in a collagen sponge-based 3D culture system, the proliferation and tenogenic differentiation of rat BMSCs can be enhanced. The 3D culture significantly improved the differentiation of BMSCs into tenocytes compared to 2D culture, with TGF-beta 1 playing a crucial role in this process.
WORLD JOURNAL OF STEM CELLS
(2021)
Article
Biochemistry & Molecular Biology
Joao Aguilar, Leonel Malacrida, German Gunther, Belen Torrado, Viviana Torres, Bruno F. Urbano, Susana A. Sanchez
Summary: Cells adapt to their environment to maintain their identity, and the plasma membrane plays a crucial role in this adaptation. Nanometer and micrometer areas in the plasma membrane change their distribution in response to mechanical signals. However, investigations on the connection between fluidity domains and mechanical stimuli are still ongoing.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Materials Science, Multidisciplinary
Shikha Chawla, Giovanna Desando, Elena Gabusi, Aarushi Sharma, Diego Trucco, Juhi Chakraborty, Cristina Manferdini, Mauro Petretta, Gina Lisignoli, Sourabh Ghosh
Summary: One major limitation of 3D bioprinting is the lack of understanding of the role of bioink in modulating molecular signaling pathways. The interaction between SF-G bioink and hMSCs enhanced several chondrogenic pathways, providing potential for further research in this area. This study represents the first detailed proteomics analysis to identify articular cartilage-specific pathways in SF-G-based 3D bioprinted constructs.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Behavioral Sciences
Farah Chamaa, Batoul Darwish, Ziad Nahas, Elie D. Al-Chaer, Nayef E. Saade, Wassim Abou-Kheir
Summary: This study demonstrates that sustained activation of the anteromedial thalamic nucleus boosts neurogenesis and improves spatial reference memory. Both single and multiple sessions of deep brain stimulation prompt an increase in novel arm exploration, with multiple sessions having a greater effect starting from week 1.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pathology
Jacopo Baglieri, Cuili Zhang, Shuang Liang, Xiao Liu, Takahiro Nishio, Sara B. Rosenthal, Debanjan Dhar, Hua Su, Min Cong, Jidong Jia, Mojgan Hosseini, Michael Karin, Tatiana Kisseleva, David A. Brenner
Summary: The study found that although Col(r/r) mice have increased liver fibrosis, the incidence of HCC in various models is actually reduced.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Sharon O. Bolanta, Sigita Malijauskaite, Kieran McGourty, Emmet J. O'Reilly
Summary: The fabrication of highly customizable scaffolds is crucial in developing predictive in vitro cell models. This study introduces a printable synthetic hydrogel with tunable mechanical properties by incorporating acrylic acid into the network and cross-linking. The hydrogel exhibited excellent cell adhesion and viability without additional modification, making it suitable for various applications.
Article
Engineering, Biomedical
Imke Jansen, Hanneke Crielaard, Tamar Wissing, Carlijn Bouten, Frank Gijsen, Ali C. Akyildiz, Eric Farrell, Kim van der Heiden
Summary: The presence of microcalcifications on the surface of atherosclerotic plaques may increase the risk of plaque rupture. In this study, a novel tissue-engineered model was developed to mimic atherosclerotic caps with microcalcifications and assess their impact on cap mechanics. The results showed that caps with microcalcifications had lower stiffness and ultimate tensile stress, indicating an increased risk of rupture in atherosclerotic plaques with microcalcifications.
APL BIOENGINEERING
(2023)
Article
Engineering, Mechanical
N. W. Khun, P. Q. Trung, D. L. Butler
TRIBOLOGY TRANSACTIONS
(2016)
Article
Engineering, Mechanical
Pham Quang Trung, Nay Win Khun, David Lee Butler
SURFACE TOPOGRAPHY-METROLOGY AND PROPERTIES
(2016)
Article
Engineering, Mechanical
Pham Quang Trung, Nay Win Khun, David Lee Butler
JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME
(2018)
Article
Materials Science, Coatings & Films
Trung Quang Pham, Nay Win Khun, David Lee Butler
SURFACE ENGINEERING
(2017)
Article
Materials Science, Multidisciplinary
Pham Quang Trung, David Lee Butler, Nay Win Khun
MATERIALS RESEARCH EXPRESS
(2017)
Article
Engineering, Mechanical
Chun Wai Kum, Takashi Sato, Jiang Guo, Kui Liu, David Butler
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2018)
Article
Engineering, Mechanical
Pham Quang Trung, David Lee Butler, Sridhar Idapalapati
JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME
(2018)
Article
Chemistry, Analytical
Shaowei Fu, Fang Cheng, Tegoeh Tjahjowidodo, Yu Zhou, David Butler
Review
Orthopedics
Nathaniel A. Dyment, Jennifer G. Barrett, Hani A. Awad, Catherine A. Bautista, Albert J. Banes, David L. Butler
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Review
Cell & Tissue Engineering
David L. Butler
Summary: This paper reviews the history of research leading up to the introduction of functional tissue engineering (FTE) for tendon and ligament repair, highlighting the importance of collaborations among surgeons, biologists, and engineers.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Green & Sustainable Science & Technology
Kantapich Preedakorn, David Butler, Joern Mehnen
Summary: The impacts of electric vehicles (EVs) on transportation and logistics systems are an emerging topic that has gained public interest in many countries. Developing countries relying on automobile manufacturing are preparing national strategies to mitigate the negative impacts of the shift toward EVs. Additionally, restructuring transportation systems and traffic regulations to integrate EVs into current models is a concern for policymakers. Understanding potential impacts and barriers will aid in implementing public policy and making better industrial, transportation, and environmental decisions.
Article
Engineering, Multidisciplinary
Nay Win Khun, Pham Quang Trung, David Lee Butler
Summary: Shot peening at higher pressures improves the surface roughness and hardness of AA7075-T6 aluminum alloy samples, reducing wear. Lubrication with mineral oil further decreases frictional wear and improves bearing surfaces when sliding. The tribological properties of shot peened samples are affected by shot peening pressure.
ENGINEERING RESEARCH EXPRESS
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Stephen P. Hanna, Perry L. Carter, Amy E. Potter, Candace Forbes Bright, Derek A. Alderman, E. Arnold Modlin, David L. Butler
JOURNAL OF HERITAGE TOURISM
(2019)
Meeting Abstract
Psychology, Multidisciplinary
David L. Butler, Yarrow Dunham
INTERNATIONAL JOURNAL OF PSYCHOLOGY
(2016)
Meeting Abstract
Psychology, Multidisciplinary
David L. Butler
INTERNATIONAL JOURNAL OF PSYCHOLOGY
(2016)