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Biochemistry & Molecular Biology
Zahra Eydian, Alaleh Mohammad Ghasemi, Samira Ansari, Ali Naghi Kamali, Maryam Khosravi, Sima Momtaz, Sanaz Riki, Laleh Rafighdoost, Reza Entezari Heravi
Summary: This study demonstrates the differentiation of mesenchymal stem cells (MSCs) from human adipose tissue and bone marrow into functional beta-islet cells. It suggests that adipose stem cells may be a better choice for the treatment of diabetes mellitus due to their higher potency.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Health Care Sciences & Services
Suncica Kapor, Milica Vukotic, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milica Radojkovic, Vladan P. Cokic, Juan F. Santibanez
Summary: The study found that HU inhibits the growth of BMMSC, causing senescence-like changes and affecting cellular differentiation and immunoregulatory functions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati, Xinming Tong, Yuting Wang, Holly M. Steininger, Malachia Y. Hoover, Lauren S. Koepke, Matthew P. Murphy, Jan Sokol, Eun Young Seo, Ruth Tevlin, Michael Lopez, Rachel E. Brewer, Shamik Mascharak, Laura Lu, Oyinkansola Ajanaku, Stephanie D. Conley, Jun Seita, Maurizio Morri, Norma F. Neff, Debashis Sahoo, Fan Yang, Irving L. Weissman, Michael T. Longaker, Charles K. F. Chan
Summary: Aging of skeletal stem cells in mice alters bone marrow signaling and differentiation of bone and blood lineages, resulting in fragile bones with poor regeneration. Aged SSCs have decreased bone-forming potential but produce more stromal lineages expressing pro-inflammatory cytokines, contributing to bone marrow niche transformation.
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Cell Biology
Domenico Aprile, Nicola Alessio, Ibrahim H. Demirsoy, Tiziana Squillaro, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi
Summary: The study demonstrated that multi-lineage stem cells can be isolated from a mouse model, offering a valid alternative for disease research and cell therapy, and showing potential applications for these cells.
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Lei Qi, Weiwen Ge, Cancan Pan, Weidong Jiang, Dan Lin, Lei Zhang
Summary: Stem cell senescence causes functional declines and disrupts bone environment homeostasis. Stem cell-derived exosomes are a promising therapy for aging-related osseous diseases. This study demonstrates the potential of osteoinductive exosomes in bone repair for aging individuals and highlights the importance of considering endocytic mechanisms and avoiding negative effects in future therapeutic design for aging populations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Duaa Abuarqoub, Sofia Adwan, Rand Zaza, Suha Wehaibi, Nazneen Aslam, Hanan Jafar, Nidal Qinnah, Abdalla Awidi
Summary: Diabetes Mellitus Type 1 is an autoimmune disease that destroys insulin-producing cells, leading to hyperglycemia. This study examined the differentiation potential of dental stem cells (SCAP) and bone-marrow-derived stem cells (BM-MSCs) into functional islet cell aggregates (ICAs). The results showed that both types of stem cells successfully differentiated into beta-cell-like cells.
Article
Endocrinology & Metabolism
Fei Xiao, Jianping Peng, Yang Li, Xing Zhou, Ding Ma, Liming Dai, Jie Yuan, Xiaodong Chen, Chuandong Wang
Summary: This study investigated the cellular senescence mechanism of BMSCs and identified the expression changes of small noncoding RNAs during the senescence process, providing potential clues for developing new targeting senescence strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrea Sorrentino, Emil Malucelli, Francesca Rossi, Concettina Cappadone, Giovanna Farruggia, Claudia Moscheni, Ana J. Perez-Berna, Jose Javier Conesa, Chiara Colletti, Norberto Roveri, Eva Pereiro, Stefano Iotti
Summary: Biomineralization is the process by which living organisms generate organized mineral crystals, especially in human cells the mechanism and propagation of the mineral remain largely unexplained and controversial. This study provides insight into the calcium depositions in human bone mesenchymal stem cells, suggesting a potentially redefined model for biomineralization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Yongbo Li, Zhe Tan, Jixiang Zhang, Junhan Mu, Han Wu
Summary: In this study, nano-deer bone meal was successfully prepared and found to have a higher Ca/P ratio and enriched beneficial trace elements compared to cow bone. The nano-deer bone meal showed good biocompatibility and met the standards of medical biomaterials. Cell function studies demonstrated its excellent performance in the proliferation and differentiation of bone marrow mesenchymal stem cells. These findings suggest the potential use of nano-deer bone meal as an active nanomaterial in bone tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Guangyue Li, Leilei Zheng, Jinlin Song
Summary: This study investigated the effects of AGEs on BMSCs and elucidated the role of m(6)A modification in diabetes-associated periodontitis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Cui Zhang, Shali Wu, Erman Chen, Luyang Yu, Jinfu Wang, Mengrui Wu
Summary: This study reveals that the lncRNA AC132217.4 plays a critical role in BMSC osteogenesis, promoting the development and function of osteoblasts. AC132217.4 interacts with IGF2 mRNA to regulate its expression and activate the AKT pathway, thereby controlling osteoblast maturation and function. Additionally, the splicing factors SC35 and HNRNPA1 are involved in the biogenesis of AC132217.4, while the transcription factor ALX1 regulates the expression of AC132217.7 to promote osteogenesis. In vivo over-expression of AC132217.4 significantly promotes bone healing in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Poonam Meena, Vishal Nemaysh, Manisha Khatri, Apra Manral, Pratibha Mehta Luthra, Manisha Tiwari
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Chemistry, Medicinal
Jitendra Kumar, Poonam Meena, Anju Singh, Ehtesham Jameel, Mudasir Maqbool, Mohammad Mobashir, Ashutosh Shandilya, Manisha Tiwari, Nasimul Hoda, B. Jayaram
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Neurosciences
Apra Manral, Poonam Meena, Vikas Saini, Fouzia Siraj, Shruti Shalini, Manisha Tiwari
NEUROTOXICITY RESEARCH
(2016)
Article
Chemistry, Multidisciplinary
Poonam Meena, Apra Manral, Vishal Nemaysh, Vikas Saini, Fouzia Siraj, Pratibha Mehta Luthra, Manisha Tiwari
Article
Chemistry, Medicinal
Ehtesham Jameel, Poonam Meena, Mudasir Maqbool, Jitendra Kumar, Waqar Ahmed, Syed Mumtazuddin, Manisha Tiwari, Nasimul Hoda, B. Jayaram
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Pharmacology & Pharmacy
Vikas Saini, Apra Manral, Rashi Arora, Poonam Meena, Siddharth Gusain, Daman Saluja, Manisha Tiwari
PHARMACOLOGICAL REPORTS
(2017)
Article
Neurosciences
Poonam Meena, Apra Manral, Vikas Saini, Manisha Tiwari
NEUROTOXICITY RESEARCH
(2015)