Article
Cell Biology
Jiro Miyamae, Masaharu Okano, Fumihiko Katakura, Jerzy K. Kulski, Tadaaki Moritomo, Takashi Shiina
Summary: Polymorphisms and genetic diversity of DLA-88, DLA-12/88L, and DLA-DRB1 loci were examined in 829 dogs of 59 breeds in Japan. Multiple alleles and various 88-12/88L-DRB1 haplotypes were detected. The findings suggest that high DLA homozygosity rate and low DLA diversity within a breed are beneficial for transplantation therapy but may affect biological fitness as homozygosity progresses.
Article
Biochemistry & Molecular Biology
M. Cortazar-Chinarro, A. Richter-Boix, P. Rodin-Morch, P. Halvarsson, J. B. Logue, A. Laurila, J. Hoglund
Summary: Microbiomes play a crucial role in determining the ecology and behavior of their hosts. This study investigated the effects of geography, evolutionary history, and host genetics on the skin microbiome diversity and structure in a widespread amphibian. The results showed that microbiome diversity was correlated with host genetic diversity, and the bacterial community composition varied between geographical clusters and specific host genetic variations.
Article
Biochemistry & Molecular Biology
Zhixuan Loh, Xuelu Huan, Sunita Awate, Markus Schrittwieser, Laurent Renia, Ee Chee Ren
Summary: This study characterizes a single MHC-I gene in Asian seabass and reveals its role in immune responses and similarities with other species. The findings provide new tools for studying fish immune responses to pathogen infections and the phylogeny and evolution of antigen-specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Valery Cheranev, Irina Bulusheva, Valery Vechorko, Dmitriy Korostin, Denis Rebrikov
Summary: HLA genes are important in the immune response to COVID-19 infection. High-resolution sequencing of HLA genes revealed notable alleles and haplotypes associated with COVID-19 outcome. These findings could be potential markers for triage in hospital admission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Biswanath Patra, Manjit Panigrahi, Harshit Kumar, Kaiho Kaisa, Triveni Dutt, Bharat Bhushan
Summary: This study investigated the polymorphism of the MHC class I (BoLA-A/BuLA-A) gene in Sahiwal, Jersey, Hariana, and Tharparkar breeds of cattle, as well as Murrah, Mehsana, and Bhadawari breeds of buffalo. The results revealed that the MHC class I gene in buffalo has a higher level of nucleotide changes compared to cattle, indicating a higher degree of polymorphism in buffalo at the nucleotide level.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Genetics & Heredity
Paola Mendoza-Ramirez, Mildred Alejandra Lopez-Olaiz, Adriana Lizeth Morales-Fernandez, Maria Isabel Flores-Echiveste, Antonio de Jesus Casillas-Navarro, Marco Andres Perez-Rodriguez, Felipe de Jesus Orozco-Luna, Celso Cortes-Romero, Laura Yareni Zuniga, Maria Guadalupe Sanchez Parada, Luis Daniel Hernandez-Ortega, Arieh Roldan Mercado-Sesma, Raul C. Baptista-Rosas
Summary: This study identified 10 novel nucleotide variants associated with T2D in the Mexican population, providing insights into the role of MHC Class I polymorphisms in the development of T2D.
Review
Genetics & Heredity
Chester A. Alper
Summary: This review discusses the history and development of CEHs, focusing on complement, haplotypes, and the MHC. It highlights the genetic factors associated with diseases like type 1 diabetes and the concept of CEHs in understanding complex genetic traits.
FRONTIERS IN GENETICS
(2021)
Article
Veterinary Sciences
Navapon Techakriengkrai, Teerawut Nedumpun, William T. Golde, Sanipa Suradhat
Summary: This study characterized the SLA class I and II diversities in commercial pig populations, finding a moderate level of diversity despite performance-oriented breeding schemes. Common SLA class I alleles included SLA-1*08:XX, SLA-2*02:XX, and SLA-3*04:XX, while common class II alleles were DRB1* 04:XX, DQB1*02:XX, and DQA*02:XX. The study also identified common haplotypes in the population, with LR-22.15 being the most predominant.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Oncology
Natalia Aptsiauri, Federico Garrido
Summary: HLA class I molecules play a crucial role in tumor recognition and T cell-mediated elimination, and loss of tumor HLA class I expression reduces antigen presentation and facilitates cancer immune evasion. This review summarizes the current advances in understanding the mechanisms of MHC/HLA class I alterations during tumor progression and highlights the importance of detecting and correcting tumor HLA expression absence to improve immunotherapy protocols.
CLINICAL CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Shidi Qin, Peter O. Dunn, Yang Yang, Hongyi Liu, Ke He
Summary: Our study revealed a stronger positive selection on exon 2 of MHC class I in ducks, indicating a potentially greater diversity in immune genetics influenced by pathogen selection. The high similarity in immune genetic polymorphism among four Anas species suggested a shared evolutionary history of at least 10 million years.
Article
Biochemical Research Methods
Laura C. Demmers, Wei Wu, Albert J. R. Heck
Summary: HLA molecules play critical roles in the adaptive immune system by presenting small peptides to signal cell health status to the immune system. This study investigated the adaptive response of a B lymphoblastic cell line to high temperature treatment, revealing potential preparations for immune-like responses in the absence of invading pathogenic peptides. The findings suggest intriguing temperature-sensitive adaptations in this particular B cell line.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Biochemical Research Methods
Raphael Trevizani, Zhen Yan, Jason A. Greenbaum, Alessandro Sette, Morten Nielsen, Bjoern Peters
Summary: An approach to assess the reliability of different metrics for evaluating the performance of MHC class I binding predictors was developed. The study found that using percentile-ranked results improved the stability of the ranks and identified the top-performing tools in the benchmark.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Clinical Neurology
Shuqiong Zheng, Jia Guo, Qianqian Xin, Hanga Galfalvy, Youran Ye, Na Yan, Rongrong Qian, J. John Mann, Enze Li, Xiang Xue, Honglei Yin
Summary: This study investigated the association of EPHX2 and P2X2 polymorphisms and mRNA expression with depression and suicidal behavior, as well as the mediating role of cognition in these associations. The results showed that cognitive function played a significant mediator role in the genetic effect on depression. The rs202059124 C allele was associated with increased depression risk, and P2X2 mRNA expression was related to depression. Furthermore, a haploblock (rs9331942 and rs2279590) was associated with suicide attempts. These findings suggest that EPHX2 and P2X2 genes are implicated in depression and suicidal behavior.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Nina Geng, Tuo Hu, Chunbo He
Summary: Immune checkpoint blockade therapies show durable responses in a subset of colorectal cancer patients, but the majority do not respond. Our study suggests that DDX60 may regulate MHC-I expression in colorectal cancer, and targeting DDX60 could potentially improve the efficacy of immunotherapy.
Review
Biochemistry & Molecular Biology
Akhil Shukla, Maryse Cloutier, Madanraj Appiya Santharam, Sheela Ramanathan, Subburaj Ilangumaran
Summary: The immune system constantly monitors and eliminates cancerous cells, with CD8(+) cytotoxic T lymphocytes playing a key role in tumor cell killing. Cancer cells evade immune surveillance by downregulating MHC-I and key proteins of the antigen processing and presentation machinery. NLRC5 has been identified as the key transcriptional activator of MHC-I and APM genes, and genetic lesions and epigenetic modifications of NLRC5 are common causes of MHC-I defects in cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Multidisciplinary
WenWu Wang, Ping Yu, Yuejin Zhou, Tiejun Tong, Zhonghua Liu
Summary: In this paper, the authors focused on the mediation test based on the indirect effect in social and behavioral sciences. They examined the difference method and the product method in mediation models and demonstrated their equivalence in various scenarios. The authors also provided insights on the empirical distributions of indirect effect estimators and introduced popular R packages for mediation analysis.
CURRENT PSYCHOLOGY
(2023)
Article
Immunology
Xiaofang Lu, Yong Wang, Ying Ma, Dong Huang, Yuying Lu, Xiang Liu, Ruijia Zhou, Ping Yu, Lei Zhang, Jianlin Chen, Rong Lu, Fuyan Wang
Summary: This study reveals the involvement of MDSCs in the immune escape mechanism of C. trachomatis mediated by YAP1. The proportion of MDSCs increases, while the proportion of CD4+T and CD8+T cells decreases after C. trachomatis infection. The upregulation of Arg-1 and iNOS in MDSCs, as well as YAP1 in host cells, is observed. Inhibition of YAP1 leads to the inhibition of C. trachomatis growth.
IMMUNOLOGY LETTERS
(2022)
Article
Engineering, Multidisciplinary
Jie Cao, Jialin Ma, Dailin Huang, Ping Yu
Summary: In this paper, a neural architecture search network algorithm called NAS-PERIRB is proposed to simplify the design of deep learning network structures, with the use of Pareto efficiency reward and insert replay buffer. The algorithm improves training efficiency by employing early stopping and insert replay buffer techniques. Evaluation on two datasets demonstrates that the NAS-PERIRB achieves 99% accuracy in various situations, indicating its capability in independently designing network structures.
Article
Geriatrics & Gerontology
Jiaying Zheng, Ping Yu, Xueping Chen
Summary: Active game play can significantly improve the quality of life and alleviate depression in older people with dementia, but has no significant effect on cognitive status.
CLINICAL GERONTOLOGIST
(2022)
Article
Geriatrics & Gerontology
Yunshu Zhu, Ting Song, Zhenyu Zhang, Chao Deng, Mohammad Alkhalaf, Wanqing Li, Mengyang Yin, Hui Chen (Rita) Chang, Ping Yu
Summary: This study used artificial intelligence technologies to analyze the prevalence of agitated behaviors in people with dementia in residential aged care facilities in Australia. A total of 59 observable agitated behaviors were found. No significant differences were found in agitation prevalence between genders or facility types. Multiple coexisting agitated behaviors were found in a high percentage of dementia patients, indicating a heavy caregiver burden in these facilities. Improving caregiver training and care models are urgently needed for the sustainability of dementia care in residential aged care facilities.
JOURNAL OF GERONTOLOGICAL NURSING
(2022)
Article
Integrative & Complementary Medicine
Yuangeng Li, Ping Yu, Wenwen Fu, Shuo Wang, Wenjun Zhao, Yue Ma, Yi Wu, Heming Cui, Xiaofeng Yu, Li Fu, Huali Xu, Dayun Sui
Summary: Ginsenoside Rd protects against carbon tetrachloride-induced acute liver injury by inhibiting ferroptosis and activating the cGAS/STING pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Management
Haiyan Yu, Ching-Chi Yang, Ping Yu
Summary: Diabetic patients require personalized treatments, and stratifying patients into sub-classes can help determine the optimal treatment for each group. However, challenges arise in conducting counterfactual inference and dealing with confounding effects of covariates. To address these challenges, a method called COSTAR is proposed, which uses constrained optimization to find the optimal treatment considering missing outcomes and covariate balance constraints. Experimental results with real-world data show that COSTAR outperforms related methods in reducing hospital readmission rates within 30 days and provides robust estimation of mean treatment response in each sub-class.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Yiqin Hu, Xinbo Lu, Wanjun Zheng, Luting Wang, Ping Yu
Summary: In daily decision-making, the human brain is modulated by the prefrontal cortex (PFC), particularly the dorsolateral prefrontal cortex (DLPFC), in risk and ambiguity decision-making. Through the use of transcranial direct current stimulation (tDCS), researchers revealed the causal relationship between the DLPFC and ambiguity decision-making. The study showed that the left DLPFC stimulation had a significant effect on ambiguity to loss, while its effect on ambiguity to gain was insignificant, and the right DLPFC stimulation had an insignificant effect on both ambiguity to gain and ambiguity to loss. Furthermore, participants who received anodal stimulation in the left DLPFC showed a lower degree of attitudes toward ambiguity loss, suggesting a strong aversion to ambiguity loss after the stimulation.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychology, Multidisciplinary
Yue Xie, Yue Ren, Changmin Niu, Ying Zheng, Ping Yu, Lin Li
Summary: Approximately 53.08% to 64% of female infertility patients worldwide are affected by the stigma of not giving birth to children. This stigma not only harms the mental health of these patients, but also affects their quality of life, leading to adverse social consequences such as domestic violence, marriage breakdown, and delay in receiving treatment. Therefore, it is crucial to understand the stigma experienced by these patients and develop effective interventions to alleviate it.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Engineering, Mechanical
Xianjun Du, Wenchao Jia, Ping Yu, Yaoke Shi, Bin Gong
Summary: In order to address the issues of insufficient feature extraction and loss of key features in the process of traditional convolutional neural network (CNN) based remaining life prediction of bearings, a CNN prediction model based on global attention mechanism (GAM) is proposed to accurately predict the remaining useful life (RUL) of bearings.
JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING
(2023)
Article
Plant Sciences
Eme Eseme John, Thomas Astell-Burt, Ping Yu, Chris Brennan-Horley, Xiaoqi Feng
Summary: This study investigates the association between different types of green spaces and a person's healthy aging score (HAS) through two years of continuous exposure. The findings suggest that for women who did not relocate, their functional capacity is lower but resilience is higher compared to those who relocated. For participants who did not relocate, 30% grass cover is associated with decreased functional capacity and HAS, while 5-9% low-lying vegetation is associated with a decline in functional capacity and HAS but improved resilience. Green spaces with over 30% tree canopy appear to be most beneficial for functional capacity, resilience, and HAS.
URBAN FORESTRY & URBAN GREENING
(2023)
Article
Health Care Sciences & Services
Mohammad Alkhalaf, Zhenyu Zhang, Hui-Chen (Rita) Chang, Wenxi Wei, Mengyang Yin, Chao Deng, Ping Yu
Summary: This study explores the risk factors for malnutrition among older people in residential aged care facilities using natural language processing (NLP) techniques. The research demonstrates the importance of NLP technology in uncovering key information about health risks for older people. It identifies that 33% of older people suffer from malnutrition and suggests that NLP can be applied to predict other health risks in this setting.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Emergency Medicine
Belinda Munroe, Kate Curtis, Margaret Fry, Sharyn Balzer, Panchalee Perara, Tracey Couttie, Karlie Royston, Ping Yu, Natasha Tidswell, Julie Considine
Summary: This study aims to evaluate the impact of implementing the Emergency Department Clinical Emergency Response System (EDCERS) on inpatient deterioration events and identify causal factors. The results demonstrate that EDCERS implementation reduces the number of inpatient deterioration events within 72 hours of emergency admission. However, there is no overall change in the rate of inpatient deterioration events. Therefore, this study supports the wider implementation of rapid response systems in the emergency department to improve the management and outcomes of deteriorating patients.
AUSTRALASIAN EMERGENCY CARE
(2023)
Article
Health Policy & Services
Eme Eseme John, Thomas Astell-Burt, Ping Yu, Chris Brennan-Horley, Xiaoqi Feng
Summary: This paper examines the factors influencing healthy ageing and constructs a healthy ageing score. Eight of the 13 health domains, including physical functioning, cognitive function, mental health, etc., were found to be crucial for ageing well. The developed healthy ageing score ranges from 0 to 16, with higher scores indicating a healthier ageing profile.
HEALTH PROMOTION INTERNATIONAL
(2023)
Review
Health Care Sciences & Services
Ping Yu, Hua Xu, Xia Hu, Chao Deng
Summary: Generative artificial intelligence and large language models have the potential to revolutionize data and information management in healthcare. This study provides guidance on integrating these technologies into medical practices, highlighting their distinct mechanisms and the opportunities and challenges they present. Continued innovation and adherence to ethical and legal guidelines are crucial for realizing the full potential of these technologies.
