Article
Immunology
Chiara Tersigni, Donatella Lucchetti, Rita Franco, Filomena Colella, Caterina Neri, Laura Crispino, Alessandro Sgambato, Antonio Lanzone, Giovanni Scambia, Manu Vatish, Nicoletta Di Simone
Summary: PE is a common pregnancy disorder characterized by hypertension and proteinuria, with aberrant expression of HLA-DR in STBEVs specifically associated with PE. Further studies are needed to define the role of abnormal placental HLA-DR expression in PE pathogenesis and evaluate the potential application of detecting circulating HLA-DR positive STBEVs in diagnosing and predicting PE in early and mid-pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Monika Zaborek-Lyczba, Jakub Lyczba, Paulina Mertowska, Sebastian Mertowski, Anna Hymos, Martyna Podgajna, Paulina Niedzwiedzka-Rystwej, Ewelina Grywalska
Summary: HLA-G, a non-classical MHC class I molecule, has been studied for its relevance in pathological conditions like autoimmune diseases. Current research aims to utilize HLA-G in clinical practice for diagnostics and therapeutic purposes, as it is known for its immunomodulatory role in reducing inflammation and immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Xiaoyan Chen, Jun Zhang, Qiao Xu, Zhaoming Liu, Jun Chen, Yong Yang, Wei Zhou
Summary: This study investigated the relevance of HLA-G 3' UTR polymorphisms with the risk of recurrent miscarriage (RM) through a combined meta-analysis. The results showed that specific HLA-G 3' UTR variants, including the 14 bp insertion allele, rs1063320 G allele, rs1710 G allele, and rs9380142 A allele, were associated with an increased or decreased risk of RM in different populations. However, further research is needed to validate these findings and eliminate potential biases.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2022)
Article
Immunology
Shihang Zhou, Ming Liu, Yuexin Xia, Li Zhang, Linnan Shao, Ni Wang, Weijian Yu, Nan Ding, Kaili Zhang, Xiaohua Liang
Summary: This study found an association between HLA-G 3'UTR polymorphisms and the susceptibility to chronic hepatitis C infection in the Chinese population. Specific UTR haplotypes showed significant associations with chronic hepatitis C.
Review
Immunology
Lian Hu, Dongmei He, Hong Zeng
Summary: HLA-G plays a central role in immune tolerance at the maternal-fetal interface and its polymorphism is associated with sHLA-G expression and the risk of recurrent implantation failure (RIF). However, the association of HLA-G polymorphisms with RIF in the general population is unclear and may vary among different ethnic backgrounds. Future studies should consider a combined genetic effect to confirm the association of HLA-G polymorphisms and sHLA-G expressions in relation to RIF.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Vladimira Durmanova, Kristina Kluckova, Barbora Filova, Gabriel Minarik, Jan Kozak, Boris Rychly, Marian Svajdler, Viktor Matejcik, Juraj Steno, Maria Bucova
Summary: This study analyzed the association between HLA-G 5 ' URR variants and risk of developing gliomas. The results showed that certain HLA-G 5 ' URR variants were more frequent in glioma patients and tended to be associated with early onset of the disease. These findings suggest a possible genetic association between HLA-G 5 ' URR variants and glioma development and contribution to disease pathology.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Virology
Zepei Feng, Peng Huang, Jinwei Zhang, Xueshan Xia, A-mei Zhang, Tian Zeng, Qiong Chen, Chuanlong Zhu, Weilong Tan, Yun Zhang, Ming Yue
Summary: The genetic variants of KIR2DL4 and HLA-G are associated with susceptibility to hepatitis C virus infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Wei Bai, Zhi Lin, Jin Ye, Linshuang Zhou, Jingqiao Xi, Wenpin Cai
Summary: Polymorphisms in the 3'UTR of the HLA-G gene are associated with the development of URSA and may serve as predictors of pregnancy outcome.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Immunology
Hidefumi Inaba, Shuhei Morita, Daisuke Kosugi, Yuki Asai, Yosuke Kaido, Saya Ito, Tomonao Hirobata, Gen Inoue, Yuki Yamamoto, Masatoshi Jinnin, Hiroaki Kimura, Masao Ota, Yuko Okudaira, Hiroyasu Nakatani, Tomoko Kobayashi, Shintaro Iwama, Hiroshi Arima, Takaaki Matsuoka
Summary: Immune-checkpoint inhibitors are effective in various advanced cancers, but the immunological mechanism behind the serious complication of ICI-T1DM is unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Bruna Miglioranza Scavuzzi, Vincent van Drongelen, Joseph Holoshitz
Summary: Human leukocyte antigens (HLA) are important genetic risk factors in many diseases, but the mechanisms underlying their associations remain unclear. The MHC Cusp theory posits that in addition to antigen presentation, MHC codes for allele-specific molecules that can trigger MHC-associated diseases through interactions with receptors. Empirical evidence has supported this theory in several HLA-Class II-associated autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Shuyi Zhong, Hejiang Wei, Mao Li, Yanhui Cheng, Simin Wen, Dayan Wang, Yuelong Shu
Summary: This study found an association between HLA single nucleotide polymorphisms and antibody response to influenza vaccine, which can help in understanding the varied responsiveness to the vaccine in different populations.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Jiro Miyamae, Masaharu Okano, Kohei Nishiya, Fumihiko Katakura, Jerzy K. Kulski, Tadaaki Moritomo, Takashi Shiina
Summary: By analyzing the DNA sequences of the DLA class I genomic region in dogs, this study discovered that DLA-88L is a hybrid gene formed by interlocus and/or intralocus gene conversion between DLA-88 and DLA-12. It was also found that at least one DLA-12 allele is generated through interlocus gene conversion. These findings suggest that intralocus gene conversion plays an important role in expanding DLA allelic variations.
Article
Obstetrics & Gynecology
Cui Ma, Yuanyuan Zheng, Xiaowei Liu, Weiyuan Zhang
Summary: The study revealed that pregnant women with PE had increased gravidity, higher BMI before delivery, reduced neonatal weight, gestational weeks, and placental weight, as well as a higher proportion of cesarean section. Significant differences in SNPs were found at locus 29794467, 29796376, and 29799440 between the PE group and the control group. In locus 29799440, patients with genotype CC had a lower risk of PE compared to patients with genotype TT, while there was no significant difference in PE risk between patients with genotype CT and TT.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Medicine, General & Internal
Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen
Summary: Sjogren's syndrome is characterized by lymphocytic infiltration and dysfunction of salivary and lacrimal glands. Studies have shown a significant genetic correlation between specific risk HLAs and SjS, with HLA-DRB1*0301 being particularly influential. The specific autoantigens attributed to SjS and the epitopes presented by HLA-DRB1*0301 remain elusive, requiring further research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Simon Jasinski-Bergner, Dominik Schmiedel, Ofer Mandelboim, Barbara Seliger
Summary: This review provides a summary of the expression, regulation, function, and impact of HLA-G in the context of different viral infections, including virus-associated cancers. It emphasizes the potential use of HLA-G as a novel diagnostic and prognostic biomarker for viral infections, as well as a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Katrine Praetorius, Stine Kjaer Urhoj, Anne-Marie Nybo Andersen
Summary: The aim of this study was to investigate the association between parental socio-economic position and the onset of type 1 diabetes in offspring. Analysis of individual data from the entire Danish population showed no clear pattern in type 1 diabetes risk according to parental educational attainment or household income.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Julie Bergeron, Luise Cederkvist, Isabel Fortier, Naja Hulvej Rod, Per Kragh Andersen, Anne-Marie Nybo Andersen
Summary: This study found that maternal life stress and emotional distress during pregnancy are associated with gestational age at birth, and pregnancy-related stress is the main driver of this association.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Isabel Fortier, Tina W. Wey, Julie Bergeron, Angela Pinot de Moira, Anne-Marie Nybo-Andersen, Tom Bishop, Madeleine J. Murtagh, Milica Miocevic, Morris A. Swertz, Esther van Enckevort, Yannick Marcon, Michaela. Th. Mayrhofer, Jos Pedro Ornelas, Sylvain Sebert, Ana Cristina Santos, Artur Rocha, Rebecca C. Wilson, Lauren E. Griffith, Paul Burton
Summary: Optimizing research on the developmental origins of health and disease involves harmonizing and integrating existing cohort study data to achieve comparability and reusability. This is crucial for comparison and validation across different studies.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Obstetrics & Gynecology
Trine Damsted Rasmussen, Sarah Fredsted Villadsen, Anne Vinkel Hansen, Laust H. Mortensen, Claus Thorn Ekstrom, Signe Smith Jervelund, Anne-Marie Nybo Andersen
Summary: This study evaluated the impact of the MAMAACT antenatal care intervention on perinatal health outcomes and reducing ethnic and social disparities in Denmark. The intervention, which included training for midwives, dialogue meetings, and health education materials, did not improve the overall composite perinatal mortality and morbidity outcome. Contextual factors, such as organizational barriers in antenatal care, may have hindered the effectiveness of the intervention.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Pharmacology & Pharmacy
Trine Lauritzen, John Munkhaugen, Kari Peersen, Oscar Kristiansen, Elise Sverre, Shane D. Nebauer, Maja Villseth, Anders M. Andersen, Anja Camilla Svarstad, Elena Prunes Jensen, Stein Bergan, Einar Husebye, Nils Tore Vethe
Summary: Self-perceived statin-associated muscle symptoms (SAMS) are common but mostly not related to the drug itself. The study aimed to determine the correlation between atorvastatin metabolites in blood and skeletal muscle, and if genetic variants of statin transporters influence this relationship. Muscle symptoms were examined in patients with coronary disease during treatment with atorvastatin 40 mg/day and placebo. The study found strong correlations between muscle and blood plasma concentrations of atorvastatin metabolites, suggesting that blood measurements can reflect muscle tissue exposure. The relationship between atorvastatin metabolites in blood and SAMS warrants further investigation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Mathilde Klinte, Asmund Hermansen, Anne-Marie Nybo Andersen, Stine Kjaer Urhoj
Summary: Parental cancer and income loss during childhood have a negative impact on the child's socioeconomic position in early adulthood, with an increased risk of low education and lower income at age 30 years for those who experienced both.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Medicine, General & Internal
Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrom, Thorkild I. A. Sorensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot de Moira, Barbara Heude, Carmen Iniguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg-Larsen, Loreto Santa-Marina, Lucinda Calas, Luise Cederkvist, Maja Popovic, Marie-Aline Charles, Marieke Welten, Martine J. Vrijheid, Meghan Azad, Padmaja Subbarao, Paul Burton, Puishkumar J. Mandhane, Rae-Chi Huang, Rebecca C. Wilson, Sido Haakma, Silvia Fernandez-Barres, Stuart Turvey, Susana Santos, Suzanne C. Tough, Sylvain Sebert, Theo J. Moraes, Theodosia Salika, Vincent W. V. Jaddoe, Deborah A. Lawlor, Anne-Marie Nybo Andersen
Summary: This study found that gestational age is positively associated with body size in infancy, but the association weakens with age. By adolescence, preterm individuals have a similar mean BMI to those born at term.
Article
Andrology
Mette Moller Dornfeldt, Anne-Marie Nybo Andersen, Karin Sorig Hougaard, Cecilia Host Ramlau-Hansen, Gunnar Toft, Jens Peter Ellekilde Bonde, Katia Keglberg Haervig, Kajsa Ugelvig Petersen, Ane Berger Bungum Kofoed, Laura Deen, Sandra Sogaard Tottenborg
Summary: A study found no strong associations between maternal fever during pregnancy and male reproductive health in young men, including timing, duration, and temperature of the fever. Concurrent use of antipyretics and antibiotics did not modify the association.
Article
Obstetrics & Gynecology
Anne K. Ortqvist, Maria C. Magnus, Anna J. M. Aabakke, Stine Kjaer Urhoj, Anne Vinkel Hansen, Anne-Marie Nybo Andersen, Lone Krebs, Karin Pettersson, Siri E. Haberg, Olof Stephansson
Summary: This study aimed to explore the characteristics of pregnant women admitted to the ICU with severe COVID-19, including maternal factors, pregnancy outcomes, vaccination status, and virus variants. The results showed that unvaccinated pregnant women of non-Scandinavian origin and lower socioeconomic status were at higher risk of ICU admission. Additionally, pregnant women admitted to the ICU for COVID-19 had a higher risk of adverse pregnancy outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Correction
Environmental Sciences
Jonathan Groot, Amelie Keller, Marie Pedersen, Torben Sigsgaard, Steffen Loft, Anne-Marie Nybo Andersen
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Marie Pedersen, Shuo Liu, Jiawei Zhang, Zorana Jovanovic Andersen, Jorgen Brandt, Esben Budtz-Jorgensen, Klaus Bonnelykke, Lise Marie Frohn, Anne-Marie Nybo Andersen, Matthias Ketzel, Jibran Khan, Leslie Stayner, Bert Brunekreef, Steffen Loft
Summary: This study found that early-life exposure to ambient air pollution increases the risk of childhood asthma.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Public, Environmental & Occupational Health
Frederikke Lihme, Saima Basit, Lucca Katrine Sciera, Anne-Marie Nyboe Andersen, Henning Bundgaard, Jan Wohlfahrt, Heather A. Boyd
Summary: A study found that parents of daughters with preeclampsia have an increased risk of cardiovascular disease. The risk was 1.19 times higher in parents with one daughter with preeclampsia compared to parents without daughters with preeclampsia.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Angela Pinot De Moira, Neil Pearce, Marie Pedersen, Anne-Marie Nybo Andersen
Summary: This study explored factors that may modify associations of early-life animal exposure with asthma and allergic disease, and found that type of animal, source of exposure, parental history of asthma or allergy, and timing of exposure can modify these associations. It is important to consider these factors when assessing the risks associated with early-life animal exposure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Johan L. L. Vinther, Claus T. T. Ekstrom, Thorkild I. A. Sorensen, Luise Cederkvist, Deborah A. A. Lawlor, Anne-Marie Nybo Andersen
Summary: Preterm birth is associated with smaller body dimensions at birth with unclear impact on BMI and height in later life. A prospective cohort study on Danish singletons born between 1996 and 2003 showed that the BMI difference between preterm and term children decreased with age, becoming insignificant in adolescence. Though the height difference decreased during childhood, preterm individuals remained slightly shorter than term peers in adolescence.
SCIENTIFIC REPORTS
(2023)
Correction
Medicine, General & Internal
Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrom, Thorkild I. A. Sorensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot de Moira, Barbara Heude, Carmen Iniguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg-Larsen, Loreto Santa-Marina, Lucinda Calas, Luise Cederkvist, Maja Popovic, Marie-Aline Charles, Marieke Welten, Martine Vrijheid, Meghan Azad, Padmaja Subbarao, Paul Burton, Puishkumar J. Mandhane, Rae-Chi Huang, Rebecca C. Wilson, Sido Haakma, Silvia Fernandez-Barres, Stuart Turvey, Susana Santos, Suzanne C. Tough, Sylvain Sebert, Theo J. Moraes, Theodosia Salika, Vincent W. V. Jaddoe, Deborah A. Lawlor, Anne-Marie Nybo Andersen