Article
Biotechnology & Applied Microbiology
Richard Jeske, Xingchi Chen, Shaoyang Ma, Eric Z. Zeng, Tristan Driscoll, Yan Li
Summary: This study compares the effects of different carriers on the growth of hASCs in a spinner flask bioreactor system and traditional 2D culture. The results show that the microenvironment in the spinner flask bioreactor enhances the stemness, metabolism, and cytokine secretion of hASCs, as well as increases the production of extracellular vesicles.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Pouria Hajmomeni, Sajjad Sisakhtnezhad, Ali Bidmeshkipour
Summary: Breast cancer, the most prevalent cancer in females, can be affected by mesenchymal stem cells (MSCs) and their paracrine effects. Thymoquinone (TQ) has various properties and affects the self-renewal and immunomodulatory properties of MSCs. The study examined the effect of TQ-treated MSC conditioned medium on the characteristics of breast cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Jeniffer Farias Dos Santos, Bruna Leticia Freitas-Marchi, Gustavo Roncoli Reigado, Silvia Romano de Assis, Silvya Stuchi Maria Engler, Felipe Santiago Chambergo Alcalde, Viviane Abreu Nunes
Summary: In skin traumas, tissue engineering using mesenchymal stem cells (MSC) from the umbilical cord shows promise for skin regeneration. MSCs can differentiate into keratinocytes and express important epidermal markers, indicating their potential use in producing skin substitutes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Giedre Valiuliene, Aiste Zentelyte, Elizabet Berzanskyte, Ruta Navakauskiene
Summary: hAFSCs derived from pathological gestations with polyhydramnios exhibit differences in metabolic and inflammatory status compared to hAFSCs from normal gestations, as well as possessing lower neurogenic potential. Further studies are necessary to explore the potential of hAFSCs from polyhydramnios in stem cell-based therapies and strategies to enhance their characteristics for regenerative medicine purposes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Chiara Argentati, Francesco Morena, Chiara Fontana, Ilaria Tortorella, Carla Emiliani, Loredana Latterini, Giulia Zampini, Sabata Martino
Summary: The study investigated the effects of chemically functionalized nanoparticles on human stem cells, finding that the stem cells exhibited similar growth and viability levels on all types of nanoparticles with morphological changes observed. Gold nanoseeds nanoparticles showed slight genotoxic effects on stem cells but did not impact their behavior.
Article
Anatomy & Morphology
Deyi Wu, Yan Zhang, Qingrong Zhao, Min Wu, Suo Li, Xin Zheng, Hainan Lan
Summary: This study reveals the effect of cellular senescence on the biological activity of growth hormone (GH) in human mesenchymal stem cells (hMSCs). The results indicate that cellular senescence reduces the internalization of GH into the cells and weakens the intracellular signaling pathways.
Article
Cell Biology
Santhosh Kacham, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, Sachin Shukla
Summary: Umbilical cord-derived mesenchymal stem cells promote the repair of injured corneal epithelium by stimulating the proliferation of corneal epithelial cells, potentially serving as a non-ocular source of stem cells for treating injury-induced bilateral corneal diseases.
Article
Biochemistry & Molecular Biology
Woo-Sup Sim, Bong-Woo Park, Kiwon Ban, Hun-Jun Park
Summary: The study explored a novel therapeutic platform called in situ preconditioning to enhance the therapeutic potential of BM-MSCs in a rat myocardial infarction model. Results showed that this approach significantly improved the survival and retention of BM-MSCs in the heart, leading to enhanced cardiac function and repair in myocardial infarction hearts. This suggests that in situ preconditioning could be an effective strategy for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Fei Xiao, Jianping Peng, Yang Li, Xing Zhou, Ding Ma, Liming Dai, Jie Yuan, Xiaodong Chen, Chuandong Wang
Summary: This study investigated the cellular senescence mechanism of BMSCs and identified the expression changes of small noncoding RNAs during the senescence process, providing potential clues for developing new targeting senescence strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Ping Du, Xuelian Tao, Kun Liu, Jiao Lin, Yue Shi, Kwideok Park, Hsien-Yeh Chen, Chao-Po Lin, Junlei Chang, Raymond Cb Wong, Haobo Pan, Peng-Yuan Wang
Summary: The study suggests that human platelet lysate has a significant impact on the bioenergetics and differentiation of mesenchymal stem cells, promoting cell proliferation and osteogenic capability. It alters metabolic pathways and functional properties of MSCs, highlighting its potential as a biological material for stem cell engineering and regenerative medicine.
APPLIED MATERIALS TODAY
(2022)
Article
Genetics & Heredity
Mohadese Hashem Boroojerdi, Vahid Hosseinpour Sarmadi, Maryam Maqbool, King-Hwa Ling, Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Rajesh Ramasamy
Summary: This study elucidates the regulatory mechanisms of mesenchymal stem cells (MSCs) on the proliferation of hematopoietic stem cells (HSCs), providing a potential approach for obtaining larger quantities of HSCs in vitro without the need for manipulating their differentiation potential.
Article
Cell Biology
Stefania Croci, Martina Bonacini, Giovanni Dolci, Marco Massari, Nicola Facciolongo, Elisa Pignatti, Alessandra Pisciotta, Gianluca Carnevale, Aurelio Negro, Giulia Cassone, Francesco Muratore, Lucia Belloni, Alessandro Zerbini, Carlo Salvarani
Summary: Mesenchymal stem cells from human dental pulp can modulate the production of cytokines in COVID-19 patients, suggesting a potential therapeutic use in COVID-19.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kuo-An Chu, Chang-Ching Yeh, Chun-Hsiang Hsu, Chien-Wei Hsu, Fu-Hsien Kuo, Pei-Jiun Tsai, Yu-Show Fu
Summary: This study compared the effectiveness of human umbilical cord Wharton's jelly-derived mesenchymal stem cells (HUMSCs) versus adipose tissue-derived mesenchymal stem cells (ADMSCs) for reversing pulmonary fibrosis in rats. The results showed that HUMSCs had better effects on lung function improvement and collagen degradation, as well as alveolar regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Erwin Pavel Lamparelli, Maria Camilla Ciardulli, Valentina Giudice, Pasqualina Scala, Rosa Vitolo, Tina Patricia Dale, Carmine Selleri, Nicholas Robert Forsyth, Nicola Maffulli, Giovanna Della Porta
Summary: This study investigated the chondrogenic potentials of 3D high-density cultures of bone marrow and Wharton's Jelly-derived mesenchymal stromal cells (MSCs) supplemented with hTGF-beta 1. The study found that high-density cultures promoted chondrogenesis and that Wharton's Jelly-derived MSCs showed potential for chondrogenic commitment. These findings have important implications for cartilage regeneration and tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Gustavo A. Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T. Munshi, Catherine Dupont, Joost Gribnau, Femke M. S. de Vrij, Steven A. Kushner, Chris I. De Zeeuw
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Annelot Wismans, Roy Thurik, Rui Baptista, Marcus Dejardin, Frank Janssen, Ingmar Franken
Summary: To achieve herd immunity for COVID-19, understanding the factors influencing vaccination intention is crucial. Through the 5C model, we found that 'Confidence' and 'Collective Responsibility' are strongly related to students' COVID-19 vaccination intention. Targeting these psychological characteristics can improve vaccination campaign effectiveness among students.
Article
Psychology, Social
Annelot Wismans, Srebrenka Letina, Karl Wennberg, Roy Thurik, Rui Baptista, Andrew Burke, Marcus Dejardin, Frank Janssen, Enrico Santarelli, Olivier Torres, Ingmar Franken
Summary: The study found a negative relationship between impulsivity and compliance with public health measures during the pandemic, while unexpectedly discovering a weak positive association between the discount rate and compliance. This highlights the importance of individual differences in impulsivity when it comes to following COVID-19 restrictions.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Article
Business
Vi Dung Ngo, Quang Evansluong, Frank Janssen, Duc Khuong Nguyen
Summary: This study examines the role of social capital and social capital inequality embedded in bank ties in enabling and diversifying new firms' debt use. Findings show that network extensity and network mobilisation increase new firms' debt use, while differences in ascribed and attained social statuses result in social capital inequality.
INTERNATIONAL JOURNAL OF ENTREPRENEURIAL BEHAVIOR & RESEARCH
(2021)
Correction
Multidisciplinary Sciences
Annelot Wismans, Roy Thurik, Rui Baptista, Marcus Dejardin, Frank Janssen, Ingmar Franken
Review
Psychology, Multidisciplinary
Roxane De Hoe, Frank Janssen
Summary: This research offers a positive approach to entrepreneurial failure by building a conceptual model based on resources, and investigates key psychological assets, such as psychological capital, that support the development of entrepreneurial resilience.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Business
Olivier Giacomin, Frank Janssen, Rachel S. Shinnar, Katherine Gundolf, Nematollah Shiri
Summary: This article explores the relationship between religion and entrepreneurship, finding that religious affiliation has a positive impact on entrepreneurial intentions and that religiosity affects intentions differently among followers of different religions.
INTERNATIONAL SMALL BUSINESS JOURNAL-RESEARCHING ENTREPRENEURSHIP
(2023)
Article
Public, Environmental & Occupational Health
Annelot Wismans, Peter van der Zwan, Karl Wennberg, Ingmar Franken, Jinia Mukerjee, Rui Baptista, Jorge Barrientos Marin, Andrew Burke, Marcus Dejardin, Frank Janssen, Srebrenka Letina, Jose Maria Millan, Enrico Santarelli, Olivier Torres, Roy Thurik
Summary: The study found a strong positive association between policy stringency and face mask use. Self-related risk perception was positively associated with mask use, but there was no relationship between mask use and experience with COVID-19 or attitudes towards government. However, government trust and perceived clarity of communication were found to moderate the link between policy stringency and mask use, with positive government perceptions relating to higher use in countries with regulations and lower use in countries without regulations.
Article
Business
Paulami Mitra, Frank Janssen, Julie Hermans, Jill Kickul
Summary: This study, based on self-leadership theory, examines the impact of rewards and prosocial motivation on the willingness to contribute to social entrepreneurial crowdfunding. The findings suggest that the expectation of natural rewards positively influences the willingness to contribute, with prosocial motivation mediating this relationship. Additionally, there is a strong negative relationship between material rewards and prosocial motivation, but it has limited impact on the willingness to contribute.
ENTREPRENEURSHIP AND REGIONAL DEVELOPMENT
(2022)
Article
Green & Sustainable Science & Technology
Olivier Giacomin, Frank Janssen, Jean-Luc Guyot, Olivier Lohest
Summary: Based on a dataset of 538 Belgian nascent entrepreneurs, this study explores the impact of entrepreneurs' background and socio-economic characteristics on their positioning on the necessity-opportunity axis. The findings highlight the existence of sub-profiles within the necessity-opportunity typology and reveal the emergence of hobby entrepreneurship. The study emphasizes the importance of considering the specific situation and individual characteristics when interpreting entrepreneurial motivations.
Article
Management
Sophie Bacq, Frank Janssen, Christine Noel
JOURNAL OF SMALL BUSINESS MANAGEMENT
(2019)
Article
Business
Amelie Wuillaume, Amelie Jacquemin, Frank Janssen
INTERNATIONAL JOURNAL OF ENTREPRENEURIAL BEHAVIOUR & RESEARCH
(2019)
Article
Business
Roxane De Hoe, Olivier Giacomin, Frank Janssen
REVUE INTERNATIONALE PME
(2018)
Article
Business
Ngo Vi Dung, Nguyen Ngoc Thang, Frank Janssen, Damian Hine
JOURNAL OF DEVELOPMENTAL ENTREPRENEURSHIP
(2017)
Article
Business
Frank Janssen, Alain Fayolle, Amelie Wuilaume
ENTREPRENEURSHIP AND REGIONAL DEVELOPMENT
(2018)