Article
Dentistry, Oral Surgery & Medicine
Rogerio S. Ferreira, Rodrigo A. da Silva, Georgia Da S. Feltran, Ericka Patricia da Silva, Rahyza I. F. de Assis, Emanuel Silva Rovai, Willian F. Zambuzzi, Denise C. Andia
Summary: The results of this study demonstrate the crucial role of JARID1B in repressing the osteogenic phenotype of PDLCs, suggesting its potential as a therapeutic target in pre-clinical protocols.
Article
Medicine, Research & Experimental
Yupeng Wu, Qi Zhang, Baodong Zhao, Xiaojing Wang
Summary: The study demonstrated that the beta-receptor blocker propranolol promoted early osseointegration of pure titanium implants by enhancing osteogenic differentiation of osteoblasts and mesenchymal stem cells. Propranolol also increased cell proliferation, calcium content, ALP activity, and mRNA/protein expression levels of osteogenic markers while decreasing the expression of beta 2-adrenergic receptor.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ying Xing, Mi-Shuai Zhang, Jian-Hui Xiao, Ru-Ming Liu
Summary: This study found that galangin can promote the osteogenic differentiation of human amniotic mesenchymal stem cells (hAMSCs) through the JAK2/STAT3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Noreen Mumtaz, Amel Dudakovic, Asha Nair, Marijke Koedam, Johannes P. T. M. van Leeuwen, Marion P. G. Koopmans, Barry Rockx, Andre J. J. van Wijnen, Bram C. J. van der Eerden
Summary: Arboviruses like Zika virus affect bone development by targeting osteoblasts and altering bone remodeling. In this study, the researchers investigated the effects of Zika virus infection on mesenchymal stromal cells (MSCs) at different stages of osteogenesis. They found that late-stage infected MSCs showed elevated osteogenic markers, calcium content, and altered gene expression compared to early-stage infected MSCs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yoon-Young Go, Chan-Mi Lee, Sung-Won Chae, Jae-Jun Song
Summary: The study demonstrated the potential of trophoblast-derived conditioned medium (TB-CM) in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) and inhibiting adipogenesis. By activating biological processes such as signaling pathways, the trophoblast-derived secretomes show promise for clinical interventions in bone regeneration and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Banafsheh Safari, Marziyeh Aghazadeh, Ayuob Aghanejad
Summary: Recent trends in bone tissue engineering have focused on developing biomimetic constructs with appropriate mechanical and physiochemical properties. In this study, a new biomaterial scaffold based on a bisphosphonate-containing synthetic polymer combined with gelatin was fabricated. The scaffold showed aligned pores, high porosity, and good biodegradability. It exhibited good cytocompatibility with human Adipose-Derived Mesenchymal Stem Cells (hADMSCs) and promoted mineralization and ALP activity. The scaffold also demonstrated high expression of osteogenic genes, suggesting its potential for bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Baojun Sun, Yajie Sun, Shuwei Han, Ruitong Zhang, Xiujuan Wang, Chunxia Meng, Tuo Ji, Chunhui Sun, Na Ren, Shaohua Ge, Hong Liu, Yang Yu, Jingang Wang
Summary: Traditional bone defect treatments face limitations due to insufficient supply of autologous bone, immune rejection of allogeneic bone grafts, and high medical costs. To overcome these limitations, bone tissue engineering with electroactive scaffolds has emerged as a promising option. However, current electroactive scaffolds are either single-function and not suitable for scientific research and clinical application, or complex and expensive to prepare. This study proposes a new tissue engineering strategy to optimize the electrical properties and biocompatibility of carbon-based materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Kantirat Yaja, Sirinda Aungsuchawan, Suteera Narakornsak, Peraphan Pothacharoen, Rungusa Pantan, Waleephan Tancharoen
Summary: This study compared the effectiveness and safety of different culture supplements (FBS or hPL) on the osteoblastic differentiation potential of hAF-MSCs under a three-dimensional gelatin scaffold. The results showed that hAF-MSCs have the potential to be used in clinical applications and hPL as a supplement significantly stimulated osteoblast differentiation and had better gene expression and cell functionality compared to FBS.
Article
Biotechnology & Applied Microbiology
Hyun-Ho Yun, Seong-Gon Kim, Se-Il Park, Woori Jo, Kyung-Ku Kang, Eun-Joo Lee, Dong-Kyu Kim, Hoe-Su Jung, Ji-Yoon Son, Jae-Min Park, Hyun-Sook Park, Sunray Lee, Hong-In Shin, Il-Hwa Hong, Kyu-Shik Jeong
Summary: Bone regeneration is a complex process influenced by factors like inflammation, tissue interactions, and progenitor cells. Bone grafting is currently the most effective treatment, but it has drawbacks. Adipose-derived stem cells show promise in accelerating bone regeneration.
BIOENGINEERING-BASEL
(2023)
Article
Cell Biology
Jin Seok, Sujin Jun, Jinki Cho, Sohea Park, Jung Ok Lee, Gi Jin Kim
Summary: The study reveals that PD-MSCs regulate the balance between survival and death of trophoblast cells, protect damaged mitochondria, and enhance trophoblast invasion. These findings suggest that PD-MSCs modulate trophoblast invasion through dynamic effects on mitochondrial energy metabolism.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Young-Bum Son, Young-Hoon Kang, Hyeon-Jeong Lee, Si-Jung Jang, Dinesh Bharti, Sung-Lim Lee, Byeong-Gyun Jeon, Bong-Wook Park, Gyu-Jin Rho
Summary: The study focused on inducing odontoblast differentiation using various dental MSCs, highlighting that DPSCs exhibited higher differentiation potential compared to SCAPs, DFSCs, and PDLSCs, and this potential could be further enhanced with 17 ss -estradiol supplementation.
Article
Engineering, Biomedical
Qian Wang, Lei Xu, Regine Willumeit-Roemer, Berengere J. C. Luthringer-Feyerabend
Summary: The study reveals that magnesium and Mg-10Gd can modulate osteogenic differentiation through various pathways, including enhancing secretion of bone formation-related signaling complexes and reducing inflammatory factor secretion in macrophages and cocultures.
ACTA BIOMATERIALIA
(2021)
Article
Oncology
Yibo Xu, Zhimeng Wang, Yakang Wang, Qiang Huang, Cheng Ren, Liang Sun, Qian Wang, Ming Li, Hongliang Liu, Zhong Li, Kun Zhang, Teng Ma, Yao Lu
Summary: This research investigated the mechanism of autophagy in bone tissue regeneration by analyzing the differential gene expression. Several autophagy-related genes associated with osteogenesis were identified and their expression levels were validated through in vitro experiments.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Anesthesiology
D. Nepogodiev, Joana F. F. Simoes, Elizabeth Li, Maria Picciochi, James C. Glasbey, Glauco Baiocchi, Ruth Blanco-Colino, Daoud Chaudhry, Ehab AlAmeer, Kariem El-Boghdadly, Funmilola Wuraola, Dhruva Ghosh, Rohan R. Gujjuri, Ewen M. Harrison, Herman Lule, Haytham Kaafarani, Mohammad Khosravi, Irmgard Kronberger, Sezai Leventoglu, Harvinder Mann, Kenneth A. Mclean, Mengistu Gebreyohanes Mengesha, Maria Marta Modolo, Faustin Ntirenganya, Lisa Norman, Oumaima Outani, Riinu Pius, Peter Pockney, Ahmad Uzair Qureshi, April Camilla Roslani, Sohei Satoi, Catherine Shaw, Aneel Bhangu, Omar M. Omar, Waheed-Ul-Rahman Ahmed, Leah Argus, Alasdair Ball, Edward P. Bywater, Ruth Blanco-Colino, Amanpreet Brar, Daoud Chaudhry, Brett E. Dawson, Irani Duran, Muhammed Elhadi, James C. Glasbey, Rohan R. Gujjuri, Conor S. Jones, Ewen M. Harrison, Sivesh K. Kamarajah, James M. Keatley, Samuel Lawday, Harvinder Mann, Ella J. Marson, Kenneth A. Mclean, Lisa Norman, Riinu Ots, Oumaima Outani, Maria Picciochi, Irene Santos, Catherine Shaw, Elliott H. Taylor, Isobel M. Trout, Chris Varghese, Mary L. Venn, William Xu, Irida Dajti, Arben Gjata, Salah Eddine Oussama Kacimi, Luis Boccalatte, Daniel Cox, Peter Pockney, Philip Townend, Felix Aigner, Irmgard Elisabeth Kronberger, Elgun Samadov, Amer Alderazi, Kamral Hossain, Greg Padmore, Gabrielle van Ramshorst, Ismail Lawani, Anis Cerovac, Samir Delibegovic, Glauco Baiocchi, Gustavo Mendonca Ataide Gomes, Igor Lima Buarque, Muhammad Gohar, Mihail Slavchev, Chukwuemeka Nwegbu, Arnav Agarwal, Amanpreet Brar, Janet Martin, Joshua Ng-Kamstra, Maricarmen Olivos, Wenhui Lou, Dong-Lin Ren, Jose Andres Calvache, Carlos J-Perez Rivera, Ana Danic Hadzibegovic, Tomislav Kopjar, Jakov Mihanovic, Pablo Mijahil Aviles Jimenez, Nikolaos Gouvas, Jaroslav Klat, Rene Novysedlak, Nicolas Amisi, Peter Christensen, Alaa El-Hussuna, Sylvia Batista, Eddy Lincango-Naranjo, Sameh Emile, Danilo Alfonso Arevalo Sandoval, Hailu Dhufera, Samuel Hailu, Mengistu G. Mengesha, Joonas H. Kauppila, Alexis P. Arnaud, Zaza Demetrashvili, Markus Albertsmeier, Hans Lederhuber, Markus W. Loeffler, Daniel Kwesi Acquah, Bernard Ofori, Stephen Tabiri, Symeon Metallidis, Georgios Tsoulfas, Maria-Lorena Aguilera-Arevalo, Gustavo Recinos, Tamas Mersich, Daniel Wettstein, Dhruva Ghosh, Gabriele Kembuan, Peiman Brouki Milan, Mohammad Hossein Khosravi, Masoud Mozafari, Ahmed Hilmi, Helen Mohan, Oded Zmora, Gaetano Gallo, Francesco Pata, Gianluca Pellino, Yuki Fujimoto, Naoto Kuroda, Sohei Satoi, Mohamad K. Abou Chaar, Faris Ayasra, Ildar Fakhradiyev, Intisar Hisham Said Hamdun, Jang Jin-Young, Mohammad Jamal, Lina Karout, Muhammed Elhadi, Aiste Gulla, Fanjandrainy Rasoaherinomenjanahary, Luc Herve Samison, April Camilla Roslani, Iran Irani Duran Sanchez, Diana Samantha Gonzalez, Laura Martinez, Maria Jose Martinez, Alejandra Nayen, Antonio Ramos-De la Medina
Summary: The study suggests that surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection, with patients experiencing ongoing symptoms >= 7 weeks from diagnosis potentially benefitting from further delay.
Article
Surgery
E. Pretzsch, J. G. D'Haese, B. Renz, M. Ilmer, T. Schiergens, R. C. Miksch, M. Albertsmeier, M. Guba, M. K. Angele, J. Werner, H. Niess
Summary: This study found that patients undergoing curative surgery for pancreatic cancer who took aspirin had significantly better survival rates, mainly due to a prolonged metastasis-free interval following surgery.
Review
Gastroenterology & Hepatology
Florian Kuehn, Ruifeng Duan, Matthias Ilmer, Ulrich Wirth, Fatemeh Adiliaghdam, Tobias S. Schiergens, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner
Summary: Intestinal alkaline phosphatase (IAP) is primarily produced and functions in the intestine, but affects other organs through specific biological axes related to its fundamental roles such as promoting gut barrier function, dephosphorylation/detoxification of lipopolysaccharides (LPS), and regulation of gut microbiota.
Article
Oncology
Iris Beirith, Bernhard W. Renz, Shristee Mudusetti, Natalja Sergejewna Ring, Julian Kolorz, Dominik Koch, Alexandr V. Bazhin, Michael Berger, Jing Wang, Martin K. Angele, Jan G. D'Haese, Markus O. Guba, Hanno Niess, Joachim Andrassy, Jens Werner, Matthias Ilmer
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer with limited treatment options. Targeting the neurokinin-1 receptor has shown promising anti-tumoral effects, with recent research indicating that inhibiting NK1R can reduce cell growth in PDAC without inducing apoptosis in most cell lines. Analysis of splice variants of NK1R may lead to better stratification of PDAC patients for targeted therapies.
Article
Surgery
Elise Pretzsch, Anna Heim, Christian Heiliger, Charlotte M. Pretzsch, Matthias Ilmer, Maximilian Weniger, Bernhard Renz, Markus Guba, Martin K. Angele, Jan G. D'Haese, Jens Werner, Hanno Niess
Summary: This study aimed to examine the impact of bacterobilia on morbidity following pancreatoduodenectomy. The results showed that positive intraoperative bile cultures were associated with higher Comprehensive Complication Index and increased risk of wound infections.
Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Review
Oncology
Matthias Ilmer, Markus Otto Guba
Summary: Liver transplantation is now being considered for non-resectable colorectal liver metastases, with good oncologic outcomes; however, due to organ shortage, strict selection of suitable candidates is necessary. Dynamic criteria based on tumor biology provide a better prediction of individual oncological outcomes.
Article
Pathology
Matthias Ilmer, Bernhard W. Renz, Florian Kuehn, Moritz Drefs, Dionysios Koliogiannis, Jens Werner, Thomas Kirchner, David Horst, Christine Woischke
Summary: Tumor cell heterogeneity in colorectal cancers is well-known. This study investigates the role of PBXIP1 in tumor cell subpopulations with different WNT activity and its associations with EMT and clinical outcomes. The results suggest that PBXIP1 expression is associated with EMT, lymph node metastasis, distant metastasis, and worse overall survival in colon cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, General & Internal
Sebastian Wolf, Verena S. Hoffmann, Florian Sommer, Matthias Schrempf, Mingming Li, Martin Ryll, Ulrich Wirth, Matthias Ilmer, Jens Werner, Joachim Andrassy
Summary: Based on network meta-analysis, ERL combined with CNI showed the strongest anti-CMV effect compared to regular CNI treatment (RR 0.27, CI 0.22-0.32, p <0.0001).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Surgery
Elise Pretzsch, Dionysios Koliogiannis, Jan Gustav D'Haese, Matthias Ilmer, Markus Otto Guba, Martin Konrad Angele, Jens Werner, Hanno Niess
Summary: Background: Textbook outcome (TO) is a multidimensional measure reflecting the ideal outcome after surgery. TO is a useful quality measure to benchmark surgical outcome. However, there is a lack of uniform definitions of TO in hepato-pancreato-biliary (HPB) surgery. This study aimed to provide a definition of TO in HPB surgery and identify obstacles and predictors for achieving it.
Article
Nanoscience & Nanotechnology
Jing Wang, Weijian Chen, Wenxiang Du, Hongjie Zhang, Matthias Ilmer, Lei Song, Yuan Hu, Xiaopeng Ma
Summary: TAM@BP-FA, a novel nanoplatform integrating black phosphorus, tamoxifen, and folic acid, was developed for synergistic endocrine and sonodynamic therapy of breast cancer. The strategy exhibited satisfactory antitumor effects through targeted therapy, sonodynamic therapy, and modulation of immune cells. The study provided a potential superior strategy for breast cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Julian Kolorz, Salih Demir, Adrian Gottschlich, Iris Beirith, Matthias Ilmer, Daniel Luethy, Christoph Walz, Mario M. Dorostkar, Thomas Magg, Fabian Hauck, Dietrich von Schweinitz, Sebastian Kobold, Roland Kappler, Michael Berger
Summary: This study found that neurokinin-1 receptor is highly expressed in Rhabdoid tumors and demonstrated that the neurokinin-1 receptor antagonist aprepitant can serve as a novel therapeutic approach in treating Rhabdoid tumors.
Review
Oncology
H. Wackerhage, J. F. Christensen, M. Ilmer, I. von Luettichau, B. W. Renz, M. Schoenfelder
Summary: This paragraph discusses the effects of exercise, psychosocial stress, and drugs on catecholamine concentrations and adrenergic signaling. While exercise studies suggest that catecholamines inhibit cancer, stress studies often report the opposite, and beta-blocker studies show varied effects. The variable effects may be due to the expression of different adrenergic receptor isoforms and the impact of catecholamines on cancer, immune, or endothelial cells. Future research should aim to understand the mechanisms behind these variable effects and utilize them for the benefit of cancer patients.
Article
Surgery
Dmitri Nepogodiev, Aneel Bhangu
Summary: Preoperative SARS-CoV-2 vaccination can support safer elective surgery. The number needed to vaccinate (NNV) to prevent COVID-19-related deaths is more favorable in surgical patients compared to the general population. Prioritizing preoperative vaccination of patients needing elective surgery globally could prevent additional COVID-19-related deaths in 1 year.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Surgery
M. Weniger, T. Hank, M. Qadan, D. Ciprani, T. Michelakos, H. Niess, C. Heiliger, M. Ilmer, J. G. D'Haese, C. R. Ferrone, A. L. Warshaw, K. D. Lillemoe, J. Werner, A. Liss, C. Fernandez-del Castillo
Summary: Microbiota may promote the progression of PDAC, with Klebsiella pneumoniae potentially influencing survival in PDAC. The study found that an increasing number of pathogen species in intraoperative bile cultures was associated with decreased progression-free survival, and that quinolone treatment improved overall survival, especially in patients positive for K. pneumoniae.
BRITISH JOURNAL OF SURGERY
(2021)